어린이에게 주는 不朽의 선물 (小波全集 新刊評)

李軒求 박문서관 1940 博文 Vol.19 No.-

小波의 印象

李軒求 박문서관 1939 博文 Vol.12 No.-

身體의 柔軟性과 運動能力間의 相觀에 關한 硏究

李憲求 동국대학교 교육대학원 1985 교육논총 Vol.5 No.-

免疫調節制가 BCG 感染動物의 細胞性 免疫反應에 미치는 影響

李憲九 전북대학교 의과학연구소 1983 全北醫大論文集 Vol.7 No.1

This study was undertaken to confirm the immunosuppressive effect of BCG and to evaluate th effect of some immunomodulators such as cyclophosphamide, indomethacin, cimetidine, and inosiplex, on the cellular immune response of mice heavily infected with BCG. From 1 to 8 weeks after infecition with a large dose of BCG(10mg), the developmen of delayed-type hypersensitivity to sheep erythrocytes(SRBC) was diminished and this to SRBC were not significantly altered by BCG infection. In an adoptive transfer system, spleen cells from BCG-infected mice markedly depressed DTH and enhanced plaque-forming cells(PFC) in recipient mice treated with a high dose of cyclo-phosphamide (350mg/kg) compared with normal spleen cells. In the BCG-infected mice spleen, cell populations responsible for the depression of DTH and Cyclophosphamide, indomethacin, and cimetidire had no effect on the immune state of BCG-infected mice, but inosiplex completely restored the depressed cellular immune response to the normal level. These results indicate that inosiplex may prove useful as an immunostimulant in clinical situations where the cell-mediated immunity has been compromised by mycobacterial infection.

질내투여 인정장(人精漿)의 인정자(人精子) 및 면양적혈구에 대한 면역반응 억제작용

이헌구,김용탁,하대유 大韓免疫學會 1987 大韓免疫學會誌 Vol.9 No.1

A number of evidence has been accumulated to show that human seminal plasma (HSP) can suppress the immune responeses in vitro and in vivo. Several immunosuppressive factors have been identified from HSP and it has been proposed that these factors play a critical role in preventing sensitization of females to spermantigens after insemination. The purpose of the present study is to answer the q question whether HSI' is able to suppress in vivo immune responses induced by some antigens such as human sperms and sheep red blood cells(SRBC) which are introduced into the vagina of females. In this study the author used an experimental model in which mice were immunized intravaginally with human sperms and SRBC, and delayed-type hypersensitivity reacion (DTH) to these antigens was eva- luated by footpad swelling reaction. Repeated simultaneous intravaginal administrations of HSP with human sperms or SRBC significantly suppressed the DTH but failed to suppress the antibody formation to these antigens. However, intravaginal administration of a high molecular weigt fraction(G― 200 F, greater than 200 KD) which was partially purified by ammonium sulfate precipitation, DEAE- cellulose and Sephadex G -200 chromatography from HSP resulted in a significant suppression of DTH as well as antibody formation to SRBC. Furthermore, when various concentrations of G―200 F were ad-ministered intraperitoneally, a dose-dependent suppression of both DTH and antibody formation to SR BC was observed. These results provide the evidence that in vivo immunosuppressive activity of HSP is mediated by a high molecular weight fraction of greater than 200 KD and strongly support the concept that HSP can prevent sensitization of females to sperm antigens after insemination.

제 3 회 신약개발 연구발표회 초록집 ( 1994 . 4 . 15 ~ 16 ) : 구두발표 제 1 분과 ( 합성 , 천연물 ) ; 상백피 (桑白皮)의 항알레르기성 효과

