CO2 레이저를 이용한 양성 피부 종양의 치료 효과

박미연,함정희 ( Mi Youn Park,Jeong Hee Hahm ) 대한피부과학회 1993 大韓皮膚科學會誌 Vol.31 No.4

Bsckground : CO laser emiis energy in the mid portion of the infrared spectrum at a wavelengt,h of 10,600nm. The CO laser is the workhorse laser in the treatment of cuianeous disease. With water as the chromophore(light-absorbing compound), CO laser light is highy absorbed in biologic tissue. Human body tissue comprises between 75% to 90% of water. The CO laser is superficially absorbed by tissue water, with little scat ter, limiting penetration into the skin to less than 0.1 mm. The beam can be delivered with a large spot size and low power density(defocus mode) or focused tightly with great power density(focused mode). As a result : the CO laser may be used both to vaporize and to cut tissue while coagulating blood vessels, providing a relatively bloodless su gical field. Objective : The purpose of this study was to evaluate the therapeutie effect of the CO laser on benign cutaneous tumors. Methods : 114 cases of benign cutaneous tumors treated with the CO laser between October 1987 and September 1992 were subjected to detailed analysis, The CO later is Pizer Laser system(U.S.A., Ca) Model 20-C CO. The laser produces power output that ranges from 0 to 25 W of continuous wave. Spot size is variable, between 0.3mm and 2mm. Results : 1. Angiofibromas and seborcheic keratoses showed very good response(95.3%, 92.8% ). 2. Syringomas showed a good esponse(82.8%). 3. Epidermal nevus and trichovpitheliomas showed a fair response(58.5%, 60%). 4. There were hypertrophic scars(10.5%) and transient hypopigmentation. Conclusion : The Co laser was a very effective modality for the treatment of benign cutaneous tumors such as angiofibromas, seborrheic keratosis and syringomas. (Kor J Dermatol 1993; (31):502-507)

요부근력운동과 기능적 전기 자극이 폐경기 여성의 요부 근력 및 복부 지방 면적에 미치는 영향

박미연(Mi Youn Park),김성수(Sung Soo Kim),김상호(Sang Ho Kim),이성기(Seong Ki Lee),김명기(Myong Ki Kim) 한국사회체육학회 2007 한국사회체육학회지 Vol.0 No.29

Quiz 6

박미연 ( Mi Youn Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Education: 1989 M.D. Ewha Womans University College of Medicine, Seoul, Korea 1992 M.S. Ewha Womans University College of Medicine, Seoul, Korea 1997 Ph.D. Ewha Womans University College of Medicine, Seoul, Korea Post-graduate training: 1989-1994 Internship and Resident in Dermatology, Ewha Womans University Medical Center, Seoul, Korea Career and position: 1994-1998 Head of department of Dermatology, Hosan Womans Hospital, Seoul, Korea 1999-2002 Director of the Youn Skin Clinic, Seoul, Korea 2004-present Head of Department of Dermatology, National Medical Center, Seoul, Korea 2007.9 Training course, Dermatology, Uppsala University College of Medicine, Uppsala, Sweden Membership and activities in professional societies: Member, Academic Affairs, the Korean Dermatological Association Director, Academic Affairs, the Korean Society for Acne Research Director, Financial Affairs, Korean Society for Cosmetics Major interest: Acne, Laser, Skin aging

Insulin resistance in acne

박미연 ( Mi Youn Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Insulin resistance is known as impaired biological response to insulin. There are many supporting evidences that insulin resistance may have a role in pathogenesis of acne by influencing adrenal and gonadal androgen metabolism. Interplaying of growth hormone, insulin, and insulin-like growth factor-1 (IGF-1) signaling during puberty may have causal role in developing acne. Physiologic insulin resistance during puberty leads to hyperinsulinemia which in turn leads to increased androgen synthesis. Increased level of both insulin and androgen provoke acne formation. Hyperinsulinemia increases the level of free IGF-1 and decreases the level of insulin-like growth factor binding protein 3. IGF-1 increases the facial sebum excretion, increases the sebum levels of dihydrotestosterone and dehydroepiandrosterone sulfate, and facilitates sebocyte proliferation. Hyperinsulinemia also increases levels of epidermal growth factors and transforming growth factor β, which elevate levels of plasma nonesterified fatty acids, thus causing inflammation and acne. Role of diet in acne is highly debated but some studies have shown that high glycemic index food may aggravate acne by increasing the insulin/IGF-1 signaling. Frequently discussed dietary triggers of acne include dairy products, high sugar foods, fat foods, and chocolates. Occurrence of acne as part of various syndromes associated with insulin resistance also provides evidence in favor of correlation between IGF-1 and acne. In this session I would like to discuss about the mechanism of insulin resistance and diet, affecting the pathophysiology of acne.

