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홍성현 ( Seong Hyun Hong ),조경현 ( Gyung Hyun Jo ),주완택 ( Wan Taek Ju ),박노동 ( Ro Dong Park ) 한국키틴키토산학회 2010 한국키틴키토산학회지 Vol.15 No.2
매미 허물로부터 화학적 처리법으로 키틴을 분리하고 그 물리화학적 특성을 조사하였다. 얻어진 키틴은 백색의 분말 형태였으며 그 수율은 31.7%였다. 매미 키틴은 30℃에서 진한 염산 가수분해 반응으로 올리고당으로 분해되었으며, 반응시간에 따라 키틴의 분해율은 증가하여 24시간에는 44.0%의 분해율을 기록하였다. GlcNAc1-3의 함량 비율은 반응 0.5시간에 66.5%, 반응 12시간에는 84.4%로 증가하였다. 반응 24시간에는 단당 GlcNAc의 함량이 79.4%를 차지하였으며, 4당 이상은 검출되지 않았다. 매미허물 키틴은 게, 새우 키틴과 같은 형태의 FT-IR 스펙트럼 양상이 나타나 α-chitin으로 확인되었고, 아세틸화도는 88.1%로 조사되었다. 매미 허물 키틴의 X-선 회절 분석결과 2θ = 9.4˚, 19.4˚에서 면간격이 9.39 Å와 4.60 Å로 각각 측정되었으며, 결정화도 및 결정크기의 값은 각각 81.9%, 4.6 nm로 α-chitin인 게, 새우 키틴의 특성치와 유사하였다. In this study, the physicochemical properties of the chitin isolated from cicadae (Platypleura kaempferi) periostracum was investigated. The prepared chitin was white flake form and the yield was 31.7%. The chitin was degraded into oligosaccharide during acid hydrolysis at 30℃ with concentrated HCl. The hydrolysis rate was 6.8% only after 0.5 h reaction, but increased to 44.0% after 24 h reaction. In distribution of the oligosaccharides in the hydrolyzates, ratio of GlcNAc1-3 content increased from 66.5% after 0.5 h reaction to 84.4% after 12 h reaction. The ratio of monomer GlcNAc content was 79.4% after 24 h reaction and no oligosaccharides bigger than GlcNAc4 was detected. It is found that cicadae periostracum chitin belongs to α-chitin resulting from the FT-IR spectra similar with those of crab and shrimp chitins. In X-ray diffractometer, two peaks were exhibited at 2θ = 9.5˚ (interplanar distance: 9.36Å) and 2θ = 19.4o(4.58Å). The crystallinity index and crystal size of the chitin were determined to be 81.9% and 4.6 nm, respectively, which are similar with those of crab and shrimp chitins, again confirming that cicadae periostracum chitin belongs to α-chitin. The degree of acetylation of cicadae periostracum chitin was calculated to be 88.1%.
응급의학과 전공의 총조사 자료를 이용한 전공의의 교육 요구도 분석
권태현,박경혜,기동훈,김인병,김호중,박송이,서범석,윤유상,이의선,이형민,조광현,최석재 대한응급의학회 2021 大韓應急醫學會誌 Vol.32 No.1
Objective: This study was conducted to identify the needs assessment for education and training of emergency medicine (EM) residents. Methods: The results of a national survey of EM residents of the Korean Society of Emergency Medicine in 2019 were used. Education was one of the five categories in the survey. The preferred learning methods and their perceived importance and ability to perform in nine competencies were assessed. The Borich’s needs assessment model was used to analyze their needs. Results: Among 591 EM residents, 382 responded, and 371 responses were finally analyzed. Regarding the learning methods, junior residents preferred in-hospital conferences, staff lectures, internet resources, and textbooks. Overall, medical knowledge and procedural skills were the most important, and research was less important to recognize. Medical knowledge showed the highest rank in the needs assessment in all years, and ethics and professionalism showed the lowest ranks. The needs for procedural skills were higher in junior years but lower in senior years. Conclusion: These results will form the basis for the design of training programs to meet the educational needs of EM residents for each grade. Furthermore, an analysis of the educational needs should be done periodically according to the changes and demands of the times.
