심전도 기반 자율감각쾌락반응의 심신안정상태 유도 효과 검증

정윤희(Yun Hui Jung),박진영(Park Jin Young),오성윤(Sung Yun Oh),정성윤(Jung Sung Yoon),정창수(Changsu Jeong),최가영(Ga-Young Choi),최수인(Soo-In Choi),황한정(Han-Jeong Hwang) 한국정보기술학회 2020 Proceedings of KIIT Conference Vol.2020 No.10

사회에 만연한 정신과 진찰에 대한 편견과 거부감으로 적절한 시기에 정신건강 상담과 치료를 받지 못하는 정신질환 환자가 지속적으로 증가하고 있다. 정신과 치료를 대체하기 위해 최근 청각, 시각적 자극을 통한 자율안정쾌락반응(autonomous sensory meridian response: ASMR)이 주목받고 있으며 많은 사용자가 심리적 안정 효과를 보고하고 있다. 그러나 현재까지 ASMR의 심리적 안정 효과를 정량적으로 확인한 연구가 미비하며, 심리적 거부감과 부담이 적은 정신건강 증진 보조 시스템으로 활용을 위해 ASMR의 객관적 안정 효과의 검증이 선행되어야 한다. 따라서 본 연구에서는 임상에서 정신 건강 진단에 사용되는 심전도를 이용하여 ASMR 자극 종류와 청취 방법별 심리적 안정 효과를 객관적으로 검증하였다. 그 결과, ASMR 자극 중 속삭임 자극이 심박수 저하 효과가 있었으며, 영상을 통한 자극 청취방법을 사용할 경우 저/고주파수 파워 비율이 감소됨을 통해 심리적 안정 효과의 가능성을 확인하였다. The number of mentally ill patients who refuse psychiatric treatment at an appropriate time is constantly increasing due to the prejudice and rejection of psychiatric assessment. Recently, the autonomous sensory meridian response (ASMR) with auditory and visual stimuli attracts attention as an alternative to psychiatric treatment, and its effect on psychological stability has been reported by users. However, most of previous studies have not quantified the positive effect of ASMR, thereby there is little objective evidence that ASMR can be used as a mental health care system with less psychological burden. Therefore, the objective psychological stability effect of ASMR should be first confirmed. In this study, the psychological stability effect on ASMR with different type and stimuli method was objectively confirmed using the electrocardiogram (ECG) used for diagnosis in clinical psychology. As a result, whispering stimuli of ASMR has effect of heart rate reduction. Moreover, the possibility of psychological stability was confirmed by decreasing the low/high frequency power ratio when stimuli presented as an video.

논문(論文) : 한의학회지의 처방명 로마자 표기에 관한 고찰

김상찬 ( Sang Chan Kim ),변성희 ( Sung Hui Byun ),오성윤 ( Sung Yun Oh ),이병욱 ( Byung Wook Lee ) 대한한의학원전학회 ( 구 대한원전의사학회 ) 2006 대한한의학원전학회지 Vol.19 No.3

불우시설 수용인에서 B형 간염 바이러스 표식자에 대한 역학 조사

오성윤,안기성,허형호,현대성,임달수 대한소화기학회 1992 대한소화기학회지 Vol.24 No.5

To investigate the seroprevalence of Hepatitis B virus markers in institutionalized population, we surveyed 1670 institutionalized persons who lived in Taegu Hope Village and 1603 controls who visited hospital for general health screening on December,1991. The poisitive rate of HBs Ag io institutionalized population (7.19%) was not significantly higher than that of control (7.05%) (p$gt;0.05). However, by age and sex matched analysis, there were some differences. The occurrence rate of HBs Ag reaches its maximal rate at forth decade, and then decreases with advancing age in institutionalized population as does it in control group, although the peak of the latter occurs a decade later. In institutionalized population there was no sexual difference in the positive rate of HBs Ag (7.02% in men and 7.42% in women), but in control group, male preponderance was seen (8.83% in men and 4.03% in women). In contrast to HBs Ag, the occurrence rate of Anti HBs in institutionalized population (10.78%) was significantly lower than that of control (30.8%) (p$lt;0.05). Female (14.1%) has higher rate of Anti HBs positivity than male (8. 4%) in Institutionalized population, but no such difference was seen in control group. Among HBs Ag positive institutionalized persons, the positive rates of HBe Ag and Anti HBe were 32.7% and 59.3% respectively. After fifth decade, the occurrence rate of HBe Ag constantly decreased with advancing age, but the reverse pattern was seen with Anti HBe.

