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다양한 코팅 처리에 의한 PEEK 추간체유합보형재의 생체 활성 표면에 관한 연구
노수빈,박수지,이문환 한국표면공학회 2023 한국표면공학회지 Vol.56 No.4
In this study, the surface of Polyetheretherketone (PEEK) disks was modified to have a hydrophilic surface by applying a coating of Polyethylene glycol (PEG), Hyaluronic acid(HA), and Poly-Dopamine(PDA). The investigation aimed to examine whether the coated surfaces showed enhanced bioactivity for orthopedic applications compared to the pure PEEK. The microstructure, surface characteristics, and wettability of PEEK coated with PEG, HA, and PDA were analyzed using scanning electron microscopy(SEM), FT-IR spectrophotometer, Roughness Measurement System, Micro-Vickers, and Contact angle measurement. The mechanical properties were analyzed using a tensile testing machine, while the MTT assay for cell activity was analyzed using a microplate reader to measure optical density. According to the SEM and FT-IR results, the composition and crystal structure of PEG, HA and PDA coated surface were verified. Also, roughness, hardness, and contact angle were all improved in the coating group compared to the pure PEEK. We checked the HepG2 cell proliferation by using MTT assay on 7th days. In MTT assay results, HepG2 cell proliferation was increased with time, at 7 days, cell viability on discs coated with PDA was significantly higher than pure PEEK, PEG, HA coated group. PDA coated PEEK exhibited the highest surface roughness, hardness, contact angle, and cell activity. The mechanical properties were not affected by the presence of the coating.
도수빈,정철훈,장용준,김병준,노영수 대한성형외과학회 2017 Archives of Plastic Surgery Vol.44 No.6
Background A pharyngocutaneous fistula is a common and difficult-to-manage complication after head and neck reconstruction. It can lead to serious complications such as flap failure, carotid artery rupture, and pharyngeal stricture, and may require additional surgery. Previous radiotherapy, a low serum albumin level, and a higher T stage have been proposed as contributing factors. We aimed to clarify the risk factors for pharyngocutaneous fistula in patients who underwent flap reconstruction and to describe our experiences in treating pharyngocutaneous fistula. Methods Squamous cell carcinoma cases that underwent flap reconstruction after cancer resection from 1995 to 2013 were analyzed retrospectively. We investigated several significant clinical risk factors. The treatment modality was selected according to the size of the fistula and the state of the surrounding tissue, with options including conservative management, direct closure, flap surgery, and pharyngostoma formation. Results A total of 127 cases (18 with fistulae) were analyzed. A higher T stage (P=0.048) and tube-type reconstruction (P=0.007) increased fistula incidence; other factors did not show statistical significance (P>0.05). Two cases were treated with conservative management, 1 case with direct closure, 4 cases with immediate reconstruction using a pectoralis major musculocutaneous flap, and 11 cases with direct closure (4 cases) or additional flap surgery (7 cases) after pharyngostoma formation. Conclusions Pharyngocutaneous fistula requires global management from prevention to treatment. In cases of advanced-stage cancer and tube-type reconstruction, a more cautious approach should be employed. Once it occurs, an accurate diagnosis of the fistula and a thorough assessment of the surrounding tissue are necessary, and aggressive treatment should be implemented in order to ensure satisfactory long-term results.
이동걸,임승철,노성우,임수빈,권양,권병덕,Lee, Dong Girl,Rhim, Seung Chul,Roh, Sung Woo,Im, Su Bin,Kwon, Yang,Kwun, Byung Duk 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.2
Vertebral artery injury is a rare complication of anterior cervical approach. We report two patients who suffered injury to vertebral artery during anterior cervical spine surgery. The mechanism of injury, their operative management, and the subsequent outcome were assessed and relevant literatures reviewed. The awareness of the possibility of vertebral artery injury is most important to prevent and it's occurrence is best avoided by a thorough understanding of the anatomical relationships of the artery, the spinal canal, and the vertebral body and careful use of surgical instruments.
고윤석,류진숙,임수빈,임승철,노성우 대한외상학회 2000 大韓外傷學會誌 Vol.13 No.1
Background: Among various complications during the management of patients with multiple injurles, pulmonary embolism (PE) is known to be rare, but catastrophic, despite aggressive treatment. We present a case control study comparing the occurrence of PE in patients with spinal injury who underwent surgery with that of patient in a control group to determine its incidence and to suggest guidelines for treating this lethal complication. Methods: A prospective analysis of a total of 98 patients (27 spinal-injury and 71 control-group patients) was done during the last 3.5 years. The control group consisted of 71 patients who had undergone spinal surgery due to non-traumatic etiology (degenerative disc disease, 51; infection, 8; instability, 7; and tumor, 5). To detect the PE, we carried out a perfusion/ventilation lung scan preoperatively and one week postoperatively. The incidence of PE and its outcome after treatment were analyzed. A statistical analysis was performed. Results: The incidence of PE in patients with spinal injury was 18.5% (5/27 patients); that of the control group was 1.4% (1/71 patients) (p $lt; 0.05). The PE was detected in 2 patients preoperatively and in 4 patients postoperatively. Among these 6 patients, three were symptomatic. All the patients with PE showed marked improvement clinically and on follow-up perfusion/ventilation lung scan after high-dose heparin therapy for 7-10 days. Conclusions: The results of the present study indicate that PEs develop so frequently in patients with spinal injury that early detection may be possible using a perfusion/ventilation lung scan. Also high-dose heparin therapy was an effective treatment for a PE.
Low-Dye 테이핑 적용이 아치회복운동을 시행한 편평족의 장딴지근력에 미치는 효과
박재규,김광록,김건우,김민지,노수빈,성누가,김진아,Park, Jae-Gyu,Kim, Gwang-Rok,Kim, Gun-Woo,Kim, Min-Ji,No, Su-Bin,Sung, Nu-Ga,Kim, Jin-A 한국임상보건과학회 2016 한국임상보건과학회지 Vol.4 No.3
Purpose. The purpose of this study was to progress the effect of gastrocnemius strength when groups are applicated on low-dye taping group and without taping group of flatfoot with arch-recovery exercise. Methods. Subjects were measured navicular drop test to confirm of 16 university student in J city, low-dye taping group and without taping group were applicated both with arch-recovery exercise, three times per a week for four weeks. The power track were measured four weeks, total 3 times. Comparative analysis of the control group and experimental group were investigated of gastrocnemius strength. Results. The results, we found that after of arch-recovery exercise were significantly increased than before of arch-recovery exercise in each foot. And application of low-dye taping(experimental group) in flatfoot with arch-recovery exercise were significantly increased than control group. Conclusions. In conclusion, the arch-recovery exercise application were effective to low-dye taping significantly increase the gastrocnemius strength of flatfoot.