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피부 건강 박람회 방문자를 대상으로 한 피부 건강에 대한 인식과 행태에 관한 조사 연구
신지연 ( Ji Yeoun Shin ),강훈 ( Hoon Kang ),김문범 ( Moon Bum Kim ),김유찬 ( You Chan Kim ),박미연 ( Mi Youn Park ),박천욱 ( Chun Wook Park ),손상욱 ( Sang Wook Son ),유박린 ( Bark Lynn Lew ),이동윤 ( Dong Youn Lee ),이동훈 ( Don 대한피부과학회 2018 대한피부과학회지 Vol.56 No.8
Background: Healthy skin is an important determinant of the quality of life and physical and mental well-being. The demand for dermatological information is increasing not only in patients with skin diseases, but also in the general population with normal/healthy skin. However, public perception and behavior with regard to skin health among Koreans are not known. Objective: To examine public perception and behaviors with regard to skin health in Koreans visiting the Skin Health Expo 2017. Methods: A total of 597 participants completed a questionnaire that assessed demographics, status, and behavior for skin health and Expo satisfaction. Results: Respondents with higher stress levels and a history of skin diseases showed lower satisfaction with self-skin health. Most participants considered adequate sleep and water intake to be important factors associated with healthy skin. One-on-one consultation with dermatologists was the most satisfactory among participants at the Expo. Conclusion: Educational tools using mass media and informative activities such as the Expo planned by dermatologists and the government are necessary to spread awareness and provide proper information to improve skin health in thegeneral population and to emphasize the key role of dermatologists in skin disorders with a social burden. (Korean J Dermatol 2018;56(8):475∼484)
소 도축 관련 종사자에서 브루셀라증의 혈청유병률 및 위험요인
유석주,최영실,임현술,이관,박미연,주재신,강영아,Yoo, Seok-Ju,Choi, Young-Sill,Lim, Hyun-Sul,Lee, Kwan,Park, Mi-Yeoun,Chu, Chae-Shin,Kang, Young-A 대한예방의학회 2009 예방의학회지 Vol.42 No.4
Objectives : The incidence of zoonoses in Korea has increased recently. However, the study of high risk groups for zoonoses has not been conducted to date in Korea. Thus, we did this study to obtain data on brucellosis among slaughterhouse workers in Korea. Methods : We evaluated the structure of slaughterhouses and the process of slaughtering by reviewing the relevant literature and doing field studies. We visited 73 slaughterhouses and 62 residual products handle houses across the country. In addition, we conducted a questionnaire survey of the work activities, and obtained blood samples in order to determine the seroprevalence and risk factors of brucellosis. The titers of brucellosis antibodies were measured using the standard tube agglutination test SAT). We diagnosed subjects as seropositive for Brucellosis if the titers were more than 1:160. The data collected was evaluated using SPSS ver. 17.0. Results : We included 1,503 subjects and obtained 1,482 blood samples among them: 849 workers involved in slaughtering, 351 handlers of residual products, 190 inspectors and their assistants, and 92 grading testers and their assistants. The seroprevalence of brucellosis among the slaughterhouse workers was 0.8% (95% CI=0.4-1.5). Broken down, the seroprevalence of brucellosis among the workers involved in slaughtering was 0.7% (95% CI=0.3-1.6), the handlers of residual products was 1.7% (95% CI=0.7-3.9) respectively. Risk factors for contracting brucellosis among slaughterhouse workers were being splashed with cattle blood around the mouth, cattle secretions around the body and not putting on protective apron while at work. Conclusions : An educational program is needed for high risk groups on zoonoses about the prevention of infection. Thus, effective working guidelines for workers who participate in the slaughter of animals must be developed in order to protect them from zoonoses.
