대칠기탕(大七氣湯)이 Glutamate에 의한 C6 Glial 세포의 Apoptosis에 미치는 영향

김혜윤,고석재,방창호,신선호,이동엽,이인,Kim, Hye-Yoon,Ko, Seok-Jae,Bang, Chang-Ho,Shin, Sun-Ho,Lee, John Dong-Yeop,Lee, In 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.4

Objectives : The water extract of Daechilgi-tang(DCGT) has traditionally been used for treatment of qi stagnation(氣滯), which is considered to be one of the important causes of neuronal disease in oriental medicine. However, little is known about the mechanism by which DCGT protects neuronal cells from brain cell damages. Methods and Results : The author tested the mechanism of the cytoprotective effect of DCGT on glutamate -stimulated rat C6 glial cells. DCGT significantly protected C6 glial cells from glutamate in MTT assay. Pre-treatment of C6 glial cells with DCGT markedly inhibited the DNA fragmentation of C6 cells induced by glutamate. Glutamate increased the generation of reactive oxygen species(ROS) and intracellular calcium level in C6 glial cells. However, pre-treatment with DCGT markedly suppressed the increase of ROS generation and intracellular calcium accumulation induced by glutamate. Among apoptosis signaling mediators, DCGT markedly increased the expression level of Bcl2 in glutamate-treated cells. It also inhibited the cleavage of caspase-3 and PARP proteins by glutamate in C6 glial cells. Conclusions : These results suggest that DCGT protects brain cells from glutamate cytotoxicity through inhibition of ROS generation and activation of apoptosis signaling pathway as well as induction of the anti-oxidant system.

십자절개침법을 이용한 멜라닌 세포성 모반 치료의 치험 1례

김혜윤,박인해,홍석훈,신선호,김효린,박승구,Kim, Hye-Yoon,Park, In-Hae,Hong, Seok Hoon,Shin, Sun-Ho,Kim, Hyo-Rin,Park, Sung-Gu 대한한방안이비인후피부과학회 2016 한방안이비인후피부과학회지 Vol.29 No.2

Objectives : The objective of this study was to report the efficacy of the Crucial Incision Acupuncture Therapy(CIAT) for removing melanocytic nevi. Methods : CIAT is penetration acupuncture to remove a lesion by sticking needles like cross-shape. We used the CIAT for treating one patient with melanocytic nevi, and then we investigated efficacy and side effect for about 5 months. Results : In 16 melanocytic nevuses treated with CIAT, one of the nevuses recurred after about 3 months. And hyperpigmentation lasted for about 2-5 months was caused after the CIAT. Conclusions : In Korean medicine, the CIAT might be used for treating melanocytic nevi. But additional studies might be needed for improvement of treatment effect.

미세피부침, 절개침법과 봉독 약침 복합 요법의 여드름 흉터 치료 27례 임상 보고

김혜윤,홍석훈,박인해,허은선,노현민,신선호,Kim, Hye-Yoon,Hong, Seok-Hoon,Park, In-Hae,Heo, Eun-Sun,Noh, Hyeon-Min,Shin, Sun-Ho 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.3

Objectives : Microneedle therapy and Subcision are commonly used for therapeutic modalities of acne scars in Korean medicine. Beevenom could promote the expression of various cytokines, enzymes and receptors related to increasing collagen content of connective tissues. Through this mechanism, we considered that Beevenom pharmacopuncture therapy is applicable to the treatment of acne scars. We investigated twenty-seven patients with acne scars treated by Microneedle therapy and Subcision combined with Beevenom pharmacopuncture therapy and evaluated the clinical effect.Methods : Twenty-seven patients with acne scars were treated by Microneedle therapy and Subcision combined with Beevenom pharmacopuncture therapy and evaluated the clinical effect. for twelve weeks. The severity of acne scars and treatment effect were evaluate by standardized photography, GASC, ECCA scale and patient`s satisfaction. And side effects was also checked.Results : After twelve weeks for treatment, there was an improvement in GASC, ECCA scale. 77.8% of patient replied excellent or good on patient satisfaction survey. One patient sufferied from pruritus, papules and comedones as side effect of treatment.Conclusion : It can be considered that Microneedle, Subcision, Beevenom pharmacopuncture combining therapy are effective method for treating acne scars.