자녀학령기 가계의 노후준비자금과 사교육비 지출에 관한 연구

박미연(Mi Youn Park),차경욱(Kyung-Wook Cha) 한국FP학회 2008 Financial Planning Review Vol.1 No.1

본 연구에서는 자녀학령기 가계의 노후준비와 사교육비 지출실태를 알아보고, 노후준비자금으로 사교육비를 지불하는 가계와 그렇지 않은 가계의 사회?경제적 특성, 노후준비특성, 사교육비 지출특성을 비교하며, 나아가 노후준비자금으로 사교육비를 지불하는 선택을 결정하는데 영향을 미치는 요인들을 분석하였다. 첫 자녀가 초등학생, 중학생, 고등학생인 총 304가계를 대상으로 설문조사를 실시하였으며, 주요 결과는 다음과 같다. 첫째, 조사대상의 69% 정도가 사교육비 지불을 위해 노후준비자금을 사용한 경험이 있는 것으로 나타났다. 가구주 교육수준이 대졸 이하인 가계가, 월평균 가계소득이 상대적으로 적고, 가구주의 퇴직금제도가 없으며, 학령기 자녀수가 많을수록 노후준비자금으로 사교육비를 지불하는 비율이 높은 것으로 나타났다. 둘째, 노후준비자금으로 사교육비를 지불하는 가계는 그렇지 않은 가계 보다 자녀 1인당 평균 사교육비가 많았고, 사교육비 지출부담 정도가 컸으며, 사교육비 증액 의향 역시 높았고, 사교육비 지불을 위해 생활비를 줄이거나 부업 및 새로운 직장을 얻은 등 다른 지불 원천을 이용한 비율도 높은 것으로 나타났다. This study examined the relationship of financial planning for retirement and the private education expenditures among households with school-aged children. It compared socio-economic, retirement-related, and private education-related characteristics between those who spent their retirement savings to pay for children"s private education and those who did not. Also, it identified factors that had significantly impact on the decision of whether to spend their retirement for private education. Data for this study were from a questionnaire completed by households with school-aged children(n=304), and were analyzed by t-tests, chi-square tests, and a logistic regression model. The findings of this study were as follows: First, about 69% of households spent their retirement savings for children"s private education. Householders who had lower incomes, no pensions, with high school graduation and large number of children were more likely to spend their retirement savings. Second, the amount and burden of private education expenditure was larger for those who spent their retirement savings for children"s private education than for those who did not. However, those who spent their retirement saving were willing to pay more money for their children"s private education, and had paid for private education by decreasing consumption expenditure or getting secondary jobs.

결핵성 림프절염에 이차적으로 발생한 결핵성 요근 농양

박미연 ( Mi Youn Park ),박진영 ( Jin Young Park ),유지연 ( Ji Youn Yu ),김승수 ( Seung Su Kim ),김명숙 ( Myung Sook Kim ),김지창 ( Ji Chang Kim ),안창준 ( Chang Joon Ahn ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.6

A tuberculous psoas abscess is a frequently described complication of tuberculous spondylitis. Although rare, a tuberculous psoas abscess can develop without any demonstrable spinal involvement. In patients with no evidence of sponylitis, the abscess may result from direct spread from the involved lymph node or via a hematogeous route. The treatment of a psoas abscess is either drug therapy or surgical intervention in conjunction with drug therapy. Image-guided percutaneous drainage in conjunction with drug therapy is also a safe and effective treatment for a tuberculous psoas abscess. We report an unusual case of bilateral tuberculous psoas abscesses without any concomitant spinal involvement. The tuberculous psoas abscess may have formed by fistulization between the necrotic lymph node and psoas sheath. The diagnosis was confirmed by computed tomography and a histology examination of the biopsy sample. The patient improved after administering anti-tuberculous agents for 2 years along with surgical and percutaneous drainage of the abscess. (Tuberc Respir Dis 2008;65:517-521)

