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루이보스차(Asphalthus linearis)의 추출방법에 따른 페놀릭류 함량 변화연구
박신희,도영숙,김윤성,김난영,이진희,김종화,윤미혜,Park, Sin-Hee,Do, Yung-Suk,Kim, Youn-Sung,Kim, Nan-Young,Lee, Jin-Hee,Kim, Jong-Hwa,Yoon, Mi Hye 한국식품위생안전성학회 2017 한국식품위생안전성학회지 Vol.32 No.5
루이보스티에서 5종의 phenolic acid (gallic acid, chlorogenic acid, caffeic acid, p-coumaric acid, trans-ferulic acid)와 9종의 flavonoid (procyanidin b1, aspalathin, rutin, vitexin, hyperoside, isoquercitrin, luteolin, quercetin, chrysoeriol)를 UPLC-MSMS를 이용하여 동시 분석하였다. 14종 페놀릭류를 동시 분석하기 위하여 기기조건과 유효성을 검증하였고 확립된 분석방법을 이용하여 시중에 유통중인 루이보스티 30건을 채취하여 페놀릭류를 분석하였다. 루이보스티 1 g 혹은 1티백에 뜨거운 물 100 mL을 가하여 3분, 6분, 30분이 경과 후 그리고 차가운 물 ($25-30^{\circ}C$)에 30분 우려낸 루이보스티의 페놀릭류 함량을 구하였다. 루이보스티에서 전체 실험대상 페놀릭류 중 rutin과 aspalathin이 가장 많이 추출되어 나왔으며 각각 물질의 함량은 제품별로 달랐다. 페놀릭류 성분의 추출효율은 14종 페놀릭류의 총합 기준으로 뜨거운 물 30분 > 6분 > 3분 > 차가운 물 30분 순으로 높았다. A simultaneous determination of 5 phenolic acids (gallic acid, chlorogenic acid, caffeic acid, pcoumaric acid, trans ferulic acid) and 9 flavonoids (procyanidin b1, aspalathin, rutin, vitexin, hyperoside, isoquercitrin, luteolin, quercetin, chrysoeriol) in rooibos tea has been carried out by ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS). A validated analysis method in this study was applied to rooibos aqueous infusions. Rooibos tea is an antioxidant-rich tea which has anti-cancer, anti-aging, anti-inflammatory, anti-diabetic effect. Extraction yield of phenolics depends on steeping time and temperature of water. Tea infusions were prepared by placing 1 g of tea leaves or 1 tea bag in 100 mL of boiled water, and then at 3, 6 and 30 minutes intervals the infused teas were taken to carry out the analysis of phenolic contents. Another tea infusion was conducted with cold water ($25-30^{\circ}C$) for 30 minuntes. As a result, the total amount of phenolics was highest in rooibos tea steeped with hot water for 30 minutes, followed by 6 minutes, 3 minutes and cold water 30minutes and the result has statistical significance.
박신희 ( Sin-hee Rark ),송서현 ( Seo-hyeon Song ),김현주 ( Hyun-joo Kim ),조윤식 ( Youn-sik Cho ),김애란 ( Ae-ran Kim ),김범호 ( Beom-ho Kim ),홍미연 ( Mi-yeun Hong ),박상현 ( Sang-hyun Park ),윤미혜 ( Mi-hye Yoon ) 대한화장품학회 2019 대한화장품학회지 Vol.45 No.3
프탈레이트는 내분비계 교란 물질로서 성호르몬과 구조가 유사하여 주로 생식독성과 발달독성을 나타낸다. 이번 연구에서는 우리나라 화장품규제 물질인 3종 프탈레이트 이외 어린이제품 안전공통기준, EU 화장품 기준(EC No. 1223/2009) 등에서 규제하고 있는 프탈레이트 종류를 추가하여 총 11종 프탈레이트에 관하여 분석을 실시하였다. GC-MS/MS를 이용하여 분석조건을 설정하였고 분석방법에 대한 유효성 검증 결과 특이성, 직선성, 회수율, 정밀성, 정량한계 등을 만족하였다. 유효성이 검증된 시험방법을 이용하여 네일 화장품 및 네일 관련 제품 82건을 대상으로 분석을 실시하였다. 네일 폴리시에서는 DBP, BBP, DEHP, DPP, DIBP, DIDP 등 6종의 프탈레이트가 1.0 ∼ 59.8 ㎍/g의 농도로 검출되었으나 우리나라 화장품기준에 적합하였다. 인조손톱에서는 DIBP, DBP 2종에서 1.1 ∼ 2.6 ㎍/g, 글루에서 DBP, DEHP 2종 1.4 ∼ 2.5 ㎍/g, 스티커 DIBP, DBP, DEHP 3종에서 2.5 ∼ 33.3 ㎍/g 의 결과가 나왔고 ‘어린이제품 공통안전기준’을 적용시 모두 적합하였다. DIBP는 우리나라에는 규제물질이 아니지만 DBP (86.6%), DEHP (63.4%)에 이어 14.6%의 검출률을 나타내었다. 현재 우리나라 기준으로는 네일제품이 프탈레이트에 대해 안전하다고 판단되지만 비규제물질에 대한 지속적인 감시와 연구도 필요할 것으로 사료된다. Phthalates, endocrine disrupting chemicals, are similar in structure to sex hormones and mainly show reproductive toxicity and developmental toxicity. In this study, we analyzed 11 phthalates, including 3 kinds of phthalates prohibited in cosmetic use and 8 kinds of phthalates regulated in ‘Common standards for children’s products safety’ and EU cosmetic regulation (EC No. 1223/2009). The phthalate analysis was optimized using GC-MS/MS. In analytical method validation, this method was satisfied in specificity, linearity, recovery rate, accuracy and MQL. Therefore, we used this method to analyze 82 products of Nail cosmetics & polish. Although six phthalates such as DBP, BBP, DEHP, DPP, DIBP and DIDP were detected at concentrations of 1.0 ∼ 59.8 ㎍/g, they were suitable to Korean cosmetic standards. DIBP and DBP were detected at concentration of 1.1 ∼ 2.6 ㎍/g in artificial nail, DBP and DEHP were 1.4 ∼ 2.5 ㎍/g in glue for nails, and DIBP, DBP, and DEHP were 2.5 ∼ 33.3 ㎍/g in nail stickers. Although substances such as DBP and DEHP in artificial nail, Glue for nails, and nail stickers were detected, they were suitable to ‘Common safety standards for children’s products. DIBP is not a regulated substance in Korea but showed the third highest detection rate following DBP (84.6%) and DEHP (63.4%). The concentration of phthalates detected in nail products is considered to be safe in current standards but continuous monitoring and research about non-regulated substances are also needed to be considered.
