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악성 신경교종에서 기관형적 배양후 형성된 미세종양 구상체의 초미세구조적연구
신형진,정천기,박인성,정영섭,정희원,한대희 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.3
The present study investigated not only the feasibility of organotypic spheroid culture system taken from human malignant gliomas but also the similarities and differences between surgical specimens and cultured spheroids using light microscopy electron microscopy, and flow cytometric examination. Surgically resected tumor specimens from eighteen human malignant gliomas were minced and explanted into agarose-coated culture wells. After three to five days these microtumor fragments emerged as spheroids and could be maintained as organotypic spheroids for more than eight weeks. Measurements of the spheroids showed that they decreased during the initial two to three weeks and afterwards remained unaltered over a specific period of time. This growth pattern of the spheroids was consistent with the condition of tumors in vivo suggesting the linkage of cell proliferation and loss. Light microscopic and electron microscopic studies of the spheroids demonstrated that morphological structures were similar to those of the original tumor tissue in vivo and histopathologic characteristics of the original tumor were maintained over a long culture period. The spheroids contained connective tissues, blood vessels, macrophages and neutrophils maintaining a three-dimensional architectural resemblance to the original tumors. Of three pairs of the surgical and spheroid specimen examined by the flow cytometry, one showed a change of ploidy pattern and two contained increased fictions of proliferating cells. It is concluded that this microtumor spheroid system can maintain the characteristics of the original tumors and may serve as an alternative to the in vivo xenograft model for the research of brain tumor biology, invasion and immunology while providing a valuable technique for the evaluation of new therapies such as biological response modifiers.
소아환자에서 후두와 종양 수술후 생긴 무언증 : 증례보고 Case Report
신형진,박용규,한종우,하충건 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.5
The authors experienced a case of mutism developed after the posterior fossa tumor surgery in a child. Mutism is a symptom mainly develped by supratentorial lesion in organic form. The possible pathogenesis of mutism after posterior fossa tumor surgery is discussed with a review of 18 additional previously reported cases.
6개월된 유아에서 다발성낭종을 동반한 뇌수막종 : 증례보고 Case Report
신형진,김동규,김형진,김재형,하충건,김선영 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.5
Meningioma, although quite common in adults, are extremely rare in infant. Only 25cases of meningioma in patients younger than 1 year old have been reported in the world literature. The authors report a case of meningioma associated with multiple cysts in a 6-month-old infant.
신형진,김동규,전시영 대한신경외과학회 1989 Journal of Korean neurosurgical society Vol.18 No.7-12
Recently, transsphenoidal approach is regarded as the principal method for the resection of pituitary tumor. The sublabial transseptal transsphenoidal hypophysectomy is a classical one, but it has certain limitations and postoperative problems. So various modifications of transsphenoidal hypophysectomy have been proposed. The columellar flap is one of such modified approaches.