허상택 ( Sang Taek Heo ),박미연 ( Mi Yeoun Park ),최영실 ( Young Sill Choi ),오원섭 ( Won Sup Oh ),고관수 ( Kwan Soo Ko ),백경란 ( Kyong Ran Peck ),송재훈 ( Jae Hoon Song ) 대한내과학회 2008 대한내과학회지 Vol.74 No.1
Q열은 국내에서도 드물지 않은 질환으로 생각되며, 조기에 진단하지 못하는 경우에 심내막염이나 혈관염 등의 만성 Q열로 진행하여 사망에 이를 수 있다. 물론 급성 Q열은 비특이적 증상에서 폐렴이나 간염 소견으로 내원하는 환자가 대부분이나 발열의 원인이 확실한 경우 원인균이 밝혀지지 않아도 Q열의 혈청학적 의뢰를 요하는 경우는 흔하지 않다. 하지만 발열을 주소로 내원한 환자들에 대하여 상기 증례들처럼 불명열의 경우 가축이나 이들의 부산물에 접촉력이 있는 경우 뿐만 아니라 특별한 접촉력이나 직업력이 없더라도 불명열로 내원한 환자들의 감별진단에서 Q열의 가능성을 고려하여 혈청학적 검사 및 핵형 분석을 시행해야 하겠다. 향후 국내에서도 사람뿐만 아니라 가축에서의 대규모의 역학적 조사가 추가적으로 필요할 것으로 생각된다. Q fever is an orthozoonotic infection caused by Coxiella burnetii, which was recently reclassified from the order Rickettsials to the order Legionellales. Although Q fever is usually mild and self-limiting, it may be manifested as a serious disease, such as pneumonia, endocarditis, or meningoencephalitis. We describe three separate cases of acute Q fever, which were diagnosed by an indirect micro-immunofluorescence assay (MIFA) test and DNA amplification (PCR). Three adult patients were admitted between December 2004 and August 2006 because of a fever of greater than three weeks duration. Only one patient had contact history with a dog. Of the three patients, two patients had myalgia, headache, skin rash, lymphadenopathy, and hepatosplenomegaly. Although all sets of blood cultures were negative, anti-phase II antibody titers by using an indirect MIFA (IgG 1:512-1,024 and IgM 1:320) were markedly increased in sera from all of three patients. Concomitant PCR assays also demonstrated the presence of OMP com1 for C. burnetii in blood from all of the three patients. Two patients had complete resolution of symptoms and signs with a two-week course of doxycycline, while one patient had spontaneous defervescence. Although the incidence of Q fever is not well known yet in Korea, it should be considered in the differential diagnosis of patients with fever of unknown origin. (Korean J Med 74:100-105, 2008)
경상북도 거주 고위험군에서 브루셀라 감염에 관한 혈청 역학적 연구
이관,박우원,김성환,이도영,박미연,허영주,임현술,Lee, Kwan,Park, Woo-Won,Kim, Sung-Hwan,Lee, Do-Young,Park, Mi-Yeoun,Hur, Young-Ju,Lim, Hyun-Sul 대한예방의학회 2007 예방의학회지 Vol.40 No.4
Objectives : Cases of human brucellosis in Korea have recently increased due to the increasing incidence of bovine brucellosis. The authors conducted this study to elucidate the status of brucellosis through seroepidemiologic study. Methods : We selected our study population from a high risk group. We conducted a questionnaire survey and obtained blood samples to determine the seroprevalence of brucellosis antibodies for 10 days in February, 2005. The titers of brucellosis were measured by the combination of standard tube agglutination test (STA) and enzyme-linked immunosorbent assay (ELISA) test. Results : Our study subjects comprised 1,075 cases: 971 livestock workers, 51 veterinarians, and 53 artificial inseminators. In the STA test, 27 cases (2.5%) had titers of greater than or equal to 1:20. Of 1,068 cases (7 cases were excluded due to previous brucellosis), 7 cases of brucellosis were diagnosed with titers of 1:160, giving a seroprevalence of brucellosis of 0.66%. The seroprevalence in the male group was 0.95%, and that of livestock workers, veterinarians, and artificial inseminators was 0.52%, 4.17%, and 0.00%, respectively. The Spearman's correlation coefficient between the positive rate of bovine brucellosis per capita and household and human brucellosis was 0.806 and 0.744, respectively. The concordance rate between the Korea National Institute of Health and the Gyeongsangbuk-do Institute of Health and Environment by the STA and ELISA tests was 94.7% and 100.0%, respectively. Conclusions : The study results indicated in higher seroprevalence rate among veterinarians than among livestock workers and artificial inseminators. Because veterinarians may be exposed to this high risk, effective working guidelines for veterinarians to guard against brucellosis must be developed. Moreover, more extensive epidemiologic research for laboratory workers and meat handlers is needed.
