기억성 경도인지장애 및 알츠하이머 치매 환자에서 해마, 편도체, 뇌들보, 내후각 피질과 혈중 지질, 호모시스테인, 엽산 농도와의 연관성

이상준,김태형,허량,최승은,이봉주,김경미,이정구,김홍대,문치웅,김영훈,Lee, Sang Jun,Kim, Tae Hyung,Huh, Lyang,Choi, Seung Eun,Lee, Bong Ju,Kim, Gyung Mee,Lee, Jung Goo,Kim, Hong Dae,Mun, Chi Woong,Kim, Young Hoon 대한생물정신의학회 2015 생물정신의학 Vol.22 No.4

Objectives In this study, the authors evaluated the correlation between levels of serum lipid, homocysteine, and folate with volumes of hippocampus, amygdala, corpus callosum, and in patients with amnestic mild cognitive impairment (aMCI) or Alzheimer's disease (AD) type. Methods The study recruited patients who visited the dementia clinic of Haeundae Paik Hospital in Korea between March 2010 and June 2014. Among those, patients who had taken the neurocognitive test, brain magnetic resonance imaing, tests for serum lipid, homocysteine, folate, and apolipoprotein E (APOE) genotyping and diagnosed with aMCI or AD were included for analysis. Bilateral hippocampus, entorhinal cortex, amygdala and corpus callosum were selected for region of interest (ROI). The cross-sectional relationships between serum lipid, homocysteine, folate and ROI were assessed by partial correlation analysis and multiple linear regression analysis. Results In patients with aMCI, old age (> 80) and APOE ${\varepsilon}4$ carrier were associated with AD [odds ration (OR) : 12.80 ; 95% confidence interval (CI) : 2.25-72.98 and OR : 4.48 ; 95% CI : 1.58-12.67, respectively]. In patients with aMCI or AD, volumes and thickness of ROI were inversely correlated with levels of serum lipid and homocysteine. In multiple linear regression analyses, higher total cholesterol level was related to lower left, right hippocampus volume and left amygdala volume ; higher low-density lipoprotein cholesterol was related to lower right entorhinal cortex thickness ; higher homocysteine level was related to lower corpus callosum volume. Conclusions Higher serum lipid and homocysteine levels are associated with decreased volume of hippocampus, amygdala, corpus callosum and entorhinal cortex thickness in patients with aMCI or AD. These findings suggest that serum lipid and homocysteine levels are associated with AD as a modifiable risk factor.

과학기술위성3호 소형영상분광기 발사모델 환경시험 결과

이상준,김정현,이준호,이치원,장태성,강경인,Lee, Sang-Jun,Kim, Jung-Hyun,Lee, Jun-Ho,Lee, Chi-Won,Jang, Tae-Sung,Kang, Kyung-In 한국광학회 2011 한국광학회지 Vol.22 No.4

과학기술위성3호 부탑재체인 소형영상분광기 COMIS(Compact Imaging Spectrometer)는 400 - 1050 nm의 관측 대역에서 분광 관측을 수행하는 영상 분광기이다. COMIS는 2012년 고도 700 km의 원 궤도에서 발사 된 후 27 m의 공간분해능과 2 - 15 nm의 파장 분해능을 갖도록 설계되었다. 본 논문에서는 COMIS 비행 모델의 환경시험 수행결과를 기술한다. 발사 환경인 진동 가진에 의한 영상분광기의 광학적, 구조적인 변화 여부와 우주환경인 열.진공 상태에서의 기능 시험을 수행하여 안정성 및 신뢰성을 검증 받았다. 우주공간에서의 환경으로 일컬어지는 고진공($10^{-5}$ torr이하)과 $-30^{\circ}C{\sim}35^{\circ}C$의 고온 및 저온의 열적 변화 상태를 모사하는 시험에서 정상적인 기능을 보였고, 10 grms의 랜덤 진동 가진 전.후의 고유 진동수는 1% 이내의 변화량을 보였다. 환경시험 전 후로 영상분광기의 변조전달함수(MTF, Modulation Transfer Function) 측정을 하여 광학 성능이 유지됨을 확인하였다. 환경시험을 마친 영상분광기는 현재 과학기술위성3호 본체와의 조립을 진행 중에 있으며 2012년 발사 예정에 있다. A compact imaging spectrometer (COMIS) was developed for a microsatellite STSAT-3. The satellite is now rescheduled to be launched into a low sun-synchronous Earth orbit (~700 km) by the end of 2012. Its main operational goal is the imaging of the Earth's surface and atmosphere with ground sampling distance of 27 m and 2 - 15 nm spectral resolution over visible and near infrared spectrum (0.4 - 1.05 ${\mu}m$). A flight model of COMIS was developed following an engineering model that had successfully demonstrated hyperspectral imaging capability and structural rigidity. In this paper we report the environmental test results of the flight model. The mechanical stiffness of the model was confirmed by a small shift of the natural frequency i.e., < 1% over 10 gRMS random vibration test. Electrical functions of the model were also tested without showing any anomalies during and after vacuum thermal cycling test with < $10^{-5}$ torr and $-30^{\circ}C\;-\;35^{\circ}C$. The imaging capability of the model, represented by a modulation transfer function (MTF) value at the Nyquist frequency, was also kept unvaried after all those environmental tests.

