계통해석법에 의한 I-131 대기방출의 영향평가

陸鍾澈,李鍾一,河正雨 대한방사선 방어학회 1988 방사선방어학회지 Vol.13 No.1

영광 원자력 발전소 영광 1, 2호기로부터 대기방출되는 I-131에 의한 주민피폭선량을 ICRP 29에서 제안한 계통해석법(system analysis method)으로 계산하였고, I-131의 연간 섭취에 의한 갑상선의 실효 예탁선량당량을 ICRP 29와 ICRP 30의 개념을 결합하여 계산하였다. 그리고, 계산에 사용한 모델의 감도(sensitivity)와 견고도(robustness)도 아울러 분석 평가하였다. 단기방출에 따른 최대 연간 개인피폭선량 계산결과는 정상가동에 따른 연속방출가정에 의한 계산결과보다 1.4내지 1.7배나 높았고, 연간 핵연료 손상율이 0.12%인 경우, 갑상선에 대한 집단피폭선량은 3.05×10 -3 man-thyroid-Sv으로서 GASPAR 전산코드에 의한 값 2.3×10 -3 man-thyroid-Sv보다 높았다. 사용한 모델의 평균 견고도 지수는 0.5이하로 변수값에 많은 영향을 받는 것으로 나타났으며, 경구섭취를 통한 각 피폭경로의 감도 게산결과 유아의 경우는 우유를 통하여, 그리고, 소아, 십대 및 성인의 경우는 농작물을 통한 피폭이 가장 민감한 것으로 나타났다. The annual individual and collective doses to the thyroids of four age-dependent groups due to the intake of 1-131 released from the Younggwang nuclear power plant NU-1 & 2, Korea, are estimated using the model presented in ICRP 29. Sensitivity and robustness of the model are analyzed. In case of 0.12 % fuel defect during normal operation, the collective dose is founded to be 3.05×10 -3 man-thyroid-Sv, which is higher than the value calculated by the GASPAR code, 2.3×10 -3 man-thyroid-Sv. The maximal individual annual doses resulting from an acute release are higher than those calcualted under the assumption of continuous release by 1.4~1.7 times. The most important pathway to the infant is milk and, in contrast, that to child, teen and adult is ingestion of crops. The model used is the calculation appears to be influenced by the variables such as roubstness-index. The weighted committed dose equivalent obtained by the ICRP 29 model is slightly higher than that calculated by the three-compartment model.

코쉬섬 1차 반복 형태의 마이크로스트립 패치 안테나에 관한 연구

김일권,유태훈,육종관,박한규 연세대학교 전파통신연구소 2001 電波通信論文誌 Vol.5 No.1

In this paper, the microstrip patch antenna applying the koch island fractal geometry is introduced in order to reduce the antenna patch size. By space-filling property of fractal geometry, the microstrip patch applying koch island has low frequency compared with square patch antenna. In the case of 1st order iteration patchs are investigated by simulator and experiment. Through this, it is found that as the fractal iteration factor increase, the resonant frequency of koch island patch is lower. therefore koch island patch antenna can reduce patch size compared with square patch antenna. and The fabricated patch antenna is matched by using quarter wave length impedance transformer and return loss and radiation patterns are measured. The measurement result shows that the copolarization pattern of koch patch is similar to that of square patch. The cross polarization power level is -15∼-20dB.

