건조방법에 따른 생식 원료 곡류의 이화학적 특성 및 가능성 성분의 변화

김철암 ( Tie Yan Jin ),오덕환 ( Deog Hwan Oh ),엄애선 ( Ae Son Om ),이헌옥 ( Heon Ok Lee ),은종방 ( Jong Bang Eun ) 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2005 한국식품저장유통학회지 Vol.12 No.5

Comparison of the Effects of 1 Hz and 20 Hz rTMS on Motor Recovery in Subacute Stroke Patients

김철,최희은,Hee Jin Jung,이병주,Ki Hoon Lee,Young-Joon Lim 대한재활의학회 2014 Annals of Rehabilitation Medicine Vol.38 No.5

Objective To compare the low frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) with high frequency (20 Hz) rTMS on motor functional improvement of the affected upper extremity in subacute stroke patients.Methods Forty patients with subacute ischemic stroke participated in this study. The first group received 10 sessions of 20 Hz rTMS at ipsilesional M1 area and the other group received 10 sessions of 1 Hz rTMS at contralesional M1 area. Motor training of the hemiparetic hand was conducted after each rTMS train. All the patients received conventional occupational therapy immediately after each rTMS session. Manual function test (MFT), Fugl-Meyer Assessment scale (FMS), Modified Barthel Index (MBI), Brunnstrom recovery stage, and grip strength were used to assess motor function before, at the end of, and one month after the last session of rTMS.Results No adverse side effects were reported during the course of the experiment using rTMS. No significant difference in motor function of the affected upper extremity was observed between the two groups before rTMS. Significant improvements in MFT, FMS, MBI, and Brunnstrom stage were observed in the both groups at the end of the last rTMS session and one month later (p<0.05). No significant difference was found between the two groups (p>0.05)Conclusion There was no significant difference in motor function of the affected upper extremity between 1 Hz and 20 Hz rTMS during the subacute period of ischemic stroke. Thus, we cannot conclude which has a greater effect.

Prognostic Influences of Cardiac Rehabilitation in Korean Acute Myocardial Infarction Patients

김철,Chang Jin Moon,Duk You Kim 대한재활의학회 2011 Annals of Rehabilitation Medicine Vol.35 No.3

Objective To observe the prognostic influences of the cardiac rehabilitation (CR) program in Korean acute myocardial infarction (AMI) patients during the fi rst year after an occurrence of the disease. Method A total of 141 AMI patients who underwent percutaneous coronary intervention (PCI) were recruited consecutively for this study and divided into the CR group and the control group. The CR group completed the phase 2 CR program in the hospital for a period of 6-8 weeks and maintained self-exercise in their community by exercise prescription for a year after AMI. We performed a prospective comparison of the patients’ demographic data, high sensitive C-reactive protein (hs-CRP) level after the 4-month CR program, and the rate of recurrence (AMI, re-hospitalization, positive coronary angiogram, needed revascularization procedure, or death) between the two groups. Results Compared to the control group (0.33±0.48 mg/dl), the hs-CRP level was lower in the CR group (0.18±0.32mg/dl) after 4 months of exercise. Th e recurrence rate was lower (10%, 7/69) in the CR group, compared to the control group (24%, 17/72, p<0.05). The number of disease-free days was larger in the CR group (354±38.34),compared to the control group (316±99.96, p<0.05). In a comparison of statistical methods used for testing the equality of two survivor distributions, the CR group showed a lower recurrence rate than the control group (p<0.05). Conclusion Participation in the CR program designed for AMI patients who underwent PCI-induced normalization of the serum hs-CRP level and lowering of the recurrence rate by 14% during the first year.

정규화 신뢰도를 이용한 핵심어 검출 성능향상

김철,이경록,김진영,최승호,최승호,Kim, Cheol,Lee, Kyoung-Rok,Kim, Jin-Young,Choi, Seung-Ho,Choi, Seung-Ho 한국음향학회 2002 韓國音響學會誌 Vol.21 No.4