한약과 압출 치료에 병행한 황련해독탕 약침의 여드름 치료 22례 임상 보고

김혜윤,홍석훈,박인해,신선호,권영미,Kim, Hye-Yoon,Hong, Seok-Hoon,Park, In-Hae,Shin, Sun-Ho,Kwon, Young-Mi 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.3

Objectives : The objective of this study was to evaluate the effect of Herbal medicine, extrusion and Hwangryunhaedok-tang Pharmacopuncture therapy for treating Sil-Yol(Excess heat) type acne.Methods : Total of 22 patients with Sil-Yol(Excess heat) type acne were treated with the Herbal medicine(Chungsangbangpoong-tang, Yangkyuksanwha-tang, Hwalhyeolsano-tang, Galgeunhaegi-tang, Daeshihotang) and weekly Hwangryunhaedok-tang Pharmacopuncture & extrusion therpay. By the standardized photography before and after treatment, KASG and survey for patient`s satisfaction, we checked effect of Herbal medicine and Hwangryunhaedok-tang Pharmacopuncture therapy for treating acne.Results : 1. In 22 patients who underwent the Herbal medicine, extrusion and Hwangryunhaedok-tang Pharmacopuncture therapy, there was an significant improvement in KASG. Mean value of KAGS before treatment is 3.59±0.80, mean value of KAGS after treatment is 1.95±65.2. The responses to the survey for satisfaction revealed that 5 patients were very satisfied with their outcomes, 11 patients were satisfied, 5 patients were somewhat satisfied, 1 patient was dissatisfied.Conclusion : In Korean medicine, Herbal medicine and Hwangryunhaedok-tang Pharmacopuncture therpay might be effective method for treating Sil-Yol(Excess heat) type acne.

반성적 저널을 통한 유아교육과 교육실습생의 수업경험 연구

김혜윤(Kim Hye Yoon),강유진(Kang Yu Jin) 인문사회과학기술융합학회 2018 예술인문사회융합멀티미디어논문지 Vol.8 No.8

본 연구의 목적은 교육실습일지의 자기평가란 분석을 통해 예비유치원 교사들이 교육실습 기간 동안 경험한 교육 유형이 무엇인지 알아보는 것이다. 연구방법은 교육실습생 16명이 교육실습 기간 동안 작성한 교육실습일지 중 자기평가 부분 291개와 실습 종료 후 포커스 그룹 인터뷰를 실시한 자료를 바탕으로 분석을 실시하였다. 교육실습생의 교육경험이야기를 분석한 결과, 교수학습방법이 33%로 제일 높았으며, 두 번째로 교사아동상호작용이 9,3%, 세 번째로 건강영양안전 2.4%, 네 번째로 생활지도 6,6%, 다섯 번째 운영관리 10,3%, 여섯 번재 지도교사의 격려에 대한 감사 15,1%, 일곱 번째 자기반성 및 각오 22.3%, 여덞번째 기타 1%로 분류되었다. 본 연구 결과를 통해 교육실습생이 교육실습기간 중 경험한 교육의 유형이 무엇인지 파악하여 교육실습 전 교원양성대학에서 어떠한 내용으로 실습에 대비한 교육과정을 구성할지, 또한 기존 교육과정에 대한 반성과 더불어 앞으로 현장실무적인 능력을 함양 할 수 있는 교육과정 수립에 도움을 줄 수 있을 것이다. The study attempted categorizing educational experience types that pre-service teachers encounter while participating in teaching practicum session by analyzing self-reflection sections of their practicum journal writings. For this purpose, 16 pre-service participants conducted self-reflection sections of their practicum journals; these contents were analyzed by the authors using focus group interview(FGI), which was organized upon the completion of the practicum experience. The analysis results demonstrated that the pre-service participants’ educational experiences are categorized into the following five: 33% of teaching methods, 9.3% of teacher-child interaction, 2.4% of health and nutrition safety, 6.6% of child guidance, 10.3% of facility management, 15.1% of gratitude for guidance teachers’ encouragement, 22.3% of self-reflection and determination, and 1% of the others. These outcomes would be appropriately applied for teacher trainers to conduct educational programs before running teaching practicum in college settings. Also, the results of the study showed a series of methods to support pre-service teachers during the four-week-long practicum in order for them to grow as well-trained ` teachers.

