Expression Pattern of Immunoproteasome Subunits in Human Thymus

오권익,서재남 대한면역학회 2009 Immune Network Vol.9 No.6

The expression pattern of immunoproteasomes in human thymus has not been analyzed but may have important consequences during thymic selection. Here we examined the expression patterns of immunoproteasome subunits in fetal and adult thymic tissues by immunohistochemistry and found that all three subunits are expressed in both cortical and medullary stromal cells. These data suggest that thymic selection in human can be affected by peptide repertoires generated by immunoproteasomes. The expression pattern of immunoproteasomes in human thymus has not been analyzed but may have important consequences during thymic selection. Here we examined the expression patterns of immunoproteasome subunits in fetal and adult thymic tissues by immunohistochemistry and found that all three subunits are expressed in both cortical and medullary stromal cells. These data suggest that thymic selection in human can be affected by peptide repertoires generated by immunoproteasomes.

작명(作名) 관련 가정의례(家庭儀禮) 고찰

권익기(權益棋) 원광대학교 원불교사상연구원 2023 원불교사상과 종교문화 Vol.98 No.-

가정의례란 가족의 인생에 중요한 전기마다 가정에서 행하는 의례이다. 관혼상제로 널리 알려져 있지만 전통적으로는 유사즉고 등의 통례도 있고, 현대는 작명례와 수연례도 포함한다. 이름은 당사자를 특정하고 정체성을 나타내며, 작명은 사회적 출생의 의미를 갖는 우리 일생의 중요한 전기이기에, 과거부터 가정의례 대상이었으므로 이를 살폈다. 작명 관련 가정의례는 전통적으로 작자례가 있었고, 1990년대부터는 작명례도 행하고 있다. 자를 짓고 설하는 작자례는 전통적 성년례인 관례의 한 부분으로 포함되어 있었다. 관례는 16세기 초 정착한 이후에도 상층 일부만 행하다가 조혼과 단발령으로 일제강점기에 사라졌다. 하지만 성인의 인격을 갖추기 위한 교육적 성격이 강해서 1999년 관례는 성년례로 다시 부활한다. 그러나 이와 별개로 민적법 시행 이후 경명사상과 피휘가 사라지면서 자가 없어짐에 따라서 작자례는 부활하지 못하고 명맥조차 끊겼다. 작명례란 어린 아이에게 본명을 부여하는 가정의례로, 『주자가례』와 우리 가례서에도 명기되어 있을 정도로 그 역사는 깊다. 조선시대에도 시행했다고 주장하나 확인되지 않고, 1990년대부터 작명례를 가정의례에 포함하였지만 아직 거의 시행되지 않는다. 그러나 육체적 출생과 사회적 출생인 작명을 포함하는 작명례는 우리 일생에 중요한 전기이므로 당연히 가정의례의 대상이었기에, 가례서를 바탕으로 가정의례에 작명례를 포함한 것은 높이 평가받아야 한다. 또한 우리는 작명례 활성화를 위해서 명첩의 현대화와 작명법 역시 상세한 기록이 필요하다. Family rites are performed rites by family in each important turning point of family members. Even though it is known as Gwanhonsangje, traditionally, there is also Tonglye like Yusajeuggo. Today, both Suyeonlye and Jagmyeonglye are also included. Name specifically identifies a person, has identitis, and naming has the meaning of social birth. As an important turning point of our lives, it has been an object of family rites from the past, so this thesis examined this. As the family rites related to naming, traditionally, there was Jagjarye included in Gwanlye. From the 1990s, Jagmyeonglye has also been carried out. Gwanlye which was the traditional coming of age ceremony included Jaseol and Jagmyeonglye of Ja. Even after Gwanlye was settled down in the early 16th century, it was carried out only by some of the upper class. Due to the early marriage and Danballyeong, Gwanlye gradually disappeared in the Japanese colonial era. However, because of the strong educational feature for getting equipped with adult’s character, it was revived as coming of age ceremony in 1999. However, separately from this, after the enforcement of Minjeogbeob, Gyeongmyeongsasang and Pihwi disappeared, and along with the disappearance of ja, Jagjarye also disappeared. Jagmyeonglye is the family rites that name a Bonmyeong to a young child. The history is long enough to be recorded in Jujagarye and traditional Garyeseo. Even though it is argued to be carried out in the Joseon Dynasty, it has not been verified. From the 1990s, Jagmyeonglye was included in family rites, which has still rarely been carried out yet. Jagmyeonglye, which includes both physical birth and naming was an important turning point of our lives, so it was an object of family rites. Therefore, it should be highly evaluated that Jagmyeonglye was included in family rites based on Garyeseo. For the vitalization of Jagmyeonglye, we also need modernization of Myeongcheob and detailed records of naming methods.

