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담도결찰 흰쥐에서 영지배양 균사체 유래 다당체의 항섬유화 효과 검색 및 용량의존성시험
박은전(Eun Jeon Park),고건일(Geon Il Ko),김재백(Jae Baek Kim),손동환(Dong Hwan Sohn) 대한약학회 1997 약학회지 Vol.41 No.2
This study was carried out to investigate the dose dependent antifibrotic effects of polysaccharide from mycelium of Ganoderma lucidum. The experimental hepatic cirrhosis was induced by bile duct ligation/scission (BDL/S) in rats. BDL/S rats in each group were dosed 0.5 mg, 2.0 mg, 5.0 mg or 10.O mg/rat/day orally for 4 weeks after the operation. Antifibrotic effects were evaluated by serum biochemical values, hydroxyproline contents, and light microscopical histology. The results obtained were as follows: 1) Hydroxyproline contents in liver of 5.0 and 10.0mg polysaccharide-treated BDL/S rats were significantly reduced 2) In serum test, ALT, AST, ALP values in polysaccharide from Ganoderma lucidum-treated group were lower than BDL/S control group 3) The hepatic damage such as hepatocellular necrosis, inflammation, bile duct proliferation and fibrosis was less severe in the livers of 2.0 mg and 5.0 mg polysaccharide-treated rats. These results suggest that polysaccharide from mycelium of Ganoderma lucidum to be a promising agent for the inhibition of hepatic cirrhosis.
남극성,박은전,손동환,고건일,Na Ji-Xing,Park Eun-Jeon,Sohn Dong-Hwan,Ko Geon-Il 대한한의학방제학회 2004 大韓韓醫學方劑學會誌 Vol.12 No.2
This study was carried out to investigate the liver protective effects of extracts from Persicae Semen (WT-003, WT-005, WT-006). The acute hepatic injury was induced by intraperitoneal injection of alpha-naphtylisothiocyanate (75 mg/kg, p.o.) and treated with WT-006 (100 mg/kg/day, 200 mg/kg/day, 400 mg/kg/day). The experimental hepatic fibrosis was induced by bile duct ligation/scission(BDL/S), duration of 4 weeks and treated with WT-003, WT-005 or WT-006 (200 mg/kg/days for 4 week). In acute liver injury, WT-006 (200 or 400 mg/kg) lowered serum alanine transferase(ALT) and aspartate transferase(AST) significantly. In fibrotic rats, WT-006 treatment inhibited the hydroxyproline deposition in liver and lowered serum AST, ALT and ALP, significantly. These results suggest WT-006 extract, which does not contain amygdalin, from Persicae Semen have liver protective and antifibrotic effects in rats.
글리시리진이 마우스에서 세포성 면역 반응에 의한 접촉성 과민반응에 미치는 영향
김형민 ( Hyung Min Kim ),김재백 ( Jae Baek Kim ),고건일 ( Geon Il Ko ),윤명자 ( Myung Ja Youn ),박래길 ( Rae Kil Park ),정헌택 ( Hun Taeg Chung ) 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.4
Licorice extract is a well known herbal drug. Glycyrrhizin(GL), a kind of saponin, is one of the main active components of licorice extract. The reported effects of GL on the biological system are anti-inflammatory, anti-ulcerous, anti-cariogenic, and anti-viral. In this study, the authors investigated the effects of GL on contact hypersensitivity (CHS) to dinitrofluoro-benzene(DNFB). GL inhibited the elicitation of the CHS only when given between the period of sensitization and ear challenge. By using adoptive transfer experiments, the authors confirmed that GL effects only the efferent phase of the immune responses.
박은전(Eun Jeon Park),김재백(Jae Baek Kim),손동환(Dong Hwan Sohn),고건일(Geon Il Ko) 대한약학회 1997 약학회지 Vol.41 No.5
Hepatic cirrhosis is a common response to chronic liver injury from many causes and is one of the most common cause of all deaths. This study was carried out to compare experimental hepatic cirrhosis in rats to understand this disease and to apply for the pharmacokinetics in disease state. Following three kinds of experimental models were induced; 1) Bile duct ligation/scission (BDL/S), 2) N, N-dimethylnitrosamine(DMN), 3) Carbon tetrachloride. The hepatic cirrhosis was characterized by examing the liver/body weight ratio, serum biochemical values, hydroxyproline content in liver and histopathological lesions in cirrhotic rat liver. The results are as follows : (1) In BDL/S, the liver was enlarged to 250% of normal liver. In contrast the liver was shrinked to 48% and 78% of the normal liver in DMN and carbon tetrachloride, respectively. (2) In carbon tetrachloride and BDL/S, the serum ALT, AST, ALP and total bilirubin levels were significantly increased to 200~300% of normal level, while ALT and total bilirubin levels were significantly increased in DMN group. (3) Hydroxyproline content in cirrhotic rat liver was significantly 200~500% higher than that of normal liver. (4) Nodular formation with fibrosis was observed in BDL/S, DMN, carbon tetrachloride induced cirrhotic rat liver.
리포폴리사카라이드와 갈락토사민의 투여로 인한 생쥐 치사율에 미치는 글리시라진의 억제효과
오창욱(Chang Wook Oh),송경(Kyung Song),박은전(Eun Jeon Park),손동환(Dong Hwan Sohn),김재백(Jae Baek Kim),고건일(Geon Il Ko) 대한약학회 1996 약학회지 Vol.40 No.1
This study was done to investigate the effect of glycyrrhizin on the lethality induced by galactosamine and lipopolysaccharide coadministration in mice. Glycyrrhizin was injected intravenously as a multiple dose at 20, 15, 10, 5, and O hr before galactosamine and lipopolysaccharide coadministration. Lethality and tumor necrosis factor (TNFalpha) level in serum were surveyed as markers of glycyrrhizin effect. Glycyrrhizin had no effect on the lethality induced by galactosamine and lipopolysaccharide when glycyrrhizin was administered as a single dose. Glycyrrhizin reduced the lethality induced by galactosamine and LPS in dose-dependent manner when glycyrrhizin was administered as a multiple dose at 20, 15, 10, 5 and O hr before galactosamine and lipopolysaccharide coadministration. Glycyrrhizin reduced the serum TNFalpha level.