관절함몰형 종골 골절에 대한 다공성 하이드록시 아파타이트를 이용한 수술적 치료

최의성,김용민,김동수,손현철,박경진,조병기,박지강,유준일,Choi, Eui-Sung,Kim, Yong-Min,Kim, Dong-Soo,Shon, Hyun-Chul,Park, Kyoung-Jin,Cho, Byung-Ki,Park, Ji-Kang,Yoo, Jun-Il 대한족부족관절학회 2010 대한족부족관절학회지 Vol.14 No.1

Purpose: This study was performed to evaluate the clinical outcomes of operative treatment using porous hydroxyapatite for intraarticular calcaneal fracture of joint depression type. Materials and Methods: Twenty patients with intraarticular calcaneal fracture were followed up for more than 1 year. The period to union was calculated to evaluate the osteoconductivity of porous hydroxyapatite used as bone graft substitute. The measurement of Bohler angle, Gissane angle and the degree of articular surface depression was performed through preoperative and postoperative radiographs. The clinical evaluation was performed according to hindfoot score of the American Orthopaedic Foot and Ankle Society (AOFAS) and scale of the Creighton-Nebraska health foundation (CNHF). Results: Bohler angle and Gissane angle had improved significantly from preoperative average $10.4^{\circ}$, $117.8^{\circ}$ to average $22.6^{\circ}$, $113.5^{\circ}$ immediate postoperatively, and had maintained to average $21.2^{\circ}$ and $114.4^{\circ}$ at the last follow-up. The degree of articular surface depression had improved significantly from preoperative average 4.8 mm to 1.5 mm at the last follow-up. All cases achieved bone union, and the interval to union was average 12.8 weeks. AOFAS score was average 85.2 points at last follow-up. There were 7 excellent, 10 good, and 3 fair results according to the CNHF scale. Therefore, 17 cases (85%) achieved satisfactory results. Conclusion: Plate fixation using porous hydroxyapatite seems to be one of effective treatment methods for intraarticular calcaneal fracture of joint depression type, because of supporting the reduction of subtalar articulation by augmenting bony defect and facilitating bone formation. Further evaluation about long-term radiological changes and histological analysis on hydroxyapatite implantation site should be required.

트레드밀 순시소비전력 정보를 이용한 보행분석

조현상(Cho, Hyun Sang),김성은(Kim, Sung Eun),유준일(Yoo, Jun Il) 한국정보과학회 2021 한국정보과학회 학술발표논문집 Vol.2021 No.12

8주간의 복합운동이 80세 이상 초고령 여성 노인의 근력 및 신체기능 개선에 미치는 효과

김인규 ( In-gyu Kim ),백경완 ( Kyung-wan Baek ),성창수 ( Changsu Sung ),유준일 ( Jun-il Yoo ),김지석 ( Ji-seok Kim ) 한국운동생리학회(구 한국운동과학회) 2020 운동과학 Vol.29 No.1

PURPOSE: The purpose of this study was to determine whether combined exercise-mediated acquisition on the body composition, muscular strength, blood variables and physical fitness occur in female elderly aged over 80 years. METHODS: Total 63 elderly (Control group, CON, n=36; Exercise group, EXE, n=27) aged between 80 and 90 years participated in this study. EXE group performed combined exercise for an hour at a time, twice a week for 8 week. RESULTS: Body composition was not significantly changed before and after 8-week treatment in both groups. However, systolic blood pressure was increased and HDL-cholesterol was decreased in CON group. Also, muscular strengths in quadriceps femoris, biceps femoris and triceps brachii were significantly decreased in CON group, while there was no statistical change in EXE group. Fasting blood-glucose in EXE group was significantly decreased. Physical-fitness factors determined by senior fitness test were all significantly improved only in EXE group, while there was no change in CON group. These results suggest that combined exercise is very effective prescription in the super-aged elderly. CONCLUSIONS: Combined exercise is very effective prescription in the super-aged elderly. Based on our study, we propose that need to develop various programs using combined exercise for super-aged elderly.

