당귀(當歸)가 간성상세포의 섬유화 기전 억제에 미치는 영향

손현수,김영철,Son, Hyun-Soo,Kim, Young-Chul 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.3

Objectives : This study was performed to investigate the anti-fibrogenic effect of Angelica Gigantis Radix on cultured rat hepatic stellate cells. Materials and Methods : Hepatic stellate cells(HSC-T6) were treated with various concentrations of Angelica Gigantis Radix extract for both 24 and 48 hours. The extraction was done either with distilled water or 80% EtOH. After the treatment, cell viability, cell proliferation, procollagen production and the mRNA expression of the ASMA, TIMP1, TIMP2, procollagen Type 1a2, and Cytokine IL-6 production were measured by using MTT assay, BrdU assay, RT-PCR, procollagen Type I C-peptide EIA and IL-6 ELISA assay. Results : The cell viability treated with water extraction was significantly increased, but there were no significant changes treated with 80% EtOH extraction. The cell proliferation treated with water extraction decreased only in the 24 hours group, while there were significant decreases either in the 24 and 48 hours groups treated with 80% EtOH extraction. The mRNA expressions of the ASMA, TIMP2 and procollagen 1a2 decreased in a concentration-dependent manner in the 48 hours group. Procollagen production decreased in a concentration-dependent manner in both the 24 and 48 hours groups. Cytokine IL-6 production increased in a concentration-dependent manner in both the 24 and 48 hours groups. Conclusion : These results suggest that Angelica Gigantis Radix is beneficial in the treatment of cirrhotic patients as well as for patients with chronic hepatitis.

본대학교(本大學校) 자매부락(姉妹部落)의 새마을 운동(運動) 가열화방안(加熱化方案)

손현수 ( Hyun Soo Son ),손해식 ( Hai Sik Son ),이태일 ( Tai Il Lee ),이대규 ( Dai Gyu Lee ) 東亞大學校附設 石堂傳統文化硏究院 1979 石堂論叢 Vol.3 No.-

Gudukryoung Village, with which the University formed sisterhood relationship in 1977, still remains in the primary stage of development due to unsatisfactory progress in the Saemaul Undong there. The village is situated on the slopes of Mt, Guduk, 250 meters above sea level, in Daeshin-dong, Busan. This half-farming half-commercial community is also called "The Flower Village" because most of the villagers are engaged in growing and selling flowers for their primary source of income. It is to be noted that the 260-odd families(about 1,400 inhabitants) were originally outsiders who have come to settle here for the past 70 or 80 years. This paper attempts to show ways for the village to lead to the final self-support stage through the self-help stage by accelerating the Saemaul Undong in terms of rebuilding the Saemaul spirit, improving their environment and increasing their income. Following points according to the three divisions of study are suggested to accelerate the Saemaul Undong in the village. 1. Suggestions for rebuilding the Saemaul spirit: a. Expand the Saemaul education. b. Establish the Saemaul library. c. Hold "Clean the Village" contests. d. Conduct industrial tours. e. Hold combined "bansang" meetings. f. Inspect examplary self-support villages. g. Learn from successful stories of the Saemaul Undong. h. Show films in the Saemaul Undong. 2. Suggestions for improving environment a. Provide sense of ownership for their village and houses. b. Strengthen the villagers` efforts to improve their environment. c. Have the students in the village participate in the activities to improve environment. 3. Suggestions for increasing income: a. Find ways to make the village a flower complex and sell flowers directly means of area specification. b. Raise goats for a subsidiary income. c. Enlarge community funds by developing village construction projects and the Saemaul bank. d. Increase income by growing such vegetable as strawberry, onion and garlic.