간경화증 및 소화기계 악성종양에서의 혈청 CA 19-9와 CA 125의 임상적 의의

오성윤,안기성 대한소화기학회 1992 대한소화기학회지 Vol.24 No.2

To analyze the clinical significance of CA 19-9 and 125 in the liver cirrhosis and malignant diseases, the levels of both tumor markers were determined in 49 patients with liver cirrhosis (38 cases with ascites and 11 cases without ascites) and 21 patients with malignant diseases (10 cases with hepatoma and 11 cases with GI malignancy) among the patients admitted in Taegu Catholic University Hospital. The results were as follows; 1) Serum Ca 19-9 levels in malignant diseases were significantly higher than those of liver cirrhosis. 2) Serum CA 19-9 levels were elevated above the cutoff value (37 u/㎖) in 29% of liver cirrhosis, in 45% of gastrointestinal malignancy, and in 50% of hepatoma. 3) Serum CA 125 levels, although was not statistically significant, were elevated in regular sequence among patients with liver cirrhosis without ascites, those with liver cirrhosis with ascites, and those with hepatoma. 4) Serum CA 125 levels were elevated above the cutoff value (35 u/㎖) in 64% of patients with liver cirrhosis without ascites, in 91% of those with liver cirrhosis with ascites, and in 100% of those with hepatoma. 5) Positive predictive value of hepatoma against liver cirrhosis was very low (about 20%) with single or combined test of CA 19-9 and CA 125. In conclusion, although both tumor markers are useful in screening test of hepatoma, quantitative evaluation of tumor markers, CA 125 and CA 19-9, is essential for hepatoma to differentiate from liver cirrhosis.

혈소판막 당단백질 전기영동으로 확진된 혈소판 무력증 1 예

오성윤,송경순,황기석,현대성,임달수 대한내과학회 1992 대한내과학회지 Vol.43 No.1

Glanzmann`s thrombasthenia is a rare autosomal recessive inherited bleeding disorder associated with abnormal clot retraction and a normal platelet count. This disorder is characterized by the inability of the aggregation of platelets in response to the stimulation of ADP, epinephrine or collagen but it can aggregate by ristocetin. The primary feature of this disorder is the deficiency or abnormality of the glycoprotein IIb/IIIa complex, one of the major surface proteins of the platelet membrane participating in the aggregation between the platelets with fibrinogen. This disorder can be detected by the analysis of the glycoprotein IIb/IIIa complex on the platelet membrane of the patient by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). We experienced one case of Glanzmann's thrombasthenia with iron deficiency anemia in a 16-year-old male, who had suffered from frequent gingival bleeding, epistaxis, and easy bruising. After platelet function test and SDS-PAGE, we diagnosed him as Glanamann`s thrombasthenia with iron deficiency anemia due to chronic blood loss.

식도정맥류에 대한 내시경적 정맥류 결찰요법 후 재출혈 및 재발과 연관된 위험인자들

이석호,이규택,김재준,백승운,최문석,이종균,이준혁,고광철,이풍렬,오성윤,이종철,최규완 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.1

