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Hypoplasia of Left Vertebral Artery with Intimal Fibromuscular Dysplasia in a Korean Woman
현창림,Hyun Sik Park,Hyun Jo Shin,윤상필 대한의학회 2012 Journal of Korean medical science Vol.27 No.7
We found a case of hypoplasia of vertebral artery with fibromuscular dysplasia in an 82-yr-old Korean female cadaver during a routine dissection course. In the present case,intracranial hypoplasia in left vertebral artery and bilateral origin of posterior inferior cerebellar artery at the vertebrobasilar junction were recognized. Histopathologically, left vertebral artery showed intimal type of fibromuscular dysplasia both in its extracranial and intracranial courses. These results indicate that the association of fibromuscular dysplasia and hypoplasia does exist in the vertebral artery, although the etiologies are not verified yet.
Conservative therapy of extensive unicystic ameloblastoma: a case report
현창림,송지영,Hyun, Chang Lim,Song, Ji-Young Korean Academy of Stomatognathic Function and Occl 2018 구강회복응용과학지 Vol.34 No.3
법랑아 세포종은 치성 상피에서 기인한 양성 종양의 일종이다. 하악골에 가장 흔하게 발생하는 양성종양이며 공격적인 성장과 국소적 침범의 특징을 가진다. 그 중 단방성 법랑아 세포종은 방사선학적으로는 단방성의 특징을 가지며 병리학적으로는 낭종의 특징을 가진다. 낭종성 법랑아 세포종의 병소의 크기가 큰 경우 감압술 및 조대술이 보존적인 치료 방법으로 사용된다. 이 치료 방법의 목적은 병소의 크기를 줄여 완전 적출이 손쉽게 하며 악안면 부위 변형이나 신경 손상을 방지하는데 있다. 본 증례에서는 병소의 크기가 큰 낭종성 법랑아 세포종을 감압술 및 조대술로 성공적으로 치료한 치험례를 논문 고찰과 함께 보고하고자 한다. Ameloblastoma is a benign neoplasm originating from odontogenic epithelium. It is the most common neoplasm in the jaws and is characterized by aggressive behavior and local invasion. Unicystic ameloblastoma (UA) has a unilocular feature in radiologic examination and a cystic feature histologically. Decompression and marsupialization are conservative method of treatment of large UA. The purpose of decompression and marsupialization are size reduction of the mass, which makes it easy to handle at total enucleation with protection of nerve damage and facial deformity. Here we report successful conservative treatment of extensive UA using decompression and marsupialization with a review of literatures.
경직장초음파유도 전립샘침생검 1,000예의 병리학적 검색:새로운 검체처리 방법의 수립 및 면역조직화학검사의 유용성 평가
현창림,이희은,김혜령,이혜승,박소연,정진행,최기영 대한병리학회 2006 Journal of Pathology and Translational Medicine Vol.40 No.6
We developed a new processing method for extended prostate needle biopsy, and evaluated diagnostic utility of routine immunohistochemistry in 1,000 consecutive unselected cases of transrectal ultrasound-guided systematic prostate biopsy. Methods : Four to five biopsy cores were embedded in one paraffin block. All the biopsy cores were immunohistochemically stained with basal cell markers. Results : The new sample processing method was technically perfect for making a diagnosis from extended prostate needle biopsy. Among 1,000 cases, there were 323 cases (32.3%) of adenocarcinoma, 5 cases of other malignant tumors, 9 cases of high-grade prostatic intraepithelial neoplasia without a carcinoma, and only 8 cases of atypical small acinar proliferation. Among the 323 cases of adenocarcinoma, there were 38 cases (11.8%) of microcarcinomas <0.1 cm and 101 cases (31.3%) of small adenocarcinomas <0.3 cm in length. In the needle biopsy specimens, 59 cases (18.3%) were classified as clinically insignificant carcinomas. Among them, 37 cases underwent radical prostatectomy, which turned out to be clinically significant carcinomas in 24 cases (64.9%). Conclusions : Routinely performed immunohistochemistry combined with the new sample processing method is very effective for detecting microscopic carcinoma foci as well as differentiating carcinoma from benign conditions mimicking cancer.