정전가미이진탕(正傳加味二陳湯)이 흰쥐의 위배출능(胃排出能)에 미치는 영향(影響)

김회영,손현수,임성우,남효익,Kim, Hoi-Young,Son, Hyun-Soo,Lim, Sung-Woo,Nam, Hyo-Ik 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.2

Background & Objective : The herbal medicine JGT has been used for the treatment of functional dyspepsia, generally categorized as a gastric disease. However, its effect and mechanism are not yet well known. Therefore, the effects of JGT on gastric emptying in rats was investigated to know its effectiveness and mechanism. Methods : Gastric emptying effect was measured by the number of glass beads expelled from the stomach within an hour after glass beads and test drugs were administered. In another series of experiments to evaluate the mechanisms of JGT under delayed conditions, the rats were treated with atropine sulfate Results : Intragastric administration of JGT significantly increased gastric emptying of glass beads Under the gastric emptying delayed with atropine sulfate, JGT insignificantly increased gastric emptying of glass beads. Conclusions : These suggest that JGT has a significant effect to stimulate gastric emptying. Results are indicative of JGT as an especially effective remedy for dysmotility-like functional dyspepsia with impaired reservoir function such as gastric adaptive relaxation.

과민성장증후군 환자의 정전가미이진탕(正傳加味二陳湯) 투여(投與) 1례(例)

김회영,남효익,손현수,박상무,Kim, Hoi-Young,Nam, Hyo-Ik,Son, Hyun-Soo,Park, Sang-Moo 대한한의학방제학회 2007 大韓韓醫學方劑學會誌 Vol.15 No.2

The irritable bowel syndrome(IBS) is the most common gastrointestinal disorder in clinical practice and is characterized by abdominal pain associated with a chronic disturbance of defecation. The subject is a-69-year-old man who has abdominal pain, chronic diarrhea. anorexia. general weakness and has been diagnosed as irritable bowel syndrome. We diagnosed this patient as the Gastrointestinal Phlegm(食痰) and prescribed Jengjengamiyijin-tang (Zhengchuanjiaweierchen-tang). In the result, we had improvement of his symptoms.

익명의 알코올 중독자 모임의 불안, 우울에 대한 효과 연구

김회영 ( Hoi Young Kim ),손현수 ( Hyun Soo Son ),강지홍 ( Ji Hong Kang ),심소라 ( So Ra Shim ),박보라 ( Bo Ra Park ),김지훤 ( Ji Hwon Kim ),김태헌 ( Tae Heon Kim ) 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.2

Objectives: This study was performed to assess the benefits of Alcoholics anonymous program for anxiety and depression of alcoholics. And we investigate Sasang constitution in Alcoholics Anonymous(A.A.) members to study relation between alcoholic and constitution. Methods: 21 members of A.A. groups in korea who agreed to the purpose of this study were selected. We evaluated anxiety by BAI, depression by BDI-Ⅱ and sasang constitution by QSCCⅡ+. Results: The research result is as follows. 1. Eighteens of 21 A.A. members are men and the rest are women. First alcohol drinking age(mean) is 15. Getting alcohol drunk age(mean) is 20.9. 2. The duration of alcohol drinking before A.A. participation(mean) is 20.2 years. The duration of giving up drinking after A.A. participation(mean) is 26.5 months. 3. A.A. program significantly reduced anxiety of A.A. members from 10.43±1.37(mean±S.E.)(light anxiety) to 6.86±1.24(normal). 4. A.A. program significantly reduced depression of A.A. members from 4.14±1.14(mean±S.E.)(normal) to 2.33±0.75(normal) in the statistics, but it does not have the meaning clinically. 5. Sasang constitution classification result was Taeum group 10 people(47.6%), Soyang group 9 people(42.9%), Soeum group 2people(9.5%), Taeyang group 0 people(0%), Taeum group and Soyang group were relatively more than Soeum group. Conclusions: Participation in the A.A. program reduce anxiety and depression of A.A. members. This research provide data on positive effect of A.A program and may prove that the self-help program(A.A.) can help to maintain long term sobriety and improve the quality of life of its members.

