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리포폴리사카라이드와 갈락토사민의 투여로 인한 생쥐 치사율에 미치는 글리시라진의 억제효과
오창욱(Chang Wook Oh),송경(Kyung Song),박은전(Eun Jeon Park),손동환(Dong Hwan Sohn),김재백(Jae Baek Kim),고건일(Geon Il Ko) 대한약학회 1996 약학회지 Vol.40 No.1
This study was done to investigate the effect of glycyrrhizin on the lethality induced by galactosamine and lipopolysaccharide coadministration in mice. Glycyrrhizin was injected intravenously as a multiple dose at 20, 15, 10, 5, and O hr before galactosamine and lipopolysaccharide coadministration. Lethality and tumor necrosis factor (TNFalpha) level in serum were surveyed as markers of glycyrrhizin effect. Glycyrrhizin had no effect on the lethality induced by galactosamine and lipopolysaccharide when glycyrrhizin was administered as a single dose. Glycyrrhizin reduced the lethality induced by galactosamine and LPS in dose-dependent manner when glycyrrhizin was administered as a multiple dose at 20, 15, 10, 5 and O hr before galactosamine and lipopolysaccharide coadministration. Glycyrrhizin reduced the serum TNFalpha level.
리포폴리사카라이드와 갈락토사민의 투여로 인한 생쥐 치사율에 미치는 글리시리진의 억제효과
오창욱,송경,박은전,손동환,김재백,고건일 圓光大學校 藥品硏究所 1996 藥品硏究所報 Vol.11 No.1
This study was done to investigate the effect of glycyrrhizin on the lethality induced by galactosamine and lipopolysaccharide coadministration in mice. Glycyrrhizin was injected intravenously as a multiple dose at 20. 15. 10. 5. and 0 hr before galactosamine and lipopolysaccharide coadministration. lethality and tumor necrosis factor(TNFα) level in serum were surveyed as markers of glycyrrhizin effect Glycyrrhizin had no effect on the lethality induced by galactosamine and lipopolysaccharide when glycyrrhizin was administered as a single dose. Glycyrrhizin reduced the lethality induced by galactosamine and LPS in dose-dependent manner when glycyrrhizin was administered as a multiple dose at 20. 15. 10. 5 and 0 hr before galactosamine and lipopolysaccharide coadministration. Glycyrrhizin reduced the serum TNFα level.
동측 대퇴골의 경부 및 간부 동시 골절의 치료의 문제점
이종민,경희수,인주철,오창욱,김신윤,소형태,위호욱 대한골절학회 2001 대한골절학회지 Vol.14 No.2
Purpose : This retrospective study was performed to know the difficulties and efficient methods of treatment after several types of operations for ipsilateral femoral neck and shaft fracture. Materials and Methods: Thirteen cases (12 patients) with ipsilaternl femoral neck and shaft fracture at the mean age of 36.6(range 21-51), have been followed up over the minimum of one year. All the patients suffered from motor vehicle accidents(11 in dash-board injury), and most of patients associated with multiple injuries including other fractures. All of femoral neck fracture were same type in basicervical area and 4 of them were missed initially. According to the classification of femoral shaft fractures, middle 1/3 fracture was most common in 10 cases and type C in 8 cases. In neck fractures, all cases were treated with multiple pinning, but in shaft fractures, 6 were treated by open plating, 5 by closed antegrade nailing, and 2 by retrograde nailing. Results: The mean union period was 12.1 weeks in neck fractures and 9.9 months in shaft fractures. In complications, there were I case of nonunion and 1 case of avascular necrosis in neck fractures, and 8 of delayed union, 3 of nonunion, and 2 of malunion, in shaft fractures. The methods of treatment had no influence on the results of this injury, but we had 1 failure in antegrade nailing prior to operation of neck fracture. Conclusion: After operation of ipsilateral femoral neck and shaft fracture, the shaft fracture needed longer time of union and had many problems in spite of different methods. We suppose that many problems in shaft are affected not only by characteristic mechanism of injury, but also by multiple associated injury.