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Cystic Adventitial Disease of the Popliteal Artery: Resection and Repair with Autologous Vein Patch
맹영희,장지원,Sun Hyung Kim 대한흉부외과학회 2011 Journal of Chest Surgery (J Chest Surg) Vol.44 No.3
Cystic adventitial disease is rare, but it is one of the well-recognized causes of non-atherosclerotic arterial stenosis or obstruction. Despite one of its most common symptoms being chronic intermittent claudication, it may be misdiagnosed as arterial embolism when presented with acute ischemic symptoms. Surgical resection is recommended because of recurrence or a low success rate with aspiration or endovascular stent. We performed resection and repair with autologous vein patch for cystic adventitial disease of the popliteal artery of a 57-year-old man presenting with pain, pallor, and paresthesia, without any postoperative complications or recurrence.
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방광의 요로상피암에서 Minichromosome Maintenance7 증식표지자의 발현과 임상적 의의
맹영희,강현욱,허정식 대한비뇨의학회 2008 Investigative and Clinical Urology Vol.49 No.1
Purpose: The antibodies for minichromosome maintenance(MCM) proteins have been reported as potential proliferative markers and prognostic indicators in various human malignancies. The present study examined the expression pattern of MCM proteins in bladder carcinomas, and we also evaluated their prognostic significance as well as their potential applicability as proliferation markers. Materials and Methods: Immunohistochemistry for MCM7 and Ki-67 was performed on paraffin sections from 47 cases of bladder carcinoma. The MCM7 and Ki-67 expressions were quantified and then analysis was carried out for determining the association between the expressions of MCM7 and Ki-67 and the clinicopathological parameters. Results: A significant correlation existed between the expression rate of MCM7 and the histological grade(p<0.0001). The Ki-67 expression rate was significantly related to the tumor grade(p=0.002) and the pathological stage(p=0.011). On multivariate analysis, MCM7 was not found to be an independent prognostic factor for predicting the recurrence of bladder carcinoma. Conclusions: The results suggest that MCM is a reliable proliferation marker, but not an independent predictive factor for recurrence of bladder carcinoma. (Korean J Urol 2008;49:12-17) Purpose: The antibodies for minichromosome maintenance(MCM) proteins have been reported as potential proliferative markers and prognostic indicators in various human malignancies. The present study examined the expression pattern of MCM proteins in bladder carcinomas, and we also evaluated their prognostic significance as well as their potential applicability as proliferation markers. Materials and Methods: Immunohistochemistry for MCM7 and Ki-67 was performed on paraffin sections from 47 cases of bladder carcinoma. The MCM7 and Ki-67 expressions were quantified and then analysis was carried out for determining the association between the expressions of MCM7 and Ki-67 and the clinicopathological parameters. Results: A significant correlation existed between the expression rate of MCM7 and the histological grade(p<0.0001). The Ki-67 expression rate was significantly related to the tumor grade(p=0.002) and the pathological stage(p=0.011). On multivariate analysis, MCM7 was not found to be an independent prognostic factor for predicting the recurrence of bladder carcinoma. Conclusions: The results suggest that MCM is a reliable proliferation marker, but not an independent predictive factor for recurrence of bladder carcinoma. (Korean J Urol 2008;49:12-17)
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맹영희,은수용,허정식 대한비뇨의학회 2010 Investigative and Clinical Urology Vol.51 No.2
Purpose: The fibroblast growth factor receptor 3 (FGFR3) gene is known to be frequently mutated in noninvasive urothelial carcinomas of the bladder. In this study, we investigated the expression of FGFR3, Ki-67, and p53 in bladder cancers and the effects of expression on tumor recurrence. Materials and Methods: Fifty-five cases of primary bladder cancer were examined by immunohistochemistry. The relationship of these markers with various clinicopathological factors, including recurrence, was assessed. Results: Positivity for cytoplasmic FGFR3 (FGFR3-c) was associated with a lower cancer grade (p=0.022) and stage (p=0.011). Recurrence was more frequent in patients with a higher stage, negative FGFR3-c, and high Ki-67 expression. According to univariate analysis, predictors of recurrence-free survival included the following: age, stage, FGFR-c, Ki-67, and p53. However, none of these was independent from the other parameters in multivariate studies. Conclusions: The immunohistochemical expression of FGFR3 is not only one of the characteristic features of lower-grade and lower-stage urothelial carcinoma but also a possible marker in predicting disease recurrence. Purpose: The fibroblast growth factor receptor 3 (FGFR3) gene is known to be frequently mutated in noninvasive urothelial carcinomas of the bladder. In this study, we investigated the expression of FGFR3, Ki-67, and p53 in bladder cancers and the effects of expression on tumor recurrence. Materials and Methods: Fifty-five cases of primary bladder cancer were examined by immunohistochemistry. The relationship of these markers with various clinicopathological factors, including recurrence, was assessed. Results: Positivity for cytoplasmic FGFR3 (FGFR3-c) was associated with a lower cancer grade (p=0.022) and stage (p=0.011). Recurrence was more frequent in patients with a higher stage, negative FGFR3-c, and high Ki-67 expression. According to univariate analysis, predictors of recurrence-free survival included the following: age, stage, FGFR-c, Ki-67, and p53. However, none of these was independent from the other parameters in multivariate studies. Conclusions: The immunohistochemical expression of FGFR3 is not only one of the characteristic features of lower-grade and lower-stage urothelial carcinoma but also a possible marker in predicting disease recurrence.