국소 전뇌 허혈 모델 백서에서 加減定志丸과 吳茱萸가 기억증진과 신경세포보호에 미치는 효과

김희영(Hoi Young Kim),손현수(Hyun Soo Son),강지홍(Ji Hong Kang),최우정(U Jeong Choi),이진석(Jin Seok Lee),양재훈(Jae Hoon Yang),설재균(Jae Kyun Seol),이언정(Eon Jeong Lee) 한의병리학회 2008 동의생리병리학회지 Vol.22 No.6

지렁이의 농업적(農業的) 이용(利用)에 관한 연구(硏究)

김정기 ( Jeung Gi Kim ),손현수 ( Hyun Soo Son ),조종택 ( Jong Taek Joe ),배태웅 ( Tae Woung Bae ),한희세 ( Hee Sai Han ),하상영 ( Sang Young Hah ),문병주 ( Byung Joo Mun ) 東亞大學校附設 石堂傳統文化硏究院 1979 石堂論叢 Vol.3 No.-

腐植含量이 지렁이 生育에 미치는 영향을 調査하기 위하여 각각 다른 腐植水準의 土壤에서 지렁이의 飼育試驗, 그리고 지렁이의 土壤中 生活生態 및 作物에 對한 農業撤布가 作物(早生大長가지) 生育에 미치는 영향에 관한 試驗, 그러고 지렁이 個體數가 가지生育에 미치는 영향에 관한 試驗, 또한 3種의 土壤病菌의 菌系生長에 대한 지렁이의 糞 및 磨碎濾液의 沮止效果를 檢計한 試驗 等에서 다음과 같은 結果를 얻었다. 1. 生存率은 낙시지렁이에서는 g, d, f處理에서 줄지렁이는 g, d處理에서 왕지렁이는 g, d處理에서 높은 傾向을 보였다. 2. 繁殖率은 낙시지렁이, 줄지렁이는 d處理에서 왕지렁이는 f, g處理에서 좋은 結果를 보였다. 3. 繁殖率과 Total-N은 낙시지렁이, 줄지렁이, 왕지렁이에서 正相關이 인정되었다. 4. 生存率과 腐植含量에서는 낙시지렁이, 줄지렁이에서 正相關이 인정되었다. 5. 繁殖率과 Total-N 및 腐植含量에서는 낙시지렁이, 줄지렁이에서만 正相關 인정되었다. 6. 農藥處理는 가지 및 지렁이의 生育과 生存數에서 有意性이 認定되지 아니했다. 7. 草丈. 無處理區에서 73.67cm, NAC-Wp區가 73cm로 크고 Nitrofen-Wp區은 59.67cm로 작았다. 8. 收量은 CAT-Wp區가 27個, Nitrafen-Wp區, 無處理區가 各 26個로 많고 Heptachlor-D區는 17個로 적었다. 9. 果重은 除草劑인 CAT-Wp區, Nitrofen-Wp區가 119,9g, 118,73g으로 무겁고 Reldan-Ec區은 93.70g으로 가벼웠다. 10. 果長은 無處理區, NAC-Wp區가 17.98cm, 15.84cm였고 Reldan-Ec區는 14.27cm로 작았다. 11. 지렁이 生存數는 Heptachlor-D區가 약 21마리로 높고 CAT-Wp區가 17마리로 제일 낮았다. 12. 收獲期別 收量은 8月 29日 57個로 많은 8月 17日 11個로 적었다. 13. 收獲期別 果長은 8月 17日은 20.99cm 길었고 9月 8日은 13.56cm였다. 14. 收獲期別 果重은 8月 4日 159.24g으로 무거운 9月 8日 65.11g였다. 15. Reldan-Ec, DEP-Ec는 Nitrofen-Wp부다 TLM의 相對效果가 29.64倍 20.41倍의 傾向을 보였다. 16. 지렁이의 무게가 395±25mg일 때 Redan-Ec, 0.0075% DEP-Ec0.0108%, Heptachlor-D 0.0114%, CAT-Wp0.0699%가 TLM濃度였다. 17. 農藥 DEP-Ec, Re1dan-Ec Heptachlor-D NAC-WpCAT-Wp Nitrofen-Wp의 LD90의 濃度는 0.0416%, 0.0305%, 0.0368%, 0.2416%, 0.3097%, 0.8277%였다. 18. 지렁이 個體數는 가지葉數에서 有意的인 增加를 보였다. 19. 지렁이 個體數는 가지의 果實數量增收에는 별다른 영향을 주지 않았다. 20. 지렁이 個體數는 가지栽培에서 안산과 加里質 肥料의 適量 混合施用이 必要하다고 認定되었다. 21. 供試된 3個菌株 모두 菌系生長을 抑制하는 지렁이糞의 沮止效果는 나타나지 않았다. 22. 菌系生長을 抑制하는 지렁이의 磨碎濾液의 沮止效果는 供試된 菌株中 Sclerot ium rol-fsii에서는 明白히 나타났으나 Rhizoctonia solani에서는 諸定할 수 없었으며, Fusarium solani는 오히려 菌사生長이 促進되었다. In order to study the effect of compost application on earthworm cultivation, a factorial experiment was carried out at each level of compost application, and also to check the effect of ecology of earthworms in soil as an effect of spraying crops is a field with agricultural chemicals, and also to check the effect of earthworm number to eggplant growth, to investigate the inhibitory effects of earthworm fecal wastes and earthworm extracts on the mycelial growth of soil pathogen fungi; and the results were as follows. 1. Relatively high increasing trend of the reproductive rate of earth worm was appeared at plots, d g f in Allolobophora japonica of g plot in Eisenia foetida, and plots f g in Pheretima communissima, respectively. 2. Reasonablely good effect of earthworm survival rate was shown at the plot d in Allo1ophora japonica, Eisenia foetida and plot f g in Pheretima communissima. 