삼출성 중이염으로 환기관삽입술을 받은 소아에서 중이삼출액 내의 면역세포 유형과 환기관 이루 발생의 관계
임길채,현창림,김동영,최승효,송찬일 대한이비인후과학회 2018 대한이비인후과학회지 두경부외과학 Vol.61 No.3
Background and Objectives Tympanostomy tube insertion is one of the most commonsurgical procedures in children. Despite aseptic procedures with prophylactic antibiotic treatment,postoperative otorrhea may be encountered in some patients. The purpose of this study isto identify the relation between the types of immune cells in otitis media with effusion (OME)and tympanostomy tube otorrhea (TTO) in children. Subjects and Method Fifty-six patients underwent tympanostomy tube insertion withOME were analyzed retrospectively. Fluid from OME was harvested by suction via syringe connectorafter myringotomy. Light microscopic examination of middle ear effusion was performedby a pathologist after hematoxylin and eosin staining. We analyzed the relation between the typesof immune cells from middle ear effusion and TTO. Results Of 56 children, 36 were male and 22 were female. The mean age for tympanostomytube insertion was 3.56 (±2.63) years, with the average follow-up period of 12.56 (±9.96)months. Neutrophils were detected in 19, eosinophils in 14, lymphocytes in 22, mast cells in 2,plasma cells in 7, and histiocytes in 9. TTO occurred in 15 patients. In patients with early TTO,eosinophils were detected more frequently than in patients without TTO (p=0.006). Plasmacells were detected more frequently in patient with late TTO than without TTO (p=0.011). Conclusion According to the analysis of different types of immune cells, eosinophils in themiddle ear effusion related with the occurrence of TTO.
정원석,현창림,박민규,Jeong-Min Park,Hyun-Ouk Song,Taejin Park,Young Su Lim,조춘규,강포순,권희욱 대한마취통증의학회 2012 Korean Journal of Anesthesiology Vol.62 No.2
Background: Soman, a potent irreversible acetylcholinesterase (AChE) inhibitor, induces delayed neuronal injury by reactive oxygen species (ROS). Midazolam is used in patients with pathologic effects of oxidative stresses such as infection, hemodynamic instability and hypoxia. We investigated whether midazolam protects the Central Nervous System (CNS) from soman intoxication. The present study was performed to determine whether midazolam protects B35 cells from ROS stress for the purpose of exploring an application of midazolam to soman intoxication. Methods: Glucose oxidase (GOX) induced ROS stress was used in a B35 neuroblastoma cell model of ROS induced neuronal injury. To investigate the effect of midazolam on cell viability, LDH assays and fluorescence activated cell sorting (FACS) analysis was performed. Western blotting was used for evaluating whether Akt-phosphorylation is involved in cell-protective effects of midazolam. Results: GOX derived ROS injury decreased cell viability about 1.6-2 times compared to control; midazolam treatment (5 and 10 μg/ml) dose-dependently increased cell viability during ROS injury. On western blots, Aktphosphorylation was induced during pretreatment with midazolam; it was diminished during co-treatment with LY-294002, an inhibitor of Akt-phosphorylation. FACS analysis confirmed that the cell protective effect of midazolam is mediated by an anti-apoptotic effect. GOX-induced apoptosis was inhibited by midazolam and the finding was diminished by LY-294002. Conclusions: Midazolam protects neuronal cells from GOX-induced ROS injury; this effect is mediated by an antiapoptotic effect through Akt-phosphorylation. This shows that midazolam may be useful in soman intoxication.
고실내 덱사메타손(Dexamethasone) 주입술로 호전된 난치성 이루를 동반한 호산구성 중이염 : 사례 연구
김민범,현창림,김세형 대한이비인후과학회 부산,울산,경남 지부회 2016 임상이비인후과 Vol.27 No.2
Eosinophilic otitis media (EOM) is a newly recognized intractable middle ear disease, characterized by a highly viscous otorrhea and an accumulation of eosinophils in middle ear effusion and middle ear mucosa. Since EOM can cause gradual or sudden deterioration of hearing, it is important to properly diagnose EOM. Systemic or topical steroid administration is known as the most effective treatment for patients with EOM ; however, oral steroid therapy has the potential to cause adverse drug effects. Recently, we experienced two cases of EOM that were given intratympanic dexamethasone injection had improvement in otologic symptoms including otorrhea and hearing loss. The instillation of dexamethasone into the middle ear cavity is noninvasive and effective treatment for controlling eosinophilic inflammation in this report. Identification of the characteristic manifestations of EOM, and the consequent definite diagnosis and an adequate treatment for EOM can help prevent sensorineural hearing loss in early stage.
이희은,현창림,이유정,설혜실,장자준 대한병리학회 2006 Journal of Pathology and Translational Medicine Vol.40 No.6
An association between choledochal cyst and carcinoma is well established. Here, we report an extremely rare case of undifferentiated carcinoma exhibiting extensive sarcomatous features arising in a choledochal cyst. The patient in our case had a radiologically confirmed choledochal cyst and anomalous pancreaticobiliary ductal union, and mild wall thickening in the cyst was observed on endoscopic retrograde cholangiopancreatography. The patient underwent common bile duct excision and cholecystectomy. In the choledochal cyst, a nodule measuring 1.5×1 cm was detected. The lesion was composed of atypical, spindle-shaped and large, round pleomorphic tumor cells simulating sarcoma. Neither glandular nor squamous differentiation was observed. These cells were immunoreactive for both vimentin and cytokeratin by immunohistochemistry. These histologic and immunohistochemical findings were consistent with undifferentiated carcinoma, spindle and giant cell type, according to the WHO classification.