새로운 백금 착체(II) 화합물의 흰쥐 혈장에서 대사체 확인

김종환,조요나,노영수,서성훈,정지창,장성구,이규홍,이주한,이경태,Kim, Jong-Whan,Jo, Yo-Na,Rho, Young-Soo,Seo, Seong-Hoon,Jung, Jee-Chang,Chang, Sung-Goo,Lee, Kyoe-Heung,Lee, Joo-Han,Lee, Kyung-Tae 한국약제학회 1998 Journal of Pharmaceutical Investigation Vol.28 No.3

KHPC-002 $[(trans-l-diaminocyclohexane-bis-l,2(diphenylphosphinoethane)platinum)\;{\cdot}2NO_3]$ and $KHPC-006[(cis-diaminocyclohexane-bis-1,2(diphenylphosphinoethane)platinum)\;{\cdot}2NO_3]$ were synthesized as candidates for third platinum antitumor agent. Before their pharmacokinetic study, we optimized the analytical condition with HPLC and identified the major metabolites in the rat plasma. HPLC analysis by $C_{18}$ reverse-phase column showed that standard peak of both compounds appeared rapidly at around 1 minutes, whereas metabolites of KHPC-002 and KHPC-006 which were extracted from plasma after single I.V. administration in rats or incubation for 24 hr at $37^{\circ}C$ showed retention time of $10{\sim}11$ minutes. These metabolites were identified as the major compound by Matrix Associated Laser Deposition/Ionization (MALDI), which only lose the 2 molecules of $NO_3$. Based on these results, we suggest that the major metabolites of KHPC-002 and KHPC-006 were [trans-l-diamino-cyclohexane-bis-l,2(diphenylphosphinoethane)platinum] and [cis-diaminocyclohexane-bis-l.2(diphenylphosphinoethane)platinum], respectively.

골다공증(骨多孔症)에 관(關)한 문헌적(文獻的) 고찰(考察) -주로 최근(最近)의 한의학적(韓醫學的) 임상(臨床) 및 실험논문(實驗論文)을 중심(中心)으로

김종환,Kim Jong-Hwan 대한침구의학회 1998 대한침구의학회지 Vol.15 No.2

Osteopotosis is a disease characterized by reduced amount of bone mass leading to enhanced bone flagility. The number of patients with osteoporotic vertebral fracture is increasing and it is one of the leading causes of morbidity in the elderly and postmenopausal women. It is a condition in which bone mass decrease, causing bones to be more susceptible to fracture. A trivial trauma can easily cause one or more bones to break in a person with severe osteoporosis. So it is a major health problem. Pysicians and patients are concerned with the optimum approach to the treatment and prevention of osteoporosis. Until a recent date, many oriental medicine studies were performed to find the preventive and curative efficacy on the osteoporosis, which is differ from therapeutics of Western-medicine. The proper use of Herb-med and role of Accupuncture are issues that have generated major research efforts. This study was carried out to investigate evaluation of clinical and experimental study on the osteoporosis. So, these are to be mentioned in this paper.

고분자 기판위에 다층 구조의 박막형 보호층을 적용한 투습률 향상

김종환,한진우,김영환,서대식,Kim Jong-Hwan,Han Jin-Woo,Kim Young-Hwan,Seo Dae-Shik 한국전기전자재료학회 2006 전기전자재료학회논문지 Vol.19 No.3

In this paper, the inorganic-organic thin film encapsulation layer was newly adopted to protect the organic layer from moisture and oxygen. Using the electron beam, Sputter and Spin-Coater system, the various kinds of inorganic and organic thin-films were deposited onto the Ethylene Terephthalate(PET) and their interface properties between organic and inorganic layer were investigated. In this investigation, the SiON and Polyimide(PI) layer showed the most suitable properties. Under these conditions, the WVTR(water vapour transition rate) for PET can be reduced from level of $0.57\;g/m^2{\cdot}day$ (bare subtrate) to $1{\times}10^{-5}\;g/m^2{\cdot}day$ after application of a SiON and Polyimide layer. These results indicates that the SiON/PI/SiON/PI/PET barrier coatings have high potential for flexible organic light-emitting diode(OLED) applications.