3. statistically positive correlation was convinced at plots between reproductive rate and total-N in all experimented earthworm species. 4. Statistical significance were revealed at plots between survival rate and compost in Allolobophora japonica and Eisenia foetida. 5. Statistical significance was also revealed at plots between reproductive rate and total-N or compost application in Allolobophora japonica and Esenia foetida. 6. Spraying agricultural chemicals was not presumed to be significant as a result of the survived number of earhworms and eggplant growing. 7. The height of the herbs and the weeds in non-treated area with chemicals were 73.67cm, in the NAC-Wp, as tall as 73cm, and in the Nitrofen-Wp area, was as short as 59.67cm. 8. Yields of eggplant treated with CAP-Wp were 27pcs. and both in the Nitrofen-Wp area and non-treated area were as much as 26 pcs., respectively; and in the Heptachlor-D area was 17 pcs. 9. The weight of the eggplant in the CAT-Wp area and the Nitrofen-Wp area treated with herbicide were as heavy as 119.92 gr. and 118.73 gr. respectively. And 63.73 gr. in the Reldan-Ec area. 10. The height of the eggplant with blank test area and the NAC-Wp area was 17.98cm and 15.38cm respectively. And Reldan-Ec area was 14.27cm. 11. The survived number of earthworms at Heptachlor-D area were 21 approximately. the lowest survived number was shown in the EAT-Wp area, 17. 12. Eggplant yield classified by harvesting season were 57 pcs. on August 9th; and as little as 11 pcs. on August 17th. 13. The height of eggplants classified by harvest season was 20.29cm on August 17th; and 13.56cm on September 8th. 14. The weight of eggplant classified by harvest season was 159.24 gr. on August 4th; and 65.11 gr. on september 8th. 15. The relative affectiveness of T(LM) in Reldan-Ec and CAP-EC was shown 29.64 times and 20.41 times as compared with the Nitrofen-Wp. 16. As the weight of earthworms reached 395-25mgs, the TLM concentration in Reldan-Ec was 0.007%;and in the CAT-Wp was 0.0699% respectively. 17. The concentration of L(D) percentage in the agricultural chemicals; DEP-Ec, Reldan-Ec, Heptachlor-D,%, 0.0305%, 0.0368%, 0.2416%, 0.3097% and 0.8277%. respectively. 18. Statistically high signiftcance on the number of earthworm was revealed in terms of eggplant leaves. 19. No significant effect was convinced in terms of increasing eggplant fruits. 20. Adequate application of phosphorus and potash fertilizer to the soil in which the earth worm grown was recommended for eggplant culitivation. 21. There was no visible inhibitory effect of earth worm fecal wastes on the mycelial growth of soil pathogenic fungi examined. 22. The obvious inhibitory effect of earth worm extracts on the mycelial growth was found in Sclerotium rolfsii but was recognized in Rhizoctonia solani and oppositely the stimulating effect of earthworm extracts on the mycelial growth was noticed in Fusarium solani.

