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Fe^(+)³과의 혼합물을 이용한 알렌드로네이트의 흡광도 변화
송지근,남진경,조정원 충남대학교 약학대학 의약품개발연구소 2009 藥學論文集 Vol.24 No.-
Alendronate, one of bisphosphonates is widely used in the clinical treatment of systemic metabolic diseases, such as osteoporosis and Paget's disease as well as the sequela of malignancies including hypercalcemia. However, alendronate has no chromophore, so the method of derivatization with FMOC(9-fluorenylmethyl chloroformate) in a citrate buffer(pH 11.9) using HPLC was developed. In this study, we developed UV-VIS spectrophotometric assays for availability, simplicity and cost-effectiveness of the required instrumentation. The stoichiometric ratio of alendronate to Fe^(+3) in the chromophoric complex was determined to be 1:1.