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어린이집 만 4세 유아의 순수 놀이공간 및 놀이성과 놀이행동 간의 관계
남진경(Jin Kyung Nam),김명순(Myoung Soon Kim) 한국아동학회 2014 아동학회지 Vol.35 No.2
The purpose of this study was to investigate the relationships between play behaviors and young children`s playfulness in a variety of play space environments. The subjects were 150 4-year old children of 29 mixed-age classes in childcare centers of Seoul and Gyeonggi area. The results were as follows; (1) Their play behaviors differed according to their play environment in terms of classroom spaces. Solitary-active play behaviors were more frequently observed in large play spaces than small. (2) Leading participation, cognitive flexibility, voluntary full immersion, and total playfulness scores correlated negatively with reticent behavior. Leading participation, voluntary full immersion, and total playfulness scores, on the other hand, correlated positively with group play behavior. (3) In small play spaces, leading participation, voluntary full immersion correlated negatively with reticent behavior, but leading participation correlated positively with group play. In middle play spaces, cognitive flexibility correlated negatively with reticent behavior. In large play spaces, voluntary full immersion correlated negatively with parallel play, but leading participation, cognitive flexibility, expressions of joy, voluntary full immersion, and total playfulness score correlated positively with group play.
실외놀이터 놀이 영역과 영유아 놀이행동 및 신체활동성 간의 관계
김명순 ( Kim Myoung Soon ),신혜영 ( Shin Hye Young ),신보원 ( Shin Bo Won ),남진경 ( Nam Jin Kyung ) 한국유아교육학회 2021 유아교육연구 Vol.41 No.3
본 연구에서는 실외놀이터의 놀이영역과 영유아의 놀이행동 및 신체활동성 간의 관계를 파악하고자 하였다. 이를 위해 서울시 S구에 위치한 대학 부설 교육기관에 재원 중인 영유아 140명을 대상으로, 기관 내 환경적 특성이 다르게 구성된 4개 실외놀이터에서 놀이행동을 관찰하고, 동작가속도계를 착용하도록 하여 신체활동성을 측정하였다. 수집된 자료로 SPSS 25.0 프로그램을 통해 상관 관계를 분석한 결과, 실외놀이터 놀이영역에 따라 영유아의 놀이행동 및 신체활동성 간의 관계성이 다양하게 나타났다. 연구 결과를 바탕으로 기관에서 영유아 놀이 지원 및 신체활동성 향상을 위한 실외놀이터 환경 조성 방안을 논의하였다. This study attempted to understand the relationship of the outdoor playground areas and children’s play behaviors and physical activity. The subjects of this study were 140 children aged 2-5 who attended a university-affiliated educational institution located in Seoul. Their play behaviors were observed in the institution’s 4 playgrounds equipped with different environmental characteristics, and their physical activity was measured via accelerometers. The collected data were analyzed for correlation through the SPSS 25.0 program. The findings revealed a variety of relationships among children’s play behaviors and physical activity according to the outdoor playground areas. Based on the results, this study discussed practicable methods to create playground environment that can support children’s play and promote physical activity.
제산제 탄산수산화마그네슘의 최적 제조조건 추구 및 분체학적 성질
남진경,이계주 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-
Magnesium carbonate hydroxide (hydrotalcite) was synthesized to pursue the optimum conditions having the highest acid consuming capacity by a Box-Wilson experimental design, and micromeritical properties of samples were evaluated by laser particle size analyzer, SRD, BET system, mercury porosimeter, and several adsorption capacity test. The optimum preparation conditions for hydrotalcite were as followwws: concentration of aluminum hydroxide and magnesium hydroxide 1.17mole, reaction temp. 82.6℃, reaction time 2.32hr, ratio of (Al(OH)_3/Mg(OH)_2 4.25, drying temperature 93.2℃ respectively, and its acid consuming capacity was 286ml/g. the neutralization curve shows that sample whose acid consuming capacity was the highest has the best neutralizing capacity and duration capacity. The crystalline form of the synthesized hydrotalcite was identified with a hexagonal system, and the d (003) spacing value of three samples was large. a part of alumina crystal form was shown at 2θ=18°, 38° in sample 3. The micromeritical properties of the synthesized hydrotalcite has no relation with an acid consuming capacity, and there was a tendency that the higher the acid consuming capacity is the larger the particle size and the narrower the size distribution. The values of pore invasive volume, pore area and specific surface area of sample 1 were small among three samples. Isotherm by BET system forms hyteresis loop and it shows the synthesized hydrotacite was porous. the pore diameter was about 10Å and it verifies mesopore. The adsorption capacity measured by methylene blue has no relation with acid consuming capacity. The adsorption of quinine sulfate in aqueous solutuion was identical with the Langmuir isotherm.
