포스타 : 내분비학 ; 자궁내막증 발생과 유전자 다형성의 연관성에 관한 연구

심성신,허성은,문혜성,정혜원,안정자 대한산부인과학회 2002 대한산부인과학회 학술대회 Vol.88 No.-

자기공명담췌관조영술상에서 담관결석과 유사하게 보이는 함정들에 관한 연구

심성신,김도연,백승연 대한영상의학회 2002 대한영상의학회지 Vol.46 No.5

식도정맥류 진단을 위한 복부초음파검사의 적정 검사조건

심성신,신정희,백승연 대한초음파의학회 2002 ULTRASONOGRAPHY Vol.21 No.2

COVID-19 in Korea: What Actions Have Been Taken by Radiologists to Support the Fight Against the Disease?

심성신 대한영상의학회 2020 대한영상의학회지 Vol.81 No.3

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해독화 효소 유전자 (GSTM1, GSTT1 and CYP1A1) 다형성과 한국인 여성의 자궁내막증의 연관성에 관한 연구

심성신 ( Sung Shin Shim ),허성은 ( Sung Eun Hur ),이경순 ( Kyung Soon Lee ),문혜성 ( Hye Sung Moon ),안정자 ( Jung Ja Ahn ),유한기 ( Han Ki Yu ),김형래 ( Hyung Rae Kim ),정혜원 ( Hye Won Chung ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.2

목적 : 한국인 여성에 있어 자궁내막증의 감수성을 예측하는데 유전자의 다형성이 관련되어 있는지를 알아보기 위하여 CYP1A1, GSTT1과 GSTM1의 유전자형을 분석하였다. 연구 방법 : 이화여자대학교 산부인과를 방문한 Ⅲ, Ⅳ기의 자궁내막증 환자 74명과 자궁내막증이 없는 환자 93명을 대조군으로 하여 각각의 유전자형을 PCR 등을 이용해서 분석하였다. 결과 : 1. CYP1A1 MspI 다형성에서 wt/wt은 대조군에서 45.1%, 자궁내막증 환자 Objective : Enzymes belonging to the Glutathione S transferase and cytochrome P450 families are involved in the two-stage detoxification process of a number of pro-carcinogens. We genotyped each 74 women with moderate or severe endometriosis and a control