前腕部 經穴 取穴에서 骨度分寸法과 一夫法의 比較 硏究

박히준,채윤병,차웅석,박종배,이혜정,이향숙,인창식,고형균,김수영,최일환,김강식,문정배,배기태,유경환,육근영,정병주,손인철,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Background : The cun measurement System, an essential and convenient method in locating acupoints, has been widely used in the practice of acupuncture. However, traditional cun measurement has been criticized for its lack of reliability. Objectives : The purposes of this study are to determine if one cun measured by the directional methods have a consistency with that of proportional methods and to investigate which factors are related with these differences, especially in forearm. Methods : The distance between the elbow crease and the wrist crease of forearm was compared to a reference value of one cun obtained by the directional method. In this method, one cun is one third of the distance between index finger and Small finger of a subject, measured at proximal interphalangeal joint. In addition, to investigate the factors influencing the differences between these two methods, we measured the height and body weight and calculated body mass index (BMI). Finally we analyzed the factors correlated with these lengths by linear regression test. Results : The results showed that one cun obtained by the directional methods were significantly different from one cun by the proportional methods in forearm. It was demonstrated that the length acquired with the directional method was more correlated with body weight and body mass index, while the length obtained by the proportional method was more correlated with the height.

Anti-Inflammatory Effect of Mangostenone F in Lipopolysaccharide-Stimulated RAW264.7 Macrophages by Suppressing NF-κB and MAPK Activation

( Byoung Ok Cho ),( Hyung Won Ryu ),( Yang Kang So ),( Chang Wook Lee ),( Chang Hyun Jin ),( Hong Sun Yook ),( Yong Wook Jeong ),( Jong Chun Park ),( Il Yun Jeong ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.4

Mangostenone F (MF) is a natural xanthone isolated from Garcinia mangostana. However, little is known about the biological activities of MF. This study was designed to investigate the anti-infl ammatory effect and underlying molecular mechanisms of MF in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. MF dose-dependently inhibited the production of NO, iNOS, and pro-infl ammatory cytokines (TNF-α, IL-6, and IL-1β) in LPS-stimulated RAW264.7 macrophages. Moreover, MF decreased the NF-κB luciferase activity and NF-κB DNA binding capacity in LPS-stimulated RAW264.7 macrophages. Furthermore, MF suppressed the NF-κB activation by inhibiting the degradation of IκBα and nuclear translocation of p65 subunit of NF-κB. In addition, MF attenuated the AP-1 luciferase activity and phosphorylation of ERK, JNK, and p38 MAP kinases. Taken together, these results suggest that the anti-infl ammatory effect of MF is associated with the suppression of NO production and iNOS expression through the down-regulation of NF-κB activation and MAPK signaling pathway in LPS-stimulated RAW264.7 macrophages.

위절제술 환자의 표준진료지침 개발 및 적용 효과

김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2

Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.

p53 Nuclear Accumulation as a Possible Biomarker for Biological Radio - dosimetry in Oral Mucosal Epithelial Cells

KIM, JONG IL,Son, Young Sook,Kim, Jin,Kim, Tae Hwan,Kim, Youn Young,Yook, Jong In 생화학분자생물학회 2002 BMB Reports Vol.34 No.2

Cellular response to ionizing radiation is affected by cell types, radiation doses, and post-irradiation time. Based on the trypan blue dye exclusion assay in normal oral mucosal cells (OM cells), a 48 h post-irradiation was sufffcient and an adequate time point for the evaluation of radiation sensitivity Its LD_(50) was approximately 1.83 Gy To investigate possible biomarkers useful for the biological radiodosimetry of normal epithelial cells (p53, c-fos, cyclin Dl, cdc-2, pRb) EGF receptor phosphorylation and Erk activation were evaluated at different radiation doses and different post-irradiation times. Frorn 0.5 Gy, p53 was accumulated in the nucleus of basal cells of the OM raflk culture at 4 h post-irradiation and sustained up to 24 h post-irradiation, which suggests that radiation-induced apoptosis or damage repair was not yet completed. The number of p53 positive cells and biosynthesis of p53 were correlated with radiation doses. Both cyclin D1 and c-fos were only transiently induced within 1 h post-irradiation. Cyclin D1 was induced at all radiation doses. However, cfos induction was highest at 0.1 Gy, approximately 7.3 fold more induction than the control, whose induction was reduced in a reverse correlation with radiation dose. The phosphorylation pattern of cdc-2 and pRb were unaffected by radiation. In contrast to A431 tails overexpressing the EGF receptor approximately 8.5 fold higher than normal epithelial, the OM cells reduced the basal level of the EGF receptor phosphorylation in a radiation dose dependent fashion. In conch~sion, among radiation-induced biomolecules, the p53 nuclear accumulation may be considered for the future development of a useful marker far biological radiodosimetry in normal epithelial tissue since it was sustained for a longer period and showed a dose response relationship. Specific c-fos induction at a low dose may also be an important finding in this study It needs to be studied further for the elucidation of its possible connection with the low dose radio-adaptive response.