Background/Aims: Rebleeding and recurrence of varices are frequent problems following endoscopic variceal ligation (EVL). However, few data are available on the risk factors associated with rebleeding and recurrence. Our aims were to elucidate the clinical feaNres and risk factors associated with rebleeding and recuuence. Methods: One-hundred and eight patients who had undergone EVL due to bleeding esopltageal varices were included in the study. EVL was performed with the Stiegman-Goff Endoscopic Ligator at 2 week intervals until the varices are eradicated or reduced to grade 1 without red color sign (defined as successful EVL), followed by gastroscopy every 3 months. Rebleeding was defined using the descriptions from the Second Baveno International Consensus Meeting, in 1995. Recurrence was defined as increments of varices to grade 2 or greater or appearance of red color sign on follow-up examinations. The Kaplan-Meier method was used to determine the rebleeding and recurrence rate. The Log-rank lest and Cox regression lest were used for univariale and multivariate analysis of risk factors, respectively. Results: 1) The most common cause of rebleeding within 2 weeks from the EVL was esophageal ulcer (50%); whereas, the most common cause of rebleeding after 2 weeks was recurrent varices (38%). 2) In univariate analysis, persistence of esophageal ulcer at 2 weeks after the first EVL was associated with rebleeding (p=0.01); whereas, age, Child class, grade and extent of varices, presence of gastric varices and/or portal hypertensive gastropathy, total number of bands and sessions for successful EVL were not (p >0.05). Persistence of esophageal ulcer at 2 weeks after the first EVL was associated with rebleeding also in multivariate analysis (relative risk 5.87, p=0.01). 3) In univariate analysis, grade (p=0.01) and extent (p=0.01) of varices were related to recurrence; whereas, age, Child class, presence of gastric varices and/or portal hypertensive gastropathy, total number of bands and sessions for successful EVL were not (p >0.05). In multivariate analysis, grade of varices was the only risk factor associated with recurrence (relative risk 3.76, p=0.01). Conclusions: 1) Persistence of esophageal ulcer at second week after the first EVL was associated with rebleeding. 2) Frequent follow-up endoscopic examinations are necessary in patients who present with high grade of vaces since risk of recurrence is high even after successful EVL.

위내시경으로 진단된 원발성 위 유전분증 1예

이석호,손희정,이규택,김재준,강인구,백승운,이종균,이준혁,고광철,이풍렬,오성윤,이종철,최규완,오영륜 대한소화기내시경학회 1998 Clinical Endoscopy Vol.18 No.4

Amyloidosis is characterized by deposition of amyloid, which is resistant to proteolysis & phagocytosis, in intercellular spaces & vascular walls. The amyloid deposition provokes dysfunction of an accumulated organ & displays variable clinical symptoms depending upon the involved organ. A diagnosis is rendered through a biopsy of the affected organ, followed by staining using congo red which reveals an apple greenish refractile birefringence via polarizing microscopy. Using an electro-microscopy specific filaments can be found. Amyloidosis is classified into primary amyloidosis, composed of light chain filaments (AL) and secondary amyloidosis, comprised of A protain (AA). The AL type of amyloidosis shows deposition of amyloid in muscularis mucosa & muscularis externa. Priunary amyloidosis on the other hand, is relatively rare. We experienced primary stornach amyloidosis (AL), which was mistaken for stomch cancer.

간암 환자의 술전 검사로서 CTAP와 CTHA 의 유용성

이석호,이규택,김재준,강인구,김승훈,백승운,도영수,이종균,이준혁,고광철,이풍렬,최규완,오성윤,이종철 대한간학회 1997 Clinical and Molecular Hepatology(대한간학회지) Vol.3 No.4

Background / Aims : Combined computed tomography during arterial portography(CTAP) and computed tomography during hepatic arteriography(CTHA) are more sensitive methods compared to conventional spiral CT in detection small hepatocellular carcinoma. However, there are few data available on the influence of combined CTAP and CTHA on decision making for treatment of hepatocellular carcinoma. We aimed to evaluate the usefulness of CTAP and CTHA as a preoperative study of hepatocellular carcinoma for surgical treatment. Methods : Eighty -two patients with histologically proven hepatocellular carcinoma who were considered to be surgical candidates on spiral CT and angigraphy were included. CTAP and CTHA were performed as the routine protocol. The findings of CTAP and CTHA were analyzed and compared to conventional spiral CT and angiography. Results : 1)105 nodules were found on spiral CT plus angiography , whereas, 138 nodules found on combined CTAP and CTHA : 33 additional nodules were found in 23 cases(28%). 2) The treatment plan changed from surgery to nonsurgical treatment in 10(12%) cases : 9 cases(10%) with bilobar involvement, and 1 case(1%) with more than three nodules. 3) The larger the tumor nodules on the spiral CT, the more additional tumor nodules were found on CTAP and CTHA : combined CTAP and CTHA were able to find more nodules in 21% of tumor ≤3cm, 27% of tumor with 3- 10cm, and 71% of tumor > 10 am on spiral CT (p=0.03). Conclusion : Compared to spiral CT plus angiography, CTAP and CTHA may be useful in avoiding unnecessary operation of hepatocellular carcinoma, especially in large tumors.