신형진,이재영,이재남,구재혁,차상선,박찬기 경상국립대학교 농업생명과학연구원 2023 농업생명과학연구 Vol.57 No.4
This study identified the spatiotemporal water shortage quantity of representative field crops by region to construct data to respondto drought preemptively. Five representative field crops, such as chili peppers and five regions of Chungcheong-province were selected. The water shortage amount was calculated considering the required water amount for each crop and the supplied water amount by region. Using the HOMWRS (Hydrological Operation Model for Water Resource System) model of the Korea Rural Community Corporation,the water supply by region was evaluated by investigating the required water amount of crops, the yield of public and private wells,and the water supply amount. The drought level and timing were analyzed based on the water shortage amount according to the differencebetween the average monthly required water amount and the supply amount for five years from 2014 to 2018. As a result of calculatingthe difference between the required water amount and the supplied one in the order of public wells, private wells, and water supply,the June of Yesan-gun (apples) was the highest, and the August of Goesan-gun (soybeans) was the second. In other regions, stablesupply was generally possible considering wells and water supply. However, the supplied water amount needed to be increased in Julyand August 2018 in the Cheongyang-gun (chili peppers). The spatiotemporal drought level analysis results are expected to be used asbasic data for determining spatial priorities and securing supply by period. 본 연구에서는 밭가뭄을 선제적으로 대응하기 위한 자료를 구축하고자 충청도 지역 대표 밭작물의 시공간적 부족수량을 파악하였다. 고추 등5개 대표 밭작물과 충청도의 5개 지역을 선정하였고, 작물별 필요수량과 지역별 공급량을 고려하여 부족수량을 산정하였다. 한국농어촌공사의HOMWRS (Hydrological Operation Model for Water Resource System) 모형을 이용한 작물의 필요수량과 공공관정과 민간관정의 채수량,상수도 공급량을 조사하여 지역별 용수공급량을 평가하였다. 2014년부터 2018년까지 5년간의 월별 평균 필요수량과 공급량의 차이에 따른 부족수량을 기준으로 가뭄수준과 시기를 분석하였다. 공공관정, 민간관정, 상수도 공급량 순으로 필요수량과 차이를 산정한 결과 예산(사과)의 6월 부족수량이가장 높았고, 괴산(콩)의 8월이 두번째로 나타났다. 그 외 지역에서는 관정과 상수도 공급량을 모두 고려할 경우 대체적으로 안정적인 공급이가능하였으나, 청양(고추)에서 2018년 7월과 8월에 공급량이 부족한 것으로 나타났다. 시공간적 가뭄수준 분석 결과는 공간적 우선순위 결정과시기별 공급량 확보를 위한 기초자료로 활용될 것으로 판단된다.
신형진,박관,이승훈,김현집,심보성,최길수 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.2
Cerebral cysticercosis presents a quite variable clinical picture in its manifestation and course. This clinical polymorphism produces principal difficulties in its diagnosis and in planning therapeutic strategies as well as in evaluating therapeutic results. The author reviewed his experience with 52 cases of cerebral cysticercosis, surgically treated from 1977 to 1987 in Department of Neurosurgery, Seoul National University Hospital. The age of patients at time of diagnosis varied between 9 and 66 years(mean 43.4 years), with 75% from the fourth to the seventh decade. There was a 1.6:1 male to female ratio. The two most common residency of the patients, nest to the Seoul area, were Cheju Provience(21%)and Chollanam Province(15%). The chief symptoms and signs were those of increased ICP(94%), focal neurological deficits(69%), seizure(40%), mental change(33%) and meningismus(21%). We classified 52 cases into the following groups based on the location of lesion in the brain CT scans : a) Parenchymatous(34%), b) Intraventricular(25%), c) Meningocisternal(18%), and d) Mixed type(33%). ELISA was highly reliable in making the diagnosis, this test, however, should not be regarded as a quantitative clue to evaluate the degree of curability. In cases no improvenent was achived clinically after praziquantel therapy and/or surgical treatment despite disappeared cysts in follow-up brain CT, a further diagnostic work-up to search for a intraventricular or mixed type is recommended. In 2 cases with a single, superficially located parenchymatous cyst, one burr hole trephination followed by aspiration using a brain needle was proved to be very effective. Surgical treatment in combination with a praziquantel therapy produced a marked improvement in 47 cases(90.4%) out of 52 cases. In the mixed type, the surgical outcome was unfavorable compared with other types.
척추강 협착증 및 척추전방전위증의 Transpedicular Screw를 이용한 수술적 치료 및 추적결과
신형진,김동규 대한신경외과학회 1991 Journal of Korean neurosurgical society Vol.20 No.7
Transpedicular screw instrumentation allows good fixation to the unstable spine after wide laminectomy procedure. The authors experienced 30 cases of transpedicular screw instrumentation in lumbar spine surgery, which had been operated from November, 1989 and had follow up at least for 6 months. We evaluated and reviewed the advantages and problems of transpedicular screw instrumentation through our experiences and literatures.