Mohs 미세도식 수술 및 쌈지봉합 복원술을 이용한 융기성 피부섬유육종의 치험

최유원,황규광,함정희,이정복,Yoo Won Choi,Kyu Kwang Whang,Jeong Hee Hahm,Jung Bock Lee 대한피부과학회 1995 대한피부과학회지 Vol.33 No.6

Dermatofibrosarcoma protuberans is an uncommon, locally aggressive fibroblastic tumor, characterized by infrequent metastasis and a marked tendency of local recurrence after excision. Histologically, it shows large uniformed spindle shaped cells arranged in a cartwheel or storiform pattern. We report a case of dermatoribrosarcoma protuberans on the lower abdomen of a man aged of thirty, treated with Mohs micrographic surgery and purse-string suture repair. (Kor J Dermatol 1995;33(6): 1108-1113)

건강한 사람에서 발생한 다발성 조직구증

최유원,임연순,최혜영,명기범 ( Yoo Won Choi,Yeon Soon Lim,Hae Young Choi,Ki Bum Myung ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.4

Multiple histiocytomas are rare and defined when more than 15 lesions are present according to Baraf and Shapiro. It has been reported occurring in patients with autoimmune disease, who were receiving immunosuppressive treatment. Reports in the literature of these multiple lesions occurring in a healthy person are very rare. A 45-year-old man had 26 asymptomatic nodules on the trunk and upper extremities of two years duration. The lesions varied from 5mm to 2cm in size, were brownish, round, firm, nontender and positive for dimple signs. Microscopic examination of the lesions were indistinguish able from those seen in dermatofibroma. Most cells react intensively with factor XIIIa. (Kor J Dermatol 1997;35(4): 819-823)

인체 표피의 자외선 투과율에 관한 연구

최유원,강형철 ( Yoo Won Choi,Hyung Chul Kang ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.3

Background: Ultraviolet light induces sunburn, ageing of the skin, pigmentation and even promotes skin cancers. As there has been a recent decrease in the ozone layer surrounding the earth, increasing attention has been given to the effects of ultraviolet light on the skin. Through human epidermis, ultraviolet light is reflected, scattered, absorbed or transmitted. In caucacians, the rate of transmitted ultraviolet light A from the epidermis to the dermis is 50% and the rate of transmitted ultraviolet light B is below 10%. Objective '. The purpose of this study was to evaluate the transmittance of UVA and UVB on Korean normal epidermis. Methods : Pure epidermis was obtained from normal human epidermis by suction of blisters in 12 patients with vitiligo. All specimens were irradiated respectively with UVA and UVB and the amount of transmitted energy was measured. Results 1. The transmittance of UVA energy density by normal epidermis was 47.7+11.2% of irradiated UVA energy. 2. The transmittance of UVB energy density by normal epidermis was 32.4+3.4% of irradiated UVB energy. Conclusion : UVA energy transmission through normal epidermis of Korean is less than those of Caucacians but UVB energy transmission through nor mal epidermis of Korean is more than those of Caucacians. It is suggested that this could be an important basic data to study for photoaging and photoprotection in Korean population. (Kor J Dermatol 1997;35(3): 485-490)

두피의 원형결손에서 일측성 선상 전진피판의 Pinch 변형 ( Peng 피판 ) 에 의한 복원 2예

최유원,황규광 ( Yoo Won Choi,Kyu Kwang Whang ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.5

Pinch modification of the linear advancement flap(Peng flap) is a hybrid of the transitional linear advancement flap and two bilateral rotation flaps. The advantages of this technique are a wider and shorter flap and an increase of the skin survival rate. This technique can be applied not only to the dorsum of the nose, but also to large defects of the scalp secondary to the surgical excision of benign or nalignant. lesions, scars, aplasia cutis and cicatricial alopecia. We pres ent, two cases of round defects on the scalp. The first case is an 8-year-old boy suffering from cicatricial alopecia on the right temporal area. The second case is a 12 year-old boy who had had nevus sebaceus on the right temporal area since birth. Pinch modification of the linear advancement flap can be erformed after excision without changing the direction of hairs. (Korean J Dermatol 1997;35(5): 1027-1030)

비전형적인 임상 양상을 보인 호산구성 농포성 모낭염

최유원 ( Yoo Won Choi ),최혜영 ( Hae Young Choi ),명기범 ( Ki Bum Myung ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.4

We report a case of eosinophilic pustular folliculitis in a 42-year-old woman who had atypical clinical findings with moderately pruritic erythematous follicular papules and pustules on the face and neck. Histopathologically miny eosinophils and neutrophils infiltrated around the follicles, within the follicles and around tbe vessels. The follicular walls showed spongiosis. The differential count of eosinophils in seram was 1.9%. The patient responded well to systemic steroid and dapsone. (Kor J Dermatol 1995;33(4): 717-721)

한공각화증, 광선각화증 및 편평세포암에서 세포사멸과 p53, bcl-2, bax, PCNA, 및 cyclin D1 발현에 관한 연구

최유원(Yoo Won Choi),최혜영(Hae Young Choi),명기범(Ki Bum Myung) 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.11

