하시모토병과 동반된 진성적혈구무형성증 1예

김훈구,이경원,김광민,강명희,주지현,강정훈,이종석 대한혈액학회 2007 Blood Research Vol.42 No.2

후천성 진성적혈구무형성증(acquired pure red cell aplasia)은 골수에서 백혈구계 및 거핵구계의 성숙이나 수에는 이상이 없이 적혈구계의 선택적인 심한 결핍을 나타내는 드문 혈액 질환이다. 이 질환의 원인으로 자가면역이 관여한다고 제시되고 있으며, 진성적혈구무형성증이 전신홍반루푸스, 류마티스관절염, 흉선종, 혼합결합조직병, 쇼그렌증후군 등 다양한 면역질환과 연관되어 발생한다는 사실은 이를 뒷받침한다. 그러나, 하시모토병(Hashimoto disease)과 진성적혈구무형성증이 다른 동반된 자가면역질환 없이 병발된 예는 국내 및 영문 문헌 고찰상 보고된 바가 없다. 이에 저자들은 62세된 여자 환자에서 하시모토병으로 인한 갑상선기능저하증과 동반된 진성적혈구무형성증을 진단하고, 갑상선호르몬제제의 단독 투여만으로 조혈기능의 회복을 보인 증례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

Randomized Phase III Trial of Irinotecan Plus Cisplatin versus Etoposide Plus Cisplatin in Chemotherapy-Naïve Korean Patients with Extensive-Disease Small Cell Lung Cancer

김동완,김훈구,김주항,박근칠,김훈교,장정순,김봉석,강진형,이경희,김상위,류헌모,김진수,이기형,권정혜,최진혁,신상원,한서경,허대석 대한암학회 2019 Cancer Research and Treatment Vol.51 No.1

Purpose This randomized phase III study was designed to compare the efficacy and safety of irinotecan plus cisplatin (IP) over etoposide plus cisplatin (EP) in Korean patients with extensivedisease small-cell lung cancer (SCLC). Materials and Methods Patients were randomly assigned to receive IP, composed of irinotecan 65 mg/m2 intravenously on days 1 and 8+cisplatin 70 mg/m2 intravenously on day 1 every 3 weeks, or EP, composed of etoposide 100 mg/m2 intravenously on days 1, 2, 3+cisplatin 70 mg/m2 intravenously on day 1, every 3 weeks for a maximum of six cycles, until disease progression, or until unacceptable toxicity occurred. The primary endpoint was overall survival. Results A total of 362 patients were randomized to IP (n=173) and EP (n=189) arms. There were no significant differences between IP and EP arms for the median overall survival (10.9 months vs. 10.3 months, p=0.120) and the median progression-free survival (6.5 months vs. 5.8 months, p=0.115). However, there was a significant difference in response rate (62.4% vs. 48.2%, p=0.006). The pre-planned subgroup analyses showed that IP was associated with longer overall survival in male (11.3 months vs. 10.1 months, p=0.036), < 65 years old (12.7 months vs. 11.3 months, p=0.024), and Eastern Cooperative Oncology Group performance status 0/1 (12.4 months vs. 10.9 months, p=0.040) patient groups. The severity of treatment-related adverse events such as grade 3/4 anemia, nausea and diarrhea was more frequent in patients treated with IP. Conclusion The IP chemotherapy did not significantly improve the survival compared with EP chemotherapy in Korean patients with extensive-disease SCLC.

