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노덕영 ( Duck Yeong Ro ),신화정 ( Hwa Jeong Shin ),김길중 ( Gil Joong Kim ),권지영 ( Ji Young Kwon ),박철훈 ( Cheol Hoon Park ),김용욱 ( Yong Wook Kim ),김태웅 ( Tae Eung Kim ),정재근 ( Jae Keun Jung ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.9
Carcinomas of Bartholin`s gland are rare tumors that account for less than 1% of all gynecological malignancies. Two major histological types, squamous cell carcinoma and adenocarcinoma, account for 80% to 90% of primary cases. The remainders are adenosquamous carcinoma, adenoid cystic carcinoma and so on. We experienced a case of squamous cell carcinoma of the Bartholin`s gland managed by wide local excision and chemotherapy with cisplatin and 5-fluorouracil (5-FU). We present this case with a brief review of the leteratures.
정상 임신과 비정상 임신의 초기 혈중 CA - 125 수치에 관한 연구
노덕영(Duck Yeong Ro),김도강(Do Kang Kim),김수평(Soo Pyung Kim),문희봉(Hee Bong Moon),강규섭(Gyu Sub Kang),황지영(Jee Young Hwang),신봉영(Bong Young Shin),장병우(Byeung Woo Jang) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.11
N/A A prospective study was initiated to compare maternal serum concentration of CA-125 during the first trimester of normal and abnormal pregnancies. Serum specimens were obtained from 87 women with a normal intrauterine pregnancy and 47 women with abnormal pregnancies which were ended in spontaneo abortion or pathologically confirmed to be missed abortion. In normal pregnancies, the mean serum CA-125 concentrations were increased significantly from amenorhea 6 weeks (139.838.7 IU/ml), and were higher statistically than the values tested in the same weeks of abnormal pregnancies. In abnormal pregnancies serum CA-125 concentations were relatively lower than those of normal pregnancies. But these differences were not statistically significant except the values tested in amenorhea 6weeks. So serum levels of CA-125 may not be proved useful in monitoring of early pregnancies outcome.
노덕영 ( Duck Yeong Ro ),김용욱 ( Yong Wook Kim ),김태응 ( Tae Eung Kim ),이혜영 ( Hye Young Lee ),정동섭 ( Dong Sup Chung ),이안희 ( Ah Hi Lee ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.1
With the exception of choriocarcinoma, the central nervous system (CNS) is rarely associated with metastases from gynecological malignancy. Cerebral involvement in ovarian carcinoma is generally regarded as occurring in 1% of cases. Overall incidence of c
임신능이 확인된 가임 여성에서의 Deciduosis의 유병율
김미란,유영옥,노덕영,류순원,권동진,김장흡,김진홍,임용택,김은중,정재근,이진우,Kim, Mee-Ran,Lew, Young-Oak,Ro, Duck-Yeong,Ryu, Sun-Won,Kwan, Dong-Jin,Kim, Jang-Heub,Kim, Jin-Hong,Lim, Yong-Taik,Kim, Eun-Jung,Jung, Jae-Keun,Lee, Jin-Woo 대한생식의학회 2000 Clinical and Experimental Reproductive Medicine Vol.27 No.4
Objective: Extrauterine formation of decidua of stromal cells has been well described, particularly in the cervix and ovary. The apparent hormonal mechanisn of this phenomenon suggestes a relationship to endometriosis. Whether formation of ectopic decidua represents a marked progestational response of endometriosis or an independent peritoneal-stromal reaction to pregnancy is unclear. This study was designed to determine the prevalence of deciduosis in the patients whose fertility were proven. Design: Prospective study of patients who had undergone cesarean delivery without history of endometriosis. Materials and Methods: The study was performed in 179 full tenn pregnant women. During the cesarean section, the pelvic organs were thoroughly investigated and the biopsies were collected at the lesions suspicious endometriosis. And then microscopic examination of removed tissues were done. Results: Of the 179 patients who underwent cesarean delivery, 48 women (26.8%) had the lesions suspicious endometriosis such as adhesion, pigmented spots. The ovary was the most frequently ocurred site (79.2%). Microscopically, decidual cells were observed in 34 cases (70.8%) of 48 biopsed patients. Conclusion: Endometriosis has been known to be associated with subfertility. Our observations found the prevalence of deciduosis was 19.0% (34/179) in tenn pregnant women whose fertilites were proven. We suggests that the deciduosis maya manifestation of endometriosis during pregnancy. However, further follow up study should be done to confirm this clinicopathologic process.
