한공각화증과 광선각화증에서 세포사멸과 p53, bcl-2, PCNA 및 iNOS 발현에 관한 연구 (제1보)

명기범(Ki Bum Myung) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.2

N/A Background:Porokeratosis is characterized by cornoid lamellae histologically and evolve cutaneous malignant tumors in about 7% of the patients. Actinic keratosis is the most common premalignant lesion and progressed into squamous cell carcinoma in 20% of the patients. It has been reported that the expression of p53 increased within or beneath the cornoid lamellae of porokeratosis and actinic keratosis. Objective:The purpose of this study was to understand the role of apoptosis in pathogenesis and progression into malignant tumors and to investigate whether a positive correlation occurs between apoptosis index and expression of p53, bcl-2, PCNA and iNOS in porokeratosis and actinic keratosis. Methods:TUNEL staining and immunohistochemical staining with p53, bcl-2, PCNA and iNOS antibody were done in paraffin-embedded tissue sections of 10 cases of porokeratosis and 12 cases of actinic keratosis. Results:The results are summarized as follow: 1. The mean of apoptosis index(%) was 27.3±7.82 in porokeratosis, 36.3±10.32 in cornoid lamellae of porokeratosis. 2. The mean of apoptosis index(%) of actinic keratosis was 41.5±8.98 and statistically significant higher than that of porokeratosis(p=0.002). (Korean J Dermatol 2000;38(2):207~212)

수장족저부 농포성 건선 및 한포진에서 국소 Bath-PUVA 요법과 스테로이드 요법의 효과에 대한 비교

명기범(Ki Bum Myung),김문정(Moon Jung Kim),최유원(Yoo Won Choi),최혜영(Hae Young Choi) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.6

Background:Local bath-PUVA(LB-PUVA) therapy has been recently tried for the treatment of palmoplantar pustular psoriasis and chronic eczema with successful results. However it has not been reported that the effectiveness of LB-PUVA was compared with that of steroid treatment which is the most available treatment. Objectives:The purpose of this study was to assess the effectiveness, symptom-free interval, recurrence rate and side effects of local bath-PUVA(LB-PUVA) therapy in palmoplantar pustular psoriasis and dyshidrotic eczema which had been resistant to conventional treatments and to compare these results with those of the steroid treatment. Methods:Twenty four patients with palmoplantar pustular psoriasis, dyshidrotic eczema and palmoplantar keratoderma were treated with local bath-PUVA and the control group of twenty patients with systemic and topical steroid. 1. Local bath-PUVA therapy After a 15-minute bath in 1mg/L of methoxsalen solution(0.0001%), the palms or soles or both were exposed immediately to UVA radiation by UV/PUVA200. The initial standard dose was 1.5 J/cm2, and the patients were treated three times a week. 2. Systemic and topical steroid therapy The patients treated with 10-15mg of oral prednisolone once a day and high-potency steroid(Dermovate ointment) to the lesion topically for 4-8 weeks. The efficacy, symptom-free interval and side effects were assessed for 6-12 months after termination of the treatments. Results:The following results were obtained from this study. 1. In the objective study, severity scores before and after treatment significantly differed in palmoplantar pustular psoriasis treated with local bath-PUVA (p<0.001). 2. In the subjective study, steroid treatment was more effective than LB-PUVA treatment for dyshidrotic eczema and palmoplantar pustular psoriasis. 3. Remission period was significantly longer (mean 9.1±2.8 months vs. 5.2±3.1 months) and recurrence rate, lower (26.7% vs. 68.9%) after LB-PUVA treatment than after steroid treatment in palmoplantar pustular psorisis and dyshidrotic eczema. 4. One patient with palmoplantar keratoderma was effectively treated by LB-PUVA. Conclusion:Local bath-PUVA therapy can be used as an effective and safe treatment method of palmoplantar pustular psoriasis and possibly palmoplantar keratoderma. (Korean J Dermatol 2000;38(6):742~749)