복수 재발한 급성림프구성 백혈병 1예에서중추신경계 질환 치료 방법
지종현,홍유라,박성인,박재선 고신대학교(의대) 고신대학교 의과대학 학술지 2003 고신대학교 의과대학 학술지 Vol.18 No.1
Methotrexate (MTX) is one of the most widely used drugs for the treatment of childhood acute lymphoblastic leukemia (ALL) and is commonly given in high doses. Systemic chemotherapy, triple intrathecal (TIT) treatment and craniospinal radiation was given to a child with meningeal involvement at presentation. But meningeal leukemia was recurred 3 months later, which was remissioned secondly by TIT chemotherapy. One year later from first diagnosis, second meningeal relapse was presented with immature cell count of 12/mm3 in CSF and a large intracerebral mass on brain CT. A high-dose methotrexate (HDMTX) had been challenged in dose of 2.8-5.0 g/m2 with TIT chemotherapy. In HDMTX schedule, leucovorin (LCV) was administered orally (12 times, 15 mg/m2 every 6 hours), 24 hours later from the start. Intracerebral mass disappeared two weeks later (with 2 weekly administration of HDMTX) and the third remission was lasted for 80 months. Third isolated meningeal relapse, which occurred on July 28, 2000, remissioned again with HDMTX plus TIT chemotherapy, but he died of fungal sepsis and interstitial pneumonia. Although the patient died of treatment related disease, systemic intravenous HDMTX and TIT therapy appears to provide another option in the treatment of relapsed meningeal leukemia after craniospinal irradiation.
안주현,박수완,오창현 대한상하수도학회 2024 상하수도학회지 Vol.38 No.2
In this study, an evaluation system that can be used to evaluate the feasibility of developing and supplying hydrothermal energy for the operation of large-scale complex facilities was developed. To this end, this study derived factors to be considered when selecting a location for the use of hydrothermal energy using raw water from multi-purpose dams and regional water supply systems through literature survey and expert interviews. The evaluation indicators derived from this study are divided into four sectors: hydrothermal energy utilization factors, location factors, planning factors, and disaster safety factors, and are composed of 10 mid-level indicators and 34 detailed planning indicators. The relative importance of all factors was derived using the Analytic Hierarchy Process (AHP) technique, and the developed evaluation indicators and relative importance were applied to four multi-purpose dam regions in the country. As a result, it was found that in the development and use of hydrothermal energy utilizing regional raw water supply line the urban planning conditions of the supply site can have a greater impact on the location selection results than the hydrothermal energy development itself. Due to the characteristics of the evaluation indicators developed in this study and their nature as comprehensive indicators, it is believed that the results should be applied to determine the overall adequacy of site selection in the early stages of hydrothermal energy development. In the future, it is believed that it will be necessary to analyze the problems in supplying and operating hydrothermal energy using raw water from multi-purpose dams and regional water resources. Based on the analysis the evaluation system developed in this study is expected to be improved and supplemented.
응급의학과 수련 만족도에 대한 분석과 향후 교육 수련 발전 방향에 대한 제안
박송이,박경혜,김인병,양혁준,이기중,임태호,한승백,강구현,강영준,김주영,김 철,박유석,박주옥,박준범,박준석,박현경,손재돈,오세현,오영민,이동욱,이형민,정시영,정진우,조광현,조영순,조한진,최대해 대한응급의학회 2016 대한응급의학회지 Vol.27 No.5
Purpose: At 1990, the first emergency medicine residency training was started in Korea. However, there was no date and discussion about the satisfaction of emergency medicine residency training and improvement point. The aim of this study is to investigate the satisfaction of emergency medicine residency training and suggest for improvement on the future emergency medicine residency training. Methods: A nationwide survey was conducted with a representative sample of 432 emergency medicine specialist involved in emergency care in 2015. Results: The average score of satisfaction for emergency medicine residency training was 3.29±1.09. The most satisfied part was about procedure skills as 3.70±0.99, and the most needed part for future residency training was about communication skill as 4.27±0.77. Satisfaction gap among each training hospitals was significant. Emergency physicians in training hospital considered that patient management and administration, communication skills, prehospital emergency medical service system, educational methods, and research are important in this order. On the other hand. Emergency physicians in non-training hospital considered that medical knowledge, procedure skills, professionalism, and resource utilization are more important. However there was no difference in recommendation between clinical practitioners and non-clinical practitioner. Conclusion: Korean emergency physicians are satisfied with residency training in procedure skills, patient management and administration, and professionalism and highly recommended them. Communication skill is most highly recommended, but show low satisfaction. Developing the advanced competency assessment for specialist board can lead to residency curriculum change. Furthermore, the Korean Society of Emergency Medicine needs to provide standardized and systematic residency curriculum in order to minimize the disparity between the training hospitals.