자궁경부암 조직에서 미세절제술을 이용한 아데노 연관바이러스와 고위험군 인유두종 바이러스의 상관관계
정재은 ( Jae Eun Chung ),노덕영 ( Duck Yeong Ro ),배정훈 ( Jeong Hoon Bae ),진동근 ( Dong Kun Jin ),이상형 ( Sang Hyung Lee ),고현선 ( Hyun Sun Ko ),배수미 ( Su Mi Bae ),이헌경 ( Hyun Kyung Lee ),김병기 ( Byung Kee Kim ),김종국 ( 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.2
목적 : 아데노연관바이러스 (adeno-associated virus : AAV)는 인체 DNA 바이러스로서 Parvo virus family에 속한다. 최근 여러 연구에 의해서 자궁조직에서 AAV의 DNA가 존재하는 것이 보고되었다. 또한 in vitro에서 AAV 감염이 자궁경부암 세포주의 성장을 억제한다는 보고와 AAV가 HPV와 역 감염관계 (negative infection)에 있다는 보고가 있다. 본 연구는 한국여성의 자궁경부 조직에서 AAV Objective : Adeno associated virus (AAV) is a human DNA virus and is included in the Parvovirus family. AAV has been detected in cervical tissues as well as cervical cancer cell lines. Previous studies showed that AAV infection has some negative effects o
기은영 ( Eun Young Ki ),노덕영 ( Duck Yeong Ro ),김효진 ( Hyo Jin Kim ),박병준 ( Byung Joon Park ),김용욱 ( Yong Wook Kim ),김태응 ( Tae Eung Kim ),정재근 ( Jae Keun Jung ),이안희 ( An Hi Lee ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.1
Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix, also called lymphoepithelioma or medullary carcinoma, is a very rare variant of squamous cell carcinoma. Histologically, the tumor is characterized by groups and nests of poorly differentiated tumor cells with abundant cytoplasm and ill-defined cell borders, surrounded by an intense chronic inflammatory infiltrate. Epstein-Barr virus (EBV) may be involved in the development of LELC but the exact role remains unclear. The relationship between human papillomavirus (HPV) and LELC of the uterine cervix has also not been reported. The prognosis of LELC of the uterine cervix seems to be better than that of cervical squamous cell carcinoma. We report a case of LELC of the uterine cervix with a brief review.
임선옥 ( Sun Ok Lim ),기은영 ( Eun Young Key ),노덕영 ( Duck Yeong Ro ),박병준 ( Byung Joon Park ),김용욱 ( Yong Wook Kim ),김태응 ( Tae Eung Kim ),정재근 ( Jae Keun Jung ),한치화 ( Chi Wha Han ),이안희 ( An Hi Lee ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.10
Primary malignant lymphoma of the uterine cervix is very rare. Lymphomas account for 3.5% of all malignant tumors in the females. Approximately, 25% of all malignant lymphomas arise from extranodal sites, most frequently from gastrointestinal tract and skin. Although the incidence of systemic non-Hodgkin`s lymphoma (NHL) and extranodal NHL has increased in recent decades, only 1 to 1.5% arises from female genital tract. Primary pelvic sites include ovary, which is the most common site, uterine corpus, cervix, vagina, and vulva. Primary cervical lymphomas account for 0.12~0.6% of all extranodal lymphomas. However, there is still no consensus on the management of cervical lymphomas due to low incidence of the disease and limited experience in the literature. We experienced two cases of primary malignant lymphoma of the uterine cervix. A 41-year-old woman, Ann Arbor stage IE, was treated with laparoscopically assisted vaginal hysterectomy and both salpingo-oophorectomy and 4 cycles chemotherapy. A second case was a 73-year-old postmenopausal woman, Ann Arbor stage III, received five courses chemotherapy without any surgery. In this article, two cases of uterine cervical lymphoma are presented with a review of the available literature.