가토 (家兎) 에서 실험적으로 유도한 면포 의 전자현미경적 관찰

명기범 (Ki Bum Myung) 대한피부과학회 1987 大韓皮膚科學會誌 Vol.25 No.4

Accurnulation of keratinized cells within the infundibulum of pilosebaceous canal is important in the pathogenesis of acne. Light and electron microscopic study of experimentally induced comedones, from the rabbit's external ear canal, was performed to define the earIy morphologic changes within and around the epithelial lining of the comedones. In light microscopic observation, early comedone was composed of loose cohesive horny cells and late comedone was composed of a mixture of loose and tight cohcsive horny cells. Cohesion between horny cells occured, in eIectron microscopic study, in two different ways: initially, by the persistence of desmosomes; later, and to a lesser extent, by tight junctions, which tightly bound the horny cells together. Multiple lipid droplets within the horny ceIls and a gradual decrease in the numbrane coating granules were observed.

실험적으로 유도된 가토의 면포에 수종 여드름 국소치료제의 면포 용해 능력에 대한 비교연구

이미경,명기범,국홍일 ( Mi Kyung Lee,Ki Bum Myung,Hong Il Kook ) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.5

혈관육종 2예

이경신,명기범,국홍일 ( Kyung Sin Lee,Ki Bum Myung,Hong Il Kook ) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.2

We present two cases of angiosarcoma occuring on the scalp of aged person. The case 1 was a 74 year-old male who have had purplish colored, slightly raised irregular surfaced plsque on frontal scalp. The other case was a 69-year-old man who have had purplish nodule with satellite lesions on the right frontal area. The cases were confirmed by clinical picture, histologic findings. Treatment was not done because of refuse by patient.

Oak Moss에 의한 접촉 피부염

이기홍(Ki Hong Lee),명기범(Ki Bum Myung) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.3

Oak moss is a lichen extract obtained from Evernia prunastri and Pseudovernia furfuracea. It is the potent,ial allergen in contact dermatitis to perfumes. Sensitivity to oak moss has been atributed mainly to atranorin, evernic acid, usnic acid and fumarprotocetraric acid. We report a 44-year-old female patient presenting with features of contact dermatitis due to oak moss in perfumes. Patch test results revealed positive reactions to fragrance mix, oak moss, atranorin and evernic acid. (Kor J Dermatol 1992; 30(3): 377-380)

켈로이드와 비후성 반흔에서 냉동 외과술 후 스테로이드 병변내 주사의 병용 요법에 관한 임상적 분석

황규광,박혜진,명기범 ( Kyu Kwang Whang,Hae Jin Park,Ki Bum Myung ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.3

Background: Keloids and hypertrophic scars are benign fibrous growths which usually occur in predisposed individuals after trauma. Numerous modalities have been used to treat keloids and hypertrophic scars, but the final results have been so far unsatisfactory. Objective : The purpose of tlis study was to evaluate the effect of the combination of cryosurgery and intralesional corticoster oid for treatment of these scars. Method : Thirty patients, aged 17 to 45 years old, with keloids or hypertrophic scars(mean duration, 6.4 years) were treated using solid CO2 followed by intralesional injection of triamcinolone acetonide(13.3 mg/ml). Two freeze-thaw cycles per lesion were employed. Freezing time was chosen arbitrarily from 7 to 20 sec depending on the characteristics of each scar. Results . The results are summarized as follows. 1. Excellent and good results were achieved in 57% of all subjects on average, 77% of those who were treated more than 3 times, and 48% of those treated less than twice. 2. The keloid of less than 2 years duration showed better results than older ones. 3. No recurrence was seen in 63% of patients, but partial recurrence in 21% of patients and complete recurrence in 10% were observed. Lesions on the trunk showed less improvement(p<0. 05) and were more recurrent than other lesions. 4. There were complications in 9 patients, such as hyperpigmentation(6), hypopigmentation(1), infection(1) and telangiectasia(1). Conclusion : Cryosurgery and intralesional corticosteroid injections produced synergistic advantages. A cornbination of these modalities might be an effective treatment modality in keloids and hypertrophic scars. (Kor J Dermatol 1997;35(3): 450-457)

