한의학과 아유르베다의학의 약재 비교 고찰(I)

박지하,이봉효,이상남,송익수,안상영,한창현,Park, Ji-Ha,Lee, Bong-Hyo,Lee, Sang-Nam,Song, Ick-Soo,Ahn, Sang-Young,Han, Chang-Hyun 대한본초학회 2010 大韓本草學會誌 Vol.25 No.4

Objectives & Methods : To compare the medicinal herbs between Ayurvedic medicine and traditional Korean medicine(TKM), we took reference of major publications related to Ayurvedic medicinal herbs such as Indian Herbal Remedies, Prime Ayurvedic Plant Drugs, with those of TKM. We selected most widely used 130 herbal species of Ayurvedic medicine and compared the similarities and differences with TKM. Comparative factors were the origin, habitation, synonyms, usage, medicinal parts, and precautions. Results : 1. The medicinal herbs Resinatum Lignum(沈香), Arecae Pericarpium(大腹皮), Arecae Semen(檳榔), Carthami Flos (紅花), Camphorum(樟腦), Crotonis Semen(巴豆), Curculiginis Rhizoma(仙茅) used in TKM did exactly correlate in their origins with those of Ayurvedic medicine. 2. Varieties of allied species were found in their origins. Benincasae Pericarpium(冬瓜皮), and Benincasae Semen(冬瓜子) derive from the same plant Benincasa hispida Cogn. for both Ayurvedic medicine and TKM. Interestingly, B. cerifera Savi. is also claimed for same uses in Ayurvedic medicine. This broadened use of allied species is found in various Ayurvedic herbal medicine such as Cannabis Semen(火麻仁) using Cannabis indica Lam., and Curcuma Longae Rhizoma(薑黃) using Curcuma domestica Valeton. This suggests the possibility of their usage also in TKM. 3. Myrrha(沒藥), and Curculiginis Rhizoma concorded their usage with TKM. While Arecae Pericarpium(大腹皮), Arecae Semen(檳榔), Aquilariae Resinatum Lignum(沈香), Pericarpium(冬瓜皮), Benincasae Semen(冬瓜子), Cannabis Semen(火麻仁), Carthami Flos(紅花), Camphorum(樟腦), Crotonis Semen(巴豆), Curcumae Radix(鬱金), Curcuma Longae Rhizoma(薑黃) and Zedoariae Rhizoma(莪朮) revealed varied efficacies according to their part used or usage forms. Conclusion : Both Ayurvedic medicine and TKM reflect the traditional medicine of its regions where is founded. Mutual understanding improves the capability of coping of diverse ailments of present days and also replacing some plants in the days of increasing threat to our environment. Abundant external applications of various plants found in Ayurvedic medicine were particularly useful for TKM to complement its strength in herbal intake.

국내 기공관련 무작위 임상연구에 대한 현황 검토

한창현 ( Chang Hyun Han ),이상남 ( Sang Nam Lee ),박지하 ( Ji Ha Park ),안상우 ( Sang Woo Ahn ) 대한경락경혈학회 2009 Korean Journal of Acupuncture Vol.26 No.1

Background: Qigong is an energy-healing intervention used to prevent and cure ailments and to improve health through regular practice. Although qigong-neither itself nor its postulated mechanism of action-are within the paradigm of modern Western medical science, its effects on the human body could be possible. Objectives: This study aims to review the bibliography, biological responses and therapeutic effects of Qigong. In the process, this review will grasp trends in this field of studies and will direct further researches into the right direction. Method: The computerized Korean databases were searched from their respective inceptions up to January 2008. The search terms used were `qi`, `qigong`, `doin`, `training`, `bioenergy`, `life nurturing` and random or Korean language terms related to qigong. Several specialized journals were also manually searched for relevant articles. Result: Since the 1990s, Qigong papers in the Korean Literature are increased. The articles on Korean traditional medicine had been published more than those on physical education or nursing etc. However, since the majority of the trials determine questionnaire, it was difficult to determine the efficacy of a specific intervention. The methodological quality of the trials was generally low (Jadad score: mean, 1.3; range, 1 to 4), questioning their reliability. Conclusions: More profound studies for Qigong are needed. Further rigorous clinical trials with more objective outcome measures that include sham procedures should be performed. Specifically, we think it should be clinical studies and qualitative research methods for evaluation are needed.