표피낭종에 발생한 전염성 연속종

박미연(Mi Youn Park),명기범(Ki Bum Myung) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.6

We report a case of molluscum contagiosum occurring in an epidermal cyst. A-38-year old male patient had the lision which was a 1.2 x 1cm sized, elevated, round nodule on the right cheek. Histology showed true epidermal cyst containing molluscum bodies throughout the cyst wall and laminated keratotic material within the cyst itself. (Kor J Dermatd 1992; 30(6): 917-919)

신이식 환자의 기저 신장에 발병한 Post-transplant Lympoproliferative disorder (PTLD) 1예

유지연 ( Ji Youn Yu ),박미연 ( Mi Youn Park ),정연오 ( Yeon Oh Jeong ),이혜경 ( Hae Kyung Lee ),박지찬 ( Ji Chan Park ),이상주 ( Sang Ju Lee ),장윤경 ( Yoon Kyung Chang ),박석영 ( Suk Young Park ),김석영 ( Suk Young Kim ) 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.6

Post-transplant lymphoproliferative disorder (PTLD) following solid organ transplantation is an important form of post-transplant malignancy. PTLD is typically associated with Epstein-Barr virus (EBV) and occurs in the setting of immunosuppression resulting in a deficiency of EBV-specific cytotoxic T lymphocytes. PTLD encompasses heterogeneous lymphoproliferative diseases, from polyclonal proliferation resembling infectious mononucleosis to aggressive monomorphic proliferation such as diffuse large B-cell lymphoma. Clinically, PTLD is usually manifested as lymph nodal mass or extranodal mass of solid organs such as liver, transplanted kidney, tonsil, bone marrow or spleen. The authors experienced very rare case of PTLD manifested as a single mass in a native kidney. According to a review of the literature, this is a rare case of PTLD which developed in a native kidney after kidney transplantation. Initially under the impression of renal cell carcinoma, unilateral nephrectomy of the native kidney had performed, and after confirmed as PTLD by histologic diagnosis the patient had treated with reduction of immunosuppressants and chemotheraphy for PTLD, and eventually has got in complete remission.

만성 두드러기 환자의 삶의 질 평가

신미선 ( Mi Seon Shin ),이시현 ( See Hyun Lee ),김민수 ( Min Soo Kim ),이정연 ( Jung Yeon Lee ),최연진 ( Yeon Jin Choi ),안지영 ( Ji Young Ahn ),박미연 ( Mi Youn Park ),김명남 ( Myeng Nam Kim ) 대한피부과학회 2010 大韓皮膚科學會誌 Vol.48 No.7

Background: Chronic urticaria (CU) is one of the most common skin disorders. This disease commonly induces emotional, social and psychological problems due to the erythematous lesion and intense pruritus. But there has been inadequate objective evaluation of the quality of life (QOL) of the patients with CU in Korea. Objective: The purpose of this study was to investigate the QOL of the Korean patients with CU by means of a new disease-specific tool and to assess the association between the QOL and the severity of disease. Methods: A total of 118 patients with CU were interviewed using the CU QOL questionnaire (CU-Q2oL). Their symptoms were evaluated with the urticaria severity score. We analyzed the relationship between the severity score and the CU-Q2oL score with Pearson`s correlation test. Results: The average score of the CU-Q2oL was 50.08±18.68. It was high when the patients had high severity scores (p<0.01). The severity score was increased in the patients with old age and when they were married. Comorbid systemic and skin diseases, a long duration of urticaria and systemic symptoms accompanying urticaria were also related to a high severity score. Conclusion: This study showed that CU has a significant impact on the QOL of Korean patients with CU in proportion to the disease severity. Clinicians need to consider the QOL and the CU severity of their patients to achieve the ideal goals of treatment. (Korean J Dermatol 2010;48(7):567∼572)