16열 다중 검출 전산화 단층촬영을 이용한 관상동맥 혈관조영술: 영상의 질과 영상 재구성 창의 최적화

김유경,심성신,임수미,황지영,김윤경 대한영상의학회 2005 대한영상의학회지 Vol.52 No.1

Purpose: The purpose of this experiment is to investigate the image quality of CT coronary angiography using a 16-slice multi-detector row CT and to determine the optimal image reconstruction window. Materials and Methods: CT coronary angiography was obtained in 36 nonsymptomatic volunteers using a 16- slice multi-detector row CT (SOMATOM Sensation, Siemens Medical System). The mean heart rates were 70 beats per minute (bpm) or less in 18 persons and more than 70 bpm in 18 persons. Eleven data sets were obtained for each patient (reconstructed at 30%-80% of the cardiac cycle with an increment of 5%). Image quality of the eight coronary segments [left main coronary artery (LM), proximal and middle segments of left anterior descending artery (p-LAD, m-LAD) and left circumflex coronary artery (p-LCx, m-LCx) and proximal, middle and distal segments of right coronary artery (p-RCA, m-RCA, d-RCA)] was assessed. Results: The optimal reconstruction windows in the cardiac cycle for the best image quality were 60-70% for the segments of the LM, LAD, and LC arteries in two groups (bpm<70, bpm>70) and 55-65% (bpm<70) or 30-40% and 65-70% (bpm>70) for the segments of the RCA. On the best dataset for each coronary segment, the following diagnostic image quality was achieved in the two groups: LM: 100%, 83%; p-LAD: 100%, 88%; m-LAD: 100%, 72%; p-LCx: 100%, 72%; m-LCx: 100%, 72%; p-RCA: 94%, 72%; m-RCA: 61%, 50%; d-RCA: 100%, 88%. Conclusion: The 16 slice multi-detector row CT scan provided visualization of the coronary arteries with high resolution. Especially in the group with a mean heart rate of 70 bpm or less, all the coronary segments except the RCA showed diagnostic image quality. Optimal image quality was achieved with a 60-70% trigger delay for all coronary arterial segments, but the best images of RCA were achieved in the earlier cardiac phase in the patients with a mean heart rate of more than 70 bpm. 목적: 16열 다중 검출 CT를 이용한 전산화단층촬영 관상동맥 혈관조영술(CT coronary angiography, CTCA)의 영상의 질과 최적의 영상재구성창에 대하여 알아보고자 하였다. 대상과 방법: 무증상 지원자 36명에서 16열 다중 검출 CT(SOMATOM Sensation, Siemens Medical System)를 이용하여 CTCA를 시행하였다. 평균 분당 심박동수가 70회 이하인 사람이 18명, 71회 이상인 사람이 18명 이었다. 영상 재구성은 모든 대상에서 심장주기의 30%-80%까지 5% 간격으로 시행하여 11세트의 영상을 얻었고, 총 396개의 영상세트에서 관상동맥의 8분절(좌측 주 관상동맥(LM), 좌측 전하행 관상동맥과 좌측 회선 관상동맥의 근위부(p- LAD, p-LCx) 및 중간부(m-LAD, m-LCx) 분절, 우측 관상동맥의 근위부, 중간부, 및 원위부 분절(p-RCA, m-RCA, d-RCA)의 영상의 질을 평가하였다. 결과: 최고의 영상을 얻기 위한 심장주기의 재구성 창은 평균 분당 심박동수가 70회 이하인 그룹에서는 LM, LAD, LCx의 분절들은 60%-70%, RCA의 분절들은 55%-65%였고, 71회 이상인 그룹에서는 LM, LAD, LCx는 60%-70%, RCA는 30%-40%와 65%-70%였다. 최고의 질을 보이는 영상세트에서 진단에 적절한 영상을 보인 분절 수는 평균 분당 심박동수가 70회 이하와 71회 이상인 그룹으로 나누었을 때 각각의 분절에서 LM: 100%, 83%; p-LAD: 100%, 88%; m-LAD: 100%, 72%; p-LCx: 100%, 72%; m-LCx: 100%, 72%; p-RCA: 94%, 72%; m-RCA: 61%, 50%; d-RCA: 100%, 88%였다. 결론: 16열 다중 검출 CT는 고해상도로 관상동맥을 영상화 할 수 있고, 특히 평균 심박동수 70회 이하에서는 RCA를 제외한 모든 관상동맥에서 진단적 영상을 얻을 수 있었다. 대부분 심장주기의 60%-70%에서 모든 관상동맥 분절의 최고 영상을 얻을 수 있었으나, 평균 심박동수 71회 이상에서는 RCA가 더 이른 심장주기에서 최고의 영상을 보이기도 하였다.

p53 Codon 72 다형성과 한국인 여성의 자궁내막증의 연관성에 관한 연구

허성은,심성신,이경순,문혜성,유한기,정혜원,Hur, Sung-Eun,Shim, Soung-Shin,Lee, Kyung-Soon,Moon, Hye-Sung,Yu, Han-Ki,Chung, Hye-Won 대한생식의학회 2002 Clinical and Experimental Reproductive Medicine Vol.29 No.4

Objective: The present study was performed to evaluate the association o f p53 codon 72 polymorphism and endometriosis. Materials and Methods: We investigate 74 women who were operated for endometriosis and 93 women who had no endometriotic lesion proved by operation. Polymerase chain reaction was used to detect p53 codon polymorphisms. Result: We have found no significant difference between endometriosis and control group in the p53 codon polymorphism. The respective proportion of arginine homozygotes, heterozygotes and proline homozygotes in endometriosis group were 18.9%, 62.2% and 18.9%, respectively, and were 12.9%, 75.2% and 11.9%, respective in the group without endometriosis. Conclusion: Endometriosis is not associated with p53 polymorphism in Korean endometriosis patients.

