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정상 성인의 말초 혈액 림프구에 표현된 Humkv325-derived κ 경쇄에서의 N-region addition
송준현,이찬희,이지수,이수곤 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.2
Complementarity determining region(CDR3) of immunoglobulin is the center of antigen binding site. Changes in the number of amino acids of CDR3 may result in change in antigen binding specificity and affinity. The majority of immunoglobulin x chain has 9 or 10 amino acid co-dons in the CDR3 region. Immunoglobulin x chain containing CDR3 with 11 amino acid codons cannot be made without N-region addition. The aims of this study were to evaluate the presence of immunoglobulin x light chain with 11 amino acid codons in its CDR3 domain expressed in the peripheral blood lymphocytes(PBLs) of normal individuals and to correlate amino acid codon length in CDR3 region with age and sex. RNA was isolated from PBLs of normal individuals and x chain was PCR amplified. Amino acid length of CDR3 region was determined by polyacrylamide gel electrophoresis. A low but constant expression of immunoglobulin x chain with 11 amino acid codons in CDR3 region in normal individuals was found (mean±SD=11.72±1.80%). Significant correlation was not found between amino acid length in CDR3 region of x chain and age or sex. These findings suggest that the concept that N-region addition in x light chain does not occur due to absence of terminal deoxynucleotidyl transferase (TdT) needs to be reconsidered. The existence of long CDR3 K chain in PBLs of normal individuals may reflect that CDR diversity in is quite common. Amino acid length of x chain CDR3 is not regulated during development and there is no influence of sex on the expression of x chain containing CDR3 with 11 amino acids.
대학생의 분리-개별화와 의존성 우울취약성의 관계에서공적자의식, 거부민감성, 정서표현양가성의 매개효과
송준현,백용매 한국임상심리학회 2018 한국심리학회지: 임상심리 연구와 실제 Vol.4 No.1
The purpose of this study was to investigate the structural relationship and mediating effects of variables affecting dependent depression vulnerability in college students in the secondary separation-individualization periods and to verify whether gender differences were present in the structural relationship. To achieve this goal, the public self-consciousness, rejection sensitivity, and ambivalence over emotional expressiveness were selected as mediators affecting dependent depression vulnerability, and the relationship between variables was analyzed through the structural equation model(SEM). The main findings of this study were as follows. First, separation-individualization had a negative relationship with public self-consciousness, rejection sensitivity, ambivalence over emotional expressiveness, and dependent depression vulnerability. Second, public self-consciousness, rejection sensitivity, and ambivalence over emotional expressiveness mediated in the relationship between separation-individuation and dependent depression vulnerability. Third, the level of separation- individualization was lower in women than in men, and the levels of rejection sensitivity and dependency depression were higher. Lastly, women may present a high dependent depressive vulnerability, even if they have a high level of separation-individuation. Based on these results, the academic and clinical implications of this study were discussed according to the object relations theory. 본 연구는 2차 분리-개별화 시기에 있는 대학생을 대상으로 의존성 우울취약성에 영향을 미치는 변인들의 구조적 관계와 매개효과를 살펴보고, 구조적 관계에서 남녀 간에 차이가 있는지를 확인하고자 하였다. 공적자의식, 거부민감성, 정서표현양가성을 의존성 우울취약성에 영향을 미치는 매개변인으로 선정하였으며, 구조방정식모델(SEM)을 통해 변인들 간의 구조적 관계를 분석하였다. 본 연구에서 밝혀진 결과는 다음과 같다. 첫째, 분리-개별화는 공적자의식과 거부민감성, 정서표현양가성, 의존성 우울취약성과 부적 관계에 있는 것으로 나타났다. 둘째, 분리-개별화는 공적자의식, 거부민감성, 정서표현양가성을 매개하여 의존성 우울취약성에 영향을 미치는 것으로 나타났다. 셋째, 여성은 남성에 비해 분리-개별화 수준이 낮았으며, 거부민감성과 의존성 우울취약성의 수준은 높았다. 마지막으로, 여성은 분리-개별화 수준이 높아도 의존성 우울취약성이 높을 수 있다. 이러한 결과를 바탕으로 본 연구의 학문적, 임상적 시사점을 대상관계이론에 기반하여 논의하였다.