Quad Chip 외관 불량 검사를 위한 2D/3D 광학 시스템

한창호(Han, Chang Ho),이상준(Lee, Sang-Jun),박철근(Park Chul-Geun),이지연(Lee, Ji-Yeun),유영기(Ryu, Young-Kee),고국원(Ko, Kuk-Won) 한국산학기술학회 2016 한국산학기술학회논문지 Vol.17 No.1

LQFP/TQFP(Low-profile Quad Flat Package/Thin Quad Flat Package) 패키지 공정에서는 높은 수준의 품질 관리를 위해 3차원 형상 측정 방법을 도입하고 있어 본 연구에서는 최종 외관 불량 검사를 위하여 projection moire 방식의 3D 영상 검사를 위한 광학 시스템과 영상처리 알고리즘을 개발하였다. LQFP/TQFP칩에서 발생하는 불량들은 2D 불량항목과 3D 불 량 항목으로 구분하여 불량 항목을 상세히 정의하였다. 광학계를 설계함에 있어서 2D 측정 광학계는 돔 조명을 사용하여 일정한 광분포도를 갖도록 설계하고, 3D 측정 광학계는 PZT를 이용하여 모아레 패턴이 90도씩 정확한 위상을 갖도록 이송을 위한 기구적 메커니즘을 설계한다. 물체의 모아레 측정시 위상 변화에서 나타나는 2 모호성을 해결하기 위해 측정된 모아 레 무늬를 비교하여 2 위상의 모호성이 발생하는 부분에서 수정된 다른 위상을 참고하는 알고리즘을 적용하였다. 개발된 검사 시스템은 LQFP/TQFP 외관 검사 공정에 적용하였으며, 실험에서 최대 높이의 측정 오차는 1.34μm 이내로, 3차원 외관 형상 불량 검사 조건을 만족할 만한 성능을 보였다. In the manufacturing process of the LQFP/TQFP (Low-profile Quad Flat Package/Thin Quad Flat Package), the requirement of a 3 dimensional inspection is increasing rapidly and a 3D inspection of the shape of a chip has become an important report of quality control. This study developed a 3 dimensional measurement system based on PMP (Phase Measuring Profilometry) for an inspection of the LQFP/TQFP chip and image processing algorithms. The defects of the LQFP/TQFP chip were classified according to the dimensions. The 2 dimensional optical system was designed by the dorm illumination to achieve constant light distribution, In the 3 dimensional optical system, PZT was used for moving 90 degree in phase. The problem of 2 ambiguity was solved from the measured moir? pattern using the ambiguity elimination algorithm that finds the point of ambiguity and refines the phase value. The proposed 3D measurement system was evaluated experimentally.

일개 보건소를 방문하는 고혈압, 당뇨 및 관절염환자의 보완요법 이용실태

박애주(Ae-Ju Park),박재용(Jae-Yong Park),한창현(Chang-Hyun Han) 한국농촌의학 지역보건학회 2003 농촌의학·지역보건 Vol.28 No.2

한국 저널에 게재된 기공관련 대조군 임상연구 현황 분석

한창현(Chang Hyun Han),권영규(Young Kyu Kwon),이상남(Sang Nam Lee),박지하(Ji Ha Park),안상우(Sang Woo Ahn) 한의병리학회 2009 동의생리병리학회지 Vol.23 No.2

한의학과 아유르베다의학의 약재 비교 고찰(1)

한창현 ( Chang Hyun Han ),박지하 ( Ji Ha Park ),이봉효 ( Bong Hyo Lee ),이상남 ( Sang Nam Lee ),송익수 ( Ick Soo Song ),안상영 ( Sang Young Ahn ) 대한본초학회 2010 大韓本草學會誌 Vol.25 No.4

