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유체-구조 연성해석 기법을 이용한 LNG 화물창 강도평가
박준형(Jun-Hyeong Park),남재형(Jae-Hyung Nam),김성훈(Seong-Hoon Kim),오병택(Byung-Taek Oh),양영철(Young-Chul Yang),전인기(In-Ki Jun) 대한기계학회 2018 대한기계학회 논문집. Transactions of the KSME. C, 산업기술과 혁신 Vol.6 No.1
이 연구의 목적은 슬로싱 현상에 의한 CCS 강도평가를 위해 FSI 수치방법을 사용하여 계산된 슬로싱 압력의 유효성을 검증하는 것이다. FSI 슬로싱 해석을 위해, 상용소프트웨어인 STAR-CCM+과 ABAQUS를 사용하였으며, 1-way FSI와 2-way FSI 해석방법에 따른 슬로싱 압력을 비교하였다. 그 다음 슬로싱 압력에 의한 CCS 시스템의 구조안전성 결과를 평가하였다. The purpose of this study is to evaluate the validity of the sloshing pressure calculated by the FSI numerical method for the structurul strength assessment of CCS system on sloshing-phenomenon. For FSI sloshing analysis, we used both Star-CCM+ and Abqus in commercial software and compare sloshing pressure according to 1-way and 2-way FSI analysis methods. Then we evaluated the structural safety of CCS system by sloshing pressure.
천식 환자에서 집먼지진드기 감작 유무에 따른 임상적 차이: 순천향 코호트 분석
김정현 ( Jung Hyun Kim ),장안수 ( An Soo Jang ),정신옥 ( Shin Ok Jeong ),지영석 ( Young Seok Ji ),서현정 ( Hyun Jung Seo ),남재형 ( Jae Hyung Nam ),문종주 ( Jong Joo Moon ),백애린 ( Ae Rin Baek ),박종숙 ( Jong Sook Park ),이준혁 ( 대한소아알레르기호흡기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.1
Purpose: The majority of patients with allergic disease are highly sensitized to house dust mites (HDM). There is few data to observe sensitization rate to HDM in asthmatics in Korea. The aim of this study was to observe the differences of clinical profiles by HDM sensitization in patients with asthmatics in Soonchunhyang University Hospital (SCH) cohort. Methods: We recruited 2,345 asthmatic patients in SCH cohort. Lung function, body mass index and sputum and blood eosinophils, and PC20, and clinical profiles were compared by HDM sensitization. Results: Dermatophagoides farinae (Derf) and/or Dermatophagoides pteronyssinus (Derp) (+) sensitization rate was higher prevalence in male than in female. Compared with nonatopy asthmatics, Derf and/or Derp (+) asthmatics had early onset of age [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 32.5±0.51 vs. 36.1±0.88 vs. 43.1±0.54, P<0.05]. Derf and/or Derp (+) asthmatics had shorter duration of asthma symptom than that of nonatopy asthmatics. Derf and/or Derp (+) asthmatics had lower forced expiratory volume in one second and forced vital capacity than those of Derf and Derp (-) asthmatics. PC20 in Derf and/or Derp (+) asthmatics had lower than those of Derf and Derp (-) and nonatopy asthmatics [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 5.4±0.24 mg/ mL vs. 6.59±0.52 mg/mL vs. 7.19±0.33 mg/mL, P<0.05]. Blood eosinophils number in Derf and/or Derp (+) asthmatics had higher than that of nonatopy asthmatics (414.7±131.1 vs. 350.6±14.0, P<0.05). Total immunoglobulin E (IgE) in Derf and/or Derp positive asthmatics had higher than that of Derf and Derp negative and nonatopy asthmatics. There was no difference of body mass index among three groups. Conclusions: Our data indicate that atopy asthmatics sensitized to Derf and/or Derp had early onset of age, high total IgE and airway responsiveness, and eosinophilic inflammation. (Allergy Asthma Respir Dis 1(1):50-54, 2013)
