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청심연자탕으로 호전된 뇌경색을 동반한 심방세동 환자 치험 3례
김정철,오성원,송창훈,이슬희,정종진,김종윤,선승호,Kim, Jung-Chul,Oh, Sung-Won,Song, Chang-Hoon,Lee, Seul-hee,Jeong, Jong-Jin,Kim, Jong-Yun,Sun, Seung-Ho 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.3
Atrial fibrillation (AF) is a common arrhythmia that is a potent independent risk factor for stroke. The incidence of AF increases with age and most affected people have underlying cardiac disease. An aging society increases the incidence of AF patients. The case was designed to evaluate the improving effect of Chengsim Yeunja-tang (CYT) for atrial fibrillation (AF) with Cb-infarction patients. This patient was treated with CYT and had significant improvement in symptoms and change of EKG. -Heart rate decreased in patients with higher than normal heart rate -RV5+SV1 voltage decreased (LVH improved) -Arrhythmia remained steady. -Palpitation. chest discomfort, dyspnea, headache, dizziness diminished. Results suggest that CYT is an effective treatment for Taeumin AF patients.
고위험군 유두상 갑상선암 환자에 대한 방사성옥소 최대허용선량 측정법 및 치료법의 검증
김정철,윤정한,제갈영종,범희승<SUP>1<.SUP>,Jung Chul Kim,M.D.,Jung Han Yoon,M.D.,Young Jong Jaegal,M.D. and Hee Seung Bum,M.D.<SUP>1<.SUP> 대한갑상선-내분비외과학회 2002 The Koreran journal of Endocrine Surgery Vol.2 No.2
Purpose: Radioiodine (I-131) therapy is an effective modality to reduce both recurrence and mortality rates in differentiated thyroid cancer. Whether higher doses shows higher therapeutic responses was still debatable. The purpose of this study was to validate curve-fitting (CF) method measuring maximum permissible dose (MPD) by a biological dosimetry using metaphase analysis of peripheral blood lymphocytes. Methods: Therapeutic effects of MPD was also evaluated in 58 patients (49 females and 9 males, mean age 50⁑11 years) of papillary thyroid cancer. Among them 43 patients were treated with ≤7.4 GBq, while 15 patients with ≥9.25 GBq. The former was defined as low-dose group, and the latter high-dose group. Therapeutic response was defined as complete response when complete disappearance of lesions on follow-up I-131 scan and undetectable serum thyroglobulin levels were found. Statistical comparison between groups were done using chi-square test. P value less than 0.05 was regarded as statistically significant. Results: MPD measured by CF method using tracer and therapeutic doses were 13.3⁑1.9 and 13.8⁑2.1 GBq, respectively (P=0.20). They showed a significant correlation (r=0.8, P<0.0001). Exposed doses to blood measured by CF and biological methods were 1.54⁑0.03 and 1.78⁑0.03 Gy (P=0.01). They also showed a significant correlation (r=0.86, P=0.01). High-dose group showed a significantly higher rate of complete response (12/15, 80%) as compared to the low-dose group (22/43, 51.2%) (P=0.05). While occurrence of side effects was not different between two groups (40% vs. 30.2%, P=0.46). Conclusions: measurement of MPD using CF method is reliable, and the high-dose I-131 therapy using MPD gains significantly higher therapeutic effects as compared with low-dose therapy. (Korean J Endocrine Surg 2002;2:97-104)
김정철(Kim Jung-Chul),김대광(Kim Dea-Kwang),김봉철(Kim Bong-Chul),박영호(Park Yeong-Ho),최종묵(Choi Jong-Mook) 한국철도학회 2007 한국철도학회 학술발표대회논문집 Vol.- No.-
The traction motor for High Speed Train is being required reliability and stability for high-speed operation. And also required low noise level, high performance, compact size owing to the space and weight limitation for attaching to train, etc. As a result of requiring the low noise level and high power capacity, it is adopted forced-air-ventilation insead of self-ventilation that is generally used on electric multiple unit. Traction motor is cooled by cooling air through the air-ventilation hole. When the traction motor is operated with forced-air-ventilation, there is some abnormal noise in the specific RPM. This paper is dealing with the method to reduce the resonance phenomena by adopting the rotor blade.