Glucose-deprivation으로 유발된 PC-12 cell의 세포 고사에 대한 黃連解毒湯의 보호 효과

김혜윤(Hye Yoon Kim),신선호(Sun Ho Shin),이인(In Lee) 한의병리학회 2008 동의생리병리학회지 Vol.22 No.6

보육실습생이 가진 갈등의 정도, 행복감 및 자아탄력성의 관계 분석

김혜윤(Hye Yoon Kim),김길숙(Gil Sook Kim),김평호(Pyong Ho Kim) 인문사회과학기술융합학회 2019 예술인문사회융합멀티미디어논문지 Vol.9 No.6

본 연구는 보육실습생들이 보여주는 갈등의 수준, 행복감 및 자아탄력성의 정도를 분석하고 이러한 요인들이 서로에게 어떠한 영향을 끼치는지 알아보기 위해 실시되었다. 이를 위해 경상남도 4년제 대학교 유아교육과에 재학 중인 174명의 예비유아교사를 대상으로 설문조사가 이루어졌다. 수집된 자료를 바탕으로 평균 및 표준편차를 알아보는 단순 통계, Pearson 상관관계 및 상대적 설명력을 분석하기 위한 중다회귀분석을 실시하였다. 연구 결과, 보육실습생들이 가진 갈등 요인의 ‘자신갈등’, 행복감 요인의 ‘자기조절행복’, 그리고 자아탄력성 요인의 ‘감정조절’이 가장 높게 나타났다. Pearson 상관관계 결과 갈등(전체 평균)과 행복감(전체 평균)이 -.556(p<.01) 라는 높은 부적 상관관계를 나타내었다. 또한 중다회귀분석 결과 보육실습생의 갈등(전체 평균)은 행복감(전체 평균)에 영향을 끼치는 것으로 나타났다(t=-3.77, p<.001). 본 연구의 결과를 기반으로 하여 보육실습생들이 추후 교사직을 수행하면서 다양한 상황에 요구되는 행복감 및 자아탄력성을 증진시킬 수 있는 교사 프로그램의 개발이 필요하다는 시사점을 얻을 수 있었다. The current article aimed to analyze the early childhood education pre-service teachers’ levels of conflict, happiness, and ego-resilience, and how these factors affect each other. 174 pre-service teachers in department of early childhood education of a four-years university in Gyeongsangnam-do participated in surveys, then the researchers conducted a preliminary statistics, a Pearson correlation, and a multiple regression analysis. The results showed that ‘self-conflict’ among the conflict factors, ‘self-control’ among the happiness factors, and ‘emotion-control’ among the ego-resilience factors came out to be the highest. Second, the results of Pearson correlation displayed -.556 between their levels of conflicts and happiness, which demonstrated a relatively high level of negative correlation. Third, the multiple regression analysis showed that the pre-service teachers’ conflict(the total average) affected their level of happiness(the total average) the most(t=-3.77, p<.001). The results suggested implications regarding developing educational programs for pre-service teachers to enhance their levels of happiness as well as ego-resilience.