CdTe QDs 용액 안정성의 장시간 유지지속을 위한 TGA(thioglycolic acid)의 첨가효과

김종환,김태희,구동건,기경범,최원규,한경석,류봉기,Kim, Jong-Hwan,Kim, Tae-Hee,Gwoo, Dong-Gun,Kee, Kyung-Bum,Choi, Won-Gyu,Han, Kung-Seok,Ryu, Bong-Ki 한국재료학회 2012 한국재료학회지 Vol.22 No.9

This paper focuses on the after synthesis of CdTe quantum dots(QDs) in aqueous solution. CdTe nanoparticles were prepared in aqueous solution using mercaptocarboxylic acid or thioglycolic acid(TGA) as stabilizing agents. QDs emit light smaller than the nano size. The contents of the mercaptocarboxylic acid, and a kind of raw material, were revealed for a period of time. We succeeded in synthesizing a very high quality QDs solution; we discussed how to make QDs better and to keep them stabilized. TGA is known as one of the best stabilizing agents. Many papers have mentioned that TGA is a good stabilizing agent. We dramatically confirmed the state of QDs after the experiments. The QDs solution can be influenced by several factors. Different content of TGA can influence the stability of the CdTe solution. Most papers deal with the synthesis of CdTe, so we decided to discuss the after synthesis process for the stability of the CdTe solution.

Geochemistry and Genesis of the Guryonsan(Ogcheon) Uraniferous Back Slate

김종환,Kim, Jong Hwan The Korean Society of Economic and Environmental G 1989 자원환경지질 Vol.22 No.1

구룡산(九龍山)(또는 옥천(沃川)) 함(含)우라늄 흑연질점판암(黑鉛質粘板岩)은 옥천대(沃川帶) 서북부(西北部)에 따라 증상(層狀) 또는 부딘상(狀)으로 90km이상(以上) 연장(延長) 분포(分布)한다. 함(含)우라늄점판암(粘板岩)의 오토레디오그라프에 나타나는 퇴적(堆積), 속성(續成), 변성구조(變成構造)는 우라늄과 동시퇴적물(同時堆積物)로서 속성작용과정(續成作用過程)에서 전혀 이동(移動)하지 않고 황성변성(廣域變成) 초기(初期)에 제자리에서 미립(微粒)우라니나이트로 재결정(再結晶)하였음을 보여준다. 동시(同時)에 유기물(有機物)은 미세환장흑연(微細環狀黑鉛)으로 되었다. 라미나구조(構造)의 발달(發達)과 평균(平均) 19.64% C, 2.32% S의 함유(含有)는 함(含)우라늄흑니(黑泥) 퇴적(堆積)의 일반조건(一般條件)으로서의 극(極)히 낮은 퇴적화(堆積比), 고유기물함유(高有機物含有), 염기성황경등을 충족(充足)하였으며 Th/U가 0.07로서 해수원(海水源)임을 뜻한다. 지역별(地域別) CaO, $P_2O_5$의 평균치(平均値)가 매우좁은 범위(範圍)의 일정치(一定値)이며 높은 CaO 평균치(平均値)를 나타내어 전퇴적(全堆積)분지를 통(通)하여 동일(同一) pH(7.8-8.0)조건(條件)의 환경(環境)에서 퇴적(堆積)하였음을 나타낸다. 함(含)우라늄점판암(粘板岩)은 같은 성인(成因)의 타산장(他産狀)에 비(比)하여 미량원소(微量元素) 부화도(富化度)가 매우 높다. 고부화(高富化)의 중요(重要)한 원인(原因)으로서 미량원소(微量元素)의 소스(source)인 해수(海水)의 주기적(週期的) 교체(交替)가 요구(要求)되는데 사이크릭퇴적구조(堆積構造)는 그러한 현상(現象)을 뒷받침하여 준다. 흑니(黑泥)의 성인별(成因別) 구성광물(構成鑛物)과 원소(元素)의 수반관계(隨伴關係)에서 쇄설성광물(鑛物)에는 Si, Al, K, Na, Ti, Zr, Th, Be, B, Li, 유기물(有機物)후락숀에, U, Ni, Cu, Co, Zn, Ag, Mo, Pb, Sn, Cd, S, Fe, V, Cr, Y, 탄산염광물(炭酸鹽鑛物)에 Ca, Mg, Mn, P, Ba가 높은 상관(相關)을 나타낸다. 유기물(有機物)의 우라늄고정심전능력(固定沈澱能力)에 있어 사프로페릭(Sapropelic)형(型)보다 휴믹(Humic)형(型)에서 더 높다. 육성식물(陸性植物)의 분해물(分解物)인 휴무스(Humus)는 고대성(古生代) 중기(中期)에 출현(出現)한다. 우라늄 함유(含有) 흑니(黑泥)는 이 시대(時代)의 형성물(形成物)로서 이런 형(型)의 광상(鑛床)은 생물상(生物相)의 진화(進化)에 규제(規制)된 광화작용(鑛化作用)의 산물(産物)이다. Geochemical characteristics of the Guryongsan (Ogcheon) uraniferous black slate show that this is an analogue to the conventional Chattanooga and Alum shales in occurrences. Whereas, its highest enrichment ratio in metals including uranium, among others, is explained by the cyclic sedimentation of the black muds and quartz-rich silts, and the uniform depositional condition with some what higher pH condition compared to the conditions of the known occurrences. The cyclic sedimentation, caused by the periodic open and close of the silled basin, has brought about the flush-out) of the uranium depleted water and the recharge with the new metal-rich sea water, which consequently contributed to the high concentration of metals in mud. The metal-rich marine black muds, which mostly occur in the early to middle Palaeozoic times, is attributed by the geologic conditions which related to the atmospheric oxygen contents, and these are scarcely met in the late Precambrian and/or with the onset of Palaeozoic era in the geologic evolution of the earth.

