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석재연,김세훈,권태정,권지은,이윤희,신규호,양우익 대한병리학회 2007 Journal of Pathology and Translational Medicine Vol.41 No.5
Glomus tumors are neoplasms that are composed of modified smooth muscle cells of the glomus body. Here, we report a case of multiple glomus tumors of the ankle that showed various histologic types, including the solid type (glomus tumor proper) and angiomatous type (glomangioma). The tumor cells observed in this case also showed prominent intranuclear inclusions, which has not yet been reported in glomus tumors. Ultrastructural examination demonstrated that the nuclear inclusions were not true inclusion bodies but were intranuclear cytoplasmic pseudoinclusions formed by cytoplasmic invaginations that formed as a result of the deep and complex nuclear contours.
귀밑샘에 발생한 점액 화생을 동반한 만성 경화침샘염의 세침흡인 세포소견 -증례 보고-
석재연,정우희,허상범,김진,홍순원,Seok, Jae-Yeon,Jung, Woo-Hee,Fan, Xu Xiang,Kim, Jin,Hong, Soon-Won 대한세포병리학회 2005 대한세포병리학회지 Vol.16 No.2
Chronic sclerosing sialadenitis, also known as Kuttner tumor, is a benign chronic inflammatory lesion of the salivary gland. Here, we describe a case of chronic sclerosing sialadenitis with mucinous ductal metaplasia in a parotid gland, which was confused with low-grade mucoepidermoid carcinoma on aspiration cytology.
Human Cutaneous Protothecosis: Report of a Case and Literature Review
석재연,송지선,이윤호,이혁민,이상엽,오화은 대한병리학회 2013 Journal of Pathology and Translational Medicine Vol.47 No.6
The Prototheca species is achlorophyllic algae and rarely causes human infection. Human protothecosis presents clinically as a cutaneous infection, olecranon bursitis, and disseminated systemic disease. We report a case of human cutaneous protothecosis involving the left wrist. A 68-year-old man presented with an ill-defined erythematous lesion with crust at the dorsal aspect of his left wrist. A punch biopsy was performed to reveal the histologic features of granulomatous inflammation with necrosis at the upper dermis, containing Prototheca organisms, of which, the characteristic features were highlighted by special staining. Through a molecular study, the Prototheca zopfii species was identified.
수모세포종에서 Vimentin과 Survivin의 표현율과 예후와의 관계
석재연,김세훈,이윤희,권지은,김태승 대한병리학회 2007 Journal of Pathology and Translational Medicine Vol.41 No.2
Background : A medulloblastoma is a primitive neuroepithelial tumor of the cerebellum that occurs in children and metastasizes through the cerebrospinal fluid. It is highly malignant and invasive, and the 5-year survival rate is only 60%. Surgical resection techniques, radiation, and chemotherapy have improved the overall survival but the patients suffer life-long cognitive dysfunctions or endocrine abnormalities as the side effects of treatment. Therefore it is essential to identify prognostic markers to determine the appropriate treatment strategy in order to minimize the side effects. Methods : This study evaluated the immunohistochemical differentiation and survival rate with synaptophysin, glial fibrillary acidic protein, epithelial membrane antigen, vimentin and primitive neuroepithelial marker nestin of 55 paraffin-embedded medulloblastomas, using a tissue microarray. The expression of survivin, the apoptotic inhibitor, and the survival rate with regard to the proliferation index of Ki-67 were also investigated. Results : The group testing positive to vimentin, a mesenchymal differentiation marker, had a worse prognosis and there was a strong correlation between vimentin expression and nestin expression. Patients with a survivin expression rate >35% had a significantly poorer clinical course and there was a correlation between the survivin expression rate and Ki-67 expression rate. Conclusion : In conclusion, vimentin and survivin are negative prognostic markers in medulloblastomas.
Parathyroid Cancer: Comparison with Benign Hyperparathyroidism
석재연,이준협,이시훈,정유승,강석하 대한갑상선-내분비외과학회 2019 The Koreran journal of Endocrine Surgery Vol.19 No.2
Purpose: The preoperative diagnosis of parathyroid cancer (PC) is challenging. The purpose of this study was to identify the differences between PC and benign primary hyperparathyroidism. Methods: The medical records of 85 hyperparathyroidism patients that underwent surgery between 2001 and 2017 were retrospectively reviewed. Results: Seven of the 85 were diagnosed with PC. Mean age was 53.0±13.0 years and 66 (77.6%) were women. Follow-up duration was 52.9±44.4 months. Tumors were larger (3.50±1.26 cm vs. 2.10±0.84 cm, P=0.002), and intact parathyroid hormone (iPTH) (1,142.8±524.5 pg/mL vs. 461.2±513.5 pg/mL, P=0.002) and alkaline phosphatase (ALP) (398.6±493.6 U/L vs. 166.7±181.1 U/L, P=0.01) levels were higher in cancer patients than in benign primary hyperparathyroidism. Intraoperatively, adhesion to surrounding soft tissue or the thyroid gland was detected more frequently in cancer (85.7% vs. 12.8%, P<0.001). Two patients experienced recurrences and one of them died from PC. Conclusion: PC patients had larger tumors size, and higher serum iPTH and ALP levels. Intraoperative detection of adhesion to surrounding soft tissue/thyroid importantly raised suspicion of PC. Surgeons operating for hyperparathyroidism should be prepared to perform an appropriate en bloc resection initially upon suspicion of PC.
석재연,안정석,하승연,정동해,이상호,Hyunchul Kim 대한병리학회 2016 Journal of Pathology and Translational Medicine Vol.50 No.2
Background: The cytopathic effects of cytomegalovirus (CMV) infection have been well described since the virus was first reported; however, the morphology of CMV infection has not been clearly studied. We examined the difference in detailed cytologic findings in bronchial washing cytology between liquid-based and conventionally prepared smears. Methods: Bronchial washing cytology was processed using either the conventional preparation (CP) or liquid-based preparation (LBP). Sixty-nine cells with typical cytopathic effects of CMV infection were detected on CP slides and 18 cells on LBP slides. Using the image analyzer, area, circumference, major axis, and minor axis of the cytoplasm, nucleus, and intranuclear inclusion were measured in singly scattered CMV-infected cells, and histiocytes were used as a control. Results: The mean cytoplasmic area of CMVinfected cells was 1.47 times larger than that of histiocytes in CP and 2.92 times larger in LBP (p < .05). The mean nuclear area of CMV-infected cells was 2.61 times larger than that of histiocytes in CP and 4.25 times larger in LBP (p < .05). The nucleus to cytoplasm ratio and intranuclear inclusion to cytoplasm ratio of the mean area, circumference, major axis, and minor axis in CP were larger than those in LBP (p < .05). Conclusions: The sizes of cytoplasm, nucleus, and intranuclear inclusion were larger in LBP than in CP, indicating that CMV-infected cells are easily detectable in LBP. However, the nucleus-to-cytoplasm ratio was larger in CP, suggesting that differentiation from malignancy or regenerative atypia requires caution in CP.