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조창현,전철우,송원재,김성후,정덕환,Cho, Chang-Hyun,Jeun, Churl-Woo,Song, Won-Jae,Kim, Sung-Hoo,Chung, Duke-Whan 대한미세수술학회 2006 Archives of reconstructive microsurgery Vol.15 No.1
Purpose: The purpose of this study was to evaluate the effectiveness of limb reconstruction and functional recovery using vascularized fibular graft in the treatment of extensive bone defect of long bone caused by various diseases. Materials and Methods: From september 1995 to March 2005, 21 patients with segmental bone defects were managed with vascularized fibular graft: 13 males and 8 females, aged 39 years on average (range, $8{\sim}65\;years$). The reconstructed site was the humerus in 9 patients, the femur in 5, the tibia in 4 and the forearm bone in 3. The length of bone defect ranged from $8{\sim}17\;cm$. Results: Twenty grafts were successful. The mean period to obtain radiographic bone union was 5.7 months on average. Conclusion: Fibular grafts allow the use of a segment of diaphyseal bone and of sufficient length to reconstruct most skeletal defects of the long bone. The vascularized fibular graft is indicated in patients with intractable nonunions where conventional bone grafting has failed or large bone defects.
IL-4와 다른 여러가지 cytokines이 사람 편도 단핵세포의 IgE 생산에 미치는 영향
이헌구,송원재,하대유 大韓免疫學會 1995 大韓免疫學會誌 Vol.17 No.3
The present study was desinged to compare IgE producing ability of cultured human tonsillar mononuclear cells (TMNC) stimulated by rhIL-4 between complete Iscove's modified Dulbeco's medium (C-IMDM, which was composed of IMDM enriched with bovine serum albumin, fetal calf serum, transferrin, insulin, and mixture of saturated and unsaturated fatty acids) and RPMI-1640 supplemented with FCS (RPMI-1640), as well as to investigate a single or combined effects of IL-4 and 7 different human cytokines (IL-2, IL-5, IL-6, IL-7, TNF-a, IFN- 7' and TGF-fi ) in a culture system on IgE production of human TMNC. It was found that C-IMDM was superior to RPMI 1640 as a culture medium for supporting the synthesis of IgE by TMNC stimulated with rhIL-4. In fact, RPMI-1640 failed to induce significant IgE synthesis by TMNC cultured for 21 days in the presence of rhlL-4 (100 U / ml). In addition, 7 different cytokines other than IL-4 failed to induce the significant IgE synthesis by TMNC cultured in C-IMDM when tested alone. However, IL-2 or IL-6, which was ineffective in inducing IgE production when tested alone, enhanced IL-4-mediated IgE production, indicating - that IL-2 or IL-6 acts synergistically with IL-4. In contrast, IFN- Y . or TGF-J1 demonstrated the inhibition of IL-4 dependent IgE synthesis by TMNC. Interestingly, IL-5, IL-7 and TNF-a had no modulatory effect on the IL-4 dependent IgE response in the applied experimental conditions. Taken together, the present results strongly suggested that 1) C-IMDM may be superior to RPMI-1640 as a culture _medium for IgE production, 2) Only IL-4 had the ability to stimulate in vitro with IgE synthesis by TMNC when tested alone. 3) IL-2 and IL-6 may be synergistic with IL-4 in IgE synthesis, 4) IFN- F and TGF-P may have the antagonistic effects on IL-4 dependent IgE synthesis and 5) IL-5, IL-7 and TNF-a may have no modulatory effects. This study also suggested that increased insight into various mechanisms of IgE regulation by cytokines may eventually lead to improve therapeutic strategies in the clinical management of IgE-mediated allergy.
조명래,박정호,손정환,송원재 대한골절학회 2002 대한골절학회지 Vol.15 No.1
소아 대퇴 경부 골절은 성인에 비하여 드물게 발생하나 강력한 외력에 의하여 주로 발생하며 골두 무혈성 괴사, 내반 고, 성장판 조기유합 및 불유합 등의 합병증의 발생이 높은 골절이다. 7세 된 여아로 교통사고로 인한 대퇴 경부 골절로 도수 정복 및 내고정 시행하였으며, 술 후 1년에 내반 변형과, 대퇴 골두 골단 분리증 및 골두의 무혈성 괴사 소견 보여 외반 절골술 및 골단 고정술을 시행하였다. 소아대퇴 경부 골절 후의 합병증으로는 여러 가지가 있으나 부정 유합, 내반 변형, 대퇴 골두 골단 분리증 및 무혈성 괴사가 모두 동반된 경우는 흔하지 않은 상태로 본원에서 경험하였기에 문헌고찰과 함꼐 보고 하고자 한다.