근적외선분광광도법을 이용한 식용유지의 산가, 요오드가, 지방산 정량법에 관한 연구
김재관(Jae-Kwan Kim),최옥경(Ok-Kyung Choi),황선일(Sun-Il Hwang),정진아(Jin-A Jeong),김윤성(Yun-Sung Kim),박신희(Sin-Hee Park),손미희(Mi-Hui Son),권혜정(Hye-Jung Kwon),이정복(Jung-Bock Lee),김종찬(Jong-Chan Kim) 대한환경위생공학회 2007 대한환경위생공학회지 Vol.22 No.4
The possibility of rapid quantitative analysis of AV(Acid Value), Ⅳ(Iodine Value) and fatty acids in vegetable oils with NIRS(Near-infrared spectroscopy) was evaluated. A calibration equation calculated by MPLS regression technique was developed and correlation coefficient of determination for AV, Ⅳ, C16:0, C16:0, C16:1, C16:2, C16:6, and C20:0 content were 0.9727, 0.997, 0.9805, 0.942, 0.9987, 0.9994, 0.9966, and 0.975 respectively. According to the data obtained from validation study, R² of contents of perilla, corn, soybean, rapaseed oils were 0.897, 0.993, 0.935, 0.707, 0.994, 0.996, 0.984, 0.798, SEP of contents of 0.185, 1.367, 0.899, 0.640, 1.498, 1.360, 0.476, 0.076 by MPLS. The results indicate that the NIRS procedure can potentially be used as a non-destructive analysis method for the rapid and simple measurement of AV, Ⅳ and fatty acids in vegetable oils.
최상용,한호용,박신희,김진승,신용원,송병주 대한외상학회 1997 大韓外傷學會誌 Vol.10 No.2
We have reviewed 73 acute traumatic death patients who visited from January 1994 to June 1996 to evaluate the quality of inhospital care. Deaths that occurred within 48 hours of admission were classified as acute stage. The age of the patients ranged from 15 to 97 years(mean age 48.1). Male was 56 and female was 17 in number with a ratio of 3.3:1. Motor vehicle trauma was the most common cause of injury leading to death(72.6%). Central nervous system injuries were the most common cause of death(53.4%). Overall motality was 8.1%. Injury Severity Score(lSS) ranged from 9 to 50(mean ISS 28.9). Not all the victims had severe anatomic injuries, however;19.2% had an ISS of 25 or less, suggesting that futher improvements in care could reduce motality. All body systems were equally represented. Most patients had more than two system involved(67.1%). Ten patients(13.6%) had pre-existing disease. Possibly preventable deaths occurred in 8 cases(11.0%): 3 case in surgical delay, 3 case in delayed diagnosis and 2 case in no surgery. These data reinforce the continuing need for physician trainning in proper management and careful, through diagnostic evaluation of critically injured patients.
이향주,신용원,한호용,박신희,전하영,장석,권학중,신경철 대한소화기학회 1998 대한소화기학회지 Vol.31 No.5
Biliary cystadenomas and cystadenocarcinomas are rare tumors of biliary origin and constitute less than 5% of the total intrahepatic cysts of bile duct origin. They occur most commonly in middle age females. Clinical manifestations are non-specific, so these tumors are incidentally found during autopsy or surgery. The ultrasonogram, abdominal CT scan, angiography and aspiration cytology are valuable diagnostic methods. The typical sonographic appearance of these tumors is a large intrahepatic globular or ovoid thick-walled cystic mass which often contains multiple septations or papillary infoldings. The characteristic CT appearance of these tumors is similar to that of a low-density intrahepatic mass which may cantain mural nodule or internal septation. However, regardless of the diagnostic modalities, pre-operative diagnosis as well as intra-operative one is difficult. Since biliary cystadenocarcinomas are believed to arise from benign cystadenornas, complete surgical resections, if possible, is a warranted method to avoid malignant change of these tumor. We report one of biliary cystadenocarcinoma canfirmed by the operation with review of the literatures.