Objectives & Methods: To compare the medicinal herbs between Ayurvedic medicine and traditional Korean medicine(TKM), we took reference of major publications related to Ayurvedic medicinal herbs such as Indian Herbal Remedies, Prime Ayurvedic Plant Drugs, with those of TKM. We selected most widely used 130 herbal species of Ayurvedic medicine and compared the similarities and differences with TKM. Comparative factors were the origin, habitation, synonyms, usage, medicinal parts, and precautions. Results: 1. The medicinal herbs Resinatum Lignum(沈香), Arecae Pericarpium(大腹皮), Arecae Semen(檳랑), Carthami Flos(紅花), Camphorum(樟腦), Crotonis Semen(巴豆), Curculiginis Rhizoma(仙茅) used in TKM did exactly correlate in their origins with those of Ayurvedic medicine. 2. Varieties of allied species were found in their origins. Benincasae Pericarpium(冬瓜皮), and Benincasae Semen(冬瓜子) derive from the same plant Benincasa hispida Cogn. for both Ayurvedic medicine and TKM. Interestingly, B. cerifera Savi. is also claimed for same uses in Ayurvedic medicine. This broadened use of allied species is found in various Ayurvedic herbal medicine such as Cannabis Semen(火麻仁) using Cannabis indica Lam., and Curcuma Longae Rhizoma(薑黃) using Curcuma domestica Valeton. This suggests the possibility of their usage also in TKM. 3. Myrrha(沒藥), and Curculiginis Rhizoma concorded their usage with TKM. While Arecae Pericarpium(大腹皮), Arecae Semen(檳랑), Aquilariae Resinatum Lignum(沈香), Pericarpium(冬瓜皮), Benincasae Semen(冬瓜子), Cannabis Semen(火麻仁), Carthami Flos(紅花), Camphorum(樟腦), Crotonis Semen(巴豆), Curcumae Radix(鬱金), Curcuma Longae Rhizoma(薑黃) and Zedoariae Rhizoma(莪朮) revealed varied efficacies according to their part used or usage forms. Conclusion: Both Ayurvedic medicine and TKM reflect the traditional medicine of its regions where is founded. Mutual understanding improves the capability of coping of diverse ailments of present days and also replacing some plants in the days of increasing threat to our environment. Abundant external applications of various plants found in Ayurvedic medicine were particularly useful for TKM to complement its strength in herbal intake.

Ac/Ds 삽입 변이체를 이용한 벼 유전자 기능 연구

이강섭,박성한,윤도원,안병옥,김창국,한창덕,이기환,박동수,은무영,윤웅한,Lee, Gang-Seob,Park, Sung-Han,Yun, Do-Won,Ahn, Byoung-Ohg,Kim, Chang-Kug,Han, Chang-Deok,Yi, Gi-Hwan,Park, Dong-Soo,Eun, Moo-Young,Yoon, Ung-Han 한국식물생명공학회 2010 식물생명공학회지 Vol.37 No.2

Rice is the staple food of more than 50% of the worlds population. Cultivated rice has the AA genome (diploid, 2n=24) and small genome size of only 430 megabase (haploid genome). As the sequencing of rice genome was completed by the International Rice Genome Sequencing Project (IRGSP), many researchers in the world have been working to explore the gene function on rice genome. Insertional mutagenesis has been a powerful strategy for assessing gene function. In maize, well characterized transposable elements have traditionally been used to clone genes for which only phenotypic information is available. In rice endogenous mobile elements such as MITE and Tos (Hirochika. 1997) have been used to generate gene-tagged populations. To date T-DNA and maize transposable element systems has been utilized as main insertional mutagens in rice. A main drawback of a T-DNA scheme is that Agrobacteria-mediated transformation in rice requires extensive facilities, time, and labor. In contrast, the Ac/Ds system offers the advantage of generating new mutants by secondary transposition from a single tagged gene. Revertants can be utilized to correlate phenotype with genotype. To enhance the efficiency of gene detection, advanced gene-tagging systems (i.e. activation, gene or enhancer trap) have been employed for functional genomic studies in rice. Internationally, there have been many projects to develop large scales of insertionally mutagenized populations and databases of insertion sites has been established. Ultimate goals of these projects are to supply genetic materials and informations essential for functional analysis of rice genes and for breeding using agronomically important genes. In this report, we summarize the current status of Ac/Ds-mediated gene tagging systems that has been launched by collaborative works from 2001 in Korea.