Pneumatosis Intestinalis Associated with Pulmonary Disorders

고영선,심성신,김유경,장중현 대한영상의학회 2019 대한영상의학회지 Vol.80 No.2

Purpose To determine the clinical features, imaging findings and possible causes of pneumatosis intestinalis (PI) in thoracic disorder patients. Materials and Methods From 2005 to 2017, Among 62 PI patients, four of PI related with thoracic disease (6%) were identified. Medical records were reviewed to determine the clinical presentation, laboratory findings and treatment at the time of presentation of PI. Two experienced chest radiologists reviewed all imaging studies and recorded specific findings for each patient. Results The causative thoracic diseases for each four patient were severe asthma, emphysema and airway obstruction. The imaging appearance of PI, including the involved bowel segment and pattern of the air, were divided into two mesenteric vascular territories; three of our cases showed linear pattern of PI located in the ascending & proximal transverse colon and the fourth case (lung cancer) had bubbly and cystic PI in the distal transverse and descending colon. All of the remaining 3 patients, except one patient who had not been followed up, improved within 1 month by conservative treatment. Conclusion Thoracic disorder with obstructive lung disease may result in the development of benign PI. Such PI in thoracic disease patients has a similar linear and cystic appearance with ischemic bowel disease, but can nevertheless be managed by conservative treatment.

Chest CT Findings in Patients with Non-Cardiovascular Causes of Chest Pain: Focusing on Pulmonary Tuberculosis in a Tuberculosis Endemic Country

이소원,심성신,김유경,류연주 대한영상의학회 2015 대한영상의학회지 Vol.73 No.4

Purpose: To review the common causes of non-cardiovascular chest pain (NCCP) according to the location and lesion type as seen on chest CT, and to evaluate CT findings in tuberculosis (TB) as a cause of NCCP. Materials and Methods: In the period 2009 to 2012, patients having NCCP without definitive evidence of acute myocardial infarction, pulmonary thromboembolism, and aortic dissection, were included. In total, 162 patients (60.5% male; 39.5% female), with a mean age of 51 years, were enrolled. CT images were evaluated by location and lesion type, for causes of NCCP. Results: Chest CT revealed that the most common location for the cause of NCCP was the pleura (45.1%), followed by the subpleural lung parenchyma (30.2%). The most common lesion causing NCCP was TB (33.3%), followed by pneumonia (19.1%). Of the 54 TB cases, 40 (74.1%) were stable TB and 14 (25.9%) were active TB; among these 54 patients, NCCP was most commonly the result of fibrotic pleural thickening (55.6%), followed by subpleural stable pulmonary TB (14.8%). Conclusion: Results of chest CT revealed that TB was a major cause of NCCP in a TB endemic area. Among the TB patients, fibrotic pleural thickening in patients with stable TB was the most common cause of NCCP.

Assessment of Maxillary Sinus Wall Thickness with Paranasal Sinus Digital Tomosynthesis and CT

변지은,심성신,김유경,공경애 대한영상의학회 2017 대한영상의학회지 Vol.76 No.5

Purpose: This study was performed to compare paranasal sinus tomosynthesis with computed tomography (CT) imaging as a radiologic tool to evaluate the paranasal sinuses, using measurement of the soft tissue thickness of the maxillary sinus. Materials and Methods: A total of 114 patients with sinusitis who underwent both paranasal sinus digital tomosynthesis (DT) and CT were enrolled in this retrospective study. Two observers independently assessed soft tissue thickness in both maxillary sinus chambers using both DT and CT images. Results: The mean difference in soft tissue thickness measured by each observer was -0.31 mm on CT and 0.15 mm on DT. The mean differences in soft tissue thickness measured with DT and CT were -0.15 by observer 1 and -0.31 by observer 2. Evaluation of the agreement in measurement of soft tissue thickness in the maxillary sinus using DT and CT showed a high intraclass correlation, with the 95% limit of agreement ranging from -3.36 mm to 3.06 mm [intraclass correlation coefficient (ICC), 0.994: p < 0.01] for observer 1 and from -5.56 mm to 4.95 mm (ICC, 0.984: p < 0.01) for observer 2. Conclusion: As an imaging tool, DT is comparable to CT for assessing the soft tissue thickness of maxillary sinuses in patients with sinusitis.