브랜드 파트너링(Brand Partnering): 부정적 정보의 역할

최인혁,김훈구,조희정 한국기업경영학회 2014 기업경영연구 Vol.21 No.6

In recent years, the importance of brand marketing is increasing day by day because this companies are multi-pronged effort to raise its brand value through brand alliances. In addition, companies are feeling the only limit its brand to meet the needs of various consumer made, resulting in a tendency to partnering with other brands is increasing gradually. In addition, as full-fledged research on brand equity is also being began research on the reliability with businesses and brands. Some people believe that trust is the authenticity and integrity of the partners, the company is associated with the idea of forming the consumer will provide the best benefit to the consumer. Also, when the consumer confidence is placed in the uncertain was a decision situation, reduces the uncertainty of the consumer. For this reason companies are multi-faceted effort to increase the reliability of the consumer to the enterprise. This means that the company is a reliable enterprise faith of consumers for companies that provide goods that meets the needs of the consumer, and is composed of the technical aspects of professionalism and moral aspects of authenticity. Therefore, companies are simply trying to get the trust of consumers rather than businesses to improve the economic indicators. This study is being conducted actively in recent reliable study on the company's reputation by combining the branded indeed why do you evaluate the companies improve reliability and characters. And previous studies have also conducted a study to limit the strength of some of the information or information specific to consumers encounter. But the problem Consider the strength to see all of the information consumers feel the same way for the same information. This study is divided into factual information and evaluative information, based on the demonstrated significant potential in contact with the information consumer, the strength of the information, also the separation of the groups according to the strength of consumers feel the same information for the study was performed. Research, led companies brand has been shown to negatively evaluate information differently depending on the reliability of the partner brands. Results reliable partners due to the high negative information on affiliated enterprises is lower than brand partners studied the effect appears to be larger. In other words, consumers were more negative information is evaluated largely due to spillover effects are highly reliable partner for the corporate brand of corporate brand. Consumers also showed that the reliability of corporate brand, consumers rated highest by far in the negative for the company's brand partnership with the strength of the negative information when you encounter factual information on the partner company's brand. However, the reliability of corporate brands showed lower consumer does not have a significant impact on the assessment of the affiliated company's brand, regardless of the type or intensity of the information of the partner company's brand. This gives indirectly show that the more reliable the brand transition effects for negative information appears to be greater for the brand the more reliable the brand more measures are required with respect to the type and intensity of negative information. 최근 브랜드의 중요성은 나날이 증가하고 다양해진 소비자들의 욕구를 충족시키기 위해 기업들은 브랜드 제휴를 통해 브랜드의 자산 가치를 높이려는 노력을 많이 하고 있다. 이에 최근 기업의 평판에 대한 분야에서 논의되고 있는 기업 신뢰성을 브랜드 제휴에 접목시켜 브랜드 신뢰성으로 확장하여 브랜드 신뢰성에 따라 파트너 기업 브랜드가 제휴 기업 브랜드에 어떠한 영향에 미치는지에 대하여 알아보았다. 여기서 좀 더 나아가 파트너 기업 브랜드의 신뢰성의 정도가 제휴 기업 브랜드에 끼치는 영향이 부정적 정보의 강도와 유형에 따라 어떻게 다른지에 대하여도 자세히 알아보았다. 연구결과, 파트너 기업 브랜드의 신뢰성 수준은 제휴 기업 브랜드의 소비자 태도에 영향을 미치는 것으로 나타났으나 부정적 정보의 강도와 부정적 정보의 유형은 제휴 기업 브랜드에 영향을 미치지 못하는 것으로 나타났다. 하지만, 파트너 기업 브랜드의 신뢰성은 파트너 기업 브랜드의 부정적 정보의 강도와 유형에 따라 제휴 기업 브랜드의 태도에 영향을 미치는 것으로 나타났다

