부록 : 제 1 회 ( 1984 학년도 ) 졸업생 졸업 논문 요약 / 관형사끼리의 제약에 관한 연구 - 관형사와 체언과의 공존 관계 및 관형사 형태끼리의 배열 순서를 중심으로 -

박은향 새얼어문학회 1985 새얼語文論集 Vol.1 No.-

Detection of Targetable Genetic Alterations in Korean Lung Cancer Patients: A Comparison Study of Single-Gene Assays and Targeted Next-Generation Sequencing

박은향,심효섭 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2

Purpose Epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and ROS proto-oncogene 1 (ROS1) are ‘must-test’ biomarkers in the molecular diagnostics of advanced- stage lung cancer patients. Although single-gene assays are currently considered the gold standard for these genes, next-generation sequencing (NGS) tests are being introduced to clinical practices. We compared the results of current diagnostics and aimed to suggest timely effective guidance for their clinical use. Materials and Methods Patients with lung cancer who received both conventional single-gene assays and subsequent targeted NGS testing were enrolled, and the results of their tests were compared. Results A total of 241 patients were enrolled, and the EGFR real-time polymerase chain reaction, ALK fluorescence in situ hybridization (FISH), and ROS1 FISH assays exhibited 92.9%, 99.6%, and 99.5% concordance with the NGS tests, respectively. The discordant cases were mostly false-negatives of the single-gene assays, probably due to technical limitation. Of 158 cases previously designated as wild-type, EGFR, ALK, and ROS1 alterations were identified in 10.1%, 1.9%, and 1.3%, respectively, and other targetable alterations were identified in 36.1% of the cases. Of patients with additionally identified actionable alterations, 32.6% (31/95) received matched therapy with a clinical benefit of 48.4% (15/31). Conclusion Even though the conventional and NGS methods were concordant in the majority of cases, NGS testing still revealed a considerable number of additional EGFR, ALK, and ROS1 alterations, as well as other targetable alterations, in Korean advanced-stage lung cancer patients. Given the high frequency of EGFR and other targetable mutations identified in the present study, NGS testing is highly recommended in the diagnosis of Korean lung cancer patients.

박하분말 첨가량을 달리한 초콜릿의 품질 특성

박은향,진소연 한국식품영양학회 2021 한국식품영양학회 학술대회논문집(학술심포지움) Vol.2021 No.05

Membranous Insulin-like Growth Factor-1 Receptor (IGF1R) Expression Is Predictive of Poor Prognosis in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Lung Adenocarcinoma

박은향,정진행,박수영,김효진,Pingli Sun,Yan Jin,조석기,김관민,이춘택 대한병리학회 2015 Journal of Pathology and Translational Medicine Vol.49 No.5

Background: Insulin-like growth factor-1 receptor (IGF1R) is a membrane receptor-type tyrosine kinase that has attracted considerable attention as a potential therapeutic target, although its clinical significance in non-small cell lung cancer (NSCLC) is controversial. This study aimed to clarify the clinical significance of IGF1R expression in human NSCLC. Methods: IGF1R protein expression was evaluated using immunohistochemistry in 372 patients with NSCLC who underwent curative surgical resection (146 squamous cell carcinomas [SqCCs] and 226 adenocarcinomas [ADCs]). We then analyzed correlations between expression of IGF1R and clinicopathological and molecular features and prognostic significance. Results: Membranous and cytoplasmic IGF1R expression were significantly higher in SqCCs than in ADCs. In patients with SqCC, membranous IGF1R expression was associated with absence of vascular, lymphatic, and perineural invasion; lower stage; and better progression-free survival (PFS) (hazard ratio [HR], 0.586; p = .040). In patients with ADC, IGF1R expression did not have a significant prognostic value; however, in the subgroup of epidermal growth factor receptor (EGFR)-mutant ADC, membranous IGF1R expression was associated with lymphatic and perineural invasion, solid predominant histology, and higher cancer stage and was significantly associated with worse PFS (HR, 2.582; p = .009). Conclusions: Lung ADC and SqCC showed distinct IGF1R expression profiles that demonstrated prognostic significance. High membranous IGF1R expression was predictive of poor PFS in EGFR-mutant lung ADC, while it was predictive of better PFS in SqCC. These findings will help improve study design for subsequent investigations and select patients for future anti-IGF1R therapy.