일본 신문광고 캐치카피의 기호학적 분석에 관한 연구

권익호(權益湖),송숙정(宋淑正) 중앙대학교 일본연구소 2013 日本 硏究 Vol.0 No.34

This study verified through the used sentences whether the word ‘日本", employed in the catchphrases in Japanese newspaper advertisements, plays the role of a linguistic sign with connotations. As a result, it is known that the connotation of the word ‘日本" serves as an ideological subject to be protected, saved and safeguarded, identified with the world as the supreme value, getting beyond Japan and the image based on the national value. The research further shows that ‘日本’ implies a stronger connotation when pronounced as ‘にっぽん’ than when pronounced as ‘にほん’, and in a sentence in which the state ideology of nationalism is strongly expressed, ‘日本 is pronounced as ‘にっぽん". The study also shows that the word ‘日本’ as a linguistic sign has developed into a myth through the interaction with the signs connected with each other.

CD99 activates T cells via a costimulatory function thatpromotes raft association of TCR complex and tyrosinephosphorylation of TCR ζ

오권익,Young Larn Ban,최은영,정경천,이임순,박성회,Byoung Kwon Kim 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.2

We investigated the co-stimulatory role of a cellsurface protein, CD99. Co-ligation of CD99 and suboptimal CD3 induced T-cell activation to a level comparable to that obtained with optimal CD3 or CD3+CD28. We also noted concomitant enhancement of the earliest T-cell receptor (TCR) signaling events. In addition, co-ligation of CD99 and CD3 led to translocation of TCR complexes into the lipid raft, without concomitant migration of CD99 to the raft, and consequent enhancement of TCR ζ-mediated signal 1. These data demonstrate the unique pro - perties of CD99 co-stimulation that distinguish this molecule from CD28 and other raft-resident costimulatory factors.

仮定条件と反語的意味に関する小考

권익호(權益湖),김창휘(金昌輝) 중앙대학교 일본연구소 2009 日本 硏究 Vol.0 No.26

Sepsis Mortality in CIITA Deficient Mice is Associated with Excessive Release of High-mobility Group Box 1

오권익,김지영,김지현,서재남 대한면역학회 2008 Immune Network Vol.8 No.2

Background: Down regulation of major histocompatibility complex class II transactivator (CIITA) has been identified as a major factor of immunosuppression in sepsis and the level of CIITA expression inversely correlates with the degree of severity. However, it has not been fully elucidated whether the lower expression of CIITA is a cause of disease process or a just associated sign. Here we determined whether the CIITA deficiency decreased survival rate using murine sepsis model. Methods: Major histocompatibility complex class II (MHC-II) deficient, CIITA deficient and wild type B6 mice were subjected to cecal ligation puncture (CLP) surgery. CIITA and recombination activation gene (RAG)-1 double deficient mice were generated to test the role of lymphocytes in CIITA-associated sepsis progression. Results: Sepsis mortality was enhanced in CIITA deficient mice, not by impaired bacterial clearance resulted from CD4 T cell depletion, but hyper-inflammatory response such as excessive release of a pro-inflammatory cytokine, high-mobility group box 1 (HMGB1). Conclusion: Our results demonstrate that CIITA deficiency affects the course of sepsis via the unexpected function of CIITA, regulation of cytokine release. Background: Down regulation of major histocompatibility complex class II transactivator (CIITA) has been identified as a major factor of immunosuppression in sepsis and the level of CIITA expression inversely correlates with the degree of severity. However, it has not been fully elucidated whether the lower expression of CIITA is a cause of disease process or a just associated sign. Here we determined whether the CIITA deficiency decreased survival rate using murine sepsis model. Methods: Major histocompatibility complex class II (MHC-II) deficient, CIITA deficient and wild type B6 mice were subjected to cecal ligation puncture (CLP) surgery. CIITA and recombination activation gene (RAG)-1 double deficient mice were generated to test the role of lymphocytes in CIITA-associated sepsis progression. Results: Sepsis mortality was enhanced in CIITA deficient mice, not by impaired bacterial clearance resulted from CD4 T cell depletion, but hyper-inflammatory response such as excessive release of a pro-inflammatory cytokine, high-mobility group box 1 (HMGB1). Conclusion: Our results demonstrate that CIITA deficiency affects the course of sepsis via the unexpected function of CIITA, regulation of cytokine release.