Background:Apoptosis is an important negative growth regulatory mechanism in tumors. In some malignancies, the apoptotic index(the percentage of apoptotic cells/bodies in the total number of tumor cells) may reflect the degree of carcinogeneity. In cells lacking functional p53, there is reduced susceptibility to apoptosis, thereby facilitating tumor growth. The bcl-2 gene product is a potent inhibitor of apoptosis and increases proliferation. The bcl-2/bax ratio is the critical determinant for the induction or inhibition of apoptosis. Proliferating cell nuclear antigen(PCNA) is present in nuclei throughout the cell cycle and is synthesized in the late G1 and S phases. Cyclin D1 is a major regulator of the G1 restriction point and may act as an oncogene; it is altered in several neoplasms. Objective:Our purposes were to investigate the apoptotic index and the correlation between the apoptotic index and p53, bcl-2, bax, PCNA, and cyclin D1 in porokeratosis, actinic keratosis, and squamous cell carcinoma. Methods:We investigated the apoptotic index by TUNEL and the expression of p53, bcl-2, bax, PCNA, and cyclin D1 by immunohistochemistry in 12 cases of porokeratosis, 18 cases of actinic keratosis, and 7 cases of squamous cell carcinomas. Results 1. The apoptotic index(%) in the epidermis central to the cornoid lamella was significantly higher than that of the peripheral epidermis in porokeratosis, 36.4±10.37 vs 24.4±8.76(p=0.004). 2. The apoptotic index(%) of actinic keratosis was significantly higher than that of porokeratosis, 37.4±7.73 vs 28.3±8.01(p=0.008). The apoptotic index(%) of squamous cell carcinoma was significantly higher than that of actinic keratosis, 45.1±6.18 vs 37.4±7.73(p=0.029). 3. p53 had significant positive correlation to the apoptotic index in porokeratosis and squamous cell carcinoma(p=0.002, 0.018). In actinic keratosis, the apoptotic index had significant positive correlation to cyclin D1(p=0.005). (Korean J Dermatol 2000;38(11):1453~1460) Conclusions:Actinic keratosis is more frequently evolved in malignant tumors than porokeratosis, which is supported by a significantly higher apoptotic index(%). Also the apoptotic index(%) of cutaneous malignant tumors was significantly higher than that of precancerous lesions. Apoptosis and p53, rather than proliferation, may provide the pathogenesis and progression into malignant tumors in porokeratosis. Apoptosis and cyclin D1 may provide the pathogenesis in actinic keratosis. In squamous cell carcinoma, p53-mediated apoptosis may be the key to pathogenesis in tumorigenesis and its proliferation.

영아에서 발생한 구진성 황색종

서승리,최유원,임연순,최혜영,명기범 ( Seung Lee Seoi,Yoo Won Choi,Yeon Soon Lim,Hae Young Choi,Ki Bum Myung ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6

Papular xanthoma is a persi;tent normolipemic, nonconfluent, eruptive xanthomatosis located on the face, trunk and rnucous m,mbranes with no internal involvement, which exclusively occurs in adults. Histologically there is an infiltration of foamy histiocyte-like cells and a few Touton giant cells in the upper dermis and middermis without inflammatovy cells or a pure histiocytic component. Papular xanthomas in the childhood age group were recently described and charact.erized by their self- healing course, leaving, anetoderma-like scars. We report a case of papylar xanthoma in a 21-month-old infant with typical clinical, histopathologic and immunohistochemical findings. The positive immunohistochemical staining with factor XIIIa confirms that papular xanthorna is included in the group of dermal dendrocytic disorder. (Korean J Dermatol 1997;35(6): 1230-1233)

경화부종에서 영상분석을 이용한 교원섬유와 탄력섬유의 비율에 대한 연구

문경원 ( Kyoung Won Moon ),김소영 ( So Young Kim ),최유원 ( Yoo Won Choi ),명기범 ( Ki Bum Myung ),최혜영 ( Hae Young Choi ) 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.9

Background: Scleredema is a rare connective tissue disorder, characterized by hard and thick skin. It is well known that collagen synthesis is increased in scleredema skin, but there has been no study on the change of elastic fibers. Objective: The purpose of this study was to compare the changes of collagen and elastic fibers in scleredema and normal skin. Methods: We retrospectively evaluated the biopsy specimens of 10 patients diagnosed with scleredema. The control group was selected by matching each scleredema case with same site and similar ages from the biopsy specimens which showed normal dermis. A computerized image analysis system was used to measure the fraction of collagen and elastic fibers and calculate the ratio of elastic fibers to collagen fibers in each group. Results: The skin of scleredema was found to have a significant increase in the percentage of collagen fibers in the dermis compared to the control group. On the other hand, the percentage of elastic fibers was significantly decreased in the scleredema group (p<0.05). Conclusion: In contrast to scleroderma which shows an increase in dermal elastic tissue and collagen fibers, we concluded that there is a decrease of elastic fibers in scleredema and that the pathogenesis and molecular involvement are different in the two diseases. we also found that the computerized image analysis system was a useful tool in the measurement of connective tissue components. (Korean J Dermatol 2006;44(9):1072~1077)

사행성 혈관종

장가연 ( Ka Yeun Chang ),최유원 ( Yoo Won Choi ),임연순 ( Yeon Soon Lim ),최혜영 ( Hae Young Choi ),명기범 ( Ki Bum Myung ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.3

Angioma serpiginosum is a rare acquired naevoid disorder, characterized by minute red or purple punta that are frequently arranged in serpiginous patterns in the lower extremities and buttocks. It usually begins in childhood and is more common in females. Histopathologically, thin-walled capillaries in the dermal papillae and the superficial reticular dermis are widely dilated without extravasation of red blood cells. We report a case of angioma serpiginosum on the lateral aspect of the right arm along the lines of Blaschko in a 36-year-old woman. (Korean J Dermatol 1998;36(3): 520-523)

모반세포성 모반에서 발생한 것으로 추정되는 악성 흑색종

김진형(Jin Hyoung Kim),최유원(Yoo Won Choi),최혜영(Hae Young Choi),명기범(Ki Bum Myung) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.8

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