Rahim의 논문 (M.G. Rahim, et al., PROC. of ICASSP96, 1996)과 같은 기존의 후처리 방법은 음소 모델과 반모델 (anti-model)의 유사도를 이용하여 음소 단위 신뢰도를 계산하고, 이들의 평균을 단어 단위 신뢰도로 정의한다. 그런데 음소단위의 신뢰도가 동일한 확률밀도함수를 갖는 것이 아니기 때문에 특정단어의 경우 계산된 신뢰도는 대체로 낮은 값을 갖는다. 이를 극복하기 위한 방법으로서, 본 논문에서는 기존의 신뢰도를 통계적으로 정규화한 신뢰도를 제안한다. 즉 음소단위의 신뢰도가 가우시안 분포를 갖는다고 가정한 후 트라이 폰(sri-phone) 단위로 정규화하여 동일한 정규분포를 갖도록 한다. 본 논문에서는 제안된 방법의 검증을 위하여 문맥종속 핵심어 모델과 문맥독립 필러 모델을 이용한 일반적인 핵심어 검출기를 사용하였다. 실험결과 제안된 정규화 신뢰도 (NCM: Normalized Confidence Measure)가 불검출율 (WDR: Missed Detection Rate) 8%정도에서 오검출율 (PAR: false alarm rate)을 0.44에서 0.33 FA/KW/HR (false alarm/keyword/hour)로 저하시켰다. 이것은 오검출율에서 성능이 25% 향상된 것이다. Conventional post-processing as like confidence measure (CM) proposed by Rahim calculates phones' CM using the likelihood between phoneme model and anti-model, and then word's CM is obtained by averaging phone-level CMs[1]. In conventional method, CMs of some specific keywords are tory low and they are usually rejected. The reason is that statistics of phone-level CMs are not consistent. In other words, phone-level CMs have different probability density functions (pdf) for each phone, especially sri-phone. To overcome this problem, in this paper, we propose normalized confidence measure. Our approach is to transform CM pdf of each tri-phone to the same pdf under the assumption that CM pdfs are Gaussian. For evaluating our method we use common keyword spotting system. In that system context-dependent HMM models are used for modeling keyword utterance and contort-independent HMM models are applied to non-keyword utterance. The experiment results show that the proposed NCM reduced FAR (false alarm rate) from 0.44 to 0.33 FA/KW/HR (false alarm/keyword/hour) when MDR is about 8%. It achieves 25% improvement of FAR.

전해수 처리한 생식 원료 곡류의 이화학적 특성 및 기능성 성분의 변화

김철암(Tie-Yan Jin),오덕환(Deog-Hwan Oh),이종욱(Chong-Ouk Rhee),정동옥(Dong-Ok Chung),은종방(Jong-Bang Eun) 한국식품과학회 2006 한국식품과학회지 Vol.38 No.4

케블라 다축경편성물 보강 복합재료의 물성에 관한 연구

김철,강태진,이승구,육종일 ( Cheol Kim,Tae Jin Kang,Sung Ku Lee,Jong Il Yook ) 한국복합재료학회 1996 Composites research Vol.9 No.4

유자 과피를 첨가하여 제조한 진양주의 품질 및 항산화 특성 변화

김철암(Tie-Yan Jin),왕명현(Myeong-Hyeon Wang),윤유(Yu Yin),은종방(Jong-Bang Eun) 한국식품영양과학회 2008 한국식품영양과학회지 Vol.37 No.1

찹쌀에 유자 과피를 각각 0, 10, 20, 30, 40% 첨가하여 제조한 진양주의 품질 및 생리활성 특성의 변화를 조사하였다. 유자 과피 첨가량의 증가에 따라 pH는 감소되었고 총산의 함량은 증가된 것으로 나타났다. 총당의 함량은 유자 과피의 첨가량의 증가에 따라 증가하였고 알코올 함량은 감소하였다. 색도 중 L값은 유자 과피의 첨가량이 증가에 따라 증가되었으나 a와 b값은 감소한 것으로 나타났다. DPPH 자유라디칼 소거 활성은 유자 과피의 첨가량의 증가에 따라 증가된 것으로 나타났다. 관능검사 결과 전체적 기호도에서 20% 유자 과피를 첨가하여 제조한 진양주가 제일 우수한 것으로 나타났다. 이화학적 특성, 항산화 특성, 관능적 특성으로 보아 20% 유자 과피를 첨가하여 진양주를 제조하는 것이 적합하다고 생각된다. The quality and antioxidant activity properties of Jinyangju, Korean traditional rice wine made with different additions of Citrus junos peel (0, 10, 20, 30, and 40%) were investigated. The pH and the total sugar content of the Jinyangju decreased, whereas the total acidity and alcohol content increased with greater additions of Citrus junos peel. The color L-value increased and the color a- and b-values decreased with increasing amounts of Citrus junos peel. The DPPH (1,1-diphenyl-2-picryl-hydrazyl) free radical scavenging activity increased with the addition of Citrus junos peel. The highest overall acceptability values in the sensory test for color, flavor, taste, and overall favorite were 4.2, 4.9, 5.6, 5.0, and 3.9, respectively, with the addition of 20% Citrus junos peel.