스월유동장의 화염전파에 미치는 난류특성의 영향에 관한 연구

이상준,이종태,이성열,Lee, Sang-Jun,Lee, Jong-Tae,Lee, Seong-Yeol 대한기계학회 1996 大韓機械學會論文集B Vol.20 No.10

Flow velocity was measured using a hot wire anemometer. Turbulence intensity was in proportion to mean flow velocity regardless of swirl velocity. And integral length scale has proportional relation with swirl velocity regardless of measurement position. Flame speed calculated by radius of visualized flame was increased and then decreased according to lapse of time from spark. Maximum flame speed was increased according to increase of turbulence intensity. Burning speed and flame transport effect increased with increase of swirl velocity, but ratio of burning speed to flame speed decreased with increased of swirl velocity. Mass fraction burned versus volume fraction burned was increased in proportion to the increase of turbulence intensity, caused by increase of combustion promotion effect according to increase of turbulence intensity and scale.

스월유동장에 있어서 연소속도에 미치는 난류특성의 영향에 관한 연구

이상준,이종태,이성열,Lee, Sang Jun,Lee, Jong-Tai,Lee, Song-Yol 대한기계학회 1996 大韓機械學會論文集B Vol.20 No.1

Flow velocity was measured by, use of hot wire anemometer. Turbulence intensity was in proportion to mean flow velocity regardless of swirl velocity. And integral length scale has proportional relation with swirl velocity regardless of measurement position. Turbulent burning speed during flame propagation which was determined by flame photograph and gas pressure of combustion chamber was increased with the lapse of time from spark and was decreased a little at later combustion period. Because of combustion promotion effect, turbulent burning speed was increased according to increase of turbulence intensity. Burning speed ratio i.e. ratio of turbulent burning speed ($S_BT$) to laminar burning speed ($S_BL$) was found out by use of turbulence intensity u' and integral length scale $l_x$ , $\delta_L$ is width of preheat zone in laminar flame.

생체 인식 시스템을 위한 심전도 개인인식 알고리즘 개발

이상준,김진권,이영범,이명호,Lee, Sang-Joon,Kim, Jin-Kwon,Lee, Young-Bum,Lee, Myoung-Ho 대한의용생체공학회 2010 의공학회지 Vol.31 No.5

This paper is about the personal identification algorithm using an ECG that has been studied by a few researchers recently. Previously published algorithm can be classified as two methods. One is the method that analyzes ECG features and the other is the morphological analysis of ECG. The main characteristic of proposed algorithm uses together two methods. The algorithm consists of training and testing procedures. In training procedure, the features of all recognition objects' ECG were extracted and the PCA was performed for morphological analysis of ECG. In testing procedure, 6 candidate ECG's were chosen by morphological analysis and then the analysis of features among candidate ECG's was performed for final recognition. We choose 18 ECG files from MIT-BIH Normal Sinus Rhythm Database for estimating algorithm performance. The algorithm extracts 100 heartbeats from each ECG file, and use 40 heartbeats for training and 60 heartbeats for testing. The proposed algorithm shows clearly superior performance in all ECG data, amounting to 90.96% heartbeat recognition rate and 100% ECG recognition rate.

