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PCI Interface HDTV 수신카드의 인식률 개선
서영하(Young-Ha Seo),김용득(Yong-Deak Kim) 한국멀티미디어학회 2009 한국멀티미디어학회 학술발표논문집 Vol.2009 No.1
본 논문은 LGDT3303(VSB IC)를 사용한 PCI 지상파 HDTV 수신카드의 인식률 개선에 관한 것이다. Desktop 시스템에서 초기 부팅시 LGDT3303 IC가 장착된 PCI HDTV card 인식률 개선방법에 대해 설명하였으며 양산제품 출하 후 PCI HDTV 인식불량 현상을 없애므로써 SCR(Service Call Rate)및 제품 유지보수 비용을 감소시킬 수 있다.
산화스트레스가 유도된 TM3 세포에서 통캇알리 추출물이 테스토스테론 생성에 미치는 영향
정재인,은상원,이재경,서영하,배문형,김룡,김은지 한국식품영양과학회 2022 한국식품영양과학회지 Vol.51 No.7
통캇알리 추출물은 선행 동물시험과 인체적용시험에서 테스토스테론을 증가시킴으로써 남성갱년기 증상 개선 가능성이 제시되었으나 테스토스테론 증가 기전에 대해 밝혀지지 않았다. 본 연구에서는 H2O2로 산화스트레스를 유도한 TM3 세포에 통캇알리 추출물이 테스토스테론 수준과 테스토스테론의 생성과 전환에 관여하는 효소의 발현을 조사함으로써 테스토스테론 증가 기전을 밝히고자 하였다. TM3 세포에 50 μM H2O2로 산화스트레스를 유도한 경우는 테스토스테론 수준이 유의적으로 감소하였고, 콜레스테롤 운반체로 작용하는 StAR 발현과 테스토스테론 생성에 관여하는 3β-HSD와 CYP17A1 발현이 유의적으로 감소하였다. 반면 테스토스테론 전환에 관여하는 5α-reductase와 aromatase의 발현은 50 μM H2O2 처리에 의해 유의적으로 증가하였다. H2O2로 산화스트레스를 유도한 TM3 세포에 통캇알리 추출물을 여러 농도(10, 25, 50 및 100 μg/mL)로 처리한 경우 테스토스테론 수준이 유의적으로 증가하였다. 통캇알리 추출물 처리에 의해 StAR, 3β-HSD 및 CYP17A1 발현이 유의적으로 증가하였으나 5α-reductase와 aromatase 발현이 유의적으로 감소하였다. 이는 통캇알리 추출물이 미토콘드리아 내로의 콜레스테롤 이동과 테스토스테론 생성을 증가하고 테스토스테론 전환을 감소함으로써 산화스트레스에 의한 테스토스테론 감소를 개선함을 나타내며, 테스토스테론 감소에 의한 남성갱년기 증상을 개선할 수 있는 가능성을 제시한다.
오미자칠해목 추출물의 과산화수소로 유발된 PC12뇌세포 사멸과 스코폴라민으로 유발된 렛드 동물모델에 대한 개선 효과
박은국,한경훈,허재혁,김남기,배문형,서영하,용윤중,정선용,최춘환,Park, Eun-kuk,Han, Kyung-Hoon,Heo, Jae-Hyeok,Kim, Nam-Ki,Bae, Mun-Hyoung,Seo, Young-Ha,Yong, Yoon-joong,Jeong, Seon-Yong,Choi, Chun-Whan 한국식품영양학회 2020 韓國食品營養學會誌 Vol.33 No.3
Cognitive impairment is considered to be key research topics in the field of neurodegenerative diseases and in understanding of learning and memory. In the present study, we investigated neuroprotective effects of Schisandra chinensis (SC) and Ribes fasciculatum (RF) extracts in hydrogen peroxide-induced neuronal cell death in vitro and scopolamine-induced cognitive impairment in Sprague Dawley<sup>®</sup> (SD) rat in vivo. Apoptotic cell death in neuroblastic PC12 cell line was induced by hydrogen peroxide for 1 hour at 100 μM. However, mixture of SC and RF treatment prevented peroxide induced PC12 cell death with no neurotoxic effects. For in vivo experiment, the effect of SC and RF extracts on scopolamine-induced cognitive impairment in SD rat was evaluated by spontaneous alternation behavior in Y-Maze test. After 30 min scopolamine injection, the scopolamine-induced rats presented significantly decreased % spontaneous alteration and acetylcholine level, compared to non-induced group. However, treatment of SC+RF extracts rescued the reduced % spontaneous alteration with acetylcholine concentration from hippocampus in scopolamine-induced rats. These results suggested that mixture of SC and RF extract may be a potential natural therapeutic agent for the prevention of cognitive impairment.
Ribes속 식물 감별을 위한 UHPLC-HR-MS/MS 기반 대사체학 접근
김진아,최윤혁,이종석,정선용,박은국,배문형,서영하,최춘환 한국약용작물학회 2018 한국약용작물학술대회 발표집 Vol.2018 No.10
Background : Ribes fasciculatum var. chinense Maxim. has been traditionally used as febrifuge, diuretic and antidote against urushiol in Korea. This study described a metabolomics approach used to discriminate the genus Ribes from different sources. Methods and Results : Four different types of Ribes from Korea were analyzed by ultra-high-resolution mass spectrometry (UHPLC-HR-MS/MS) based metabolomics. Multivariate statistical method such as principal component analysis (PCA) were used to compare the derived patterns among the samples. The data set was subsequently applied to various metabolite selection methods for sophisticated classification with the optimal number of metabolites. The results showed variations in accuracy among the classification methods for the samples of different origins, especially for cultivation region. Conclusion : This proposed analytical method coupled with multivariate analysis is fast, accurate, and reliable for discriminating the origin of the genus Ribes samples and is a potential tool to standardize quality control in the genus Ribes related products.
과산화수소로 유도된 SH-SY5Y 신경세포 사멸에 대한 오미자·칠해목 추출혼합물의 보호효과
박은국,한경훈,이승희,김남기,배문형,서영하,용윤중,정선용,최춘환,Park, Eun-kuk,Han, Kyung-Hoon,Lee, Seung-Hee,Kim, Nam-Ki,Bae, Mun-Hyoung,Seo, Young-Ha,Yong, Yoon-joong,Jeong, Seon-Yong,Choi, Chun-Whan 한국식품영양학회 2018 韓國食品營養學會誌 Vol.31 No.6
In neuronal cell deaths, oxidative stress is normally implicated with a most of these deaths occurring in neurodegenerative disorders such as the Alzheimer's and Parkinson's diseases. In this study, the neuroprotective effects of Schisandra chinensis (SC) and Ribes fasciculatum (RF) extracts on hydrogen peroxide ($H_2O_2$)-induced oxidative stress in neuroblastic cell line were investigated. For an hour, hydrogen peroxide of $100{\mu}M$ concentration, was induced on neuroblastic cells, causing apoptic cell death. For the neuroprotection, a sample of neuroblastic cells had been pre-treated with SC and RF extracts for 24 hours before application of the hydrogen peroxide. No neurotoxic effects were observed in the cells that had been treated by SC and RF. This prove that the treatment of SC and RF extract prevented apoptotic cell death of neuroblastic cell line exposed to oxidative injury. In addition, applying both SC and RF extracts at a 7:3 ratio increased the neuronal cell survival rate, compared to individual treatments of SC and RF extract. This study suggests that SC and RF extracts may be potential therapeutic agents for the prevention of neuronal cell death.