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Case Report of Imaging Analyses of the Dysplasia Epiphysealis Hemimelica (Trevor’s Disease)
서장호,조길호 대한영상의학회 2013 대한영상의학회지 Vol.69 No.2
Trevor’s disease, also known as dysplasia epiphysealis hemimelica, is a rare developmental disorder presented with epiphyseal overgrowth involving one or multiple epiphyses. Here we report the radiologic findings of two cases of dysplasia epiphysealis hemimelica in a 4-year-old boy in the knee without symptom and a 10-year-old boy in the ankle with pain. The former was observed for eight years and the latter was treated with surgical resection.
점진적 단계 단축을 적용한 cetuximab 탈감작요법 사례 1예
서장호,정지웅,윤정은,김현화,김현지,이서영,강혜련 대한 소아알레르기 호흡기학회 2022 Allergy Asthma & Respiratory Disease Vol.10 No.3
Desensitization therapy can help overcome severe hypersensitivity reactions and allow continuing administration of the culprit agents. However, this is time- and labor-intensive due to a prolonged infusion time and the serial adjustment of infusion rate between steps. Therefore, simplified protocols using fewer steps have been tested, although currently there is no established standard strategy. Cetuximab plays an important role in the treatment of metastatic colorectal cancer. Although cetuximab is well tolerated, severe infusion reactions occur in 1.1% of patients, and most occur within 1 hour of receiving the first dose. Here, we report a recent attempt to shorten the steps of gradual cetuximab desensitization. A 57-year-old male patient diagnosed with obstructive sigmoid colon cancer received cetuximab chemotherapy and experienced immediate anaphylaxis at the first cycle. A one-bag, 17-step desensitization protocol was applied to cetuximab administration. After the first successful desensitization cycle, the process of desensitization was shortened 1–2 step(s) per cycle, down to 2 steps, without a breakthrough reaction. The patient ultimately received regular infusions. Shortening of the rapid desensitization protocol can be considered if the previous cycle is well-tolerated, even in a patient who suffered previous anaphylaxis to cetuximab.
조영제 과민반응 관리의 실제: 국내 일개 대학병원 원내 관리지침 소개
서장호,정지웅,윤정은,이서영,강혜련 대한 소아알레르기 호흡기학회 2023 Allergy Asthma & Respiratory Disease Vol.11 No.1
As imaging technologies have become essential for diagnosing various diseases, the use of contrast agents is rapidly expanding. As a result, hypersensitivity reactions (HSRs) to contrast agents have also increased. However, protocols for managing, diagnosing, and preventing these reactions are not fully established yet. Since the guidelines for contrast agent hypersensitivity suggested by domestic and international academic societies are not standardized and sometimes difficult to follow in medical facilities, there is a need for practical recommendations in a real-world setting. This review introduces the strategy to manage, diagnose, and prevent HSRs to contrast agents, which have been successfully implemented at Seoul National University Hospital for a decade. First, every single HSRs should be documented in the medical records because a previous history of hypersensitivity to contrast agents is the most significant risk factor for developing HSR to iodinated contrast media. Secondly, avoidance of culprit agents is the main strategy for preventing recurrences of HSRs to contrast agents. Thirdly, it is important to identify nonsensitized contrast agents using skin tests for future exposure to contrast media. In addition to skin testing, side chains of iodinated contrast media may provide a clue to reactive contrast agents. Fourthly, provocation tests can be performed in selected cases with a nonreactive agent based on the skin testing and side chain commonness. Prior to performing imaging studies, premedication can be applied stratified to the severity of the index HSR. All of these procedures are safe and prove to be executable in the medical facilities. .
서장호,변우목,김홍철,황미수 대한영상의학회 2012 대한영상의학회지 Vol.66 No.4
Post-transplant lymphoproliferative disorder (PTLD) is a complication of organ transplantation and immunosuppression. A 36-year-old woman with a history of renal transplantation visited the hospital complaining of headache and on pathology was diagnosed with cerebral PTLD manifesting as multiple rim enhanced masses in both hemispheres. We report here a case of post-transplant lymphoproliferative disorder involving the cerebrum occurring after renal transplantation, and describe the MRI findings for this patient.
Optimal Design of an IPMSM for High-Speed Operation Using Electromagnetic and Stress Analysis
서장호,정현교 대한전기학회 2009 Journal of Electrical Engineering & Technology Vol.4 No.3
In the development of an interior permanent magnet synchronous machine (IPMSM) for high-speed operation, the problem of mechanical stress of the rotor by centrifugal force becomes more essential as the speed and size of the machines increase. In this paper, the optimal design process combined with mechanical stress analysis was presented. In the analysis of mechanical stress, the node and element data obtained by the electromagnetic field analysis program are also used in the stress analysis. Therefore, the different pre-processing for the stress analysis program is no longer required. Therefore, the computing time of the new method is very short compared with the conventional approach, and when repeated analyzes of various models are required, this method is very useful. The validity of our methods was verified by comparing simulation results with conventional and experimental data.
극 수 슬롯 조합과 운전 특성을 고려한 전기자동차용 IPM의 성능 특성에 관한 연구
서장호(Jang Ho Seo) 한국자동차공학회 2013 한국자동차공학회 지부 학술대회 논문집 Vol.2013 No.11
This paper shows the characteristics of performance for interior permanent magnet machine (IPM) considering driving conditions such as maximum torque per ampere (MTPA) and flux-weakening control especially in terms of harmonic loss. In particular, based on finite element analysis (FEA), permanent magnet (PM) eddy-current loss and the harmonic iron loss have been computed where the models have been intentionally designed to identify effects of pole-slot combinations on the loss while maintaining the required power for electric vehicle. From the analysis results, it was shown that the rotor iron loss and PM eddy-current loss of machine employing fractional slot winding has extremely large at load condition. Furthermore, it was reveal that the harmonic iron loss at high-speed operation is mainly distributed stator teeth and rotor surface, which may aggravate cooling system of the rotor structure in the vehicle.