Jet flow characteristics of sinusoidal wavy nozzles

이상준,Hak-Lim Kim,Jin-Pyung Lee,Sundara Rajagopalan 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.12

The flow characteristics of jets issued from a sinusoidal nozzle with in-phase and 180° out-of-phase exit configurations were investigated using PIV (particle image velocimetry) and flow visualization techniques. The experiments were carried out at a Reynolds number of about 6300 based on the mean width of the jet nozzle. Compared to a normal rectangular jet, the sinusoidal nozzle jets have smaller velocity deficits as the flow goes downstream. In addition, the turbulence intensity is suppressed in the horizontal center plane. For the case of in-phase wavy nozzle jet, the length of the potential core exhibits small variations along the lateral direction, while the 180° outof-phase wavy nozzle jet shows large lateral variation in the length of potential core. The turbulent kinetic energy of the 180° out-ofphase nozzle jet also shows sinusoidal variation in the horizontal planes. Large-scale vortices shed from the sinusoidal edge of the nozzle interact strongly and migrate toward the center plane as the flow develops downstream.

이중 금속선 곡선형 도파로에서의 전파특성에 관한 연구

이상준,김상인,송석호,Lee, Sang-Jun,Kim, Sang-In,Song, Seok-Ho 한국광학회 2007 한국광학회지 Vol.18 No.3

본 논문에서는 이중 금속선으로 이루어진 다양한 곡선형 도파로를 고려하고 이 구조들에서 전파하는 모드의 특성을 수치해석적으로 분석하였다. 이중 금속선들 간의 간격과 내부 유전체의 굴절률 변화에 따라 곡선형 도파로의 최적 반경과 최소손실의 경향을 조사하였으며, 그 결과 이중 금속선 구조가 단일 금속선 구조보다 전파특성이 좋은 최적 구조가 존재함을 확인하였다. In this paper, we analyze the characteristics of various curved waveguides composed of double metal strips using finite difference method (FDM). Our investigation reveals that the bending loss of the double metal strip waveguide can be improved with less degradation of the straight waveguide's propagation loss compared to the single metal strip structure. Optimization of the double metal strip waveguide structure has been conducted considering bending and propagation losses.

자기 부상 안내 기구의 불연속 특성 보상 방법

이상준,정광석,Lee, Sang Joon,Jung, Kwang Suk 한국교통대학교 융복합기술연구소 2013 융ㆍ복합기술연구소 논문집 Vol.3 No.2

These days, the quality of goods is required to improve in the process of manufacturing the semiconductor through the short working hours and clean transportation. The non-contact transport device using magnetic levitation can be a solution in the manufacturing process. The non-contact transport device, using electromagnetic actuation, is the system that can actually transport them by only using attraction force from the electromagnetic source without authentic contact. Moreover, the system using electromagnetic force has a substantial number of benefits ranging from unrestricted design to unlimited expansion. Especially, the price is competitive. The non-contact transport device, using electromagnetic force, has another merits in controlling by giving the same amount of attraction force to ferromagnetic body. By controlling the currents given to coil, the operator is able to decide the direction of the transportation. In order to design the optimal system, we implemented five different things such as the presence of the links below the electromagnetic, the electromagnet changes due to coupling method, the change according to the thickness of the links below electromagnet, due to changes in between electromagnetic distance direction, and the size of the current. Through simulations and the optimum design, it seems to control easily and figure out the exact size of power. It might definitely be the non-contact transport that can sharply reduce tiny scratches and particles in the process of manufacturing the semiconductor.

전시 컨벤션 산업의 유비쿼터스 기술 응용

이상준,나종회,Lee, Sang-Joon,Ra, Jong-Hei 한국디지털정책학회 2008 디지털융복합연구 Vol.6 No.4

The exhibition and convention industry offers facilities and services required to host expositions and conferences. Currently, it has been greatly esteemed as a promising industry because it can produce a higher added value and maintain a pure environment at the same time as an aggregate of service industries. Like other industries, the need of digitalization and information system in the exhibition and convention industry makes it introduce ERP and MIS and nowadays ubiquitous related model projects are ongoing. In this paper, we conduct researches regarding the systematic introduction of ubiquitous related technologies through the service and information system identification of exhibition and convention industry, and analysis of value chain and critical success factor. We consider RFID, ZigBee and mobile related technologies as the ubiquitous related technology types and select the exhibition witness and the maintenance of facilities as the area of related technologies introduction. In addition, we propose a scheme used to analyze and solve the problems which could be occurred when ubiquitous related technologies are applied. The results of this paper could be used as a policy to nourish exhibition and convention industry, and a guideline of the host organizations.

제언 - 노동부 공직의사들의 건투를 빌며

이상준,Lee, Sang-Jun 대한산업보건협회 2010 산업보건 Vol.262 No.-