http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
단순정맥압박검사에 의한 혈액내 FDP ( fibrinogen degradation produc ) 농도 변화를 이용한 인슐린비의존성 당뇨병환자와 뇌졸중환자의 대혈관기능 이상 진단
김상훈(Sang Hoon Kim),심성춘(Sung Chun Sim),장남수(Nam Soo Jang),박창영(Chang Young Park),최윤상(Young Sang Choi),이규백(Kyu Beck Lee),강진호(Jin Ho Kang),김향(Hang Kim),조윤경(Yoon Kyung Cho),김유리(Yoo Lee Kim),이상종(Sang Jong Le 대한내과학회 1999 대한내과학회지 Vol.56 No.5
N/A Objectives : In diabetic patients, the incidence of atherosclerotic disease are increased, which may be due to decreased fibrinolytic activity. The aim of study is to elucidate the relationship between angiopathies and vascular function evaluated by simplified venous occlusion test in patients with non-insulin dependent diabetes mellitus (NIDDM) and cerebrovascular accident (CVA). Methods : The study was conducted on 63 patients who were hospitalized during the period from March 1, 1994 to May 30, 1997. The serum concentration of fibrinogen degradation products (FDP) was measured before and 5 min after venous occlusion in 31 NIDDM patients, 16 CVA patients and 16 age-matched control subjects. FDP was measured with the anti-fibrinogen- coated latex particle agglutinin assay system. Results : 1) The basal serum FDP level was higher in diabetic patients with macroangiopathy (12.3±5.8 ug/ml) and patients with CVA (11.2±5.1 ug/ml) than in control subjects (5.7±1.8 ug/ml) (p<0.05). 2) The increment of serum FDP level after venous occlusion in diabetic patients with microangiopathy (6.6±2.2 to 10.3±4.1 ug/ml) and control subjects (5.7±1.8 to 11.4±4.3 ug/ml) was significantly higher than basal serum FDP level (p<0.05). But the increment of serum FDP level after venous occlusion in diabetic patients with macroangiopathy (12.3±5.8 to 15.2±5.1 ug/ml) and patients with CVA (11.2±5.1 to 13.7±4.8 ug/ml) wasn't significantly higher than basal serum FDP level. 3) The increment rate of serum FDP after venous occlusion in diabetic patients with macroangiopathy (24.4±29.3%) and patients with CVA (29.4±34.5%) was significantly lower than diabetic patients with microangiopathy (66.3±71.7%) and control subjects (84.1±69.3%) (p<0.05). Conclusion : The responsiveness of fibrinolytic activity to venous occlusion was significantly lower in diabetic patients with macroangiopathy, as in patients with CVA, compared with that in control subjects. We conclude that measurement of the increase in serum FDP concentration 5 min after venous occlusion may be useful to detect vascular dysfunction in patients with macrovascular disease caused by atherosclerosis.