Heterotopic Pancreas in Omphalomesenteric Duct Remnant Results in Persistent Umbilical Discharge

박은향,정진행,김효진,정규환 대한병리학회 2014 Journal of Pathology and Translational Medicine Vol.48 No.4

외식메뉴 선택속성에 따른 전통주 페어링 메뉴개발 방향 조사

박은향,정수민,정희선 한국외식산업학회 2023 한국외식산업학회지 Vol.19 No.5

This study aimed to investigate the attributes influencing the selection of dining-out menus and the preferences for menu pairing with traditional alcoholic beverages among 415 healthy adult males and females residing in the metropolitan area, aged 19 years and above. The survey results categorized the dining-out menu selection attributes into trendiness, functionality, sociability, and personal taste. Additionally, preferences for menu pairing were clustered based on personal taste and sociability, functionality, and trendiness. The menu recognition status revealed that taste, value for money, and hygiene were perceived as the most important factors. The research findings emphasized the necessity to develop traditional alcoholic beverage pairing menus while considering the characteristics of dining-out consumers. Furthermore, these results can serve as foundational data for the development and marketing of menus in traditional alcoholic beverage specialty establishments

고령자를 위한 신체활동으로서 발레

박은향(Eunhyang Park) 한국노년학연구회 2020 한국 노년학연구 Vol.29 No.1

본고에서는 신체활동으로서 무용이 고령자의 신체적, 인지적 및 사회적 기능에 미치는 영향을 살펴본 다음, 무용의 유형 중 발레의 특성 논의와 함께 고령자, 특히 고령의 환자들을 위한 발레프로그램의 필요성을 제시하였다. 먼저 노화로 인한 고령자의 특성 변화와 신체활동이 주는 효과에 대해 알아보았다. 규칙적인 신체활동은 신체기능을 개선시켜 낙상이나 만성질환의 위험을 낮추어주고, 인지기능의 저하를 예방해주고, 또 자존감을 고취시켜 긍정적인 정서 상태를 유지시켜준다. 규칙적인 신체 활동 중 무용은 일반 운동에 비해 신체적, 인지적, 사회적 기능에서 더 효과적인 활동이며, 역시 균형 및 자세 안정성 유지에 효과가 뛰어나다. 특히 발레는 다른 유형의 무용에 비해 표현성이 요구되어 언어적 소통이 뛰어난 활동으로 가장 치료적인 무용이다. 바(barre)를 이용하는 발레는 근력이 약한 고령자나 파킨슨병 환자에게도 유용한 활동이고, 복잡한 발레 기본 동작은 도전의식을 키워주는 등 정신건강에도 긍정적이며, 또 뇌 활성화를 통해 치매 예방에도 효과적이다. 이러한 발레는 해외에서 고령자를 위한 프로그램으로 개발되어 활용되고 있으나, 국내에서는 활용 수준이 미흡한 편이다. 본고의 후반부에서는 고령의 환자들에게 치료 효과를 얻기 위한 발레프로그램의 필요성을 논했다. Dancing is a beneficial physical activity to improve physical, cognitive and social functions, and all the benefits of dancing, especially ballet, for older adults including elderly patients were portrayed in this paper. Characteristics of old age and their relations with physical activities were briefly sketched at the introductory part of the paper. Regular physical activity improves the physical function and lowers the risk of falls or chronic diseases, prevents cognitive decline, and boosts self-esteem, resulting in increased positive emotions. Regular dancing is more effective in boosting physical, cognitive and social functions, especially maintaining balance and posture stability than regular exercise. Ballet, which requires more expression compared to other types of dance, would be the most therapeutic dance with verbal communication. Especially ballet barre exercising is considered to be a beneficial form of physical activity for the older adults who have weak muscles or Parkinson’s disease, and basic but complex movements of ballet are effective means of building a sense of challenge, improving mental health, and preventing dementia through brain activation. Ballet-based exercise has been extensively applied as a health promotion program for older adults in many countries, but not much in Korea. In the last part of this paper, it was discussed that effective therapy program based on ballet movement would be needed for the elderly patients.