SiHa 자궁경부암 세포주에서 인유두종바이러스 16형 E6/E7 siRNA에 의한 세포성장 억제 비교
박세현 ( Sae Hyun Park ),박병준 ( Byung Joon Park ),김용욱 ( Yong Wook Kim ),노덕영 ( Duck Yeong Ro ),김태응 ( Tae Eung Kim ),정재근 ( Jae Keun Jung ),배수미 ( Su Mi Bae ),안웅식 ( Woong Shick Ahn ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.1
목적: 인유두종바이러스 (Human papillomavirus, HPV)는 자궁경부암과 밀접한 관계가 있는 것으로 알려져 있으며, 특히 인유두종바이러스 16형은 고위험군 바이러스로 분류된다. 인유두종바이러스 16형의 암 유전자 E6와 E7의 발현 저해에 따른 자궁경부암 세포주내의 발암 유전자 특이적 변화를 확인하고자 하였다. 연구 방법: 인유두종바이러스 16형을 발현하는 자궁경부암 SiHa 세포주에서 E6 유전자에 특이적으로 작용하는 인유두종바이러스 16형 E6 siRNA (siRNA 377)와 E6와 E7 유전자에 동시에 작용하는 인유두종바이러스 16형 E6 siRNA (siRNA 3)와 인유두종바이러스 16형 E7 siRNA (siRNA 198)를 사용하였다. 각각의 siRNA를 SiHa 세포주에 이입 (transfection)시킨 후, 24시간과 48시간 후에 세포수 및 세포형태의 변화를 관찰하였다. 또한 E6와 E7에 대한 RT-PCR을 실시하여 인유두종바이러스 16형 E6, E7 siRNA의 유전자 발현 저해 정도를 확인하였다. 결과: 3종류의 siRNA 모두 세포성장 저해 효과를 나타내었으며, siRNA 377에 비해 siRNA 3와 siRNA 198의 세포성장 억제효과가 더 크게 나타났다. siRNA 377은 E6 mRNA만의 발현을 감소시켰고 siRNA 3과 siRNA 198은 E6와 E7 mRNA의 발현을 동시에 감소시켰다. 결론: 인유두종바이러스 16형이 감염된 자궁경부암 SiHa 세포주에서 E6 유전자만의 억제보다는 E6와 E7 유전자를 동시에 억제하는 것이 더 큰 세포 성장 억제를 보였다. Objective: Human cervical cancer is caused by the high-risk types of human papillomavirus (HPV) such as HPV16, which possess the E6 and E7 oncogenes, whose expressions are a prerequisite for cancer development. We performed this study to compare the efficacy of antitumor activity by HPV siRNA which silences only E6 or both E6/E7. Methods: We transfected siRNA 377 (HPV16 E6 siRNA), siRNA 3 (HPV16 E6 siRNA), and siRNA 198 (HPV16 E7 siRNA) into SiHa cell line (siRNA 377 silences only E6, and siRNA 3 and siRNA 198 silence both E6 and E7). We experimented cell counts and morphologic changes 24 and 48 hours after transfection and expressions of HPV16 E6/E7 mRNA by RT-PCR. Results: siRNA 377, siRNA 3, and siRNA 198 suppressed the cell growth. siRNA 3 and siRNA 198 were more potent than siRNA 377 in cell growth suppression. siRNA 377 knocked down the expression of E6 mRNA, and both siRNA 3 and siRNA 198 knocked down the expression of E6/E7 mRNA. Conclusion: Our results suggest that simultaneous suppression of E6 and E7 was more potent than E6-specific suppression in cancer cell growth.
