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- 저자 : 정희상(Hoe Sang Jung) (검색결과 1 건)
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백서 심장 및 현장독성에 대한 Doxorubicin 과 Epirubicin 의 영향
박유환(You Hwan Park),정희상(Hoe Sang Jung),김완중(Wan Jung Kim),권희식(Hee Sik Kwon),김용태(Young Tae Kim),문철웅(Chul Oong Moon),박찬국(Chan Kook Park),이승일(Seung Il Lee),홍순표(Soon Pyo Hong) 대한내과학회 1991 대한내과학회지 Vol.41 No.3
N/A Doxorubicin is an antibiotic of the anthracycline group which has proven effective in treating a variety of malignant disorders. Its use in cancer chemotherapy has been limitd, however, because of the its cardiotoxic side effects. Attempts to reduce the cardiotoxicity of anthracycline antibotics include the synthesis of structural analogs, e.g., epirubicin, the coupling of active drugs to carriers, and the discovery of new types of anthracyclines. In this experiment, the toxicity of epirubicin was examined in various organs of rats for levels of malondialdehyde and activity of free radical scavengers (superoxide dismutase and catalase) and compared with the toxicity of doxorubicin. The following results were obtained: 1) Doxorubicin increased the quantity of malondiadehyde by 519% (p<0.01) in the heart, 45% (p<0.01) in the kideny, 35%(p<0.05) in the lung, and 41% (p<0.05) in the liver. Epirubicin increased the quantity of malondiadehyde by 10%(p<0.05) in the heart and 26%(p<0.01) in the kidney, but there was little change in the lung and liver. 2) Doxorubicin and Epirubicin decreased the activities of catalase in the heart by 11% and 17% but increased the it in the kidney by 27% and 19%, respectively (p<0.05). 3) Doxorubicin and Epirubicin increased the activities of SOD in the heart by 24% (p<0.01) and 199%(p<0.05) and in the kidney by 23%(p<0.01) and 34% (p<0.05) respectively. In conclusion, Epirubicin shows less toxicity in the heart than the kidney and has less cardiorenal toxicity in rats compared to Doxorubicin for same doses.
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