사이버대학생의 직장유무에 따른 학업적 자기효능감, 상황적 제한, 학습시간 및 환경관리, 만족도, 전이동기의 잠재평균분석

주영주(Joo Young-Ju),이진수(Lee Jin-soo),손현수(Son Hyun-Soo) 한국평생교육학회 2011 평생교육학연구 Vol.17 No.2

본 연구는 사이버대학생의 학업적 자기효능감, 상황적 제한, 학습시간 및 환경관리, 만족도, 전이동기에 있어 직장유무에 따라 차이가 있는지, 그리고 주요변인 간 경로에 있어서 직장유무에 따라 차이가 있는지를 살펴봄으로써 사이버대학생의 효율적인 학습관리 방안을 모색하는데 그 목적이 있다. W사이버대학 2010년도 1학기에 진행된 ‘음양오행론’과 ‘명상학’ 과목에 등록한 재학생 604명을 대상으로 설문조사를 실시하고, 잠재평균분석 및 다집단 분석을 실시한 결과, 직장이 있는 학습자 집단이 직장이 없는 학습자 집단에 비해 학업적 자기효능감과 만족도, 전이동기가 높은 것으로 나타났다. 또한 학업적 자기효능감이 학습시간 및 환경관리에 미치는 영향은 두 집단간의 유의미한 차이가 있으며, 직장이 있는 학습자 집단이 직장이 없는 학습자 집단에 비해 보다 강한 영향을 미치고 있음을 확인하였다. 이러한 연구결과는 직장유무에 따른 학습자 집단 간 상이한 학습관리 접근이 필요함을 시사한다. This study was carried out to produce plans for effective learning management of cyber-university by investigating the difference of academic self-efficacy, situational constraint, time and environment management, satisfaction and transfer motivation by employment status. Data were collected from the spring semester of 2010 by conducting a survey for 604 W cyber-university students that enrolled in ‘Yin-Yang and the Five Elements theory’ and ‘meditation’. According to Multi-group analysis, Latent means analysis(LMA) where students without job are used as the reference group, students with job show higher latent mean values on academic self-efficacy, satisfaction and transfer motivation. In addition, there are significant differences of structural path coefficients between academic self-efficacy and time and environment management. However, academic self-efficacy has positive effects on time and environment management in two groups. Finally, different learning management should be applied depending on students’ employment status for effective learning achievement in cyber-university.