회전근 개 파열의 봉합 가능성 및 수술 적응증

고상훈,박한창,이선호,Ko, Sang-Hun,Park, Han-Chang,Lee, Seon-Ho 대한관절경학회 2012 대한관절경학회지 Vol.16 No.1

목적: 회전근 개 파열의 봉합 가능성은 수술적 치료의 적응증을 정립하는데 매우 중요하다. 저자는 회전근 개의 봉합 가능성 및 치유에 영향을 주는 요소들과 회전근 개 파열의 수술적 치료의 적응증에 대해서 고찰하였다. 대상 및 방법: 회전근 개 파열의 봉합 가능성은 수술적 봉합 가능성과 술 후 회전근 개 파열의 치유 가능성의 측면에서 고려되어야 한다. 회전근 개 파열의 자연 경과에 대한 이해 역시 수술적 치료를 할 것인지 보존적 치료를 할 것인지를 결정하는데 큰 도움을 준다. 결과: 회전근 개의 치유 가능성을 예측하는 세가지 일반적인 범주가 있는데 첫째로 수술적 요소, 생물학적 요소, 환경적 요소이다. 수술의는 수술적 기법을 스스로 선택함으로써 수술적 요소를 제어할 수 있으며, 생물학적 요소는 나이와 급성 외상의 유무, 만성화 정도, 파열의 정도 등을 고려하여 주의 깊게 수술 적응 대상을 선택함으로써, 환경적 요소는 흡연 및 비스테로이드성 소염진통제(nonsteroidal anti-inflammatory drug, NSAID) 사용을 피함으로써 더 좋은 임상 결과를 기대할 수 있다. 결론: 회전근 개 파열의 자연 경과와 봉합 가능성에 대한 정확한 이해는 회전근 개 파열의 수술적 치료의 적응증을 정립하고 만족스러운 임상결과를 얻는데 큰 도움을 줄 수 있다. Purpose: The reparability of rotator cuff tears is very important to establish the indication of the surgical treatment of rotator cuff tears. We reviewed the factors that effect to reparability of rotator cuff tears, and considered about the surgical indication of rotator cuff tears. Materials and Methods: The reparability was considered by the surgical reparability and the postoperative healing potentials of rotator cuff. The natural history of rotator cuff tear gives us the information to make decision about the surgical treatment or the conservative treatment. Results: There are 3 general categories of factors that help predict the healing potential of a rotator cuff tear. These include surgical technique, biology, and environmental issues. Surgeon can control the surgical technique by himself. The control of biology comes from careful operative indications by age, acute trauma history, chronicity, and tear size. And the control of environmental factor can give better outcomes by cessation of smoking and nonsteroidal anti-inflammatory drug (NSAID). Conclusion: A better understanding of the natural history and the reparability of rotator cuff tear will help us to estabilish the indication of surgical treatement of rotoator cuff tears, and lead to satisfactory clinical outcomes.