문화가 기술준비도에 미치는 영향: 위험과 브랜드 신뢰의 조절 역할

최인혁,김훈구 한국기업경영학회 2017 기업경영연구 Vol.24 No.1

The Internet, various mobile technologies, and the proliferation of smartphones make it easy for consumers to access various information. And the number of technology-based services and products and the role of technology in consumers-company interactions have been growing rapidly. Although these technologies have benefited consumers, there is also evidence of increasing consumer frustration in dealing with technologies. Consumers are also interested in the positive as well as the negative aspects of technology when they encounter new technologies. Prior researches have shown that technology readiness has a favorable influence on the consumers’ technology adoption. However, they have not considered the antecedents of technology readiness. Therefore, this study examined how cultural influence on technology readiness varies with risk level and brand trust. This research investigated the moderating roles of two critical factors on the impact of culture on positive and negative technology readiness: risk level and brand trust. Using a 2 x 2 x 2 between-subject factorial design on positive technology readiness, we have found the effect of culture on positive technology readiness. American consumers had a significantly higher level of positive technology readiness towards using mobile app than Korean consumers. In addition, the interaction of culture and risk level was marginally significant. When risk level was high, culture had no impact on positive technology readiness. However, when risk level was low, American consumers had a higher level of positive technology readiness towards using mobile app than Korean consumers. More importantly, the interaction of culture, risk level, and brand trust was significant. When brand trust was high, culture and risk level have had no impact on positive technology readiness. On the other hand, when brand trust was low, culture and risk have had interaction effect on positive technology readiness. The contrast analysis showed that culture have had no impact on positive technology readiness in the high-risk condition, whereas American consumers had a higher level of positive technology readiness than Korean consumers in the low-risk condition. The results of a 2 (culture) x 2 (risk level) x 2 (brand trust) ANOVA on negative technology readiness yielded a significant main effect for culture. Negative technology readiness was higher in Korean consumers than in American consumers. In addition, the interaction of culture and risk level was significant. When risk level was high, culture have had no impact on negative technology readiness. However, when risk level was low, Korean consumers had a higher level of negative technology readiness than American consumers. More importantly, a three-way interaction was significant. When brand trust was high, culture and risk level have had no impact on negative technology readiness. On the other hand, as our predictions, when brand trust was low, culture and risk had interaction effect on negative technology readiness. The contrast analysis showed that culture have had no impact on negative technology readiness in the high-risk condition, whereas Korean consumers had a higher level of negative technology readiness than American consumers in the low-risk condition. In addition, we investigated the impact of three factors on use intentions using 2 (culture) x 2 (risk level) x 2 (brand trust) ANOVA. The results of a ANOVA and contrast analyses revealed similar pattern with positive technology readiness. Finally, we conducted mediation analyses (Preacher & Hayes, 2008) to verify mediating roles of positive and negative technology readiness. We test the mediation using the bootstrapping technique (PROCESS model 12) with 10,000 resamples. The results showed that positive technology readiness and negative technology readiness mediated the three-way interaction of culture, risk level, and brand trust effect on use intentions. 소비자들은 새로운 기술을 접했을 때 기술의 긍정적 측면 뿐 아니라 부정적 측면에도 관심을 가진다. 이에 선행연구들은 소비자들의 기술 수용에 대한 기술준비도의 역할을 조사하였다. 하지만 이들은 기술준비도의 결과에 주로 관심을 가지고 있으며 기술준비도에 영향을 줄 수 있는 요인들에 대해선 관심이 부족하다. 이에 본 연구는 기술준비도에 대한 문화의 영향력이 위험 수준과 브랜드 신뢰에 따라 어떻게 달라지는지 살펴보았다. 실험 결과, 한국보다 미국 소비자들이 긍정적 기술준비도를 더 높게 지각하고 있으며, 미국보다 한국소비자들이 부정적 기술준비도를 더 높게 지각하는 것으로 나타났다. 또한 이러한 관계는 위험 수준과 브랜드 신뢰에 따라 차이를 보였다. 브랜드 신뢰가 높을 경우 문화와 위험 수준과 관계없이 긍정적 기술준비도는 더 높았으며 부정적 기술준비도는 더 낮아졌다. 하지만 브랜드 신뢰가 낮을 경우 소비자들의 기술준비도는 문화와 위험 수준에 따라 달라지는 것으로 나타났다. 위험 수준이 높을 때에는 문화에 따른 차이가 없었지만 위험 수준이 낮을 때에는 한국보다 미국 소비자들이 긍정적 기술준비도를 더 높게 지각하고 있으며, 미국보다 한국소비자들이 부정적 기술준비도를 더 높게 지각하는 것으로 나타났다.

