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자궁경부암에서 Glutathione-S-Transferase와 P-glycoprotein의 발현에 대한 연구
배석년,김도강,김수평,김용욱,장병우,변태섭 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.1
Expression of glutathione-S-transferase-π and multidrug resistance gene was examined immunohistochemically in relation to the response to neoadjuvant chemotherapy with cisplatin and etoposide in 23 patients with primary squamous cell carcinoma of uterine cervix(Stage ⅠB2 and ⅡA). Glutathione- S-transferase-π was detected in 19 patients(82.6%). Eleven patients(47.8%) showed positive staining for both proteins. After radical hysterectomy, 11 patients showed pathological response from no residual malignancy to microinvasive cancer. Six of 12(50.0%) tumors showing positive glutathione-S-transferase-π staining were drug resistant(no change or progressive disease), whereas six of 11(54.5%) tumors showing negative gutathione-S-transferase-π staining were drug resistant. This difference in the response rates of the two groups was not significant(p > 0.05). Ten of 19(52.6%) tumors showing positive multidrug resistance staining were diug resistant(no change or progressive disease), whereas 2 of 4(50.0%) tumors showing negative multidrug resistance staining were drug resistant. This difference in the response rates of the two groups was not significant(p > 0.05). Five of 11(45.5%) tumors showing positive staining for both gene were drug resistant, Whereas two of 4 (50%) showing negative staining for both gene were drug resistant. This difference in the response rates of the two groups was not significant(p > 0.05). These data suggest that glutathione S-transferase-π and multidrug resistance gene were not useful predictive markers of drug resistance composed of cisplatin and etoposide in squamous cell carcinoma of uterine cervix.