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      • SCOPUSKCI등재

        간세포암환자에서 C-DDP 단독 혹은 C-DDP와 Doxorubicin의 병합 간동맥화학요법의 비교

        이종인(Chong In Lee),장우익(Woo Ick jang),김현수(Hyun Soo Kim),신승준(Seung Joon Shin),이성우(Seong Woo Lee),이동기(Dong Ki Lee),권상옥(Sang Ok Kwon),심영학(Young Hak Sim),김영주(Young Ju Kim),조휘율(Whee Yul Cho),홍인수(In Soo Hong) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.2

        N/A Most of hepatocellular carcinomas, especially in Korea, are considered as inoperable due to extrerne tumor extension at the tirne of diagnosis and underlying advanced liver cirrhosis. The normal liver receives a dual blood supply from the hepatic artery and the portal vein whereas hepatoma is fed preferentially by the hepatic artery. With the background above mentioned, hepatic arterial chemotherapy or chemoembolization in hepatocellular carcinoma has been regarded as an important treatment modality for unresectable hepatocelluar carcino- ma. It has been found that the lipid lymphographic agent such as Lipiodol(ethiodized oil), which can be mixed with chemotherapeutic agents, is selectively retained within hepatocelluar carcinoma when it is injected into the hepatic artery. Based on recent promising therapeutic results in hepatocelluar carcinoma treated with hepatic arterial C DDP infusion combined with Lipiodol, we studied to elucidate the therpeutic efficacy of the hepatic arterial chemotherapy with C DDP combined with Lipiodol and to compare the differences in thera- peutic efficacy between C-DDP rnonotherapy group (Group 1) and C-DDP/doxorubicin combi- nation therapy group(Group 2). In all 42 cases there were 1 complete response(2%), 4 partial responses(10%), 7 rninimal responses(17%), 15 stab1e diseases(36%) and 15 progressive diseases (36%). There were no differences of response rate and survival duration between Group 1 and Group 2, and there was a significant difference of survival duration between responder group (CR+PR+MR) and nonresponder group(SD+PD) (P<0.01). In conclusion hepatic arterial chemotherapy with C DDP and/or doxorubicin and Lipiodol appears to have relatively weak activity in patients with hepatocellular carcinoma. (Korean J Gastroenterol 1994; 26: 298 304)

      • KCI등재후보

        포르말린에 의한 급성 부식성 위염에 병발한 급성 봉와직염성 위염 2 예

        이상수,김현수,이광훈,이재갑,장우익,권상옥,이동기,김호근,홍인수,조휘율,오미희,윤광수 대한내과학회 1991 대한내과학회지 Vol.40 No.2

        Phlegmonous gastritis is a rare form of gastritis caused by a pus-forming bacterial infection of the wall of the stomach. Emphysematous gastritis is an unusual variant of phlegmonous gastritis caused by gasforming organisms. Two cases of phlegmonous gastritis subsequent to accidental ingestion of formalin is reported. One case showed bubble air in the gastric wall on plain abdominal X-ray, UGI barium study and abdominal C-T scan suggestive of emphysematous gastritis. Fiberoptic gastroscopy showed foul odor purulent discharge in the gastric lumen and diffuse ulcerative lesion from cardioesophageal junction to pylorus. Culture of gastric aspirates grew E. coli. Total gastrectomy with esophagojejunostomy, feeding jejunostomy, and pus evacuation with drainage from left paracolic gutter were performed. This patient was died on hospital 46 day. Another patient showed similar endoscopic finding to the first patient. Culture of gastric aspirate grew Pseudomonas aerugionsa. This patient was improved with intensive antibiotics. He returned to our hospital because of progression of dysphagia. UGI films and gastroscopic findings showed marked narrowing of gastric lumen. He was transferred to another hospital for proper surgery.

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