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최춘환,Joo-Won Yoon,연규환,김영섭,유시용,석순자,Sunny Kang,김영호 한국생약학회 2012 Natural Product Sciences Vol.18 No.4
Mushrooms have a long history of use in traditional medicine, and hundreds of novel constituents in mushrooms with miraculous biological properties have been identified recently. Although diverse effects for medicinal use of mushrooms such as anticancer activity are proven, their reversal activities of drug resistance in cancer cells was rarely reported so far. In the search for novel medicinal use of mushrooms, we tested the multidrug resistance (MDR) reversal activities of diverse mushrooms collected from Korea. Among, the mushroom extracts tested, Cantharellus cibarius (M02) and Russula emetica (M12) revealed MDR reversal activities of paclitaxel in the P-glycoprotein (Pgp)-positive HCT15 and MES-SA/dX5 cancer cells, but not in the Pgp-negative A549 and MES-SA cancer cells. In addition, these mushrooms also enhanced the cytotoxicity of doxorubicin, another well-kwown Pgp-associated anticancer drug against MES-SA/DX5 cells, but not against MES-SA cells. Meanwhile, the cytotoxicity of cisplatin, a well-known Pgp-non-associated anticancer drug, was not affected by the mushrooms all the cells tested. From these results, we suspected that some ingredients of M02 and M12 have Pgp-associated MDR reversal activities.
최춘환 대한건축학회 1984 建築 Vol.28 No.2
본 논고에서는 건축예술 이념의 표현의지와 표현형식과 의 관계를 규명하기 위하여 [미적 공간체험]을 부여하는 대표적 건축공간의 구현체인 Gothic 성당의 건축공간 구성 요소중 몇가지 요소들을, 건축공간의 개념 및 성소공간 개념 분석을 전제로하여 고찰하고저 한다.
Antioxidant Constituents and a New Triterpenoid Glycoside from Flos Lonicerae
최춘환,Hyun Ah Jung,강삼식,최재수 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.1
As a component of our continuing investigations into herb-derived antioxidant agents, we have evaluated the antioxidant effects of Flos Lonicerae (Lonicera japonica flowers), via 1,1-diphenyl- 2-picrylhydrazyl (DPPH) radical, total reactive oxygen species (ROS), hydroxyl radical (·OH), and peroxynitrite (ONOO–) assays. Among the methanolic extract and the dichloromethane, ethyl acetate, n-butanol, and water fractions, the EtOAc fraction of Flos Lonicerae exhibited marked scavenging/inhibitory activities, as follows: IC50 values of 4.37, 27.58 ± 0.71, 0.47 ± 0.05, and 12.13 ± 0.79 μg/mL in the DPPH, total ROS, ONOO–, and ·OH assays, respectively. Via a bioactivity-guided fractionation approach, a new triterpenoid glycoside, oleanolic acid 28-O-α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl(1→6)]-β-D-glucopyranosyl ester (12), along with eleven known compounds, including chrysoeriol (1), luteolin (2), 5- hydroxymethyl-2-furfural (3), caffeic acid (4), protocatechuic acid (5), chrysoeriol 7-O-β-D-glucopyranoside (6), isorhamnetin 3-O-β-D-glucopyranoside (7), kaempferol 3-O-β-D-glucopyranoside (8), quercetin 3-O-β-D-glucopyranoside (9), hederagenin 3-O-α-L-arabinopyranoside (10), and luteolin 7-O-β-D-glucopyranoside (11), were isolated from the EtOAc fraction. The structures of isolated compounds 1-12 were elucidated via spectroscopic analyses. Compound 12 was isolated from a natural source for the first time. Compounds 2, 4, 5, 7, 9, and 11 evidenced marked scavenging activities, with IC50 values of 2.08-11.76 μM for DPPH radicals, and 1.47-6.98 μM for ONOO–
α-Glucosidase Inhibitiors from Seed Extract of Paeonia lactiflora
최춘환,김영호,Yeon Hee Choi,차미란,Jee Hee Park,김영섭,김영균,최상운,연규환,홍경식,유시용 한국응용생명화학회 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.6
Alpha-glucosidase inhibitors are oral antihyperglycemic agents that act on alpha-glucosidase competitively, delaying intestinal carbohydrate absorption and lessening postprandial increases in glucose levels. In the search for new classes of α-glucosidase inhibitors extracted from natural resources, 420 different plant extracts were evaluated for their inhibitory effect on α-glucosidase, in vitro. Amongst the tested extracts, the seed extract of Paeonia lactiflora (Paeoniaceae) demonstrated a significant degree of inhibition on the enzyme, according to dose. Extensive bioassay-guided fractionation of the extract resulted in the isolation of six materials, luteolin (1), resveratrol (2), trans-ε-viniferin (3), gnetin H (4), suffruticosol A (5) and suffruticosol B (6), that are active agents for α-glucosidase inhibition. Resveratrol (2) is a well-known naturally occurring hydroxystilbene, particularly abundant in wine and some related stilbene oligomers. Materials (3-6) exhibited relatively strong inhibition of α-glucosidase and their IC50 values were calculated as: 0.92mM (2), 3.15mM (3), 1.15 mM (4), 2.53mM (5) and 3.15mM (6). In contrast, the (IC50) value of the reference drug, acarbose, was estimated as 8.28mM in vitro.
崔椿煥 명지대학교 1977 明大論文集 Vol.10 No.-
This study was made to investigate elemental characteristic of Korean Wooden struetural style, established in the late period of Koryo Dynasty and the early years of Chosen Dynasty, by the method of observation and analysis about rem-ains of these periods. In Korean Architecture, elemental style of wooden strukure is classefied into the firat style, thesecond style, the third style and the lk kgong style, of the Joo simpo, and than the pure Dapo style and the Compromised style.