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각종 간질성폐질환에서 폐포 대식세포의 Superoxide 분비능과 식균 작용
송정섭(Jeong Sup Song),김영균(Young Kyoon Kim),김관형(Kwan Hyoung Kim),한기돈(Ki Don Han),문화식(Hwa Sik Moon),신완식(Wan Shik Shin),박성학(Sung Hak Park) 대한내과학회 1990 대한내과학회지 Vol.39 No.3
N/A Interstitial lung diseases are a heterogenous group of disorders characterized by various degrees of parenchymal alveolitis and fibrosis. Alveolar macrophages (AM) are the predominant inflammatory cell type within alveolar structures and function not only as phagocytic cells but also as secretory cells that release various secretory products involving oxygen metabolites. Alveolar macrophages from patients with interstitial lung disease are thought to participate in the injury to the alveolar wall and contribute to the development of interstitial fibrosis. To investigate the role of alveolar macrophages in interstitial lung diseases, we measured the amount of superoxide release and phagocytosis by AM after bronchoalveolar lavage (BAL) from the normal controls and cases with interstitial lung diseases. The results were summerized as follows: 1) The total number of inflammatory cells in the BAL fluids increased more in patients with interstitial lung diseases than in the controls (p<0.02). 2) The differential cell count of BAL inflammatory cells showed that lymphocytes were predominant in sarcoidosis, hypersensitivity pneumonitis, and collagen lung disease, while neutrophils were predominant in idiopathic pulmonary fibrosis and bleomycin-induced pneumonitis. 3) The superoxide release by AM in patients with interstitial lung diseases was higher than the normal controls, either spontaneously or after stimulation by phorbol myristate acetate (PMA)(p<0.05). 4) The phagocytosis of non-opsonized staphylococcus aureus by AM was elevated in the interstitial lung disease cases (p<0.02), but no difference was noted when using the opsonized staphylococcus aureus as a target. These results suggest that AM are activated in interstitial lung diseases, and increased production of oxidant by AM in interstitial lung diseases may play a critical role in tissue damage and pulmonary fibrosis. Elevation of oxygen metabolite release by AM could be a useful marker in the assessment of the activity of interstitial lung diseases.
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Lidocaine, Thrombin, Epinephrine 의 항균효과
김진우,이동건,전혜선,김승준,김석찬,안중현,김치홍,권순석,김영균,김관형,문화식,신완식,송정섭,박성학 대한감염학회 2005 감염과 화학요법 Vol.37 No.6
목적 : 기관지내시경 검사에서 흔히 사용되는 국소마취제인 lidocaine과 내시경시 지혈목적으로 사용되는 thrombin과 epinephrine이 각종 균주에 미치는 항균효과에 대해 알아보고자 하였다. 재료 및 방법 : 균주는 가톨릭대학교 성모병원에서 2004년 3월부터 2004년 9월까지 임상검체 에서 동정된 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 각각 42, 42, 42, 43주를 대상으로 하였다. Lidocaine, thrombin, epinephrine 감수성 검사는 National Committee for Clinical Laboratory Standards (NCCLS, 2002)의 기준에 따랐다. 결과 : Lidocaine은 S. aureus, S. pneumoniae, P. aeruginosa에서 MIC_(50), MIC_(90) 모두 20,000 ㎍/mL 이었다. K. pneumoniae는 각각 10,000 ㎍/mL이었다. Thrombin은 S. aureus와 P. aeruginosa에서 MIC50 500 lU/mL 과 MIC_(90) 500 IU/mL 이상이었고, K. pneumoniae에서는 MIC_(50)과 MIC_(90)이 모두 500 lU/mL이상이었으나 S. pneumoniae에서는 MIC_(50)과 MIC_(90)은 125 IU/mL이었다. Epinephrine은 K. pneumoniae, S. pneumoniae에 대한 MIC_(50), MIC_(90)가 모두 >500 ㎍/mL이었고, S. aureus와 P. aeruginosa에 대한 MIC_(50), MIC_(90)가 모두 500 ㎍/mL이었다. 결론 : 기관지 내시경 검사에서 흔히 쓰이는 lidocaine, thrombin, epinephrine 등의 약제들이 호흡기 질환의 흔한 병원균인 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 균주들에 대해 항균 효과가 있을 수 있어 세균배양검사에 영향을 미칠 수 있겠다. Background : We performed this stody to find out about antimicrobial effect of lidocaine which is commonly used local anesthetic, and thrombin and epinephrine used for hemostasis during bronchoscopic procedures. Materials and Methods : The microorganisms that were cultured from specimens obtained during bronchoscopy were Staphylococcus aureus (n=42), Streptococcus pneumoniae (n=42), Klebsiella pneumoniae (n=42), and Pseudomonas aeruginosa (n=43) collected from St. Mary's Hospital, from March to Sep 2004 were used for susceptibity testing. Susceptibility to lidocaine, thrombin, and epinephrine were tested according to the National Committee for Clinical Laboratory Standards. Result : MIC_(50) and MIC_(90) of lidocaine for S. aureus, S. pneumoniae, P. aeruginosa were all 20,000 ㎍/mL and that for K. pneumoniae were 10,000 ㎍/mL. MIC_(50) and MIC_(90) of thrombin for both S. aureus and P. aeruginosa was 500 IU/mL and above 500 IU/mL, respectively; that for K. pneumoniae were all above 500 IU/mL and for S. pneumoniae they were 125 IU/mL, MIC_(50) and MIC_(90) of epinephrine for K. pneumoniae and S. pneumoniae were above 500 ㎍/mL; that for S. aureus and P. aeruginosa were 500 ㎍/mL. Conclusion : We observed possible antimicrobial effect of lidocaine, thrombin, and epinephrine in vitro against pathogens such as S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa, which are common respiratory microorganisms. The use of these agants could affect the result of bacterial culture.
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빈혈과 장중첩증을 동반한 Peutz-Jeghers 증후군 1예 보고
최상욱,이영길,문화식,서은주,김치홍,김부성,박두호,정진우 대한소화기내시경학회 1989 Clinical Endoscopy Vol.9 No.1
The Peutz-Jeghers syndrome has three cardinal features: gastrointestinal polypasis, mucocutaneous piginentation and autosomal dominant heredity. This syndrome is ciinically important because of the complication caused by the gastrointestinal ployp, leading to abdominal pain, gastrointestinal bleeding and intussusception. We experienced a case of Peutz-Jeghers syndrome who complained of dizziness, vague abdominal pain, melanin pigmentations of the lips, oral mucosa and digits and reported with the review of the literature.
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