개인방호용 복합재료의 기술동향

육종일 ( Jong Il Yook ),윤병일 ( Byung Il Yoon ),백종규 ( Jong Gyu Paik ),송홍섭 ( Heung Sub Song ) 한국복합재료학회 2009 Composites research Vol.22 No.6

Novel Electromagnetic Bandgap Array Structure on Power Distribution Network for Suppressing Simultaneous Switching Noise and Minimizing Effects on High-Speed Signals

Jong Hwa Kwon,Dong Uk Sim,Sang Il Kwak,Jong Gwan Yook IEEE 2010 IEEE transactions on electromagnetic compatibility Vol.52 No.2

<P>To supply high-speed digital circuits with stable power, power/ground noise, such as simultaneous switching noise (SSN) and ground bounce noise caused in multilayer printed circuit boards (PCBs) and packages need to be sufficiently suppressed. The electromagnetic bandgap (EBG) is widely recognized as a good solution for suppressing the propagation of SSN in the gigahertz range. However, a typical coplanar EBG structure etched onto the power and ground planes may degrade the quality of high-speed signals passing over the perforated reference plane. In this paper, a novel method of arranging EBG unit cells on both the power/ground planes in multilayer PCBs and packages is proposed, not only as a means of sufficiently suppressing the propagation of power noise, but also as a means of minimizing the effect of EBG-patterned reference planes on a high-speed signal. On the assumption that noise sources and noise-sensitive devices exist only in specific areas, the proposed method partially positions EBG unit cells only near these critical areas. The SSN suppression performance of the proposed structure is verified by conducting simulations and measurements in the time and frequency domains. Furthermore, signal quality is investigated to verify whether the proposed EBG-patterned reference planes are superior to conventional EBG-patterned planes in terms of signal integrity.</P>

Multi-Radiating-Element Printed Inverted-F Antenna With Independent Resonant Frequencies for Bandwidth Enhancement

Il-Young Oh,Sang-Hyuk Wi,Yongshik Lee,Jong-Gwan Yook IEEE 2010 IEEE antennas and wireless propagation letters Vol.9 No.-

<P>This letter demonstrates a simple yet very effective method of bandwidth enhancement for popular printed inverted-F antennas (PIFAs). An additional radiating element is printed on the other side of the substrate, on the same side as the partially modified ground plane. Together with the primary radiating element, these provide different three electrical paths. The bandwidth of the antenna can be enhanced substantially by optimally locating the corresponding resonant frequencies. Most of all, each of the three radiators has negligible effect on the performance of the other two radiators, implying that they can be designed independently. While maintaining the far-field radiation patterns, as much as 12.6% increase in the relative bandwidth over the 7.0% bandwidth of a conventional PIFA is demonstrated.</P>

Modified Slot-Loaded Multi-Band Microstrip Patch Antenna

Jong-Gwan Yook,Han-Kyu Park,Man-Shik Cho,Il-Kwon Kim,Han-Back Cho 한국전자파학회JEES 2003 Journal of Electromagnetic Engineering and Science Vol.3 No.1

In this paper, a triple-band planar antenna is proposed for the application to miniaturized automobile safety devices operating at X band(10.5 GHz), K band(24.15 GHz), and Ka band(34.3 GHz). The frequency ratio between the resonant frequencies of this antenna can be adjusted from 1.99 to 2.23 for both X band and K band by varying its slit length. Parasitic elements are added on the modified slot loaded antenna to obtain the third resonance. From numerical as well as experimental results, it has been confirmed that this type of antenna is appropriate for planar multi-band antenna systems.