Naphthalate계 poly(ether ester)공중합체에서 소프트 세그먼트의 친수성이 투습도에 미치는 영향

박우리,성여삼,윤기종 한국고분자학회 2007 한국고분자학회 학술대회 연구논문 초록집 Vol.2007 No.4

내분비-대사 : 국소적 질환에서 다기관 질환으로 진행한 랑게르한스 세포 조직구증 1예 (초)

박우리,전현정,오태근 대한내과학회 2010 대한내과학회 추계학술대회 Vol.2010 No.-

부정 정서조급성이 섭식통제 상실에 미치는 영향: 정서인식 명확성의 조절효과

박우리,권석만 한국임상심리학회 2017 Korean Journal of Clinical Psychology Vol.36 No.1

The purpose of the present study is to investigate the role of emotional clarity on the relationship between negative urgency and the loss of control eating. In study I, the Eating Loss of Control Scale (ELOCS) was first translated into Korean, and then 116 undergraduate students answered it. To assess the factor structure, exploratory factor analysis was conducted. Thereafter, a confirmatory factor analysis was performed on another set of data from 128 undergraduate students. As a result, the original factor structure was tested by CFA, obtaining a poor fit. An additional model was tested, after deleting the items with bad adjustments, obtaining the best fit. The ELOCS demonstrated a good convergent validity and was significantly correlated with eating pathology, emotion dysregulation, poor self-control, and depression. In study II, the role of emotional clarity was investigated to the hypothesis that emotional clarity has a moderating effect on the relationship between negative urgency and loss of control eating. There were 227 undergraduate students who completed self-report measures. The results of hierarchical analysis showed that after controlling for sex, negative urgency predicted the loss of control eating. When emotional clarity was low, a higher level of negative urgency was associated with a greater loss of control eating. Conversely, when emotional clarity was high, the effect of negative urgency on the loss of control eating was not significant. Such results suggest that the ability to understand and explain themselves as well as the emotions of others can potentially buffer the aggravation of impulsive traits.

Prospective Observation of 5-Year Clinical Course of Subclinical Hypothyroidism in Korean Population

박우리,오태근,전현정 대한의학회 2013 Journal of Korean medical science Vol.28 No.11

Subclinical hypothyroidism (SCH) is a common clinical condition, whereas it’s natural course has not been identified distinctly. We evaluated the natural history of 169 SCH patients over 5-yr and the prognostic factors including thyroid autoantibodies and thyroid ultrasonographic (USG) findings related to develop overt hypothyroidism. After 5 yr, 47.3% of patients showed normalization of TSH, while 36.7% of patients remained persistence of high level of TSH, and overt hypothyroidism developed in 11.2% of patients. There were painless thyroiditis (2.9%) and hyperthyroidism (1.7%) during 5 yr follow-up. The thyroid nodule was seen in 48.6% of patients. Most of patients had 1 to 2 nodules whereas only 3% of patients with thyroid nodule had more than 6 nodules. Overt hypothyroidism patients had more heterogenous echogenecity in USG compared to patients with normalization or persistent SCH (76.5% vs 50.0% vs 35.0%, P=0.048) and higher prevalence positive anti-thyroid peroxidase (anti-TPO Ab) and anti-thyroglobulin antibody (anti-Tg Ab) and titer of anti-TPO Ab than other two groups. The cut off values for prediction of overt hypothyroidism were TSH>7.45 μIU/mL, free T4<1.09 ng/dL and Anti-TPO Ab>560 IU/mL. SCH has various courses and initial TSH, free T4, presence of thyroid autoantibody, titer of thyroid autoantibody; and thyroid USG findings can serve as a prognostic factor for progression of overt hypothyroidism. These parameters suggest consideration to initiate thyroid hormone treatment in SCH.

