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강직성 척추염에서 methotrexate의 임상적 유용성
손정환,정구희 고신대학교의과대학 2006 고신대학교 의과대학 학술지 Vol.21 No.2
Background: Methotrexate is used frequently as high-dose anticancer therapy and a disease modifying antirheumatic drug for rheumatoid arthritis. This study was designed to evaluate the efficacy of methotrexate treatment in patients with ankylosing spondylitis(AS) who were not improved for NSAIDs and physical therapy. Materials and Methods: Fifty-six patients with AS who were follow-up more 12 months from 1998 to 2004 year were distributed into 2 groups. In group Ⅰ(n=30), treated with methotrexate and in group Ⅱ(n=26), not methotrexate, patients were evaluated and analysed using independent samples t-test for the changes of visual analogue scale(VAS), erythrocyte sedimentation rate(ESR) and c-reactive protein(CRP). Results: The changes of VAS, ERS & CRP in groups were significantly(p<0.05). The side effects were transiently observed in 27 cases and included elevation of liver enzymes(13 cases), dyspeptic syndrome(12 cases), increased vascular marking on CPA(1 cases), and dizziness(1 cases). Conclusion: The our results suggest that the use of methotrexate is efficient for early treatment in ankylosing spondylitis.
전방 십자인대 재건술에서 발생한 이식물-터널 불일치에서 스테플을 이용한 경골 고정 방법의 비교
손정환,조율 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4
Purpose : To evaluate each clinical results of variable tibial fixation with staple to resolve graft-tunnel mismatch in arthroscopic ACL reconstruction. Materials and Methods : The operative reports of patients who underwent arthroscopic ACL reconstruction between 1998 and 2007 were reviewed. Group 1(12 patients) treated with a interference screw augmented by staple fixation, and group 2(11 patients) treated with only staples fixation to resolve graft-tunnel mismatch. Mean follow-up was 25.9 ± 14.9 months for group 1 and 25.2 ± 12.1 months for group 2. We compared the clinical results by physical examination(Lachman test, pivot shift test), Lysholm score and International Knee Documentation Committee(IKDC), objective knee evaluation form. Results : The Lachman test was acceptable result in 11(91.6%) cases of group 1, 10(90.9%) cases of group 2 at latest follow-up. The pivot shift test was acceptable result in 11(91.6%) cases of group 1, 10(90.9%) cases of group 2 at latest follow-up. Lysholm score improved from 52.8, 55.6 to 93.2, 93.6. The IKDC grade was abnormal(C) or severely abnormal(D) in all cases preoperatively. They improved 2 cases of normal(A), 9 cases of nearly normal(B), 1 case of abnormal(C) in group 1, 2 cases of normal(A), 8 cases of nearly normal(B), 1 case of abnormal(C) in group 2. Conclusion : No statistical difference of clinical result was found among two groups and no difference was noted between these results and previous result of patients undergoing conventional ACL reconstruction. So theses results demonstrate the interference screw augmented by staple fixation and only staples fixation are effective in resolving graft-tunnel mismatch in arthroscopic ACL reconstruction.
$CCI_4$ 를 사용하여 베이스를 탄소도핑한 AlGaAs/GaAs HBT의 제작 및 특성
손정환,김동욱,홍성철,권영세 대한전자공학회 1993 전자공학회논문지-A Vol.30 No.12
A 4${\times}10^{19}cm^{3}$ carbon-doped base AlGaAs/GaAs HBY was grown using carbontetracholoride(CCl$_4$) by atmospheric pressure MOCVD. Abruptness of emitter-base junction was characterized by SIMS(secondary ion mass spectorscopy) and the doping concentration of base layer was confirmed by DXRD(double crystal X-ray diffractometry). Mesa-type HBTs were fabricated using wet etching and lift-off technique. The base sheet resistance of R$_{sheet}$=550${\Omega}$/square was measured using TLM(transmission line model) method. The fabricated transistor achieved a collector-base junction breakdown voltage of BV$_{CBO}$=25V and a critical collector current density of J$_{O}$=40kA/cm$^2$ at V$_{CE}$=2V. The 50$\times$100$\mu$</TEX$^2$ emitter transistor showed a common emitter DC current gain of h$_{FE}$=30 at a collector current density of JS1CT=5kA/cm$^2$ and a base current ideality factor of ηS1EBT=1.4. The high frequency characterization of 5$\times$50$\mu$m$^2$ emitter transistor was carried out by on-wafer S-parameter measurement at 0.1~18.1GHz. Current gain cutoff frequency of f$_{T}$=27GHz and maximum oscillation frequency of f$_{max}$=16GHz were obtained from the measured Sparameter and device parameters of small-signal lumped-element equivalent network were extracted using Libra software. The fabricated HBT was proved to be useful to high speed and power spplications.
제 2형 콜라겐에 의해 유도된 쥐의 관절염에서 고용량 Methotrexate의 치료 효과
손정환,서태혁,정구희,김재도 대한정형외과학회 2002 대한정형외과학회지 Vol.37 No.1
Purpose : Rat arthritis was induced by bovine type II collagen. To present the remedial effects on type II collagen arthritis and clinical efficacy, a high dose of methotrexate, of a level similar to that used in cancer patients was given to rats. 목 적 : 쥐에서 제 2형 콜라겐 유도에 의한 인공적 관절염을 유발시킨 후 methotrexate를 단위 체표면적당 골종양 환자와 비슷한 용량(사람 Max. 12 g/BSA)으로 쥐에 투여하여 관절염에 대한 약물의 치료 효과 및 임상적 유용성을 제시하고자 하였다.
중등도의 관절강 협착 소견을 나타내는 슬관절 퇴행성 관절염의 관절경적 치료
손정환,추원권,정소학 대한정형외과학회 2002 대한정형외과학회지 Vol.37 No.1
Purpose : This study was performed to determined by follow-up observation, the result of the arthroscopic treatment for advanced degenerative arthritis of the knee joint. 목 적 : 슬관절 퇴행성 관절염은 보존적 치료에 반응이 없으면 관절경적 치료를 시행하는 것이 좋은 결과를 나타내었다고 많은 저자들이 보고하였는 바, 본 교실에서는 진행된 슬관절 퇴행성 관절염에서 관절경적 치료 후 추시 관찰 결과를 알아 보고자 한다.