Osteosarcomatous Differentiation in Rebiopsy Specimens of Pulmonary Adenocarcinoma with EGFR-TKI Resistance

안혜인,권현정,박은향,김효진,정진행 대한병리학회 2018 Journal of Pathology and Translational Medicine Vol.52 No.2

A Novel Homozygous LIPA Mutation in a Korean Child with Lysosomal Acid Lipase Deficiency

김광연,김주휘,이경재,박은향,강경훈,최영훈,김우선,고정민,문진수,고재성 대한소아소화기영양학회 2017 Pediatric gastroenterology, hepatology & nutrition Vol.20 No.4

Patients with lysosomal acid lipase (LAL) deficiency and glycogen storage disease (GSD) demonstrated hep-atomegaly and dyslipidemia. In our case, a 6-year-old boy presented with hepatosplenomegaly. At 3 years of age, GSD had been diagnosed by liver biopsy at another hospital. He showed elevated serum liver enzymes and dyslipidemia. Liver biopsy revealed diffuse microvesicular fatty changes in hepatocytes, septal fibrosis and foamy macrophages. Ultrastructural examination demonstrated numerous lysosomes that contained lipid material and in-tracytoplasmic cholesterol clefts. A dried blood spot test revealed markedly decreased activity of LAL. LIPA gene sequencing identified the presence of a novel homozygous mutation (p.Thr177Ile). The patient’s elevated liver en-zymes and dyslipidemia improved with enzyme replacement therapy. This is the first report of a Korean child with LAL deficiency, and our findings suggest that this condition should be considered in the differential diagnosis of chil-dren with hepatosplenomegaly and dyslipidemia.

Aquaporin 1 Is an Independent Marker of Poor Prognosis in Lung Adenocarcinoma

Sumi Yun,Ping-Li Sun,Yan Jin,김효진,박은향,박수영,이규호,이경열,정진행 대한병리학회 2016 Journal of Pathology and Translational Medicine Vol.50 No.4

Background: Aquaporin 1 (AQP1) overexpression has been shown to be associated with uncontrolled cell replication, invasion, migration, and tumor metastasis. We aimed to evaluate AQP1 expression in lung adenocarcinomas and to examine its association with clinicopathological features and prognostic significance. We also investigated the association between AQP1 overexpression and epithelial-mesenchymal transition (EMT) markers. Methods: We examined AQP1 expression in 505 cases of surgically resected lung adenocarcinomas acquired at the Seoul National University Bundang Hospital from 2003 to 2012. Expression of AQP1 and EMT-related markers, including Ecadherin and vimentin, were analyzed by immunohistochemistry and tissue microarray. Results: AQP1 overexpression was associated with several aggressive pathological parameters, including venous invasion, lymphatic invasion, and tumor recurrence. AQP1 overexpression tended to be associated with higher histological grade, advanced pathological stage, and anaplastic lymphoma kinase (ALK) translocation; however, these differences were not statistically significant. In addition, AQP1 overexpression positively correlated with loss of E-cadherin expression and acquired expression of vimentin. Lung adenocarcinoma patients with AQP1 overexpression showed shorter progression-free survival (PFS, 46.1 months vs. 56.2 months) compared to patients without AQP1 overexpression. Multivariate analysis confirmed that AQP1 overexpression was significantly associated with shorter PFS (hazard ratio, 1.429; 95% confidence interval, 1.033 to 1.977; p = .031). Conclusions: AQP1 overexpression was thereby concluded to be an independent factor of poor prognosis associated with shorter PFS in lung adenocarcinoma. These results suggested that AQP1 overexpression might be considered as a prognostic biomarker of lung adenocarcinoma.