Amisulpride에 의해 지연성 안검경련이 발생한 조현병 1예

박우리,공성회,유제춘,이창화,최경숙 대한정신약물학회 2012 대한정신약물학회지 Vol.23 No.3

Tardive blepharospam is characterized by repetitive, forceful, and sustained involuntary contractions of the orbicularis oculi. We report here one case of neuroleptic-induced tardive blepharospasm that developed during high-dose amisulpride treatment and was treated with clozapine. The patient was a 29-year-old man with a 6-year history of schizophrenia. After 33 months of amisulpride treatment (1200 mg/day), involuntary eye-blinking had developed. Following exclusion of all other possible etiopathological causes of the blepharospasm, we decided to switch the drug treatment from amisulpride to clozapine. On the fourteenth day of clozapine (250 mg/day) treatment, we observed significant improvements in eye-blinking and psychotic symptoms. Four months later, the eye-blinking had remitted completely. We suggest that amisulpride may cause blepharospasm and lead to an impaired ability to perform daily activities. Therefore, we recommend that clinicians regularly monitor involuntary movements in patients receiving antipsychotic treatment, especially when high doses of amisulpride are involved. 저자들은 amisulpride를 복용 중인 만성 조현병 환자에서 지연성 안검경련이 발생한 예를 보고하고자 한다. 정신과적 약물과 관련한 지연성 안검경련과 관련해서는 다양한 연구들이 보고되고 있으며 아직까지 정확한 기전에 대해서는 밝혀지지 않은 상태다. 본 증례에서 확인할 수 있듯이 amisul-pride는 비교적 적은 지연성 운동장애를 일으킨다고 알려져 있지만 장기적으로 고용량을 사용할 때에는 지연성 안검경련이 발생할 수 있고 이는 일상기능의 장해와 순응도의 문제를 야기할 수 있기 때문에 치료자는 이러한 부작용의 가능성에 대해서 항상 주의하여야 한다.

Poly(butylene 2,6-naphthalenedicarboxylate)/Poly(propylene glycol) 공중합체의 합성과 투습도 평가

박우리,윤기종,Park, Woo-Lee,Yoon, Kee-Jong 한국섬유공학회 2008 한국섬유공학회지 Vol.45 No.3

Segmented block poly(ether-ester) containing poly(propylene glycol), PPG, soft segments and Poly(butylene 2,6-naphthalenedicarboxylate), PBN, hard segments were prepared by transesterification and polycondensation. Synthesis of the PBN/PPG copolymer were confirmed by $^1H$-NMR. Thermal behavior was measured by DSC and TGA. Permeability measurements of PBN/PPG copolymer films were made using an upright cup method. Although $T_m\;and\;T_c$ of PBN/PPG copolymer decreased slightly with increase in PPG composition in the PBN/PPG copolymer, their melting points are in excess of $200^{\circ}C$ which is required for firefighter's protective clothing. The moisture vapor transmission rate(MVTR) increased with addition in the amount of PPG and rising of temperature significantly. But the reduction in density due to the introduction of PPG instead of poly(ethylene glycol), PEG, as the soft segment did not influence MVTR, and the MVTR values were lower compared with commercial breathable films.

Nitric oxide에 의해 유도된 무(Raphanus sativus L.) 자엽에서의 부정근 형성과 acid phosphatase 및 amylase의 활성도 변화

박우리,한기표,진창덕 강원대학교 기초과학연구소 2012 기초과학연구 Vol.23 No.-

In this study, we examined the effect of a nitric oxide (NO) donor, sodium nitroprusside (SNP), on the inducement of adventitious root formation in cotyledon explants prepared from 4-d-old radish seedlings. The treatment of the cotyledon explants with 50 μM SNP caused an increase in adventitious root induction and growth, as compared with the non-treated control. This enhancive effect of SNP in adventitious root formation was due to NO in that the SNP effect was prevented when the NO-scavenger, methylene blue (MB), had added with SNP. In addition, SNP treatment caused an enhancement of ac acid phosphatase and amylase activities in parallel with the inducement of rooting in radish cotyledon explants. Furthermore, experiments using a cycloheximide has showed that the activities of acid phosphatase and amylase could be regulated by the SNP in the translational level of their enzyme protein synthesis.

Sentinel Lymph Node Biopsy Versus Elective Neck Dissection: Long-Term Oncologic Outcomes in Clinically Node-Negative Tongue Cancer

박우리,진호경,허유진,정한신,손영익,정만기,백정환 대한이비인후과학회 2022 Clinical and Experimental Otorhinolaryngology Vol.15 No.1

Objectives. The aim of this study was to compare the long-term oncologic outcomes of sentinel lymph node biopsy (SLNB) versus elective neck dissection (END) in clinically node-negative (cN0) tongue cancer. Methods. This was a retrospective cohort study of patients with cN0 tongue cancer from a single institution, including 91 patients in the SLNB group and 120 patients in the END group. Results. The overall recurrence rate showed no significant difference between the two groups. The regional control rate was also comparable between the two groups (P=0.490). The 5-year recurrence-free survival (RFS) was slightly better in the SLNB group than in the END group (P=0.427). The 5-year overall survival (OS) rate was 89.9% in the SLNB group versus 91.9% in the END group (P=0.737). In a propensity-matched subgroup analysis, the type of neck management did not affect RFS or OS. Conclusion. SLNB showed non-inferior oncologic outcomes compared to END in patients with cN0 tongue squamous cell carcinoma.