추백리 혈청검사 양성 산란계로부터 Salmonella속균 분리

류재윤 ( Jae Yun Ryu ),전무형 ( Moo Hyung Jun ),장경수 ( Kyung Soo Chang ),손현수 ( Hyun Soo Son ),곽학구 ( Hak Koo Kwak ),박경재 ( Kyung Jae Park ),우용구 ( Yong Koo Woo ) 한국가축위생학회 1999 韓國家畜衛生學會誌 Vol.22 No.3

To investigate the specificity of rapid slide agglutination test for pullorum-gallinarum diseases and to obtain a basic data for avian salmonellosis control, salmonella isolation was performed for the layer chickens positively reacted in pullorum-typhoid agglutination test. The biochemical, serological and antimicrobial properties of the isolates were examined. The results obtained through this study were summarized as follows; 1. Of 2,384 chickens tested by the agglutination test, 606 chickens (25.4%) were positive reactors. 154 of 606 reactors and 49 of the non-reacting chickens were investigated for salmonella isolation, resulting in isolation of 68 strains of salmonellae from 27 chickens. 2. By organs, the isolation frequency from liver, cecum, spleen, ovary and gall bladder showed 8.9% (18 strains), 8.9% (18 strains), 7.4% (15 strains), 4.4% (9 strains) and 3.9% (8 strains), respectively. 3. By culture medium, the combination of selenite broth and MacConkey agar revealed the highest isolation rate and the enrichment culture by delayed secondary enrichment culture method was found the most effective for salmonella isolation. 4. The serotypes of 68 salmonella isolates were identified as 3 strains of S pullorum, 24 strains of S gallinarum, 15 strains of S typhimurium, 8 strains of S enteritidis, 7 strains of S paratyphi A, 5 strains of S infantis and 6 strains of the other salmonellae. 5. The serotypes of 8 salmonella strains isolated from 49 chickens non-reacting in pullorum-typhoid agglutination test were identified as 3 strains of S typhimurium and 5 strains of S infantis. 6. When 24 chickens of which 68 strains of salmonellae isolated were examined by microplate agglutination test, the average antibody titer for pullorum antigen was 2(5.25) The chickens at antibody titer between 2(3) and 2(5) showed the higher frequency of isolation as compared with the chickens at the other titers. 7. When salmonella isolates were tested the antimicrobial drug sensitivity by disk diffusion method, S paratyphi A were highly sensitive by 100% to ATM and GM, S typhimurium, by 88% to AM, CIP, IMP and TM S infantis, by 100% to AM, CR0, ENR and PIP, S enteritidis, by 100% to IMP and PIP, S pullorum, by 100% to ATM, CR0, ENR and PIP and S gallinarum, by 92% to CR0, CIP and PIP.

도축돈의 호흡기질병에 관한 연구

이은정 ( Eun Jeong Lee ),박경재 ( Kyung Jae Park ),이청산 ( Cheong San Lee ),손현수 ( Hyun Soo Son ),김원설 ( Won Seoul Kim ) 한국가축위생학회 2000 韓國家畜衛生學會誌 Vol.23 No.3

A survey on pneumonic lungs and its histopathological changes of the slaughtered pigs from the southern area of Chungbuk province was carried out during the period from January to December 1999. Pneumonic lungs were attempted bacteriological findings and antibiotic susceptibilities. The results obtained were as follows; 1. Of 158 slaughtered pigs, 97(61.4%) pigs had pneumonic lesions in the lung, and the prevalence was high in winter, spring, autumn, and summer in order. 2. The bacteria isolated from pneumonic lesions were pasteurella spp, 13 heads(34.2 %), streptococcus spp, 6(15.8 %), actinobacillus spp, 3(7.9 %), coliform 4(10.5 %) and the other bacteria, 12(31.6 %). 3. These isolates were highly susceptible to the antibiotics of enrofloxacin 30(78.9 %), cephalothin 28(73.6 %) and ceftiofur 27(71 %). 4. Histopathologically, swine enzootic pneumonia and pleuropneumonia lesions were observed. The swine enzootic pneumonia lesions were consisted of peribronchiolar lymphoid hyperplasia and exudate in alveolar lumen. The pleuropneumonia lesions were consisted of thrombosis, alveolar wall thickened by mononuclear cells and neutrophil deposition.