표류하는 여자들 : 자본주의적 가부장제에 대한 비판으로 읽는 『오릭스와 크레이크』

김혜윤(Kim, Hye-Yoon) 숙명여자대학교 숙명인문학연구소 2021 횡단인문학 Vol.7 No.1

본 논문에서는 마가렛 애트우드의 매드아담 삼부작 중 첫 번째 작품인 『오릭스와 크레이크』(2003)를 자본주의적 가부장제에 대한 비판적 시각으로 고찰한다. 특히 두 여성인물인 오릭스와 섀런을 오늘날 인류가 마주한 긴급한 문제인 전지구화, 기후변화, 자본과 생명공학기술의 결탁의 ‘부수적 피해자’로 규정하고 마가렛 애트우드가 이 여성인물들을 통해 전지구화된 자본주의적 가부장제 질서의 부조리함을 전면에 드러낸다고 해석한다. 자본주의적 가부장제에 대한 비판적 관점에서 『오릭스와 크레이크』를 읽는 것은 현실성에 입각하여 미래를 가정하는 추론소설로서의 매드아담 삼부작을 통해 오늘날 인류가 마주한 문제들에 대한 해결책을 모색하려는 시도의 첫걸음이다. This study examines Margaret Atwood s Oryx and Crake as a critical view of capitalist patriarchy. The two female figures, Sharon and Oryx, analyzed in this paper are defined as ‘collateral victims’ of the urgent problems of mankind— globalization, climate change, and biotechnology that collude with capital. Assuming that Atwood reveals the absurdity of the globalized capitalist patriarchy through Oryx and Sharon is the main argument of this study. As a Speculative Fiction, reading Oryx and Crake of MaddAddam Trilogy from a critical perspective on capitalist patriarchy suggests solutions to the problems facing humanity today.

대황이 당뇨병 백서의 신장 및 혈관에 미치는 효과

남상규,김형구,김혜윤,이정섭,정현애,고영철,신선호,장통영,Nam, Sang-Kyu,Kim, Hyeong-Gu,Kim, Hye-Yoon,Lee, Jung-Sup,Jung, Hyun-Ae,Ko, Young-Chul,Shin, Sun-Ho,Jang, Tong-Young 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.4

Objectives : This study aimed at investigating whether aqueous extract of Radix et Rhizoma Rhei (AR) ameliorates renal and vascular complications in diabetic rats. Methods : The experiment operated for 6 weeks. The rats were divided into 4 groups: normal group, diabetic group (control group), diabetic group treated with AR (100 mg/kg/day) for the last 3 weeks, and diabetic group treated with AR (200 mg/kg/day) for the last 3 weeks. Results : There were no significant changes in the renal functional parameters by treatment of AR in the diabetic rats. Aorta segment in the diabetic rats revealed a thickening of intima and media, which was ameliorated by treatment with AR. The aortic expression level of endothelin-1 was also significantly attenuated by treatment with AR. Conclusions : Treatment with AR could not ameliorate renal functional defects, but improved vascular complication in diabetic rats.

추체외로 증상에 따른 항정신병 약물 복용량과 음성 특성의 상관관계 분석

이수빈,김서영,김혜윤,김의태,유경상,이호영,이교구,Lee, Subin,Kim, Seoyoung,Kim, Hye Yoon,Kim, Euitae,Yu, Kyung-Sang,Lee, Ho-Young,Lee, Kyogu 한국음향학회 2022 韓國音響學會誌 Vol.41 No.3

본 논문은 항정신병 약물의 복용량에 따른 음성 특징의 상관관계 분석을 수행하였다. 항정신병 약물의 대표적 부작용 중 하나인 추체외로 증상(ExtraPyramidal Symptoms, EPS) 발생에 따른 음성 특징의 패턴을 알아보기 위하여, 문장 개발을 통해 한국어 기반 추체외로 증상 음성 코퍼스를 구축하였다. 수집된 자료는 추체외로 증상 군과 비 추체외로 증상 군으로 나누어 음성 특징 패턴을 조사하였으며, 특히 추체외로 증상 군의 높은 음성 특징 상관관계를 보였다. 또한, 발화 문장의 종류가 음성 특징 패턴에 영향을 미친다는 것을 확인할 수 있었으며, 이를 통해 음성 특징을 기반한 추체외로 증상의 조기 발견 가능성을 기대해볼 수 있었다.