이헌구,이무삼,양문식,이양근,허훈,손영택,전병독 한국응용약물학회 1994 학술대회 Vol.1994 No.1

Anaphylaxis의 동물 모델과 cytokine에 의한 조절

이헌구 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.3

N/A

B lymphocyte에 관한 연구동향

이헌구 한국미생물학회 1991 微生物과 産業 Vol.17 No.1

B 세포이 가장 중요한 기능은 항체를 생산하여 체액성 면역반응을 조절하는 일이다. B 세포가 항체를 생산해 내는 형질세포(plasma cell)로 분화하기 위해서는 다음의 몇 가지 단계를 거쳐야 한다. 즉 resting 상태에서 mitogen이나 항원의 자극에 의한 활성화(activation)가 첫번째 단계이고 두번째로는 증식(proliferation)이며 마지막 단계가 분화(differentiation)이다. B 세포가 일단 mitogen이나 항원에 의해 활성화가 되면 활성화 된 clone의 증식과 분화는 T 세포에서 생산되는 여러 종류의 림포카인(lymphokine)의 영향하에서 이루어진다. 따라서 B 세포 기능에 영향을 미치는 림포카인의 종류를 알아내고 최근 새롭게 발견되는 림포카인의 B 세포에 대한 영향을 연구함이 중요하리라 생각된다. 여기에서는 B 세포 기능에 영향을 미치는 여러 림포카인의 종류의 그 기능에 관해서 간략하게 기술하고자 한다.

IL-4와 다른 여러가지 cytokines이 사람 편도 단핵세포의 IgE 생산에 미치는 영향

이헌구,송원재,하대유 大韓免疫學會 1995 大韓免疫學會誌 Vol.17 No.3

The present study was desinged to compare IgE producing ability of cultured human tonsillar mononuclear cells (TMNC) stimulated by rhIL-4 between complete Iscove's modified Dulbeco's medium (C-IMDM, which was composed of IMDM enriched with bovine serum albumin, fetal calf serum, transferrin, insulin, and mixture of saturated and unsaturated fatty acids) and RPMI-1640 supplemented with FCS (RPMI-1640), as well as to investigate a single or combined effects of IL-4 and 7 different human cytokines (IL-2, IL-5, IL-6, IL-7, TNF-a, IFN- 7' and TGF-fi ) in a culture system on IgE production of human TMNC. It was found that C-IMDM was superior to RPMI 1640 as a culture medium for supporting the synthesis of IgE by TMNC stimulated with rhIL-4. In fact, RPMI-1640 failed to induce significant IgE synthesis by TMNC cultured for 21 days in the presence of rhlL-4 (100 U / ml). In addition, 7 different cytokines other than IL-4 failed to induce the significant IgE synthesis by TMNC cultured in C-IMDM when tested alone. However, IL-2 or IL-6, which was ineffective in inducing IgE production when tested alone, enhanced IL-4-mediated IgE production, indicating - that IL-2 or IL-6 acts synergistically with IL-4. In contrast, IFN- Y . or TGF-J1 demonstrated the inhibition of IL-4 dependent IgE synthesis by TMNC. Interestingly, IL-5, IL-7 and TNF-a had no modulatory effect on the IL-4 dependent IgE response in the applied experimental conditions. Taken together, the present results strongly suggested that 1) C-IMDM may be superior to RPMI-1640 as a culture _medium for IgE production, 2) Only IL-4 had the ability to stimulate in vitro with IgE synthesis by TMNC when tested alone. 3) IL-2 and IL-6 may be synergistic with IL-4 in IgE synthesis, 4) IFN- F and TGF-P may have the antagonistic effects on IL-4 dependent IgE synthesis and 5) IL-5, IL-7 and TNF-a may have no modulatory effects. This study also suggested that increased insight into various mechanisms of IgE regulation by cytokines may eventually lead to improve therapeutic strategies in the clinical management of IgE-mediated allergy.

Impact of Cooperative R&D Projects on ICT-Based Technology Convergence

이헌구,김방룡,조항정 한국전자통신연구원 2017 ETRI Journal Vol.39 No.4

This study examines how the characteristics of cooperative research and development (R&D) projects in the public domain impact information and communication technology (ICT) convergence. Based on the analysis of 416 cooperative R&D projects under the ICT-based industry convergence R&D program in Korea, the study finds that the characteristics of cooperative R&D projects significantly impact ICT convergence. Moreover, the participation of public research institutes and universities is critical for ICT convergence compared with that of firms. However, in firm-to-firm cooperation, the participation of small and medium enterprises contributes to cross-sectional convergence, while the participation of large firms leads to overall and longitudinal convergence. R&D inputs such as the number of partners and government subsidies exhibit an inverted U-shaped relationship (negative quadratic effect) with technology convergence. Project duration and homogeneous partners are also critical factors for ICT convergence. The results indicate several implications and guidelines on how to effectively organize cooperative R&D projects to facilitate technology convergence.