김호현(Ho Hyun Kim),성진식(Jin Sik Sung),허영회(Young Hoe Hur),고양석(Yang Seok Koh),김정철(Jong Chul Kim),조철균(Chol Kyoon Cho),김현종(Hyun Jong Kim) 한국간담췌외과학회 2009 한국간담췌외과학회지 Vol.13 No.3
Background : An increasing number of small prospective studies have been published, since the first report of laparoscopic liver resection by Gagner et al. in 1992. They have shown encouraging results for the feasibility and safety of the procedure. This paper provides a retrospective analysis of a single center"s experience with elective laparoscopic liver resections. Methods : We did a retrospective study on laparoscopic liver resections performed from July 2005 to April 2009, undertaken in 34 patients with preoperative diagnosis of a benign lesion(7 cases, 20.6%), hepatocellular carcinoma in absence of complicated cirrhosis (18 cases, 52.9%), or liver metastasis (9 cases, 26.4%). The mean tumor size was 2.63±1.57 cm(range 0.55-7.5) Results : We carried out 15 wedge resections(44.1%), 3 right hemi-hepatectomies(8/8%), 4 left hemi-hepatectomies(11.8%), 5 liver segmentectomies(14.7%), 7 left lateral sectionectomies(20.6%). The average duration of an operation was 175.00±129.12 minutes. There were 6 patients (15%) in which a conversion to laparotomy was required none of the conversions occurred under emergency situations. Intraoperative transfusion was required for 5 patients(14.7%). Postoperative complications developed in 2 patients (5.8%)(1 intraabdominal abscess, 1 bile leakage). There were no deaths and no reoperations for complications. The mean postoperative hospital stay was 9.9 days. Conclusion : Our experience shows that laparoscopic liver resections, including major hepatectomies, are feasible and safe. Nonetheless, a prospective randomization study with a greater number of cases and longer follow-up is needed before laparoscopic liver resection can be regarded as the gold-standard approach for hepatic lesions.
김정철(Jung Chul Kim),윤정한(Jung Han Yoon),제갈영종(Young Jong Jegal) 대한두경부종양학회 1994 대한두경부 종양학회지 Vol.10 No.2
Proliferating cell nuclear antgen(PCNA) plays an important role in DNA synthesis in nucleoli and is highly conserved non-histone nuclear protein composed of 261 amino acid. and is considered to correlated with the cells proliferative state, because it is synthesized particulary during the proliferative period of late Gland S-phase. Therefore, PCNA index meaningfully increases in the active or proliferative kinetic cells. By the use of recently developed monoclonal antibodies against PCNA, the immunohistochemical staining methods can make possible. These staining methods are the useful and productive one for ascertaining the cell's proliferating abillity. Moreover, immunohistochemical staining method with a antiPCNA antibody has particulrar advantages as follows. By means of these methods, we can stain the tissue that was already fixed in formalin or paraffin wax. We can see with naked eye that which cell is, where is differentiated through a microscope. Lastly, it maintains the whole tissue architecture and makes a search for the correlation. As we have seen above, the immunohistochemical staining methods for PCNA have been studied as an impotant factor that can find the cell proliferative kinetics in malignancy and biologic behavior of tumors. To investigate of the proliferative activity in thyroid nodule, Authors evaluated cell proliferative activity by immunostaing for PNCA in 45 pathologically confirmed solitary thyroid nodule. The results were as follows. 1) The benign nodules were 25 cases(Adenomatous Goiter: 20 cases, Follicular adenoma: 5 cases) and malignant nodules were 20 cases(Papillary Ca : 14 cases, Follicular Ca : 4 cases, Anaplastic Ca : 2 cases). 2) The Most prevalent age groups were 4th decade(11 cases), and the next group was 5th decade. 3) The average PCNA labelling indices were as follows. Adenomatous goiter(I6.9%), Follicular adenoma(37.6%), papillary Ca(26.3%), Follicular Ca(8.8%) and Anaplastic Ca(86.7%). There were no significant differences in benign(20.4) and malignant nodules (28.8%) except anaplastic Ca(p=0.3226). 4) When the average tumor size 2cm in papillary Ca, the PCNA indices were 26.0% (below 2cm) : 26.6% (above 2cm) (p=0.9642). The PCNA incidies were 23.9% (with lymphatic spread) : 28.7% (without lymphatic spread) (p=0.7056). There were no signlficant differences in the above cases. In conclusion, there were no significant differences in cell proliferative activity by staining for PCNA between benign and malignat nodules except anaplastic Ca.