단일공법 복강경하 질식자궁절제술 110예의 고찰 및 다공법과의 비교
박병준 ( Byung Joon Park ),김용욱 ( Yong Wook Kim ),노덕영 ( Duck Yeong Ro ),김태응 ( Tae Eung Kim ),류기성 ( Ki Sung Ryu ),김장흡 ( Jang Heup Kim ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.7
목적: 통상적인 복강경기구만을 사용한 단일공법 복강경하 질식자궁절제술을 다공법 복강경하 질식자궁절제술과 비교하여 안전성 및 유용성을 평가하고자 하였다. 연구 방법: 2007년 4월부터 2009년 11월까지 인천성모병원에서 자궁근종 또는 자궁샘근증의 질환으로 단일공법 복강경하 질식 자궁절제술을 시행받은 환자 110명과 다공법 복강경하 질식자궁절제술을 시행받은 환자 110명, 총 220명의 환자를 대상으로 하였다. 우리는 모든 수술에서 통상적으로 사용되는 구부러지지 않는 일직선의 복강경기구를 사용하였다. 또한 단일공법 및 다공법 복강경하 질식자궁절제술 둘 다에서 수술자 (Kim, YW)의 이름을 따서 명명한 새로운 질단부 봉합 방법인 김씨 질구개 현수법 (Kim`s Vaginal Vault Suspension Method)을 사용하였다. 결과: 환자 나이, 수술 시간, 자궁의 무게, 혈색소 수치의 변화, 수혈 빈도, 수술 후 발열에서 두 군 간에 유의한 차이를 보이지 않았다. 환자들의 평균 나이는 46.7±7.0세(단일공법)와 45.5±6.3세(다공법)이었다. 평균 수술 시간은 87.2±21.0분(단일공법)과 83.3±20.3분(다공법), 평균 자궁의 무게는 261.4±139.7 g(단일공법)과 257.8±132.9 g(다공법), 평균 혈색소 수치의 변화는 1.1±0.7 g/dL(단일공법)와 1.2±0.6 g/dL(다공법)이었다. 두 군 모두에서 수술 중 장 또는 요로의 손상은 없었다. 두 군 모두에서 각각 한 건의 개복수술로의 전환이 있었다. 단일공법을 시행한 군에서 입원 기간이 유의하게 짧았다(2.6±0.6일 [단일공법], 3.3±0.7일 [다공법], P<0.05). 결론: 통상적으로 사용하는 구부러지지 않는 일직선의 복강경기구를 이용한 단일공법 복강경하 질식자궁절제술은 다공법 복강경하 질식자궁절제술에 대한 안전하고 유용한 대체 수술이 될 수 있다. Objective: To evaluate the safety and feasibility of single-port access laparoscopically assisted vaginal hysterectomy (SPA-LAVH) using conventional laparoscopic instruments compared to multi-port access laparoscopically assisted vaginal hysterectomy (MPA-LAVH). Methods: We reviewed the medical records of 220 patients with uterine leiomyoma or adenomyosis who underwent 110 SPA-LAVH and 110 MPA-LAVH in Incheon St. Mary`s Hospital between April 2007 and November 2009. We performed SPA-LAVH with conventional rigid straight laparoscopic instruments in all cases. We also performed a new vaginal cuff closure method, Kim`s Vaginal Vault Suspension Method, named after the operator (Kim, YW) in both SPA-LAVH and MPA-LAVH. Results: There was no significant difference in patients` age, operating time, uterine weight, hemoglobin change, frequency of blood transfusion, and incidence of postoperative fever between the two groups. The patients` mean age was 46.1±7.0 years (SPA-LAVH) and 45.5±6.3 years (MPA-LAVH). The mean operating time was 87.2±21.0 minutes (SPA-LAVH) and 83.3±20.3 minutes (MPA-LAVH). The mean uterine weight was 261.4±139.7 g (SPA-LAVH) and 257.8±132.9 g (MPA-LAVH). The mean hemoglobin change was 1.1±0.7 g/dL (SPA-LAVH) and 1.2±0.6 g/dL (MPA-LAVH). Neither bowel injury nor urinary tract injury occurred during the operation in the two groups. One of the SPA-LAVH and one of the MPA-LAVH cases were converted to abdominal total hysterectomy. The mean hospital stay time was shorter with SPA-LAVH (2.6±0.6 days [SPA-LAVH] and 3.3±0.7 days [MPA-LAVH], P<0.05). Conclusion: SPA-LAVH using conventional rigid straight laparoscopic instruments can be offered as a safe and feasible alternative to MPA-LAVH.