전통시장의 물리적 환경과 접근편의성이 매출액에 미치는 영향 : 대도시 전통시장 중심으로

최인혁,김훈구 한국물류학회 2017 물류학회지 Vol.27 No.6

In overseas, the traditional market are considered as places to represent the history, and are regarded as a part of the local community's livelihood and the distribution of one part of the local economy. Against this backdrop, the traditional market has a strong reputation as a lagging region where the reputation of being a backwater is strong and deteriorating. However, the traditional market is a very important subject for revitalizing the economy and ordinary people, and the government continues to exert efforts to revitalize the traditional market. The Government's traditional market support projects can be broadly identified as a commercial infrastructure modernization project and a business modernization project. In this study, we will explore the effects of traditional markets and access facilities in traditional markets on sales of traditional markets. In this study, multiple regression analyses were used to analyse this. The data used in this analysis utilized a fact-finding survey for traditional markets and Shopping districts in 2015 The analysis showed that the composition of events in the traditional market facilities, whether the site of a traditional market facility, the introduction of market guidance, LED ad boards, and the number of commercial products are affecting the sale of traditional market, and the number of TV commercials and TV commercials does not affect sales figures. This can be seen as an effective means of providing convenience facilities for promoting convenience facilities. Next, the number of available cars in accessibility convenience facility has a significant impact on the sale of traditional markets. The number of bicycle persecutions has not been affected by the sales of traditional markets. Variables that appear to have no impact on sales of traditional markets are likely to require further studies in the future, as the number of samples pales in comparison to those of other variables. Lastly, the results of this research need to discuss the effectiveness of government support for commercial infrastructure modernization projects in the traditional market, as well as the effective support measures for future efficient support. 해외에서 전통시장은 역사를 나타내는 지역 명물로써 자리 잡고 있으며, 지역주민들의 삶의 한 부분이자 지역 경제 의 한 축을 담당하고 있는 유통분야로 간주되고 있다. 이에 반하여 국내에서 전통시장은 낙후된 지역이라는 이미지가 강하며 쇠퇴해가는 유통분야라는 인식이 강하다. 그러나 전통시장은 지역경제 및 서민경제 활성화의 매우 중요한 주체 로서 정부에서도 이러한 취지로 전통시장 활성화를 위하여 지속적으로 많은 노력을 기울이고 있다. 정부의 전통시장 지원 사업은 크게 상업기반시설 현대화사업과 경영현대화 사업으로 구분하여 볼 수 있다. 본 연구 에서는 정부의 전통시장 지원 사업 중의 하나인 상업기반시설 현대화사업 중에서 전통시장의 물리적 환경과 연관성이 높은 이벤트 광장, 테마거리, TV광고판, LED광고판, 시장안내도, 아치·조형물 등이 매출액에 미치는 영향과 전통시장 의 접근 편의성과 연관성이 높은 주차시설, 자전거 보관소 등이 전통시장의 매출액에 미치는 영향에 대해 살펴보려고 한다. 본 연구에서는 이에 대한 분석을 위하여 다중회귀분석을 이용하였으며, 2015년 전통시장 및 상점가 실태조사의 데이 터를 활용하여 분석에 사용하였다. 분석결과, 전통시장 시설의 물리적 환경 중 이벤트 광장 조성 여부, 시장안내도 설치 여부, LED 광고판 대수, 이치·조형물 수는 전통시장 매출액에 영향을 미치는 것으로 나타난 반면, 테마거리 조성여부 와 TV광고판 대수는 매출액에 영향을 미치는 않는 것으로 나타났다. 이는 정부의 전통시장 사업기반시설 현대화사업 중 홍보편의시설 지원이 효과적으로 나타나는 것으로 볼 수 있다. 다음으로 접근 편의시설인 주차가능대수와 자전거 보관함 수 중 주차가능대수만이 매출액에 유의적으로 영향을 미치는 것으로 나타났으며, 자전거보관함 수는 매출액에 영향을 미치지 않는 것으로 나타났다. 전통시장의 매출액에 영향을 미치지 않는 것으로 나타난 테마거리 조성 여부, TV광고판 대수, 자전거보관함 수의 경우는 해당 시설을 보유하고 있는 전통시장의 표본 수가 다른 변수들에 비하여 적 어 향후 이에 대한 추가 연구가 필요할 것으로 보인다.

