RE-12 : Assisted reproductive treatment is not a risk factor for chromosomal abnormalities in spontaneous abortion

심소현,차동현,이경진,심성신,조연경,김지연,김수현,박희진 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

목적: More than half first-trimester pregnancy losses are attributed to fetal chromosomal abnormalities. Recently, ART is more frequently utilized with an increase in infertility rate. However, there is a paucity of data about the frequency of embryonic chromosomal abnormalities in first-trimester miscarriage after assisted reproductive treatment (ART).We examined whether or not embryonic chromosome aberration in first-trimester pregnancy losses is more frequent in pregnant women with ART than in those with natural pregnancy. 방법: We conducted a retrospective study in CHA Medical Center. Study population consisted of 511 pregnant women (natural pregnancy group 31.31% <160/511> vs. ART pregnancy group 68.49% <350/511>) who underwent either spontaneous abortion or surgical dilatation and curettage between 2011 and 2012 with the diagnosis of missed abortion during first trimester (gestational age < 14wks). We compared the frequency of embryonic chromosome aberration according to natural pregnancy group or ART pregnancy group, BMI >= 25 or BMI < 25, the presence or absence of prior history of pregnancy loss, and maternal age >= 35 or < 35. 결과: The overall rate of aneuploidy was 51.6%, and mean maternal age 35.0 years. There was no significant difference in abnormal karyotypes between ART pregnant group and natural pregnancy group (p=0.154). However, abnormal karyotypes were significantly more frequent in patients with maternal age >= 35 years than those with maternal age < 35 years, in patients with BMI >= 25 than in those with BMI < 25, and in pregnant women with prior history of pregnancy loss than in those without prior history of pregnancy loss (each for p<.05). 결론: ART treatment is not a risk factor for chromosomal abnormalities in the first trimester miscarriage. However, maternal age more than 35 years, maternal obesity ( BMI >= 25) and prior history of pregnancy loss are associated with abnormal karyotyping in first trimester miscarriage.

서울 지역 중․고등학생들이 구성하는 한국인 정체성: 시민적 정체성 강조의 가능성과 한계

심소현,박윤경,조영달 한국다문화교육학회 2021 다문화교육연구 Vol.14 No.3

This study aims to understand the meaning of Korean identity formed by the middle and high school students. To this end, a qualitative case study on middle and high school students in Seoul using focus group interview was conducted. According to the study, high school students cited ‘acquistion of nationality’ as an essential qualification for Koreans, while middle school students cited ‘love for korea’ as an essential qualification for Koreans. When determining whether each immigrant group is Korean, students demanded additional civic qualities to grant nationality, such as ‘contribution to Korea’. Some students thought the increase in the number of migrants as a desirable phenomenon in terms of cultural diversity, but most of them regarded it as a pessimistic phenomenon because immigrants commit crimes and increase social costs. The ethnic elements, which are fundamental limitations between innate Koreans and acquired Koreans, are inherent in the civic identity that the students assume including acquisition of nationality, love for korea and civic quality. Based on the above findings, the researchers discussed the meaning of ‘ideological type of acquired Korean’ which the middle and high school students construct, suggesting implications for multicultural citizenship education and research. 이 연구는 우리나라 청소년들이 구성하는 한국인 정체성의 의미가 무엇인지를 심층적으로 탐구하기 위한 질적 사례 연구다. 이를 위해 서울 지역의 중․고등학생을 중심으로 이슈 스토리 면접 자료를 활용한 초점 집단 면접을 수행하였다. 연구 결과, 고등학생들은 ‘국적 취득’을, 중학생들은 ‘한국에 대한 사랑’을 가장 중요한 한국인의 자격 요건으로 꼽았으며, 이주민 집단별로 한국인 여부를 판단할 때에는 공동체의 기여 등 국적을 부여하기에 충분한 자질이 있는지의 여부를 추가적으로 활용하였다. 또한 문화적 다양성의 측면에서는 이주민의 증가를 긍정적으로 생각하면서도, 범죄와 사회적 비용 발생을 이유로 이주민의 증가가 부정적인 현상이라는 의견이 우세했다. 국적 취득, 한국에 대한 사랑, 시민적 자질을 포함하여 학생들이 상정하는 시민적 정체성의 본질에는 선천적 한국인과는 다른 후천적 한국인의 근본적 한계라는 종족적 요소가 내재해 있다. 이상의 연구 결과를 바탕으로 중․고등학생들이 형성하는 ‘바람직한 후천적 한국인의 이념형’의 의미에 대해 논의하고 다문화 시민 교육 및 연구에 대한 시사점을 제시하였다.