송준현(JoonHyun Song),김일곤(Ilkon Kim),조훈(Hune Cho),곽연식(YunSik Kwak) 한국정보과학회 2003 한국정보과학회 학술발표논문집 Vol.30 No.2Ⅱ
HL7(Health Level 7)은 보건의료 분야에서 ANSI에서 승인한 SDO(Standards Developing Organization)들 중의 하나이다. 대부분의 SDO들은 약제, 의료 장비 이미지, 보험 처리 등과 같은 보건 의료 분야에서의 표준을 만든다. HL7의 영역은 진료와 병원 행정적인 부분이다. HL7에서는 Version2.3, Version2.4, Version3.0 등을 포함해 Data Model, Arden Syntax, CCOW(Common Context Object Workgroup), CDA(Clinical Document Architecture) 등의 표준을 만들어 나간다. 본 논문에서는 이 표준들 중 CCOW에 대해 알아보고, 기존 Agent System에 좀 더 지능적이고 자율적인 CCOW 서비스를 제공하는 방안을 알아본다.
절점 밀도 및 이선형 보간 기반 자연적 경계면을 갖는 3차원 위상 최적 설계 기법
송준현(Joon-Hyun Song),김철(Cheol Kim) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11
In a traditional topology optimization method, material properties are usually distributed by finite element density and visualized by a gray level image. The distribution method based on element density is adequate for a great mass of 2-D topology optimization problems. However, when it is used for 3-D topology optimization, it is always difficult to obtain a smooth model representation, and easily appears a virtual-connect phenomenon especially in a low-density domain. The 3-D structural topology optimization method has been developed using the node density instead of the element density that is based on SIMP (solid isotropic microstructure with penalization) algorithm. A computer code based on Matlab was written to validate the proposed method. When it was compared to the element density as design variable, this method could get a more uniform density distribution. To show the usefulness of this method, several typical examples of structure topology optimization are presented.
만성 B형 간염 환자에서 조직 활동도와 IL-1β, IL-1RN 유전자 다형성의 관련성
송준현 ( Song Jun Hyeon ),박진홍 ( Park Jin Hong ),이동현 ( Lee Dong Hyeon ),허정 ( Heo Jeong ),김광하 ( Kim Gwang Ha ),강대환 ( Kang Dae Hwan ),송근암 ( Song Geun Am ),조몽 ( Jo Mong ),양웅석 ( Yang Ung Seog ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<배경 및 목적> 만성 B형 간염 바이러스 감염자의 일부에서 간의 염증 및 섬유화가 진행하여 간경변으로 진행한다. 만성 B형 간염환자에서 인터루킨-1 (IL-1)의 활동도 증가는 간 섬유화 정도를 증가시키는 것으로 알려져 있다. 만성 HBV 감염자에서 IL-1β와 IL-1RN 유전자 다형성을 분석하여 유전자형 및 대립형질 양상이 생화학 검사, 혈청 HBV DNA 및 간 조직 활동도에 미치는 영향을 조사하고자 하였다. <대상 및 방법> 2001년 8월부터
송준현(Jun Hyeon Song),함기백(Ki Baik Hahm),조홍근(Hong Keun Cho),강진경(Jin Kyoung Kang),박인서(In Suh Park),김은영(Eun Young Kim),임대순(Dae Sonn Yim) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.3
Multiseptate gallbladder is a rare congenital anornaly. Only 23 cases have been reported pre- viously in the world literature. Since the failure of fusion of numerous intraepithelial clefts has been considered to be a conceivable mechanism for the production of multiseptate gallbladder, the genesis of t.his anomaly is of embryologic interest. The multiseptate gallbladder has its spe- cific radiologic appearance. The septations appear as fine, radiolucent defects within the con- trast filled gallbladder, sirnulating honeycomb appearance. These septat,ions are very thin and have been over looked and confused with stones, so that careful inspection is necessary. In this case report, we described a 49 year-old female patients, whose ERCP and ultrasono- graphic findings were compatible with multiseptate gallbladder and reviewed cases which has been reported in literature. (Korean J Gastroenterol 1994; 26: 607-613)