마이코플라즈마 폐렴에서 중합 효소 연쇄반응과 효소면역측정법의 진단적 유용성

신윤호 ( Youn Ho Shin ),이병철 ( Byung Chul Lee ),송태원 ( Tae Won Song ),김경원 ( Kyung Won Kim ),이경은 ( Kyung Eun Lee ),김은수 ( Eun Soo Kim ),박미연 ( Mi Yeoun Park ),류정우 ( Jung Woo Leu ),장욱 ( Wook Chang ),손명현 ( Myun 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2006 소아알레르기 및 호흡기학회지 Vol.16 No.1

목 적 : Mycoplasma pneumoniae 폐렴은 소아 및 청소년기에 주로 호흡기 질환을 일으키는 주요 원인이다. M. pneumoniae 폐렴을 진단하기 위해서는 한랭응집소 검출반응, 마이코플라즈마 특이 항체 측정법, 배양 검사 등의 방법이 이용되고 있으나 초기 진단에는 효용성이 떨어진다. 본 연구는 중합 효소 연쇄반응과 효소면역측정법을 이용한 M. pneumoniae 폐렴의 진단적 유용성에 대해 평가하고자 하였다. 방 법 : 연세대학교 의과대학 부속 세브란스병원 및 영동세브란스병원 소아과에 입원한 환자 중 입원 당시 시행한 흉부 X-선 검사 및 흉부 청진상 폐렴 소견을 보인 환아 111명의 임상 검체를 대상으로 M. pneumoniae를 분리, 동정하였다. 마이코플라즈마 특이항체가 1 : 320 이상이거나 추적 관찰 시 4배 이상 역가가 증가하는 경우를 M. pneumoniae 폐렴으로 진단하였고 이를 기준으로 중합 효소 연쇄반응과 효소면역측정법을 수행하였다. 결 과 : 중합 효소 연쇄반응의 민감도는 40.6 %, 특이도 63.3%, 위양성률 69.1%, 위음성률 27.5%로 나타났고, 효소면역측정법에서 M. pneumoniae 특이 IgM은 민감도 9.4%, 특이도 100%, 위양성률 0%, 위음성률 26.9%를 나타내었다. 중합 효소 연쇄반응과 효소면역측정법을 조합한 결과는 민감도 46.9%, 특이도 63.3%, 위양성률 65.9%, 위음성률 25.4%로 나타났다. 결 론 : M. pneumoniae 폐렴의 진단에 있어서 미세입자 응집법을 이용한 특이항체 검사와 더불어 중합 효소 연쇄반응과 효소면역측정법을 시행함으로써 보다 정확한 진단을 할 수 있을 것으로 사료된다. Purpose: Mycoplasma pneumoniae is a common respiratory pathogen responsible for acute respiratory infections in young children. The standard laboratory methods for the specific diagnosis of M. pneumoniae infection have been isolation in culture and serological methods. The objective of this study was to compare the performance of enzyme-linked immunosorbent assays (ELISA) for the detection of M. pneumoniae specific IgG and IgM antibodies and polymerase chain reaction (PCR) in diagnosis of M. pneumoniae pneumonia. Methods : For a 1-year period, 111 patients admitted to Severance Hospital and Yong-dong Severance Hospital with clinical features of pneumonia and radiographically defined pneumonia were included. Serum specimens and throat swab specimens were obtained at the time of admission. Patients who showed M. pneumoniae antibody titer 1 : 320 or greater or a fourfold increase in M. pneumoniae antibody titer between acute and convalescent sera obtained 5 days to 3 weeks after the onset of illness were diagnosed as having M. pneumoniae pneumonia. PCR and ELISA were also performed. Results :The sensitivity, specificity, false positivity, and false negativity of PCR were 40.6 percent, 63.3 percent, 69.1 percent, and 27.5 percent, respectively. The sensitivity, specificity, false positivity, and false negativity of ELISA IgM were 9.4 percent, 100 percent, 0 percent, and 26.9 percent, respectively. The sensitivity, specificity, false positivity, and false negativity of the use of PCR and ELISA in combination were 46.9 percent, 63.3 percent, 65.9 percent, and 25.4 percent, respectively. Conclusion : These observations suggest that the use of PCR and ELISA in addition to the detection of serum antibody to Mycoplasma pneumoniae using microparticle agglutination would allow the maximal number of diagnoses to be made at a very early phase of infection. [Pediatr Allergy Respir Dis(Korea) 2006;16:47-56]