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송지인,박민지,이유민,김춘동,이희경,김성수,이종현 순천향대학교 순천향의학연구소 2017 Journal of Soonchunhyang Medical Science Vol.23 No.1
Objective: Rotavirus and norovirus are the most common pathogens causing acute gastroenteritis in children. As the incidence of noroviral gastroenteritis increases, it is becoming more important to identify the clinical features of noroviral infection. We compared the clinical features of noroviral gastroenteritis and rotaviral gastroenteritis. Methods: This study included 79 children with noroviral and 151 children with rotaviral gastroenteritis, who were admitted to the Soonchunhyang University Gumi Hospital between January 2013 and December 2014. We reviewed their medical records and compared the clinical features of gastroenteritis between the two groups respectively. Results: In those belonging to the norovirus group, the mean age was 29.65 months, which was younger than that of the rotavirus group, at 34.74 months. Patients suffering from noroviral gastroenteritis experienced more vomiting (5.6 episodes/day) than diarrhea (3.5 episodes/day). Vomiting, diarrhea, and fever were all less severe in those suffering from noroviral gastroenteritis. It is commonly noted that patients with noroviral infection have vomiting and diarrhea without fever (55.0%), while those with rotaviral infection present with vomiting, diarrhea, and fever (44.3%). Conclusion: Although noroviral gastroenteritis is less severe than rotaviral gastroenteritis, the incidence of noroviral infection is increasing, and the mean age group infected with this virus is getting younger; thus, noroviral infection must be considered in the differential diagnoses in young patients with gastroenteritis.
장재율,장서혁,송다운,송노준,한새로아름,오승준,윤의정,안지인,이석찬,구진모,박계원 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.12
Butea monosperma (Lam.) Taub. has been applied to treat inflammatory, metabolic, and infectious diseases. However, the antiobesity effects of B. monosperma (Lam.) Taub. flower (BMF) and the underlying mechanisms have not been determined. In this study, we analyzed the various extraction procedures, investigated the antiobesity effects, and identified the main chemical constituents of BMF. The BMF was subjected to acid hydrolysis in 5% H2SO4 in methanol at 50°C for 48 h and partitioned with ethyl acetate. The acid-hydrolyzed BMF ethyl acetate extracts (BMFE) strongly induced the expression of uncoupling protein 1 (Ucp1) and other thermogenic genes in C3H10T1/2 adipocytes. Daily oral administration of 70 mg/kg BMFE (BMFE70) to mice with diet-induced obesity resulted in less body weight gain, increased glucose tolerance, higher rectal temperature, and increased oxygen consumption. Qualitative and quantitative analyses along with treatments in Akt1 knockout mouse embryonic fibroblasts indicate that butein is a major active ingredient of BMFE, which stimulates Ucp1 gene expression. These data show the effects of butein-containing B. monosperma flower extract on thermogenesis and energy expenditure, further suggesting the potential role of BMFE as a functional ingredient in obesity and related metabolic diseases.