Hb Heathrow [β103(G5)Phe→Leu], a First Report in an Asian Patient with Erythrocytosis

신상용,김훈구,김현영,김희진 연세대학교의과대학 2017 Yonsei medical journal Vol.58 No.3

Congenital erythrocytosis (CE) is a rare and heterogeneous disease. The high oxygen affinity hemoglobin (Hb) variants are the most common cause of CE. Herein, we report a Korean patient with isolated erythrocytosis. A 25-year-old man was referred to our hospital for evaluation of high Hb level (Hb 20.4 g/dL, hematocrit 58%, reticulocyte count 2.90%, white blood cell count 6.83×109/L, and platelet count 195×109/L). Bone marrow biopsy revealed normocellular marrow without myeloproliferative features. JAK2 (V617F, exon 12), CALR (exon 9), and MPL W515K/L mutations were not detected. P50 (partial pressure at which Hb is half saturated with oxygen), which is an indicator of left-shift of oxygen dissociation curve (high oxygen affinity state), was 14.3 mm Hg (reference value 22.6–29.4 mm Hg). He was suspected to have CE. Mutation analysis of the HBB gene revealed the known Hb variant, Hb Heathrow [β103(G5)Phe→Leu]. This is the first report of Hb Heathrow in Asian.

조혈모세포이식 후 재발한 환자에서 구제치료로 시행한 DLI (donor Lymphocyte infusion)의 효능에 대한 연구

김병수,김진수,김훈구,홍용상,김인호,윤성수,이종석,박선양,김병국 대한내과학회 2005 대한내과학회 추계학술대회 Vol.2005 No.1

석유난로심지 생산기업에서 글로벌 가전기업으로 성장한 파세코

조희정,최인혁,김훈구 한국경영교육학회 2016 경영교육연구 Vol.31 No.6

[Purpose]Paseco, formerly a kerosene heater wick manufacturer emerged as a global appliance company through the market and product diversification on the basis of the technology accumulation. This study is intended to deduce the key success factors for Paseco through the case study and also to offer strategic implications for the growth strategy for small and medium businesses. [Methodology]For this case study, we collected the various data including the previous study, literatures and publication on Paseco; and further we conducted a several interviews with the high-rank employees. The data was scrutinized to find the key success factors for the diversification; and the factors were classified and analyzed. [Findings]Paseco is found to continuously move to the related areas for business expansion based on the capacity of technology accumulation as a core competence. The diversification for Paseco was successful in that they enter the new business which is closely related with their exising business where they have a core competence. [Implications]This study offers the strategic implications for small and medium businesses in the diversification for growth. It is more likely to be successful that the diversification to the related area should be based upon a core competence acquired through the existing business. [연구목적]본 연구는 기술 축적을 통해 시장 및 제품 다각화 전략으로 심지 생산 기업에서 가전기업으로 성장한 중소기업 파세코의 사례연구를 통해 성공요인을 분석하고 중소기업성장을 위한 전략적 시사점을 제공하고자 하는 것이다. [연구방법]본 사례연구는 해당 기업과 관련한 기존의 연구자료 및 출판물, 기업 홍보자료, 신문기사 자료 수집하는 문헌연구와 회사 관계자를 대상으로 인터뷰 조사를 실시하여 해당 기업이 사업다각화에 성공한 요인을 분석하고 이를 유형화 하였다. [연구결과]파세코는 신규 사업 확장 시에 자사의 핵심역량인 기술축적 능력을 활용하여 인접 사업 영역으로 반복적인 이동을 보이고 있는 유형을 보였다. 파세코의 다각화는 핵심사업을 기점으로 하여 면밀한 검토를 거쳐 인접한 영역으로 신규 사업을 전개하여 사업다각화에 성공한 것으로 나타났다. [연구의 시사점]중소기업이 성장을 위한 방편으로 사업다각화전략을 추진할 시에는 자사의 핵심사업을 기반으로 한 인접영역으로 신규 사업을 전개하는 것이 그 성공률이 높아질 수 있다는 시사점을 제공하였다.

