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간세포암환자에서 C-DDP 단독 혹은 C-DDP와 Doxorubicin의 병합 간동맥화학요법의 비교
이종인(Chong In Lee),장우익(Woo Ick jang),김현수(Hyun Soo Kim),신승준(Seung Joon Shin),이성우(Seong Woo Lee),이동기(Dong Ki Lee),권상옥(Sang Ok Kwon),심영학(Young Hak Sim),김영주(Young Ju Kim),조휘율(Whee Yul Cho),홍인수(In Soo Hong) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.2
N/A Most of hepatocellular carcinomas, especially in Korea, are considered as inoperable due to extrerne tumor extension at the tirne of diagnosis and underlying advanced liver cirrhosis. The normal liver receives a dual blood supply from the hepatic artery and the portal vein whereas hepatoma is fed preferentially by the hepatic artery. With the background above mentioned, hepatic arterial chemotherapy or chemoembolization in hepatocellular carcinoma has been regarded as an important treatment modality for unresectable hepatocelluar carcino- ma. It has been found that the lipid lymphographic agent such as Lipiodol(ethiodized oil), which can be mixed with chemotherapeutic agents, is selectively retained within hepatocelluar carcinoma when it is injected into the hepatic artery. Based on recent promising therapeutic results in hepatocelluar carcinoma treated with hepatic arterial C DDP infusion combined with Lipiodol, we studied to elucidate the therpeutic efficacy of the hepatic arterial chemotherapy with C DDP combined with Lipiodol and to compare the differences in thera- peutic efficacy between C-DDP rnonotherapy group (Group 1) and C-DDP/doxorubicin combi- nation therapy group(Group 2). In all 42 cases there were 1 complete response(2%), 4 partial responses(10%), 7 rninimal responses(17%), 15 stab1e diseases(36%) and 15 progressive diseases (36%). There were no differences of response rate and survival duration between Group 1 and Group 2, and there was a significant difference of survival duration between responder group (CR+PR+MR) and nonresponder group(SD+PD) (P<0.01). In conclusion hepatic arterial chemotherapy with C DDP and/or doxorubicin and Lipiodol appears to have relatively weak activity in patients with hepatocellular carcinoma. (Korean J Gastroenterol 1994; 26: 298 304)
간경변증 환자의 비정형 선종성 증식성 결절 ( Atypical Adenomatous Hyperplastic nodule ) 에서 발생한 소 간세포암
권상옥(Sang Ok Kwon),노병선(Byoung Seon Rhoe),장우익(Woo Ick Jang),이동기(Dong Ki Lee),이용규(Yong Gyu Lee),한병근(Byoung Geun Han),심영학(Young Hak Sim),조미연(Mi Yeon Cho) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.4
Adenornatous hyperplasia (AH), defined as a sizable parenchymal nodules that may follow acute or chronic liver injury, has been reported as precursor lesion of hepatocellular carcinoma in the cirrhotic liver. These lesions often coexist with obvious rnalignant foci as small nodule-in-nodule. Morphologically AH can be divided into 'ordinary' and atypical (AAH)' types. The former consisted of hepatocytes similar to those of the surrounding liver. The latter type was composed of hepatocytes showing nuclear, cellular and structural atypia relative to the surrounding liver, and shoved irregular or sparse portal tracts. Cytological and structural pattens are characteristically heterogenous within a nodule. Now AAH are considered to be precancerous lesion evolving to early hepatocellular carcinoma. Authots report one case of hepatocellular carcinoma eithin an atypical adenomatous hyperplastic nodule in 55-years-old male with a review of literatures.
유광하,진춘조,김홍승,이종인,심영학,정순희,이창훈 건국대학교 의과학연구소 1997 건국의과학학술지 Vol.7 No.-
저자등은 전신적인 소양감을 동반한 홍반성 판상의 피부 병변과 자가 면역성 용혈성 빈혈이 동반된 Sezary 증후군을 진단하고 복합 화학 요법 CHOP으로 치료하여 피부 증상과 빈혈이 호전된 예를 문헌고찰과 함께 보고하였다. Sezary syndrome(SS), a leukemic variant of cutaneous T-cell lymphoma(CTCL), is monoclonal proliferation of CD4 T-cell having cerebriform nuclei in the skin and the peripheral blood. It is associated with erythroderma, pruritis, lymphadenopathy with protracted clinical course and systemic spread. We present a case of SS i a 38-year-old woman with generalized exfoliative erythroderma, plaques, and pruritus. Histopathologic findings of the skin lesions revealed infiltration of atypical lymphocytes in the dermis and epidermis. Electron microscopic findings of peripheral blood and skin showed atypical lymphocytes with cerebriform nuclei. Laboratory findings revealed direct Coombs' positive autoimmune hemolytic anemia, a rare association of SS. Chemotherapy with CHOP produced improvement of the skin manifestation and anemia.
Graves 씨 병에 동반된 특발성 혈소판 감소성 자반증의 면역 억제제 치험 1 예
이화영,임채선,최미란,이재순,김원천,심영학 대한내과학회 1987 대한내과학회지 Vol.32 No.5
Graves' disease associated with idiopathic thrombocytopenic purpura has been recorded many times in Korea. Although the autoimmune mechanism of these diseases is already thought to be significant role in the pathogenesis, the genetic factors also seem to be significant contributions recently. Even the understandings for relation of these two conditions and their pathogenesis are poor, the therapeutic results are relative satisfactory by antityroid medications, corticosteroid and/or operation. So that refractory cases are uncommon. Recently we experienced extreme hyperthyroid state with thrombocytopenia even after subtotal thyroidectomy and splenectomy followed by antithyroid medications. The cause of recurrence was thought due to autoimmune mechanism such as common antibody to thyroid gland and platelet. In these situations the conventional therapy were not satisfactory. A 38 year old female was admitted to our hospital two times due to recur after medication and operation. So she had treated with immunosuppressive agent (Cyclo-phosphamide), and then platelet count was increased, the level of thyroid hormone became normal and general symptoms were markedly improved. Although immunosuppressive agents were not the choice of drug in the treatment of Graves disease with idiopathic thrombocytopenic purpura, we proposed immunosuppressive agent might be a alternative therapeutic method when the various conventional treatment were failed. We report a case of Graves disease with idiopathic thrombocytopenic purpura treated well by immunosuppressive agent who had been recurred by conventional treatments.