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Squamous Cell Carcinoma and Lymphoma of the Oropharynx: Differentiation Using a Radiomics Approach
배소희,최윤성,손범석,안성수,이승구,양재문,김진아 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.10
The purpose of this study was to evaluate the diagnostic performance of magnetic resonance (MR) radiomics-based machine learning algorithms in differentiating squamous cell carcinoma (SCC) from lymphoma in the oropharynx. MR images from 87 patients with oropharyngeal SCC (n=68) and lymphoma (n=19) were reviewed retrospectively. Tumors were semi-automatically segmented on contrast-enhanced T1-weighted images registered to T2-weighted images, and radiomic features (n=202) were extracted from contrast-enhanced T1- and T2-weighted images. The radiomics classifier was built using elastic-net regularized generalized linear model analyses with nested five-fold cross-validation. The diagnostic abilities of the radiomics classifier and visual assessment by two head and neck radiologists were evaluated using receiver operating characteristic (ROC) analyses for distinguishing SCC from lymphoma. Nineteen radiomics features were selected at least twice during the five-fold cross-validation. The mean area under the ROC curve (AUC) of the radiomics classifier was 0.750 [95% confidence interval (CI), 0.613–0.887], with a sensitivity of 84.2%, specificity of 60.3%, and an accuracy of 65.5%. Two human readers yielded AUCs of 0.613 (95% CI, 0.467–0.759) and 0.663 (95% CI, 0.531–0.795), respectively. The radiomics-based machine learning model can be useful for differentiating SCCfrom lymphoma of the oropharynx.
Breast Microcalcifications: Diagnostic Outcomes According to Image-Guided Biopsy Method
배소희,윤정현,문희정,김민정,김은경 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.5
To evaluate the diagnostic outcomes of ultrasonography-guided core needle biopsy (US-CNB), US-guided vacuum-assisted biopsy (US-VAB), and stereotactic-guided vacuum-assisted biopsy (S-VAB) for diagnosing suspicious breast microcalcification. We retrospectively reviewed 336 cases of suspicious breast microcalcification in patients who subsequently underwent image-guided biopsy. US-CNB was performed for US-visible microcalcifications associated with a mass (n = 28), US-VAB for US-visible microcalcifications without an associated mass (n = 59), and S-VAB for mammogram-only visible lesions (n = 249). Mammographic findings, biopsy failure rate, false-negative rate, and underestimation rate were analyzed. Histological diagnoses and the Breast Imaging Reporting and Data System (BI-RADS) categories were reported. Biopsy failure rates for US-CNB, US-VAB, and S-VAB were 7.1% (2/28), 0% (0/59), and 2.8% (7/249), respectively. Three false-negative cases were detected for US-CNB and two for S-VAB. The rates of biopsy-diagnosed ductal carcinoma in situ that were upgraded to invasive cancer at surgery were 41.7% (5/12), 12.9% (4/31), and 8.6% (3/35) for US-CNB, US-VAB, and S-VAB, respectively. Sonographically visible lesions were more likely to be malignant (66.2% [51/77] vs. 23.2% [46/198]; p < 0.001) or of higher BI-RADS category (61.0% [47/77] vs. 22.2% [44/198]; p < 0.001) than sonographically invisible lesions. Ultrasonography-guided vacuum-assisted biopsy is more accurate than US-CNB when suspicious microcalcifications are detected on US. Calcifications with malignant pathology are significantly more visible on US than benign lesions.
내시경 보조하에 제거한 추체 첨부의 콜레스테롤 육아종 1예
나지나,배소희,이전미,문인석 대한이비인후과학회 2019 대한이비인후과학회지 두경부외과학 Vol.62 No.1
A cholesterol granuloma is the most common primary lesion of the petrous apex, and accountsfor 40% of the pathologies that arise in this region. The primary treatment for symptomatic lesionsis by surgery to decompress and drain or to completely remove the lesion. Here we describethe use of infralabyrinthine approach to access a lesion through the temporal bone andcompletely remove it with the assistance of a 0-degree endoscope. A 43-year-old man visitedour clinic for diplopia. Magnetic resonance imaging revealed a 2.3-cm cholesterol granulomalocated in the left petrous apex that caused deviation of the left abducens nerve. The tumor wascompletely removed using the endoscopic-assisted infralabyrinthine approach; the patient iscurrently being followed up, and there is no evidence of disease recurrence. This case report describesthe successful completion of a petrous apex cholesterol granuloma that preserved thecochlear and vestibular systems.