Potassium iodide(KI)로 치료한 Sweet 증후군

김진형(Jin Hyoung Kim),임연순(Yeon Soon Lim),최혜영(Hae Young Choi),명기범(Ki Bum Myung) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.8

N/A

광노화 병변의 유병률 조사 및 단일성과 다발성 광선각화증 환자들의 특성 비교: 환자 61명에 대한 후향적 연구

고병용 ( Byoung Yong Koh ),명기범 ( Ki Bum Myung ),한형진 ( Hyung Jin Hahn ),정승현 ( Seung Hyun Cheong ) 대한피부과학회 2017 大韓皮膚科學會誌 Vol.55 No.9

Background: Photoaged skin is characterized by actinic skin lesions such as wrinkling, elastosis, and premalignant and malignant lesions. Actinic keratosis (AK) is one of the most common precancerous lesions, and multiple actinic keratosis lesions are one of the risk factors for skin cancer. Few studies have investigated the prevalences of actinic skin lesions and compared the characteristics of the lesions and the patients with sinle and multiple AK lesions. Objective: The aim of this study was to evaluate the prevalences of actinic skin lesions and to compare characteristics between single and multiple lesions in Korean patients with AK. Methods: We retrospectively reviewed the medical records and biopsy specimens of 61 patients. Results: Frequencies of deep wrinkle, solar elastosis, cutis rhomboidalis nuchae, and senile purpura were higher in the multiple lesions group. The ratio of males to females was 1:3.43 and the mean age was 79 years in the multiple lesions group, both of which were higher than those in the single lesion group (1:1.14, 72 years). The mean duration was longer in the multiple lesions group. Sun protective behavior was more frequent in the single lesion group, and the occupation of farmer was more common in the multiple lesions group. There was no statistically significant clinicopathological difference between the two groups. Conclusion: This study may improve our understanding of the characteristics of actinic keratosis with both single and multiple lesions. (Korean J Dermatol 2017;55(9):580∼587)

한국에서 구입한 벨트 버클에서의 니켈과 코발트 검출에 관한 연구

권은선 ( Eun Sun Kwon ),명기범 ( Ki Bum Myung ),정승현 ( Seung Hyun Cheong ) 대한피부과학회 2016 大韓皮膚科學會誌 Vol.54 No.6

Background: Among metals, nickel and cobalt are very important contact allergens. They are widely used in products that have direct and prolonged contact with the skin. A frequent cause for nickel-induced allergic contact dermatitis is a nickel-containing belt buckle. The belt buckle showed a relatively high positive rate in the cobalt spot test in our previous study. Studies regarding nickel and cobalt release from belt buckles in Korea have been scarce. Objective: We attempted to assess nickel and cobalt release from belt buckles purchased in Korea by conducting spot tests. Methods: Belt buckles of various brands and prices were randomly purchased in Korea. They were tested using the dimethylglyoxime (DMG) test and cobalt spot test for detection of nickel and cobalt release. Results: A total of 97 belts including 61 brand-name and 36 non-brand-name belts were sampled. Of 91 belt buckles tested using the DMG test, 45 (49.5%) demonstrated a positive reaction. There were statistical differences among the positive rates according to brand/non-brand and price. All belt buckles tested negative for the cobalt spot test. But in the EN1811 test, some belt buckles with a positive reaction in the DMG test showed a low nickel release rate. Conclusion: Although cobalt was not leached, nickel showed a relatively high positive rate in the belt buckles purchased in Korea. Therefore, we suggest that belt buckles purchased in Korea could be a common source of nickel-induced allergic contact dermatitis. (Korean J Dermatol 2016;54(6):438∼443)