저인산혈염증과 심부전증으로 발현한 당뇨병성 케톤산증 환자 1예

이대환,정태식,김훈구,이경원,정효영,이강완,강석진,함종렬,최동주,정순일 대한당뇨병학회 2001 임상당뇨병 Vol.2 No.2

당뇨병성케톤산증의 치료중에 저칼륨혈증은 흔하지만 심한 저인산염혈증은 매우 드문 것으로 되어 있다. 이전 보고에서 0.32mmol/L 이하의 심한 저인산염혈증은 심근수축력을 감소시켜 울혈성 심부전을 일으키는 것으로 되어 있다. 평소 기저 심장질환이 없었던 34세 여자 환자가 당뇨병성케톤산혈증으로 내원하여 치료 경과도중 폐부종이 발생하였다. 당시 심초음파상 심근수축력의 감소와 혈중 인의 수치가 0.13mmol/L로 심한 저인산염혈증을 보였다. 인 보충 후에 심근수축력이 회복되었으며 심부전을 일으킬만한 다른 원인은 배제하였다. 이에 당뇨병성케톤산증의 치료 경과중 생긴 저인산염혈증에 의한 심부전을 경험하였기에 보고하는 바이다. Hypokalemia is comment observed during the treatment of diabetic ketoacidosis, but hypophosphatemia is relatively rare. Severe hypophosphatemia (0.32 mmol/L or below) might cause congestive heart failure due to decrease of myocardial contractility. In this reprt we observed that thirty four-year-old female had a pulmonary edema during the treatment of diabetic ketoacidosis. She had no cardiac problem before. We noted the decrease of cardiac wall motion and contractility in echocardiography and severe hypophophatemia(0.13 mmol/L). The myocardiac dysfunction of patient has been dramatically improved after the administration of phosphate via intravenous route. Here we report a case of hypophosphatemia developed during the treatment of diabetic ketoacidosis and heart failure related to hypophosphatemia.

악성 림프종 환자에서 고용량 스테로이드 요법에 의한 급성 간부전

김문진,강명희,김훈구,강정훈,이경원,박경범,이원섭,정진명 대한암예방학회 2010 Journal of cancer prevention Vol.15 No.4

Glucocorticoid (GC) is widely used as an anti-emetic drug, an anti-inflammatory drug, or a pain killer for cancer patients. Though only a few cases of GC-induced hepatopathy were reported, the clinical course were mild and reversible, and the GC has also been used for the treatment of autoimmune hepatitis. Here, we found a case of fatal hepatic failure in a 52-year-old man with relapsed diffuse large B-cell lymphoma following high-dose glucocorticoid. Computed tomography (CT) scan revealed shrinkage of liver volume and large amount of ascites, indicating the aggravation of liver cirrhosis. The laboratory finding was consistent with hepatic failure: high bilirubin and prolonged prothrombin time. The patient died of hepatic failure and sepsis. Here, we discussed the mechanism of glucocorticoid-induced hepatopathy and proposed a new hypothesis on the glucocorticoid-induced hepatic failure in the patient with underlying liver disease.