OB-16 : Analysis of global gene expression through the amniotic fluid cell-free fetal RNA according to the gestational age

심소현,박혜리,강진희,정용욱 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

목적: To characterize the transcriptome expression patterns and biological pathways in amniotic fluid cell free fetal RNA according to gestational weeks 방법: The discarded amniotic fluids in terms of gestational weeks were prospectively collected from euploid fetuses for this study. Total RNA was extracted from cell free amniotic fluid supernatant and hybridized to Affymetrix GeneChip Human Arrays. Differentially expressed transcripts among 16-18 gestational weeks, 25-26 weeks and 37-38 weeks amniotic fluids were obtained by the Welch`s t-test. Hierachial clustering analyses were performed to visualize overall expression characteristics of all samples used for the study. The biological functions of selected genes were analyzed using various online Gene Ontology databases. 결과: There were 2902, 6035 and 6289 genes significantly expressed in early second, late second and third trimesters, respectively. Hierachial clustering showed differential transcriptome expression pattern according to gestational weeks. Comparing with the early second trimester, fetus related specific genes were more highly enriched in late second and third trimesters (471 vs 913 and 949, respectively). Gene expression analysis showed enrichment of brain transcripts in the late second trimester as compared with early second and third trimesters. Only 33 genes were differentially expressed in the first trimesters and pathway analysis revealed that those are related to cell proliferation and apoptosis pathway. The transcripts that are related to fetal brain were enriched in late second trimester. 결론: This study provides information regarding gene expression changes during normal fetal development. Brain specific transcripts are enriched in the late second trimester rather than early second trimester. This data suggests that brain development may occurs in late second trimester mainly.

Afatinib 복약 후 발생한 비소세포성 폐암환자의 피부독성 부작용에 대한 한방치료 1례

심소현,서희정,최진용,배고은,서형범,김소연,한창우,박성하,윤영주,이인,권정남,홍진우,최준용 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.5

Objectives: We report a case of traditional Korean medicine (TKM) treatment for skin side effects after taking afatinib (Giotrif®). Methods: A 62-year-old female who was diagnosed with non-small cell lung cancer stage 4 (T4N2M1b) and was on treatment with afatinib (29.56 mg/day for 4 months) complained of skin toxicity as a side effect. For 16 admission days, the patient was treated with acupuncture, moxibustion, and herbal medicine (oral decoction and external ointment). Results: Improvement of skin toxicity was measured by a numeric rating scale. In addition, Quality of life (QOL) was measured using EORTC Quality of Life Questionnaire, Core 30 (EORTC QLQ-C30) and EORTC Quality of Life Questionnaire, 13-item lung cancer–specific module (EORTC QLQ-LC13) Developed by the European Organization for Research and Treatment of Cancer (EORTC). Tumor size and carcinoembryonic antigen (CEA) were also examined during follow up. Conclusions: After a combined TKM treatment, skin toxicity symptoms and quality of life scales were significantly improved with no side effects. The tumor size was not changed on computed tomography during follow-up period. CEA levels were decreased.