New Aggregation Algorithm for Tandem queue with Finite Buffers

김종환,Hur, Sung Kwan,徐承祿 大邱大學校附設 基礎科學硏究所 1991 基礎科學硏究 Vol.8 No.-

We consider a two-stage fmite tandem queueing system with Poisson arrivals and negative exponential service times. The customer who has completed his service at the first station has to go directlty to the second station. If the queue of the second station is full at the moment of the service completion of the customer at the first station, then the customer receives, another service at the first station. This is repeated until the customer completes a service at the first station at the moment that the second station is not fulL The problem of calculating the steady-state probabilities of this queueing system by the ordinary balance equations is time consuming. We develop an efficient algorithm to obtain the steady-state probabilities that utilize the two-way state aggregation techniques.

메타데이터 레지스트리 기반의 분산 정보 통합 시스템 설계 및 구현

김종환,박혜숙,문창주,백두권,Kim, Jong-Hwan,Park, Hea-Sook,Moon, Chang-Joo,Baik, Doo-Kwon 한국정보처리학회 2003 정보처리학회논문지D Vol.10 No.2

중개기 기반 정보 통합 시스템은 서로 다른 지역 정보 시스템의 유연한 통합을 지원하나, 질의 처리시 최적화 측면과 지역 스키마 정보에 관한 메타데이터 표준화 측면에는 그리 큰 비중을 두지 않았다. 이러한 점을 개선하기 위해 제안된 분산 정보 통합 시스템은 질의 처리시 최적화 측면을 위해 질의 캐싱을 사용하며, 지역 스키마 정보에 관한 메타데이터 표준화 측면을 위해 ISO/IEC 11179 기반의 메타데이터 레지스트리를 사용한다. 이 시스템은 분산된 이기종의 비즈니스 정보 시스템들을 논리적으로 통합하여 사용자가 필요로 하는 통합된 정보를 웹 기반으로 제공한다. 이러한 시스템을 시스템 재사용성의 향상과 유지보수의 용이함을 위해 계층적 패턴을 사용하여 3계층 표현 방식 아키텍처로 표현하였고, 3계층 아키텍처의 핵심 요소들의 기능성과 흐름을 효과적으로 표현하기 위하여 UML 방법론을 확장한 EPEM 방법론을 이용하여 설계하였다. 또한 제안한 시스템의 구체적인 한 예로서, 공급망 관리 도메인에 적용하여 웹 기반으로 구현하였다. 따라서 분산 정보 통합 시스템은 질의 처리 속도 향상을 위해 질의 함수 관리기와 질의 함수 저장소를 통하여 질의 캐싱 기능을 제공하였고, 의미 이질성 해결을 위해 ISO/IEC 11179 기반의 메타데이터 레지스트리와 스키마 레파지토리를 이용함으로써 스키마 이질성과 데이터 이질성을 해결하였다. The mediator-based system integrates heterogeneous information systems with the flexible manner. But it does not give much attention on the query optimization issues, especially for the query reusing. The other thing is that it does not use standardized metadata for schema matching. To improve this two issues, we propose mediator-based Distributed Information Integration System (DIIS) which uses query caching regarding performance and uses ISO/IEC 11179 metadata registry in terms of standardization. The DIIS is designed to provide decision-making support, which logically integrates the distributed heterogeneous business information systems based on the Web environment. We designed the system in the aspect of three-layer expression formula architecture using the layered pattern to improve the system reusability and to facilitate the system maintenance. The functionality and flow of core components of three-layer architecture are expressed in terms of process line diagrams and assembly line diagrams of Eriksson Penker Extension Model (EPEM), a methodology of an extension of UML. For the implementation, Supply Chain Management (SCM) domain is used. And we used the Web-based environment for user interface. The DIIS supports functions of query caching and query reusability through Query Function Manager (QFM) and Query Function Repository (QFR) such that it enhances the query processing speed and query reusability by caching the frequently used queries and optimizing the query cost. The DIIS solves the diverse heterogeneity problems by mapping MetaData Registry (MDR) based on ISO/IEC 11179 and Schema Repository (SCR).