우울증 환자에서 D형 인격과 신체 증상 호소와의 관련성

박우리,정성훈,Park, Wu-Ri,Jeong, Seong-Hoon 한국정신신체의학회 2013 정신신체의학 Vol.21 No.1

연구목적 D형 인격(Type D personality)은 본래 심장 질환의 예후와 관련되는 성격 인자에 관한 연구에서 처음 제안되었고 이후 연구들에서는 다양한 내과적 질환들에서 D형 인격이 관련된다는 것을 보고하였다. 본 연구에서는 우울증 환자의 신체화 증상과 D형 인격의 관련성을 알아보고자 하였다. 방 법 우울 장애로 진단 받은 82명의 환자를 대상으로 D형 인격척도인 DS-14(Type D personality scale 14)를 사용하여 D형 인격 여부를 조사하였다. PHQ-9, PHQ-15(환자 건강 설문지, Patient health questionnaire-9,15)를 사용하여 우울증의 심각도와 신체화 경향에 대하여 평가하였고, TAS-20(한국판 토론토 감정표현불능증 척도, The Korean version of 20-item Toronto alexithymia scale)으로 감정표현불능증의 정도를 측정하였다. Student t-test와 선형 회귀분석을 시행하였고, 단계적(stepwise) 변수 추출을 통해 가장 설명력이 높은 모형을 선정하여 신체 증상에 영향을 미치는 요인을 확인하였다. 결 과 전체 대상자의 절반 이상(56%)이 PHQ-15에서 중증의 신체 증상을 호소하였고, 63.4%가 D형 인격으로 판정되었다. D형 인격군은 대조군에 비하여 PHQ-15 점수가 유의하게 높았다(PHQ-15 mean=12.7, $p=8.2{\times}10^{-7}$). 회귀 분석에서 최종적으로 선정된 모형은 연령, PHQ-9, 그리고 DS-14의 하위영역인 NA가 포함된 모형이었으며, 이들 중 연령($p=1.5{\times}10^{-3}$)과 NA($p=1.5{\times}10^{-7}$)가 신체 증상에 가장 큰 영향을 주는 변인으로 분석되었다. 결 론 본 연구 결과는 D형 인격이 우울증 환자의 신체 증상 호소의 강력한 예측 인자임을 시사한다. 특히 사회적 억제 성향보다 부정적 정서 성향이 신체화 경향과 더 관련성이 깊었다는 결과는 기존의 신체화에 대한 이해, 즉 부정적 정서를 표현해내는 능력이 결여된 경우 이를 신체 증상으로 표출한다는 설명과는 다소 차이가 있는 것으로 보인다. 감정표현불능증이 유의한 예측인자가 아닌 것으로 나타났다는 결과 또한 이러한 차이와 관련된다. 그러나 사회적 억제 성향과 부정적 정서 성향(r=0.65), 감정표현불능증(r=0.44) 간에는 높은 상관 관계를 보였기 때문에 이를 고려한 대규모 연구가 필요할 것으로 생각된다. Objectives : Type D personality was originally introduced to study the role of personality in predicting outcomes of heart disease. However, researches showed that other medical conditions are also affected by this personality. The purpose of this study was to evaluate the relationship between type D personality and somatic symptom complaints in depressive patients. Methods : Eighty-two individuals diagnosed with depressive disorder were included. Type D personality was measured with DS14. Patient Health Questionnaire(PHQ) 9 and 15 were used to measure depression severity and somatization tendencies. For alexithymia, TAS-20 was used. Student T-test and linear regression analysis were performed. The best regression model was determined by stepwise variable selection. Results : More than half of the subjects(56%) complained at least medium degree somatic symptoms according to PHQ-15 criteria. Two-thirds of the subjects were classified as Type D personality(63.4%). The mean PHQ-15 score of the Type D individuals was significantly higher than the remaining subjects(PHQ-15 mean=12.7, $p=8.2{\times}10^{-7}$). The best regression model included age, PHQ-9 score and NA subscale score as predictor variables. Among these, only the coefficients of age($p=1.5{\times}10^{-3}$) and NA score($p=1.5{\times}10^{-7}$) were found to be statistically significant. Conclusions : The result showed that Type D personality was one of the strong predictors of somatic complaints among depressive individuals. The finding that negative affectivity rather than social inhibition was more closely associated with somatization tendencies does not fully agree with the traditional explanation that inability to express negative emotion predispose the individuals to somatic symptoms. The finding that alexithymia was not shown to be a significant predictors also substantiated this discrepancy. However, it might be possible that the high correlation between NA and SI subscore(r=0.65) and between NA and TAS-20 score(r=0.44) hid the additional effects of social inhibition and alexithymia. Further research with a larger sample would be needed to investigate the effects of the latter two components over and above the effect of negative affectivity on the somatic complaints in depressive patients.

Pulmonary lipiodol embolism after TACE in hepatocellular carcinoma patient (초)

박우리,김기배,김성진,채희복,최강현,이기만,안진영 대한내과학회 2010 대한내과학회 추계학술대회 Vol.2010 No.-