Tissue-adhesive Sealant Using Natural Polymer

심소현,나양호 한국고분자학회 2020 한국고분자학회 학술대회 연구논문 초록집 Vol.45 No.2

Tissue-adhesive and Biodegradable Hydrogel Using Natural Polymers

심소현,나양호 한국고분자학회 2019 한국고분자학회 학술대회 연구논문 초록집 Vol.44 No.2

모체태아의학 : OB-21 ; Mullerian anomaly가 있는 여성에서의 쌍태임신에 관한 연구

심소현,김다희,신중식,성석주,김미라 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

목적: 자궁기형은 단태 임신에서 조산 및 이상태위의 위험요인으로 알려져 있으나, 자궁기형을 가진 여성에서의 쌍태임신에 대한 연구는 아직까지는 많지 않다. 이에 본원에서 분만한 쌍태임신 환자 중 자궁기형 유무에 따른 임신의 결과를 비교하고자 한다. 방법: 차의과학대학교 강남차병원 산부인과에서 2005년 1월부터 2013년 7월까지 24주 이상에서 쌍태임신으로 분만을 했던 환자에 대한 자료를 후향적으로 조사하였다. 그 중 외국인을 제외하고 임신 전 또는 임신 중 자궁기형으로 진단된 환자와 자궁기형이 없던 환자에서의 임신의 결과를 비교해 보았다. 결과: 상기 기간 동안 15명의 자궁기형이 동반된 쌍태분만 및 1428명의 자궁기형이 없는 쌍태분만이 있었다. 동반된 자궁기형은 중격자궁이 9례로 가장 많았으며, 두뿔자궁 3례, 궁상자궁 2례, 단각자궁 1례였다. 환자의 평균 나이는 31.9세 및 34.6세로 자궁기형군이 더 낮았으며, 출산력에는 차이가 없었다. 출산시 평균 주수는 자궁기형군에서는 35주 3일, 자궁기형이 없는 군에서는 36주 1일로 통계학적 차이는없었고(p=0.236), 각각을 28주 미만, 32주 미만, 34주 미만, 37주 미만 및 37주 이상으로 나누어 비교를 해 보았을때도 두군간에 유의한 차이는 없었다 (p=0.612). 출생아의 평균 체중 및 쌍태아간 체중의 차이도 각 군간에 통계학적 차이가 없었다. 결론: 자궁기형이 동반된 쌍태임신이라고 해서 조산이나 신생아 저체중의 위험도가 증가하지는 않는 것으로 보인다.

Evidence based PFMT recommendation in UI/POP: when and how

심소현 대한산부인과학회 2021 대한산부인과학회 학술대회 Vol.107 No.-

Prenatally Diagnosed TTN Mutation with Repeated Bilateral Club Foot by Whole Exome Sequencing

심소현,김지연,성세라,박지은,신윤정,심성한,차동현 한국바이오칩학회 2017 BioChip Journal Vol.11 No.3

With significant advances in genomic technologies over recent years, Next-generation sequencing (NGS) has become an important tool not only for gene discovery and research but also for clinical genetic diagnosis of rare disorders and single-gene-disorder analysis. Many hundreds of single-gene disorders have been described that can manifest prenatally and will comprise a large portion of undiagnosed, chromosomally normal cases but underlying cause of the abnormality still remains unknown for the large majority of cases with an abnormal ultrasound. However, there has been little experience and study in using trio whole exome sequencing (WES) for prenatal diagnosis. In this report the NGS method was applied for the prenatal genetic diagnosis of unidentified life-threatening phenotype in one family and confirmed the pattern of inheritance of titinopathy as well as two novel TTNgene variations. The report presented in these pages offers a unique and valuable perspective on relevance and feasibility of NGS in prenatal diagnosis field.

How to Enhance Motivation to Exert Self-control : Importance of Self-control Goals

심소현 한국전문경영인학회 2022 專門經營人硏究 Vol.25 No.2

Self-control – the capacity to modify one’s behavior – is an essential capability in society and in the workplace. This study proposes a possible self-control depleted-but-driven effect through three studies that investigated the extent to which resource depletion influences motivation to exert self-control. In Study 1, depleted participants heightened their self-control motivation to perform a persistence task. Studies 2 and 3 investigated two important boundary conditions. Specifically, Study 2 demonstrated that depletion boosts self-control motivation only when one’s self-control goals are under threat. Study 3 showed that the depleted-but-driven effect occurs only when people value long-term outcomes. The last two studies suggest that self-control goals are important factors for enhancing the motivation to exert self-control after resource depletion.