MediaPipe 보행 모델을 활용한 정형외과 질환에 대한 LSTM-Autoencoder 기반 이상탐지

윤혜린(HyeRin Yoon),류승재(SeungJae Ryu),조은아(EunAh Jo),유준일(Jun-Il Yoo),김진현(Jin Hyun Kim) 한국정보과학회 2022 한국정보과학회 학술발표논문집 Vol.2022 No.12

콩잎 추출물의 근위축 개선 효과

최혜영(Hye Young Choi),하영술(Young-Sool Hah),지영호(Yeong Ho Ji),하준영(Jun Young Ha),배환희(Hwan Hee Bae),이동열(Dong Yeol Lee),정원민(Won Min Jeong),정동규(Dong Kyu Jeong),유준일(Jun-Il Yoo),김상곤(Sang Gon Kim) 한국생명과학회 2023 생명과학회지 Vol.33 No.12

골격근량과 근력의 점진적인 감소를 특징으로 하는 근감소증은 고령화 인구에서 중요한 문제이다. 본 연구는 콩잎 추출물(Soybean Leaf extracts, SL)의 덱사메타손으로 유도된 근위축에 대한 치료적 가능성을 세포 및 동물 모델에서 조사하였다. 세포 실험 결과, SL은 C2C12 근섬유의 형태, 밀도 및 크기가 보존되어 통계적으로 유의미한 수준으로 덱사메타손에 의해 유발된 근위축을 완화하는 것으로 나타났다. 또한, SL 처리는 주요 근육 위축 조절 인자인 muscle RING-finger protein-1 (MuRF1)과 muscle atrophy F-box (MAFbx)의 발현을 mRNA 및 단백질 수준 모두에서 유의하게 하향 조절하였다. 마우스 모델에서 SL 투여는 특히 덱사메타손으로 인한 체중 감소와 근육 소모를 상쇄하여 비복근과 전경골근의 근육량을 보존하는 것으로 나타났다. 기능적으로도 SL을 투여한 마우스는 악력과 트레드밀 지구력이 향상되어 근육 성능이 개선되었다. 또한 SL은 골격근에서 근위축 관련 단백질인 MAFbx의 발현을 억제하여 덱사메타손 유도 근위축에 대한 보호 역할을 보여주었다. 이러한 연구 결과를 종합해 볼 때 SL은 근감소증과 같은 근육 소모 질환을 개선할 수 있는 유망한 천연 치료제가 될 수 있음을 시사한다. Sarcopenia, a condition characterized by the insidious loss of skeletal muscle mass and strength, represents a significant and growing healthcare challenge, impacting the mobility and quality of life of aging populations worldwide. This study investigated the therapeutic potential of soybean leaf extract (SL) for dexamethasone (Dexa)-induced muscle atrophy in vitro and in an in vivo model. In vitro experiments showed that SL significantly alleviated Dexa-induced atrophy in C2C12 myotube cells, as evidenced by preserved myotube morphology, density, and size. Moreover, SL treatment significantly reduced the mRNA and protein levels of muscle RING-finger protein-1 (MuRF1) and muscle atrophy F-box (MAFbx), key factors regulating muscle atrophy. In a Dexa-induced atrophy mouse model, SL administration significantly inhibited Dexa-induced weight loss and muscle wasting, preserving the mass of the gastrocnemius and tibialis anterior muscles. Furthermore, mice treated with SL exhibited significant improvements in muscle function compared to their counterparts suffering from Dexa-induced muscle atrophy, as evidenced by a notable increase in grip strength and extended endurance on treadmill tests. Moreover, SL suppressed the expression of muscle atrophy–related proteins in skeletal muscle, highlighting its protective role against Dexa-induced muscle atrophy. These results suggest that SL has potential as a natural treatment for muscle-wasting conditions, such as sarcopenia.

역형 견관절 전치환술 후 발생한 견봉 골절

김동수(Dong-Soo Kim),박경진(Kyoung-Jin Park),김용민(Yong-Min Kim),최의성(Eui-Sung Choi),손현철(Hyun-Chul Shon),조병기(Byung-Ki Cho),유준일(Jun-Il Yoo) 대한정형외과학회 2010 대한정형외과학회지 Vol.45 No.5

역형 견관절 전치환술은 회전근 개 파열 관절병증의 수술적 치료 방법 중의 하나로 최근 그 시술의 빈도가 증가하고 있으나 여러가지 합병증도 보고되고 있다. 저자들은 역 견관절 전치환술 후 발생할 수 있는 아주 드문 합병증인 견봉 골절 l예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Reverse total shoulder arthroplasty is one of the methods of surgical treatment for cuff tear arthropathy Reverse total shoulder arthroplasty is increasingly being performed, but various complications have been reported. We experienced a case of acromion fracture after reverse total shoulder arthroplasty, which is quite a rare complication. So we report on this case along with reviewing the relevant literature.