원발성 담즙성 간경변증으로 진단되고 자가면역성 간염의 Feature를 보이는 한국인 환자에 대한 Simplified Scoring Criteria의 의미
김민석 ( Min Suk Kim ),김영석 ( Young Seok Kim ),김상균 ( Sang Gyune Kim ),변진명 ( Jin Myung Byun ),윤라영 ( La Young Yoon ),한동훈 ( Dong Hoon Han ),문종주 ( Jong Joo Moon ),남재형 ( Jae Hyung Nam ),김태진 ( Tae Jin Kim ),이세환 대한내과학회 2013 대한내과학회지 Vol.84 No.2
목적: 원발성 담즙성 간경변증과 자가면역성 간염의 임상적, 조직학적 특징이 동시에 혼재되어 나타나는 경우가 1970년 대부터 보고되고 있다. 이를 일반적으로 중복증후군(overlap syndrome)이라고 한다. 현재까지 IAIHG에서 제시한 simplified scoring criteria를 원발성 담즙성 간경변증 환자군에서 중복 증후군을 진단하는 데 이용한 연구는 거의 없는 실정으로 본 연구에서는 simplified scoring criteria를 한국인에게 적용하여 중복증후군을 진단하는 데 있어 진단적 가치 및 유용성을 평가, 비교하고자 하였다. 방법: 2004년 11월부터 2009년 12월까지 순천향대학교 부천병원과 서울병원에서 임상양상, 생화학검사, 자가항체 및 간조직검사 결과를 통해 원발성 담즙성 간경변증으로 진단 되었던 25명의 환자를 대상으로 의무기록지를 통해 후향적으로 분석하였다. 환자군을 revised scoring criteria와 simplified scoring criteria를 각각 적용하여 중복증후군으로 진단된 군과 진단되지 못한 군으로 나누어 서로의 특성을 비교 분석하였다. 결과: simplified scoring criteria 적용 시 ANA 양성률에 있어 높은 양성률을 보여 18명에서(72%) 중복증후군에 해당되었으며 중복증후군 환자군은 원발성 담즙 간경변군과 비교하여 IgG에서 높은 수치를 나타냈으나 통계적으로 유의하진 않았다(p=0.092). 또한 중복증후군 환자군은 원발성 담즙 간경변증 환자군과 비교하여 조직학적 소견에서 섬유화가 진행된 경향(p=0.017)을 보였으며 ANA 양성률에서 높은 비율을 나타내었다(100% vs. 43%, p=0.03). 또한 양 군 간 ANA 역가를 비교하였을 때 중복증후군에서 ANA 역가가 높은 환자(ANA≥1:80)의 비율이 높은 것으로 나타났다(p=0.000, Table 6). 따라서 ANA 양성률과 역가가 중복증후군 진단에 있어 중요한 인자임을 나타내었다. 결론: 본 연구는 simplified scoring criteria를 원발성 담즙성 간경변증 한국 환자에게 적용하였을 때 중복증후군을 screening 하는 데 도움이 될 수 있다는 것을 보여주었다. Background/Aims: The diagnosis of primary billiary cirrhosis (PBC)-autoimmune hepatitis (AIH) overlap syndrome remains challenging. In 2008, a simplified scoring system was proposed by the International Autoimmune Hepatitis Group, which aimed for wider applicability in routine clinical practice. We evaluated the performance of the new simplified AIH scoring criteria as a diagnostic tool for overlap syndrome. Methods: We retrospectively reviewed the clinical histories, chemistry, autoimmune studies, and liver biopsy results of 25 patients diagnosed with PBC who visited Soonchunhyang University Hospital, Bucheon and Seoul, between November 2004 and December 2009. Parameters relevant to the revised and simplified scoring criteria were recorded, and outcomes were compared between those with and without features of overlap syndrome. Results: Of 25 patients with a definite diagnosis of PBC, five (20%) were diagnosed with overlap syndrome using the revised criteria, and 18 patients (72%) were diagnosed with the simplified criteria. Those patients diagnosed according to the simplified scoring criteria revealed an increased frequency of anti-nuclear antibody (p=0.030) and serum IgG levels (p=0.092). Additionally, advanced fibrosis was significantly more frequent in patients with overlap syndrome (p=0.017). Conclusions: The simplified scoring criteria seemed to be useful as a diagnostic tool to recognize overlap syndrome in Korea. However, a relatively small number of patients were included in our study, so further clinical trials based on larger populations should be performed. (Korean J Med 2013;84:211-220)