건강 검진 수진자에서 종양 표지자 측정의 임상적 효율성
김지연(Ji Youn Kim),심성춘(Seong Chun Shim),정현식(Hyun Sik Jeong),이승세(Seung Sei Lee) 대한내과학회 2001 대한내과학회지 Vol.60 No.2
N/A Background : Many tumor markers have been investigated for early diagnosis of the malignancy, yet they were turned out to be inappropriate for the purpose. This study was carried out to investigate the efficacy of tumor markers. Methods : Employing radioimmunoassay, CEA, AFP, CA19-9, PSA, CA125 were done in 31,389 patients(20,878 males, 10,511 females) who visited our medical screening center from Jan. 1 1997 to Dec. 31 1997. Results : Total mean value of CEA is 1.90±1.37 ng/mL(male: 2.17±1.37, female: 1.37±0.86). Male showed significantly higher level of CEA. Only 2 subjects had values over 25 ng/mL, and one was diagnosed to have stomach cancer but the other did not. Total mean value of AFP is 2.46±6.47 ng/mL (male: 2.32±3.55 ng/mL, female: 2.73±10.06 ng/mL). Female showed significantly higher level of measured AFP. One had AFP value over 400 ng/mL and was diagnosed of hepatoma. Total mean value of CA19-9 is 11.48±7.61 ng/mL,(male: 10.9±26.78 ng/mL, female: 12.61±8.97 ng/mL). Female showed significantly higher CA19-9. 65 subjects (male: 31, female: 34) showed measured CA19-9 level over 37 ng/mL. 5 subjects had values over 100 ng/mL and 1 subject was diagnosed of pancrease cancer. Total mean value of PSA is 0.79±1.88 ng/mL. 90 subjects showed measured PSA level over 4 ng/mL and mean value in this group was 10.92 ng/mL. 54 subjects were older than age 50. 4 out of 90 subjects were diagnosed of prostate cancer. Total mean value of CA125 is 13.08±10.93 ng/mL. 160 subjects showed measured CA125 level over 35 ng/mL. 19 subjects had value over 100 ng/mL and none of the malignancy was detected. Conclusion : Tumor markers are inappropriate measures for screening of malignancy. (Korean J Med 60:148-155, 2001)
급성 A형 간염의 군인에서의 다발생(Outbreak) : 암상, 역학적 연구 A Clinical and Epidemiologic Study
한성희,이동후,이숭환,손주현,기춘석,노병주,심성춘,조승철 대한간학회 2001 Clinical and Molecular Hepatology(대한간학회지) Vol.7 No.4
Background / Aims : Increasing the susceptibility of young populations to HAV infection could result in an outbreak in a high-risk group. The author investigated the characteristics of hepatitis A outbreaks among Korean military personnel to obtain the fundamental data for determining the necessity for selective HAV vaccination. Methods : A case was defined as a person who had an onset of an illness compatible with acute viral hepatitis A between 4 February and 6 April 1998. Results : A widespread outbreak of hepatitis A affected 102 military personnel. The epidemic curve indicated a common-source exposure in the initial stage. At the end of the first month of the initial onset, the occurrence was specific to the location of the military post. Investigation suggested that contamination most likely occurred prior to the local distribution of food. The mean age was 23 years. The overall attack rate was 91 cases per 10000 persons at risk. All cases were jaundiced. The most frequently reported symptoms included icteric sclerae, daek urine,anorexia, malaise and fatigue, nausea, fever,abdominal pain, headache, upper respiratory symptoms, vomiting, itching, diarrhea, light-colores stools, myalgia, arthralgia, and skinrash. The laboratory test showed the serum total bilirubin of 5.5 mg./dL, AST of 344 IU/L, and ALT of 868 IU/L(mean value). Conclusion : All patients were clinically apparently diseased with jaundice and were completely recovered. The outbreak was food borne common-source exposure. The changing epidemiology hepatitis A in Korea calls for the economic evaluation of costs and benefits for selective HAV vaccination in high risk adult groups including military personnel.
박창영,김명숙,이승원,이상종,최권,김병익,심성춘,송승호,엄현주 대한내과학회 1998 대한내과학회지 Vol.55 No.5
Primary biliary cirrhosis(PBC) is a chronic progressive disease, more often affecting women, characterised by progressive destruction of the small intrahepatic bile ducts with portal inflammation leading to fibrosis and cirrhosis. There is a close association between PBC and antibodies to antimitochondrial antibodies(AMA). The pathogenesis of PBC remains uncertain. The disease has been considered as an example of autoimmunity. Estimates of disease prevalence vary between 20 and 240 cases per milion per year. PBC is a extremely rare liver disease in Asia. There is no definitive drug treatment, liver transplantation is indicated for patients with intractable symptoms and for end-stage disease. The authors have experienced a case of PBC in 66 year-old female who suffered from lethargy, pruritus and dry mouth since 2 years ago. We report a case of PBC with a review of literatures.