장애인 건강보건관리사업의 인식도와 중요도 연구: 보건소 지역사회중심재활사업 지원 활성화를 중심으로

이해인(Lee, Hae-In),박정선(Park, Jeong-Sun),최수향(Choi, Soo-Hyang),김희지(Kim, Hee-Ji),김재형(Kim, Jae-Hyung),유준성(Yoo, Jun-Seong),신용일(Shin, Yong-Il) 대한고령친화산업학회 2020 대한고령친화산업학회지 Vol.12 No.2

연구목적 : 본 연구는 경상남도 지역장애인보건의료센터에서 운영하는 장애인 건강보건관리사업의 인식도와 중요도를 조사하고, 보건소 지역사회중심재활사업(Community Based Rehabilitation, CBR)의 지원 활성화 방안을 모색하고자 하였다. 연구방법 : 경상남도 전체 시⋅군 20개 보건소의 CBR사업 담당자 20명을 대상으로 설문조사를 하였다. 통계분석은 SPSS 21.0 프로그램을 사용하였다. 연구결과 : 경상남도 지역장애인보건의료센터의 장애인 건강보건관리사업에 대한 인식도는 보건소 CBR사업연계 및 지원, 의료서비스 연계 및 지원이 가장 높았고, 중요도는 지역사회기반 보건의료-복지 전달체계 구축, 의료서비스 연계 및 지원이 가장 높았다. 장애인 건강보건관리사업의 인식도와 중요도가 대체로 긍정적으로 나타났지만 아직까지 연계현황은 인적⋅물적 자원의 부재, 기관 간 유기적 연계체계 부족 등의 이유로 미흡한 것으로 나타났다. 경상남도 지역장애인보건의료센터의 보건소 CBR사업 지원 활성화를 위해서는 기관 간 협력을 위한 업무 매뉴얼 개발과 관련기관이나 조직 등 공식 적인 연계망 형성이 필요한 것으로 나타났다. 결론 : 경상남도 지역장애인보건의료센터의 장애인 건강보건관리사업 일환으로 기관의 역할을 정비하고, 기관 간 연계 활성화에 대한 근거를 처음으로 제시하였다. Objective : This study investigates the awareness and importance of the healthcare program operated by the Gyeongnam Regional Health & Medical Center for Persons with Disabilities(GDC), and explores options for effectively supporting Community Based Rehabilitation(CBR) in public health centers. Methods : With a questionnaire, we surveyed 20 participants who managed the CBR in Gyeongnam’s public health centers. All analyses were performed using SPSS 21.0. Results : The awareness of the healthcare program in GDC was high in theses areas: linkage and support of CBR, linkage and support medical services. The importance were perceived as high in these areas: development of community based healthcare-welfare delivery system, linkage and support medical services. Although the awareness and importance of GDC was positive, there was not enough linkage status due to the absence of human⋅material resources, the lack of linkage system among institutions. For the GDC to support the CBR more effectively, formal linkage systems for cooperation such as work manuals and organizational networks are needed. Conclusion : This study provides evidence for the first time to support defining roles clearly and increasing the linkage status among institutions of healthcare program in GDC.

덱사메타손 유도 근위축 모델에서 추출 조건에 따른 녹차 추출물의 근감소증 보호 효과

하영술(Young-Sool Hah),조경환(Kyoung Hwan Cho),김은지(Eun Ji Kim),손용휘(Yong-Hwi Son),이정현(Jung Hyeon Lee),이다예(Da Ye Lee),추호진(Ho Jin Choo),서민균(Min Gyun Seo),제회순(Hoe Soon Je),김종철(Jong Cheol Kim),유준일(Jun-Il Yoo) 한국차학회 2020 한국차학회지 Vol.26 No.1