핵연료 자원개발과 그 전망

김종환,Kim, Jong-Hwan 한국과학기술단체총연합회 1981 과학과 기술 Vol.14 No.7

Porous Resorbable Calcium Carbonate와 Porous Replamireform Hydroxyapatite가 성견치주질환 이환 발치와내 이식된 치근과 발치와 치조골 재생에 미치는 영향

김종환,최성호,Kim, Chong-Kwan,Choi, Seong-Ho 대한치주과학회 1996 Journal of Periodontal & Implant Science Vol.26 No.2

Regeneration of the periodontal tissue destroyed by periodontal disease is one of the final goals of periodontal therapy. In the past few years, periodontists have used various alloplastic grafting materials in an attempt to regenerate bone lost from periodontal disease. These materials have used widely because they have shown to be nontoxic, biologically compatible with surrounding host tissue and chemically similar to bone. The purpose of this study was to investigate the effect of Porous Resorbable Calcium Carbonate and Porous Replamineform Hydroxyapatite on the regeneration of the alveolar bone and the healing of roots transplanted into the periodontally diseased extraction sockets of dogs. The experimental chronic periodontitis was induced by elastic ligatures on the 2nd and 3rd mandibular premolars of 2 adult dogs for 8weeks after surgically creating periodontal defect. The extracted root were split in half along the long-axis, and the extend of plaque exposure was marked on the root surfaces with burs. The roots were inserted in extraction sockets with Porous Resorbable Calcium Carbonate(PRCC) in left side and with Porous Replaminefrom Hydroxyapatite(PRH) in right side. The flaps were sutured to cover the sockets completely. The animals were sacrificed after 12 weeks of healing, and the specimens were examined histologically. The results were as follows: 1. No inflammatory reactions were observed in either groups. 2. Hoot resorption was observed in both groups while the general outline of the roots were maintained. 3. PRCC was almost completely resorbed and replaced with new bone, while R.H.A. was not resorbed & remained encased in newly-formed C-T and alveolar bone. 4. PRH was encapsulated with alveolar bone which has been deposited from apical & lateral area of the sockets, while the coronal portion of the sockets were filled with C-T. 5. In both groups, the resorbed portions of the roots were replaced with new bone. These results suggest that either PRCC or PRH may not interfere with bone formation or healing in extraction sockets, and in some degree, retard the root resorption. Because the roots maintained in anatomy, we think that graft materials prevent the root resorption.

심상성(尋傷性) 좌창(?瘡)에 대(對)한 서시옥용산(西施玉容散)의 임상적(臨床的) 효능(效能)에 관(關)한 연구(硏究)

김종환,Kim, Jong-Hwan 대한한방내과학회 1995 大韓韓方內科學會誌 Vol.16 No.1