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김중근,김보현,백성민,신동훈,김원진,전윤경,김상수,김인주 대한내분비학회 2014 Endocrinology and metabolism Vol.29 No.4
Malignant pheochromocytoma (PCC) is a rare condition. Although the liver is the second most frequent site of metastasis in malignant PCC, no definite treatments have been established. Herein, we report a case of liver metastasis of PCC that was successfully treated by transcatheter arterial chemoembolization (TACE). A 69-year-old man was admitted to the Department of Gastroenterology for evaluation of an incidental hepatic mass in August 2013. He had undergone right adrenalectomy in May 2005 and PCC had been confirmed on the basis of histopathological findings. Liver biopsy was performed, and metastatic PCC was diagnosed. The lesion appeared inoperable because of invasion of the portal vein and metastases in the lymph nodes along the hepatoduodenal ligament. Thus, TACE was performed instead. After TACE, symptoms including dizziness and cold sweating improved, and the patient’s serum catecholamine levels decreased. On the basis of this case, we believe that TACE may be a useful treatment for liver metastasis in malignant PCC.
김중근,구지혜,허용도 한국지식정보기술학회 2020 한국지식정보기술학회 논문지 Vol.15 No.5
Recently, various solutions have been proposed according to the rapid increase in the level of fine dust. However, technologies such as artificial rainfall and large-sized air purifiers that have been developed or studied to date have the disadvantage of lack of feasibility. Rather, the use of a mask, which has become more important and convenient due to the corona crisis, is emerging as one of the most feasible measures among domestic fine dust countermeasures. Therefore, this paper aims to develop an app system that enables people to efficiently and conveniently pay or purchase masks. In addition, through the developed app system, a response system that allows users to know in real time when a disaster alert such as fine dust occurs can be built. When a fine dust disaster alarm occurs, information on fine dust in the area can be immediately checked in real time using a mobile phone app. When a fine dust alarm occurs, QR code issuance is activated, and through a map in the application, the location of the nearest mask dispensing station, phone number, and mask inventory can be checked in real time. When a mask is provided to a user, the mask dispensing station can modify the mask-related data in the corresponding dispensing station database in real time, and various statistics related to the mask can be checked in real time on the web page and in the dedicated application for administrators. In the future, additional functions will continue to be supplemented by securing disease information and data on various epidemic diseases such as cold and flu, and the algorithm will be continuously improved to more accurately predict the level of fine dust.
김중근,손성락,문태식,전지혜 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.10
1989년 1월부터 1993년 12월까지만 5년간 부산위생병원에 입원하여 수술한 환자중 술후 병리조직 검사에서 난소 낭성 기형종으로 확인된 63례를 대상으로 조사 분석한 결과 다음과 같은 결과를 얻었다. 1. 수술을 시행하였던 전체 난소종양 중 낭성기형종은 27.8%를 차지하였다. 2. 연령분포는 20-29세 군이 44.5%로 가장 많았다. 3. 양측성의 빈도는 17.5%였고, 좌, 우측은 각각 46.0%, 56.5%였다. 4. 평균 직경은 7cm이었고, 5-9 cm인 경우가 75.7%로 가장 많았다. 5. 주요 증상은 하복부 동통 및 불편감(50.8%), 하복부 종괴 촉지(30.2%)였으며 무증상이었던 경우도 20.6%를 차지했다. 6. 임신과 동반된 경우는 12.7%였으며 다음으로 골반내염증성 질환, 자궁근종 등이 동반되었다. 7. 합병증중 염전이 12.7%로 가장 많았고, 파열, 감염이 각각 3.1%였다. 8. 현미경적 구성성분은 피부 100%, 피부부속기 97.3%로 주종을 이루었다. A clinical and histopathological study was made on a series of 63 ovarian cystic teratomas, operatied upon and confirmed by histopathological examination during 5 years from Jan. 1989 till Dec. 1993. The results were as follows: 1. The frequency of ovarian cystic teratoma was 27.8% of all ovarian tumors, operated. 2. The incidence of ovarian cystic teratoma was greatest in third decade(44.5%). 3. The bilaterality was 17.5%, right site 46.0%, left sited 36.5%. 4. The average diameter was 7 cm, about 3/4 (75.7%) was 5-9cm. 5. The most common symptoms were abdominal pain or discomfort(50.8%) and palpable mass (30.2%), and no symptom in 20.6%. 6. Pregnancy was associated in 12.7%, and the rest were PID and uterine myoma associated. 7. Complications were torsion(12.7%), rupture(3.1%), infection(3.1%). 8. The structures observed microscopically were skin(100%), and skin appendages(97.39%), largely institued.
김중근,정주섭,신호진,송무곤,이지원,신동훈,이대성,백성민 대한혈액학회 2014 Blood Research Vol.49 No.3
Background Although adding rituximab to the chemotherapy regimen of cyclophosphamide, vincristine, doxorubicin, and prednisone (R-CHOP) has improved clinical outcomes of patients with diffuse large B-cell lymphoma (DLBCL), several recent studies have shown that the effect of rituximab is dominantly in the non-germinal center (non-GC) subtype compared to the germinal center (GC) subtype. Natural killer (NK) cell count, a surrogate marker of immune status, is associated with clinical outcomes in DLBCL patients in the rituximab era. We investigated whether the impact of NK cells on clinical outcomes differed according to the immunophenotype of DLBCL. Methods This study analyzed 72 DLBCL patients treated with R-CHOP between January 2010 and January 2014. Results Low NK cell counts (<100/μL) were associated with poor progression-free survival (PFS) and overall survival (OS) compared to high NK cell counts. In multivariate analysis, low NK cell count was an independent prognostic factor for PFS and OS. However, survival did not significantly differ between the GC and non-GC subtypes. We examined the clinical influence of NK cells according to the immunophenotype and found that low NK cell counts were significantly associated with poor PFS and OS in non-GC cases, but not in GC cases. Conclusion Low NK cell counts at diagnosis are associated with poor clinical outcomes in DLBCL patients treated with R-CHOP therapy. However, the impact is significant only in non-GC subtype DLBCL, not in the GC subtype.