주외막단백 유전자 분석을 이용한 Brucella abortus의 동정
이유지 ( Yu Ji Lee ),고관수 ( Kwan Soo Ko ),박미연 ( Mi Yeoun Park ),오원섭 ( Won Sup Oh ),권기태 ( Ki Tae Kwon ),류성열 ( Seong Yeol Ryu ),허상택 ( Sang Taek Heo ),백경란 ( Kyong Ran Peck ),이남용 ( Nam Yong Lee ),송재훈 ( Jae Ho 대한내과학회 2006 대한내과학회지 Vol.71 No.1
목적: 브루셀라증은 다양한 임상경과와 비특이적인 증상 및 까다로운 배양 조건 등으로 인하여 진단이 쉽지 않다. 최근 국내에서 발생한 발열 환자의 혈액 배양검사로부터 균주를 분리한 후 유전자 염기서열분석으로 Brucella abortus를 확인하였기에 이를 소개하고자 하였다. 방법: 발열 환자의 혈액배양검사로부터 분리된 미상의 균주로부터 DNA를 추출한 후 16S rRNA에 대한 연쇄중합반응을 시행하였고, 증폭된 결과물을 BLAST search를 통하여 GenBank의 데이터베이스의 염기서열과 비교한 결과 Brucella종임을 확인하였다. 동일한 방법으로 omp2a와 omp2b 유전자에 대한 연쇄중합반응을 시행하여 이를 GenBank의 데이터베이스와 비교하였다. 결과: 16S rRNA 염기서열을 비교하여 세 균주 모두 99.9% 이상의 유사도로 Brucella에 속하는 종임을 확인하였고, omp2a와 omp2b 유전자 염기서열을 비교한 결과 99.91% 이상의 유사도로 세 균주 모두 Brucella abortus임을 확인하였다. 결론: 유전자 염기서열분석은 비교적 짧은 시간 내에 정확한 균종의 확인이 가능하다는 이점이 있어서 생물형 분석으로 동정되지 않는 드문 균주의 동정에 매우 유용한 방법으로 생각된다. Background: As the incidence of bovine brucellosis increases in Korea, the incidence of human brucellosis is also increasing since 2002. However, it is difficult to identify Brucella species by using the conventional methods. Methods: Three strains of gram-negative coccobacilli were isolated from blood specimens of three patients with prolonged fever, which were not identified by using the conventional methods. After extracting total DNA from these isolates, PCR amplification of 16S rRNA and omp2 genes was performed. These sequences secured by PCR assay were compared with known sequences by using GenBank BLAST. Results: DNA sequences were obtained from 3 isolates by using PCR amplification of 16S rRNA. These sequences had more than 99.9% similarities with Brucella species by using GenBank BLAST. In the second place, after comparing DNA sequences secured by PCR amplification of omp2a and omp2b by using GenBank BLAST, these isolates were confirmed as B. abortus. Conclusions: DNA sequence analysis is a rapid and accurate method for identification of uncommon microorganisms, such as Brucella species.(Korean J Med 71:10-16, 2006)
임현술(Hyun-Sul Lim),송영구(Young-Goo Song),유한상(Han-Sang Yoo),박미연(Mi-Yeoun Park),김종완(Jong-Wan Kim) 한국역학회 2005 Epidemiology and Health Vol.27 No.1
Brucellosis is zoonotic disease of worldwide distribution and still remains endemic in some developing countries. The main pathogenic species worldwide are B. abortus, responsible for bovine brucellosis, B. melitensis. The B. abortus is most common in Korea. Each Brncella spp. has a preferred natural host that serves as a reservoir of infection. The incubation period varies between 5 and 60 days, and Brucella infection may be asymptomatic or symptomatic. The majority of patients complained of fever (undulating fever), sweats, malaise, anorexia, and arthralgia. The diagnosis of brucellosis requires the isolation of Brucella from blood Of body tissues, or the combination of suggestive clinical presentation and positive serology. There were first patients in 2002, thereafter 16 patients in 2003, and 47 patients in 2004, the human brucellosis are increasing more gradually in Korea. Brucellosis is an occupational risk for farmers, veterinarians, and abattoir workers. The main sources of Brucella are infected animals or their products, such as milk, blood, carcasses, and abortion products. Routes of transmission of the infection to humans include direct contact with infected animals and their secretions through cuts and abrasions in the skin, by way of infected aerosols inhaled or via the ingestion of unpasteurized dairy products. A combination of doxycycline and streptomycin has been used widely in brucellosis. Prevention of brucellosis in human still depends on the eradication or control of the disease in animal hosts, the exercise of hygienic precautions to limit exposure to infection through occupational activities and the effective heating of dairy products, and other potentially contaminated foods. Also, physicians and veterinarians must be concerned about specific environments and clinical patterns of brucellosis.