중화상 환자들에서 Western Blot 분석에 의한 골격근 니코틴성 아세틸콜린 수용체 아단위들의 변화: 화상 대 비화상 부위

오권익,김태운,장현묵,곽인숙,한태형,김광민 대한마취과학회 2005 Korean Journal of Anesthesiology Vol.48 No.6

책임, 공감, 진심, 그리고 새로운 미래: 안철수의 대선출마연설문에 나타난 정치 프레임 분석

권익수 ( Ik Soo Kwon ) 한국외국어대학교 언어연구소 2012 언어와 언어학 Vol.0 No.57

The aim of this paper is to provide cognitive semantic accounts of values and frames that structure the values in Cheol-Soo Ahn``s declaration of the candidacy for president. This paper addresses what kinds of values he uses, how he frames and structures moral values and his political philosophy - responsibility, empathy, sincerity, and new future - and how all these frames conspire to successfully build the candidate``s self-image in the speech. I explain how the candidate optimizes framing of the speech by providing in-depth cognitive semantic analyses using conceptual metaphor theory, frame semantics and conceptual blending theory. The explanation includes discussions of how the frames of his speech best-fits Ahn``s sincere, innovative, non-authoritative self-image.

베트남전쟁 반대운동과 1967년 국제전쟁범죄재판 -초국가적 사회운동의 네트워크 형성과 특성-

권익현 ( Kwon Ikhyun ) 한국서양사학회 2021 西洋史論 Vol.- No.149

이 글의 목적은 1967년 개최된 국제전쟁범죄재판(IWCT)의 활동과 참여자들의 인식을 분석하여 재판의 역사적 의의를 고찰하는 것이다. 미국이 베트남전쟁에 본격적으로 개입한 이후, 전 세계에서 베트남 반전운동이 전개되었다. 그중 영국의 철학자 버트런드 러셀은 베트남전쟁에서 벌어지는 미국과 동맹국의 전쟁범죄를 고발하기 위해 IWCT 설립을 시작했고, 이러한 러셀의 계획에 세계 전역의 지식인들이 동조하며 IWCT 활동에 참여했다. IWCT 활동에 대해 영국, 프랑스 등 각국 정부들은 국익 또는 사법권의 침해 등의 이유로 활동을 방해하였다. 특히 재판의 기소대상인 미국은 외교, 정보자산 등을 활용하여 IWCT 개최를 저지하려했다. 그렇지만 베트남 반전운동과 IWCT 지지 운동으로 인해 스웨덴과 덴마크 정부는 IWCT의 개최를 승인한다. 이를 통해 1967년 5월과 11월 각각 스웨덴의 스톡홀름과 덴마크의 로스킬레에서 IWCT가 개최되었고, IWCT를 통해 세계 각국의 지식인들은 미국과 동맹국의 전쟁범죄를 폭로하고 각자의 사상과 문제의식 등을 교류했다. 각 지식인들의 사상과 문제의식은 달랐지만, 이들은 모든 인류가 베트남전쟁에 대해 행동해야한다는 점을 강조했다. 그리고 이러한 과정을 통해 베트남 반전운동의 초국적 네트워크가 형성되었다. 비록 베트남전쟁 종식과 관련한 영향력은 미약했지만, IWCT는 전후 세계의 흐름에 맞춰 시민운동이 변화하는 모습을 보여주며, ‘세계시민’을 구현한 사례로 평가할 수 있을 것이다. This study examined the formation of the International War Crimes Tribunal (IWCT), an organization that was organized to condemn the Vietnam War in 1967, and its historical significance. On August 7 of 1964, the United States entirely intervened in the Vietnam War with the Gulf of Tonkin Incident, and provoked anti-Vietnam War movements. In the early 1960s, British philosopher Bertrand Russell, in his editorial articles and letters, condemned the US involvement in the Vietnam War, and on April 1966, he established IWCT to condemn the US military’s war crimes with intellectuals from all over the world who opposed the US involvement in the Vietnam War. Various governments, such as UK and France, did not co-operate with IWCT for several reasons including national interests, and jurisdiction. The United States, the defendant of IWCT, interfered with IWCT by means of diplomacy and intelligence services. However, the solidarity of citizens from the other countries allowed IWCT to overcome the confrontation of those governments, holding IWCT. Various perceptions and criticisms about the Vietnam War emerged during the Tribunal, and all participants in IWCT argued that the Vietnam War was a human affair, and that to resolve it, all the people in the world had to act together. Following the Second World War, a growing interconnection between countries helped render social issues rapidly internationalized. Furthermore, the ‘New Social Movement’, which claimed to depart from the conventional social movement like the labor movement, has acted on issues affecting all humans, such as human rights and peace. Therefore, IWCT which insisted that all human resist together the Vietnam War, and which formed the transnational anti-war movement network, shows how the social movement had changed with internationalization and can be considered as an event that embodies the motto ‘World Citizen’. (Kyung Hee University / soctea7@gmail.com)

나의 전부가 되어버린 당신

권익,후루이와 가오리 세계기독교통일신령협회 2001 統一世界 Vol.- No.1