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박세현 ( Sae Hyun Park ),박병준 ( Byung Joon Park ),김용욱 ( Yong Wook Kim ),김태응 ( Tea Eung Kim ),맹이소 ( Lee So Maeng ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.12
The mature cystic teratoma of the ovary (ovarian dermoid cyst) is the most common ovarian neoplasm in young women and comprises approximately 10~25% of all ovarian tumors. There are many complications such as torsion, rupture, infection, suppuration, and rarely malignancy change. Teratoma derives from the three embryonic cell lines and may contain skin, sebaceous tissue, hair, cartilage and bone, neuroglial tissue, gastrointestinal and respiratory tissue, teeth, and muscle. Even though the presence of dental tissue within dermoid cysts has been reported in the literature, the cysts containing jaw bone and teeth are extremely rare. We report a case of ruptured ovarian dermoid cyst containing jaw bones and eight well-formed teeth with a brief review of literature.
SiHa 자궁경부암 세포주에서 인유두종바이러스 16형 E6/E7 siRNA에 의한 세포성장 억제 비교
박세현 ( Sae Hyun Park ),박병준 ( Byung Joon Park ),김용욱 ( Yong Wook Kim ),노덕영 ( Duck Yeong Ro ),김태응 ( Tae Eung Kim ),정재근 ( Jae Keun Jung ),배수미 ( Su Mi Bae ),안웅식 ( Woong Shick Ahn ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.1
목적: 인유두종바이러스 (Human papillomavirus, HPV)는 자궁경부암과 밀접한 관계가 있는 것으로 알려져 있으며, 특히 인유두종바이러스 16형은 고위험군 바이러스로 분류된다. 인유두종바이러스 16형의 암 유전자 E6와 E7의 발현 저해에 따른 자궁경부암 세포주내의 발암 유전자 특이적 변화를 확인하고자 하였다. 연구 방법: 인유두종바이러스 16형을 발현하는 자궁경부암 SiHa 세포주에서 E6 유전자에 특이적으로 작용하는 인유두종바이러스 16형 E6 siRNA (siRNA 377)와 E6와 E7 유전자에 동시에 작용하는 인유두종바이러스 16형 E6 siRNA (siRNA 3)와 인유두종바이러스 16형 E7 siRNA (siRNA 198)를 사용하였다. 각각의 siRNA를 SiHa 세포주에 이입 (transfection)시킨 후, 24시간과 48시간 후에 세포수 및 세포형태의 변화를 관찰하였다. 또한 E6와 E7에 대한 RT-PCR을 실시하여 인유두종바이러스 16형 E6, E7 siRNA의 유전자 발현 저해 정도를 확인하였다. 결과: 3종류의 siRNA 모두 세포성장 저해 효과를 나타내었으며, siRNA 377에 비해 siRNA 3와 siRNA 198의 세포성장 억제효과가 더 크게 나타났다. siRNA 377은 E6 mRNA만의 발현을 감소시켰고 siRNA 3과 siRNA 198은 E6와 E7 mRNA의 발현을 동시에 감소시켰다. 결론: 인유두종바이러스 16형이 감염된 자궁경부암 SiHa 세포주에서 E6 유전자만의 억제보다는 E6와 E7 유전자를 동시에 억제하는 것이 더 큰 세포 성장 억제를 보였다. Objective: Human cervical cancer is caused by the high-risk types of human papillomavirus (HPV) such as HPV16, which possess the E6 and E7 oncogenes, whose expressions are a prerequisite for cancer development. We performed this study to compare the efficacy of antitumor activity by HPV siRNA which silences only E6 or both E6/E7. Methods: We transfected siRNA 377 (HPV16 E6 siRNA), siRNA 3 (HPV16 E6 siRNA), and siRNA 198 (HPV16 E7 siRNA) into SiHa cell line (siRNA 377 silences only E6, and siRNA 3 and siRNA 198 silence both E6 and E7). We experimented cell counts and morphologic changes 24 and 48 hours after transfection and expressions of HPV16 E6/E7 mRNA by RT-PCR. Results: siRNA 377, siRNA 3, and siRNA 198 suppressed the cell growth. siRNA 3 and siRNA 198 were more potent than siRNA 377 in cell growth suppression. siRNA 377 knocked down the expression of E6 mRNA, and both siRNA 3 and siRNA 198 knocked down the expression of E6/E7 mRNA. Conclusion: Our results suggest that simultaneous suppression of E6 and E7 was more potent than E6-specific suppression in cancer cell growth.
임희순 ( Hee Sun Im ),박세현 ( Sae Hyun Park ),이재동 ( Jae Dong Lee ),김종옥 ( Jong Ok Kim ),박은경 ( Eun Kyung Park ),이용석 ( Yong Seok Lee ),이해남 ( Hae Nam Lee ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.12
Isolated torsion of the fallopian tube is very uncommon during pregnancy. It usually confuses with acute appendicitis and torsion of the ovary. The diagnosis is usually established during operation, and a salpingectomy is almost always necessary. However, the early diagnosis and surgical treatment of the disease are mandatory to preserve oviduct. Because of safety and feasibility, laparoscopic surgery has recently become major treatment method.
서민정 ( Min Jung Suh ),이성하 ( Sung Ha Lee ),김두만 ( Du Man Kim ),국일영 ( Ill Young Kook ),박세현 ( Sae Hyun Park ),박동춘 ( Dong Choon Park ),김대훈 ( Dae Hoon Kim ),윤주희 ( Joo Hee Yoon ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.6
Malignant neoplasm of the fallopian tube is the rarest of the gynecologic cancers. Vaginal bleeding, vaginal discharge, and pelvic pain are the most common symptoms. Because of these non-specific symptoms, the diagnosis of this Least common neoplasm is rarely made before Laparotomy. The tumor is typically unilateral and has histologic subtypes, endometrioid and serous adenocarcinoma being the most common subtypes. Surgery, clearly the mainstay of treatment, is also the first approach to diagnosis. The procedure of choice is total abdominal hysterectomy with bilateral salpingo-oopho-rectomy. We had experienced one patient with primary tubal cancer, successfully evaluated with Laparoscopy. And then we intend to report the case of the above patient and have a brief discussion about that.