근감소증(Sarcopenia)은 나이가 들면서 동반되는 근육량과 근력의 감소를 말하며, 정상적인 일상 생활을 하는 데 있어 상당한 어려움을 겪게 된다. 고용량 또는 지속적인 글루코코르티코이드 (GCs)의 사용은 근위축 유발할 우려가 있다. 따라서, GC에 의해 발생한 근위축의 치료는 임상적 중요성을 가지고 있다. 천연물에서 유래한 성분으로 수행한 몇몇 연구는 이들 성분이 다양한 근위축 조건에서 근육의 약화 및 위축을 감소시키는데 효과적임을 제시하고 있다. 녹차 추출물(green tea extract, GTE)은 심혈관계질환을 포함하여 광범위한 건강 증진에 기여한다. 하지만 근위축에 미치는 GTE의 효과는 완전히 밝혀지지 않았다. 본 연구는 C2C12 myotubes 및 C57BL/6 마우스에서 덱사메타손에 의해 유도된 근위축에 대하여 여러 가지 추출 조건에서 추출한 GTE의 효과와 기본 메커니즘을 평가하기 위해 시행되었다. 시험관내 실험은 배양된 C2C12 myotube에서 덱사메타손을 처리하여 근위축 상태를 만든 후 실시하였으며 qPCR 및 웨스턴 블롯법을 사용하여 근위축 관련 유전자인 muscle atrophy F-box (MAFbx)의 발현을 비교 분석하였다. 덱사메타손-유도 근위축 마우스 모델은 8주령 C57BL/6 마우스에 고용량 덱사메타손(10 mg/kg body weight, i.p., 14 days)을 투여하여 제작하였다. 체중, 그립 강도, 러닝머신 테스트, 근 무게 및 조직학적 평가를 시행하였다. GTE는 MaFbx의 발현을 감소시켜 C2C12 myotubes에서 덱사메타손-유도 근위축을 억제하였다. 더욱이 덱사메타손에 의해 유도된 근 감소 C57BL/6 마우스에서, GTE(1000 mg/kg) 경구 투여는 러닝머신에서 달리는 시간과 그립 강도를 향상시켜 덱사메타손-유도 근 기능 감소를 어느 정도 회복하였다. 또한 GTE는 전경골근과 비복근의 근 무게와 근섬유 크기 감소를 보호하였다. 이상의 연구결과를 종합해 보면 GTE 소재는 근 감소의 예방 및 개선을 위한 기능성식품용 상업적 소재로서 높은 실용화 가능성을 시사한다. Glucocorticoids (GCs) are negative muscle protein regulators that cause muscle atrophy when used in high doses or after the sustained use of GCs in numerous pathological conditions. Thus, the development of a treatment for GC-induced muscle atrophy has clinical importance. Some natural products effectively prevent muscle loss in several muscle atrophy conditions. Green tea extract (GTE) has a broad range of health benefits, including liver injury, but its effects on muscle atrophy are unclear. In this study, GTE was isolated from different extraction processes, and the protective effect of GTE on dexamethasone (Dexa)-induced atrophy was investigated in C2C12 myotubes and C57BL/6 mice. In vitro experiments were conducted using the Dexa-induced atrophy in cultured C2C12 myotubes and were evaluated by the expression of muscle atrophy F-box (MAFbx) and MyoD using real-time PCR and western blots. Muscle dysfunction was established in male C57BL/6 mice (eight weeks old, n=6) treated with a relatively high dose of Dexa (10 mg/kg body weight, i.p., 14 days). The body weight, grip strength, treadmill test, muscle weight, and muscle histology were assessed. GTE preserved Dexa-induced muscle atrophy in C2C12 myotubes, as indicated by the decreased expression of MAFbx. In Dexa-induced muscle wasting C57BL/6 mice, the 1000 mg/kg GTE treatment rescued Dexa-induced muscle weakness, as indicated by the prolonged running exhaustive time and improved grip strength. GTE also preserved the muscles from gastrocnemius and tibialis anterior muscle mass and muscle fiber cross-sectional area losses. These results suggest that GTE ameliorates Dexa-induced skeletal muscle wasting by regulating MAFbx, which might be developed as a therapeutic agent for the treatment of muscle atrophy and weakness.

석탑구조물의 축조 및 구성형식에 따른 내진성능평가

김호수(Kim, Ho-Soo),홍석일(Hong, Souk-Il),유준(Yoo, Jun),정희범(Joung, Hee-Bum) 대한건축학회 2016 大韓建築學會論文集 : 構造系 Vol.32 No.9

In Korea, the occurrence frequency of earthquakes has recently increased, compared with the past. So, the various damages for cultural properties due to earthquake can be expected, and especially the masonry stone pagoda structure is vulnerable to earthquake. Therefore, the resonable seismic performance evaluation is required to secure the safety for the stone pagoda structure with the various configuration types. To this end, this study classifies the stone pagoda structures according to the construction and configuration types, aspect ratios, and then applies the discrete element method to model and analyze the masonry structures. Finally, the seismic performance is evaluated through the allowable story drifts due to the analysis results considering the various design variables.