티벳 전통의학(傳統醫學)에 관(關)한 고찰(考察)

이봉효,박지하,이상남,한창현,Lee, Bong-Hyo,Park, Ji-Ha,Lee, Sang-Nam,Han, Chang-Hyun 대한예방한의학회 2010 대한예방한의학회지 Vol.14 No.3

Objectives : There has been little known about the Tibetan medicine in the society for Korean medicine. The aim of this study is to review the system of Tibetan medicine and compare with Korean medicine. Methods : The authors investigated several literatures that mentioned Tibetan medicine and organized in physiology, pathology, diagnostics, and treatment. And then, we interpreted the characteristics of Tibetan medicine as well as compared Tibetan medicine with Korean medicine. After that, we analyzed the commons and the differences, and also found out the meaning of Tibetan medicine. Results : The theory of Tibetan medicine is basically constituted of three elements of Lung, Tripa, and Peken in every parts of physiology, pathology, diagnostics, and treatment. Many organs of human body are compared to the fabrications of building. There is a detail explanation about the process of the development of fetus in Tibetan medicine. Tibetan medicine uses taking pulse in wrist, analysis of urine, watching of tongue, sperm, and menstruation, and etc. for diagnosis. In Tibetan medicine, regimen is prior to other treatments such as surgical treatment and medications. Conclusions : There is the oriental thought of '3' in Tibetan medicine, and esoteric buddhism is solved in Tibetan medicine. The anatomy and the diagnostics using urine, sperm, and menstruation have especially been developed in Tibetan medicine. Tibetan medicine emphasizes the feature of preventive medicine.

제비꽃 추출물의 항산화 활성 및 α-Amylase와 α-Glucosidase에 대한 저해 활성

이보배,박순례,한창석,한동열,박은주,박해룡,이승철,Lee, Bo-Bae,Park, Soon-Rye,Han, Chang-Suk,Han, Dong-Youl,Park, Eun-Ju,Park, Hae-Ryong,Lee, Seung-Cheol 한국식품영양과학회 2008 한국식품영양과학회지 Vol.37 No.4

This study was performed to investigate the physiological activities of Viola mandshurica. Antioxidant activity was evaluated by measuring total phenolic contents, reducing power, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-di-2-ethyl-benzthiazoline sulphonate (ABTS) radical scavenging activity while anti-diabetic activity was measured by inhibition activities on ${\alpha}$-amylase and ${\alpha}$-glucosidase. V. mandshurica extracts were prepared by extracting with four different solvents (methanol, ethanol, acetone, and water). The methanol extract showed the highest total phenol content (34.49 mg/g gallic acid equivalents) among the extracts. The water extract showed the highest reducing power (0.454) at the concentration of $1,000{\mu}g$/mL. The acetone extract showed the most potent radical scavenging activity. DPPH and ABTS radical scavenging activity of the acetone extract at the concentration of $1,000{\mu}g$/mL were 21.13% and 43.53%, respectively. The inhibitory activity of acetone extracts against ${\alpha}$-amylase and ${\alpha}$-glucosidase showed more than 100% at the concentration of $1,000{\mu}g$/mL. The results indicate that V. mandshurica might have potential antioxidant and anti-diabetic activities. 민간요법에서 화농성 피부질환이나 염증성 질환에 대해 효과가 있다고 알려진 제비꽃(Viola mandshurica)의 항산화 활성과 항당뇨 활성을 조사하였다. 제비꽃 10 g에 200 mL의 네 가지 용매(메탄올, 에탄올, 아세톤, 물)를 각각 가하여 추출한 다음, 농축하여 각각의 용매별 추출물을 얻었다. 이용매별 추출물의 총 페놀 함량은 메탄올 추출물이 34.49 mg/g 갈산 당량으로 가장 높았고, DPPH 라디칼과 ABTS 라디칼 소거능은 아세톤 추출물이 $1,000{\mu}g/mL$ 농도에서 각각 21.13%와 43.53%로 가장 높은 값을 보였다. 환원력의 경우에는 물 추출물이 $1,000{\mu}g/mL$ 농도에서 0.454의 값으로 가장 높은 활성을 보였다. 항당뇨 활성은 ${\alpha}$-amylase와 ${\alpha}$-glucosidase에 대한 저해 활성으로 측정하였는데 아세톤 추출물이 가장 활성이 높았으며 $1,000{\mu}g$/mL 농도에서 모든 효소 활성들을 저해하였다. 이상의 결과로부터 제비꽃 추출물은 항산화능과, 당뇨 관련 효소에 대한 저해능이 있음을 확인할 수 있었다.