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이경렬,맹영희 대한자기공명의과학회 2019 Investigative Magnetic Resonance Imaging Vol.23 No.3
This study presents a case of diffuse large B cell lymphoma (DLBCL) in a 58-yearold man showing unusual manifestations mimicking chronic osteomyelitis. In this case review, we describe the imaging findings of DLBCL which mimics chronic osteomyelitis and review existing reports regarding the differential diagnosis of bone involvement of lymphoma and osteomyelitis through imaging and laboratory findings and diffusion-weighted magnetic resonance imaging (DWI) such as the advanced MRI sequence.
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장지원,맹영희,Su Wan Kim 대한흉부외과학회 2011 Journal of Chest Surgery (J Chest Surg) Vol.44 No.6
The relationship between the degree of expression of matrix metalloproteinases or tissue inhibitor of metalloproteinases and venous reflux remains to be investigated. Materials and Methods: Primary varicose vein tissues were obtained from 23 patients, 18 females and 5 males, aged from 19 to 73. Cephalic or basilic veins were obtained for the control group from 10 patients who underwent vascular access for maintenance hemodialysis. Two operative techniques (high ligation with stripping or endovenous laser coagulation) were used. The expression of matrix metalloproteinase-2 and 13 and tissue inhibitor of metalloproteinase-4 in the varicose vein group and control group was assessed semi-quantitatively by immunohistochemical slides stained with primary antibodies. Results: Twenty (87%) of the varicose vein group patients had greater or lesser saphenous vein diseases with reflux. The focal weak (+) stain for matrix metalloproteinases-2, and 13, and tissue inhibitor of matrix metalloproteinase-4 was dominant in the varicose vein group; the focal or diffuse strong stain (++ or +++) was prevalent in the control group. The differences were statistically significant (p<0.01). The degree of reflux and the duration of symptoms were not significantly related to the expression of MMP-13 (p=0.317 and p=0.654, respectively). Conclusion: Further study should be performed to investigate the relationship between the clinical characteristics related to venous hypertension or reflux and expression of MMPs and TIMP in varicose veins.
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Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma
고현민,맹영희,장보근,현창림,김영실,현진원,장원영 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.1
ackground: Aurora kinase A (AURKA), or STK15/BTAK, is a member of the serine/threonine kinase family and plays important roles in mitosis and chromosome stability. This study investigated the clinical significance of AURKA expression in colorectal cancer patients in Korea. Methods: AURKA protein expression was evaluated by immunohistochemistry in 151 patients with colorectal adenocarcinoma using tissue microarray blocks. We analyzed the relationship between clinicopathological characteristics and AURKA expression. In addition, the prognostic significance of various clinicopathological data for progression-free survival (PFS) was assessed. Also we evaluated copy number variations by array comparative genomic hybridization and AURKA gene amplification using fluorescence in situ hybridization in colorectal carcinoma tissues. Results: AURKA gene amplification was found more frequently in the 20q13.2–13.33 gain-positive group than the group with no significant gain on the AURKA-containing locus. AURKA protein expression was detected in 45% of the cases (68/151). Positive staining for AURKA was observed more often in male patients (p = .035) and distally located tumors (p = .021). PFS was shorter in patients with AURKA expression compared to those with low-level AURKA expression (p < .001). Univariate analysis revealed that AURKA expression (p = .001), age (p = .034), lymphatic invasion (p = .001), perineural invasion (p = .002), and TNM stage (p = .013) significantly affected PFS. In a multivariate analysis of PFS, a Cox proportional hazard model confirmed that AURKA expression was an independent and significant prognostic factor in colorectal adenocarcinoma (hazard ratio, 3.944; p < .001). Conclusions: AURKA could serve as an independent factor to
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