Fe^(+)³과의 혼합물을 이용한 알렌드로네이트의 흡광도 변화
송지근,남진경,조정원 충남대학교 약학대학 의약품개발연구소 2009 藥學論文集 Vol.24 No.-
Alendronate, one of bisphosphonates is widely used in the clinical treatment of systemic metabolic diseases, such as osteoporosis and Paget's disease as well as the sequela of malignancies including hypercalcemia. However, alendronate has no chromophore, so the method of derivatization with FMOC(9-fluorenylmethyl chloroformate) in a citrate buffer(pH 11.9) using HPLC was developed. In this study, we developed UV-VIS spectrophotometric assays for availability, simplicity and cost-effectiveness of the required instrumentation. The stoichiometric ratio of alendronate to Fe^(+3) in the chromophoric complex was determined to be 1:1.
tert-Butyl Hydroperoxide로부터 유도된 산화 스트레스에 대한 Catechol의 보호효과
신동희,남진경,박창식,고지훈,명평근 충남대학교 약학대학 의약품개발연구소 2009 藥學論文集 Vol.24 No.-
This study was to evaluate the protective effects of the catechol compound of Camellia japonica leaf on the tert-butyl hydroperoxide(t-BHP) induced oxidative injury in mice. To examine the in vitro effects of catechol on oxidative stress, human hepatoma cell line, Hep G2 was used and the tetrazolium dye colorimetric test(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT) assay was employed to monitor cytotoxicity. The in vivo study was carried out by administering catechol(0.01, 0.1, 1mg/kg b.w.) by orally for 5 days before a single dose of t-BHP(1.5 mmol/kg i.p.). When the concentration of catechol pretreatment was increased, the liver MDA level was decreased. It was shown that catechol treatment did not alter the serum levels of the hepatic enzyme markers such as aspartate amino-transferase(AST) and alanine aminotransferase(ALT). Next, expression of antioxidant enzymes in liver after catechol treatment were studied using RT-PCR. The liver mRNA expression for antioxidant enzymes; such as Cu/Zn SOD or extracellular SOD were increased after catechol treatment group. These results suggest that catechol may have a potential role in the prevention of oxidative damage of liver in living organism.
강원호,심희옥,남진경,김동출 忠南大學校 生命科學硏究院 醫藥品開發硏究所 2006 藥學論文集 Vol.21 No.-
A reversed phase HPLC method was developed and validated for the determination of nimodipine in human plasma. Nitrendipine was used as an internal standard. Calibration curves were linear in the concentration range of 5~300 ng/ml. The coefficient of variation of the intra- and inter-day precision was below 15%. The coefficient of variation of the accuracy was below 15% in the concentration range investigated. A bioavailability study was performed using the validated HPLC method. Eight healthy male volunteers were orally administered 30 mg of nimodipine. The pharmacokinetic parameters were calculated using WinNonlin. The mean values of AUC_(24hr) was 64.0±31.3 ng·hr/ml, C_(max) was 46.5±31.2 ng/ml, T_(max) was 0.54±0.17 hr and t_(1/2) was 3.03±2.26 hr. The pharmacokinetic parameters and the HPLC method can be used for the design of bioequivalence study of nimodipine.
금창구,서재석,남진경,이은주,조정원 충남대학교 약학대학 의약품개발연구소 2010 藥學論文集 Vol.25 No.-
Paclitaxel (PTX) is an anti-cancer agent extracted from the bark of the Pacific yew (Taxus brevifolia). In clinical trials, PTX has demonstrated significant activity against a variety of tumors such as drug-resistant ovarian cancer, metastatic breast cancer, non-small cell lung cancer and AIDS related Kaposi's sarcoma. However, the bioavailability of PTX is mainly limited by cytochrome P450 activity in gut wall and liver, and drug transporters, such as P-gp in gut wall and liver. As well as, PTX is very poor soluble in water (<0.5 mg/L) and other pharmaceutically acceptable solvents. The commercial formulation of PTX consists of micellar solution of the drug in cremophor EL (polyoxyethylated castor oil) containing 50% absolute ethanol. However, it is well known that the use of cremophor EL is associated with hypersensitivity reactions, neurotoxicity and nephrotoxicity and also the solubility of PTX is increasing with the addition of citric acid. Therefore, this study is to optimize the mixing order of individual components for stabilized paclitaxel injection.