층간 하이브리드화에 의한 케블라 / 스펙트라 / 유리 섬유 강화 복합재료의 물성 변화에 관한 연구

김철,강태진,이승구,윤영주 ( Cheol Kim,Tae Jin Kang,Sung Ku Lee,Young Ju Yoon ) 한국복합재료학회 1995 Composites research Vol.8 No.3

설탕을 이용하여 제조한 더덕차의 품질 특성

김철암(Tie-Yan Jin),왕명현(Myeong-Hyoen Wang) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.5

더덕에 설탕 첨가량을 달리하여 제조된 더덕차의 이화학적 및 관능적 특성, 기능성 성분의 함량 조사를 통하여 합리한 더덕차의 제조방법을 찾고자 하였다. 일반성분 함량 중 더덕 첨가량의 증가로 수분 함량은 증가하였고 탄수화물 함량은 감소되었으며 조단백질, 조지방, 회분 등 함량은 변화가 없는 것으로 나타났다. 색도는 L값은 설탕 첨가량의 증가에 따라 감소되었고 b값은 증가된 것으로 나타났으며 a값은 변화가 없는 것으로 나타났다. 총 식이섬유 함량은 변화가 없었으나 설탕 첨가량의 증가에 따라 수용성 식이섬유의 함량은 증가하고 반대로 불용성 식이섬유의 함량은 감소하는 것으로 나타났다. 총 페놀성 화합물과 총 플라보노이드 함량은 설탕 첨가량의 증가에 따라 증가되는 것으로 나타났으나 사포닌 함량은 변화가 없는 것으로 나타났다. 관능검사 결과 75% 설탕을 첨가한 시험구가 색, 맛, 향, 전체적 기호도 등에서 모두 다른 시험구보다 높게 나타났다. The physicochemical, sensory, and functional properties of Codonopsis (C.) lanceolata tea with different amounts of sugar (25%, 50%, 75%, and 100%) were investigated. There were no significant changes in crude protein, crude fat, and ash contents of C. lanceolata tea with different amounts of sugar. In contrast, carbohydrates decreased and moisture content increased in C. lanceolata tea with different amounts of sugar. The natural presumption is that carbohydrates increase with increasing amounts of sugar. In terms of color, the L-value decreased and the b-value increased with increasing amounts of sugar. Although there were no significant changes in total dietary fiber, soluble dietary fiber increased and insoluble dietary fiber decreased with increasing amounts of sugar. The total phenolic and flavonoid content increased, while saponin content remained constant with increasing amounts of sugar. The highest overall acceptability values in the sensory test for color, flavor, taste, and overall preference were 5.77, 5.82, 5.72, and 5.95, respectively, with the addition of 75% sugar.

가상세포를 활용한 항염증 효능 응용모델 연구

김철,예상준,김진현,김상균,장현철,김안나,남기엽,송미영,Kim, Chul,Yea, Sang-Jun,Kim, Jin-Hyun,Kim, Sang-Kyun,Jang, Hyun-Chul,Kim, An-Na,Nam, Ky-Youb,Song, Mi-Young 대한한의학방제학회 2010 大韓韓醫學方劑學會誌 Vol.18 No.2

Objective : The purpose of this study was to develop the simulator which can analyze the anti-inflammatory effects of herbs based on e-cell, or the virtual cell. Method : We have ensured the medical herbs and its active compounds by investigating the oriental medicine records and NBCI(Biomedicine database). Also we have developed the web-based search system for confirming database related to anti-inflammation. We have researched the cell signal pathway related with inflammatory response control and established the mathematical model of herb interaction on selected signal pathway in e-cell. Finally we have developed the prototype which can confirm the result of this model visibly. Results : We constructed the database of 62 cases of anti-inflammatory active compounds in 61 cases of medical herbs which have been known anti-inflammation effects in the paper, 16 cases of inflammatory factors, 10 cases of signal pathways related with inflammatory response and 6,834 cases of URL(Uniform Resource Locator) of referenced papers. And we embodied the web-based research system, which can research this database. User can search basic and detailed information of medical plants related with anti-inflammatory by using information system. And user can acquire information on an active compounds, a signal pathway and a link URL of related paper. Among investigated ten pathways, we selected NF-${\kappa}B$, which plays important role in activation of immune system, and we searched the mechanisms of actions of proteins which could be components of this pathway. We reduced total network into IKK-$I{\kappa}B$ - NF-${\kappa}B$, and completed mathematic modeling by using ordinary differential equations and response variables of $I{\kappa}B-NF-{\kappa}B$ signaling model network which is suggested by Baltimore Group. We designed OED(Ordinary Differential Equation) for response of IKK, $I{\kappa}B$, $NF-{\kappa}B$ in e-cell's cytoplasm and nucleus, and measured whether an active compound of medicinal plants which is inputted by an user would have a anti-inflammation effects in obedience to change in concentration over time. The proposed model was verified by using experimental results of the papers which are listed on NCBI.